CTRF Leadership Meeting
description
Transcript of CTRF Leadership Meeting
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CTRF Leadership Meeting
February 4, 2002
Institutional Partners
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Develop Infrastructure and Intellectual Property that
Enhances the Competitiveness of the Partners for Clinical and
Extramural Funds
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Evaluate gene expression (and genetic changes) in human brain, ovarian, breast and hematopoetic cancers
Link gene expression (and genetic changes) to clinical findings and clinical laboratory findings (including histopathological diagnoses) in a common database
Evaluate linked data using bioinformatics
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ChandhokeGrant
ChristensenFryxell
Jamison
Torr (Central Admin)GinderGarrettBuck
Guiseppe-ElieAbraham
Cooper
Year 1 Year 1 Year 1
$325,000 $582,000 $93,000
Total (3 yrs) Total (3 yrs) Total (3 yrs)
$975,000 $1,734,603 $290,397
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CTRF CG Administrative Assistant (Jo Ann Breaux) will monitor VCU ledger 5 and cost share accounts.
Plan is to create regular feedback to project PIs in future.
Cost share expenditures not paid from cost share linked ledger 4 account must be documented using ‘In Kind/3rd Party Cost Share form’ obtained from Margie Booker’s office.
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• Due 12/31/01• Submitted
12/28/01• Sections
– Purpose– Background– Research Plan
• Infrastructure Development– Progress Report– Specific Reportables
CTRF
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BenignBenign (not growing)
vs.BenignBenign
(not growing)
vs. BenignBenign (growing)
vs. CancerCancer (growing)
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Figure 5: Example GeneChip Result(DNA Chip)
Figure 6:Analysis: Total genes probed: ~12,500Expressed: ~4,500Not expressed: ~8,000
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Figure 7: An example of a spotted DNA microarray with two-color detection of hybridization of probe (surface) with target (sample). The two sectors of 16 x 20 elements is shown following hybridization with two differentially labeled cDNA preparations, Cy3 (pseudocolored green) and Cy5 (pseudocolored red). The overlaying of the green and red images produces the image shown. The hue of each spot, ranging from green to red, indicates the relative expression level for the gene specific for each spot. (Image courtesy Packard Biochip Technologies).
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UI-R-E1-fd-b-03-0-UI3.34 fold increaseMyogenic regulatoryfactor (MyoD) gene
UI-R-A1-ee-d-06-0-UI2.8 fold increaseSpongiotrophoblastspecific protein (SSP)
Figure 9: Over two fold increase in gene expression
Figure 8: H4IIE cells exposed to 10g/ml JP8 Jet fuel over 2 hours.
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Establish Focus Groups to address each of the basic tasks.
Each Focus Group to consist of professionals associated with the CTRF Project with special expertise or knowledge in one or more areas required to address basic tasks.
Structure work within Focus Groups to deal with interrelatedness of basic tasks.
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Tissue Bank Clinical and Pathology Laboratory
Data Database Design Data Analysis Quality Assurance in Microarray
Analysis (Chip Fabrication - proposed)
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Focus Group Leaders
GMU
G e rald in e G ran t ( G M U )S u ha il N as im ( V C U )B a rr ie C o o k ( I n o va)
Tissue Bank
L yn ne P en b e rth y (V C U )S u ha il N as im ( V C U )
J a m e s C o op e r ( I n o va)J a m e s B u rge s s ( I no va)
B a rr ie C o o k ( I n o va)
C linP ath
C u rtis J am is on ( G M U )L yn ne P en b e rth y (V C U )
G re g M ille r (V C U )M ike S he ride n ( I no va)
D B D esign
V ika s C h an d h oke ( G M U )G re g B u ck ( V C U )
D ataA nalysis
A la n C h r is ten s en ( G M U )A n d re a F e rre ira - G o n z ale z (V C U )
Q A / LQ C
VCU I nova
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• Tissue Acquisition System (TAS) Protocol Completed
• Submitted to MCC Protocol Review & Monitoring Comm
• Contents
– Tissue Handling
• residual sample
• obtained after pathology review
– IC - Obtain prior to & following surgery
– Primary Data Collection
• First Tissue Bank Staff member hired.
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Establish standing weekly
or biweekly meeting dates
and times
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CG-TISBK: Tissue Bank CG-CLNDT: Clinical and Pathology Data CG-DBDSN: Database Design CG-ANLDT: Analyze Data (Data Analysis) CG-QAQC: QAQC CG-LDRPI: Focus Group Leaders and PIs CG-MEMBS: All Members
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Address messages to: [email protected]
Unsubscribe to the listserv by submitting a message with the words SIGNOFF listname to: [email protected]
Subscribe to the listserv by asking the PI with whom you work to submit your name and E-mail address to the Program Director (C.Garrett)
USE the listserv(s) to inform members of your activity or to seek advice from the members.
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Intellectual property reporting - licenses, patents, etc
Publications
New applications identified - CTRF Administrative office
will search for new funding opportunities (SPIN)
will collect CVs, other support, facilities, interest documents
goal - 4 - 8 million in d.c. from CTRF CG Project
Any other discoveries
Federal money leveraged
Private research money leveraged
Advancement of technology and economic development in VA
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Old Business
New Business
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MondayMarch 4, 20029:30 am
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