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Cosa E’ Il Metabolismo Osseo?web.mit.edu/asabatin/www/Med/SMC1/20141020-Brandi...Oct 20, 2014 ·...
Transcript of Cosa E’ Il Metabolismo Osseo?web.mit.edu/asabatin/www/Med/SMC1/20141020-Brandi...Oct 20, 2014 ·...
Cosa E’ Il Metabolismo
Osseo?
SISTEMA DI OMEOSTASI DEL RICAMBIO CALCICO
INTESTINO OSSO1000 Gm1.0 Gm
0.36
1
0.19
1.0 Gm
LEC
0.170 Gm
2
3
ESCREZIONE URINARIA
0.83 Gm
RIASSORBIMENTO OSSEO
Gli Osteoclasti
LA FORMAZIONE OSSEA
Gli Osteoblasti
Mechanisms of osteoclastogenesis
and osteoclastic bone resorption
/
OSTEOCYTES AS MULTIFUNCTIONAL CELLS
Osteocyte Conversion of Mechanical Strain into Biochemical Signals
Osteocyte Modification of Their Microenvironment
Osteocytes as Regulators of Mineralization and Phosphate and
Calcium Homeostasis
Osteocyte Can Move
Functional syncytium comprising osteocytes, osteoblasts, bone
marrow stromal cells, and endothelial cells
Adapted from:JCI 104:1363, 1999
Mechanical strains Hormonal signals
Osteocytes Osteoblasts
Bone marrow
cellsEndothelial
cells
SOST and Wnt
SOST is a homolog of WISE, which binds to LRP-6. SOST binds to LRP-5 which is a co-
receptor in the Wnt-signalling pathway. Thus, SOST inhibits Wnt-signalling pathway,
similar to Dkk inhibition.
La Mineralizzazione