CONTENTS OF VOLUME 18

NUMBER 1, JULY 1980

G. BARBIN, J. M. PALACIOS, E. RODERGAS, J. C. SCHWARTZ AND M. GAR-BARG. Characterization of the High-Affinity Binding Sites of [3H]Histamine in RatBrain 1

PATRICK KITABGI, CLAUDINE POUSTIS, CLAUDE GRANIER, JURPHAAS VAN RIETSCHOTEN,JEAN RIVIER, JEAN-LOUIS MORGAT AND PIERRE FREYCHET. Neurotensin Binding toExtraneural and Neural Receptors: Comparison with Biological Activity and Structure-Activity Relationships 11

GILLES WAKSMAN, JEAN-PIERRE CHANGEUX AND BERNARD P. ROQUES. Structural Re-quirements for Agonist and Noncompetitive Blocking Action of Acyicholine Derivativeson Electrophorus electricus Electroplaque 20

CHARLES R. MANTIONE AND ISRAEL HANIN. Further Characterization of Human RedBlood Cell Membrane Cholinergic Receptors 28

GEORGE TOMLINSON, BULENT MUTUS AND IAN MCLENNAN. Modulation of Acetyicholin-esterase Activity by Peripheral Site Ligands 33

ALAN R. P. PATERSON, EDA Y. LAU, EWA DAHLIG AND CAROL E. CASS. A Common Basisfor Inhibition of Nucleoside Transport by Dipyridamole and Nitrobenzylthiomosme? . 40

SUMI0 SHIMA, Y0SHIK0 KAWASHIMA, MASANAO HIiw AND Muuo ASAKURA, with thetechnical assistance of HIR08HI KOUYAMA. Effects of Androgens on Lsoproterenol-Sensitive Adenylate Cyclase System of the Rat Prostate 45

ELIZABETH A. DUELL. Adenosme-Induced Alterations in the Adenosine 3’:5’-Monophos-phate Levels in Mammalian Epidermis 49

WU-HSIUNG HUANG AND AMIR ASKARI. Ouabain-Induced Changes in the Tertiary andthe Quaternary Conformations of (Na� + K’)-Activated Adenosme Triphosphatase . . 53

GEORGINA M. NEMECEK, JACK N. WELLS AND REGINALD W. BUTCHER. Inhibition ofFibroblast Cyclic AMP Escape and Cyclic Nucleotide Phosphodiesterase Activities byXanthines 57

JOHN N. KooNTz AND WESLEY D. WICKS. Cytotoxic Effects of Two Novel 8-SubstitutedCyclic Nucleotide Derivatives in Cultured Rat Hepatoma Cells 65

J. ADOLFO GARCIA-SAINZ AND JOHN N. FAIN. Effect of Adrenergic Amines on Phospha-

tidylinositol Labeling and Glycogen Synthase Activity in Fat Cells from Euthyroid andHypothyroid Rats 72

MICHAEL R. HANLEY, C. M. LEE, LYNNE M. JONES AND ROBERT H. MICHELL. SimilarEffects of Substance P and Related Peptides on Salivation and on Phosphatidylinositol

Turnover in Rat Salivary Glands 78

KAM-YEE Y. PANG, LEON M. BRASWELL, LARRY CHANG, TOBY J. SOMMER AND KEITH W.MILLER. The Perturbation of Lipid Bilayers by General Anesthetics: A QuantitativeTest of the Disordered Lipid Hypothesis 84

W. G. WAGGONER, JOHN MCDERMED AND H. J. LEIGHTON. Presynaptic Regulation ofTyrosine Hydroxylase Activity in Rat Striatal Synaptosomes by Dopamine Analogs . 91

DAVID S. DUCH, MARK P. EDELSTEIN AND CHARLES A. NICHOL. Inhibition of Histamine-Metabolizing Enzymes and Elevation of Histamine Levels in Tissues by Lipid-SolubleAnticancer Folate Antagonists 100

EWAN J. T. CHRYSTAL, RONALD L. KOCH AND PETER GOLDMAN. Metabolites from the

Reduction of Metromdazole by Xanthine Oxidase 105

JOYCE A. ARMSTRONG, GERALD S. MARKS AND PAUL W. ARMSTRONG. Absence of Metab-olite Formation during Nitroglycerin-Induced Relaxation of Isolated Blood Vessels . . . 112

PETER J. WIRTH, ERIK DYBING, CHRISTER VON BAHR AND SNORRI S. THORGEIRS-

SON. Mechanism of N-Hydroxyacetylarylamine Mutagenicity in the Salmonella Test

System: Metabolic Activation of N-Hydroxyphenacetin by Liver and Kidney Fractionsfrom Rat, Mouse, Hamster, and Man 117

PAUL R. ORTIZ DE MONTELLANO AND BRUCE A. MIC0. Destruction of Cytochrome P-450

by Ethylene and Other Olefins 128RADHEY S. GUPTA, JIRI J. KREPINSKY AND LOUIS SIMINOVITCH. Structural Determinants

Responsible for the Biological Activity of (-)-Emetine, (-)-Cryptopleurine, and (-)-Tylocrebrine: Structure-Activity Relationship among Related Compounds 136

SHORT COMMUNICATIONSI. R. NEILSON, M. A. SINGER AND G. S. MARKS. Association between the Membrane-

Fluidizing Properties and Porphyrin-Inducing Activity of Alfaxolone and RelatedSteroids 144

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AwNI M. SARRIF, HIR0SHI TONE, PETER V. DANENBERG AND CHARLES HEIDELBER-

GER. The Incorporation of Trifluorothymidine into Calf Thymus DNA in a Cell-FreeSystem Does Not Lead to Chain Termination 148

SUZANNE E. PATrON, GERALD M. ROSEN, ELMER J. RAUCKMAN, DOYLE G. GRAHAM,BARBARA SMALL AND DANIEL M. ZIEGLER. Hamster Hepatic Nuclear Mixed-FunctionAmine Oxidase: Location and Specific Activity 151

ERRATUMVolume 16, Number 3, November, 1979: Ingvar Sj#{246}holm, Bo Ekman, Anita Kober, Ingrid

Ljungstedt-P#{226}hlman, Birgitta Seiving, and Torgny Sj#{246}din,“Binding of Drugs to HumanSerum Albumin: XI. The Specificity of Three Binding Sites as Studied with AlbuminImmobilized in Microparticles,” pp. 767-777 157

NUMBER 2, SEPTEMBER 1980

MING-CHEN TSAI, EDSON X. ALBUQUERQUE, ROBERT S. ARONSTAM, AMIRA T. ELDEFRAWI,MOHYEE E. ELDEFRAWI AND DAVID J. TRIGGLE. Sites of Action of Phencyclidine. I.Effects on the Electrical Excitability and Chemosensitive Properties of the Neuromus-cular Junction of Skeletal Muscle 159

EDSON X. ALBUQUERQUE, MING-CHENG TSAI, ROBERT S. ARONSTAM, AMIRA T. ELDEFRAWI

AND MOHYEE E. ELDEFRAWI. Sites of Action of Phencycidine. II. Interaction withthe Ionic Channel of the Nicotinic Receptor 167

ROBERT S. ARONSTAM, MOHYEE E. ELDEFRAWI, AMIRA T. ELDEFRAWI, EDSON X. ALBU-

QUERQUE, KtM F. JIM AND DAVID J. TRIGGLE. Sites of Action of Phencycidine. III.Interactions with Muscarinic Receptors 179

SHIZUO YAMADA, HENRY I. YAMAMURA AND WILLIAM R. ROESKE. Alterations in Cardiac

Autonomic Receptors following 6-Hydroxydopamine Treatment in Rats 185

CRAIG C. MALBON. The Effects of Thyroid Status on the Modulation of Fat Cell /3-Adrenergic Receptor Agonist Affinity by Guanine Nucleotides 193

JAMES A. NATHANSON. /3-Adrenergic-Sensitive Adenylate Cyclase in Choroid Plexus:Properties and Cellular Localization 199

Y. C. KWOK AND G. J. MooRE. Affirnty Labeling of Angiotensin II Receptors in theIsolated Rat Uterus with a Photolabile Antagonist 210

ROBERT B. DICKSON, RAYMOND R. ATEN AND ARNOLD J. EISENFELD. Receptor-Bound

Estrogens and Their Metabolites in the Nucleus of the Isolated Rat Liver ParenchymalCell 215

HERMAN MEISNER. Binding of Anionic Ligands to Peptic Fragments of Bovine Serum

Albumin 224

HERMAN MEISNER, JAMES STAIR AND KENNETH NEET. Quantitative Assessment of the

Competitive Binding of Anionic Ligands to Albumin 230

ANITA KOBER, YLVA OLSS0N AND INGVAR SJOHOLM. Binding of Drugs to Human SerumAlbumin. XIV. The Theoretical Basis for the Interaction between Phenytoin andVaiproate 237

ETIENNE COUTURIER, ABDULLAH SENER, KOWLURU ANJANEYULU AND WILLY J. MA-LAISSE. Inhibition by Quinine of Insulin Release and Calcium lonophoresis 243

CHRISTOPHER LAU AND THEODORE A. SLOTKIN. Regulation of Ormthine Decarboxylase

Activity in the Developing Heart of Euthyroid or Hyperthyroid Rats 247

BEAT U. RAESS AND FRANK F. VINCENZI. Calmodulin Activation of Red Blood Cell (Ca2�+ Mg�i-ATPase and Its Antagonism by Phenothiazines 253

DHIRENDRA L. NANDI AND GEORGE T. OKITA. Effects ofSodium Iodide, Lithium Bromide,and Deoxycholate on Dissociation of [3H]Ouabain-Na,K-ATPase Complex during En-zyme Isolation 259

ROSA H. HUANG AND ROBERT FAULKNER. Lipid-Protein Interactions in the MultipleForms of Monoamine Oxidases: Lipases as Probes Using Purified Intact Rat BrainMitochondria 267

PAUL L. CHELLO, FRANCIS M. SIROTNAK AND DIANE M. DORICK. Alterations in theKinetics of Methotrexate Transport during Growth of L1210 Murine Leukemia Cellsin Culture 274

ROBERT C. JACKSON. Modulation of Methotrexate Toxicity by Thymidine: Sequence-Dependent Biochemical Effects 281

RANDALL C. WILLIS, ROLAND K. ROBINS AND J. EDWIN SEEGMILLER. An in Vivo and inVitro Evaluation of 1-$-D-Ribofuranosyl-1,2,4-tnazole-3-carboxamidine: An Inhibitor ofHuman Lymphoblast Purine Nucleoside Phosphorylase 287

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HIRA L. GURT00. Genetic Expressions of Afiatoxin B1 Metabolism: Effects of 3-Methyl-cholanthrene and 2,3,7,8-Tetrachlorodibenzo-p-dioxin on the Metabolism of AfiatoxinsB1 and B2 by Various Inbred Strains of Mice 296

YOSHITSUGI TAIRA, PHILLIP GREENSPAN, GORDON F. KAPKE, JAN A. REDICK AND JEFFREYBARON. Effects of Phenobarbital, Pregnenolone-16a-Carbonitrile, and 3-Methylcho-lanthrene Pretreatments on the Distribution of NADPH-Cytochrome c (P-450) Reduc-tase within the Liver Lobule 304

JAMES W. TRACY, EDWARD H. FAIRCHILD, SAMUEL V. LUCAS AND LESLIE T. WEBSTER,JR. Isolation, Characterization, and Synthesis of an Immunoregulatory Metabolite of

Niridazole: 1-Thiocarbamoyl-2-Imidazolidinone 313

L. W. SCHEIBEL AND A. ADLER. Antimalarial Activity of Selected Aromatic Chelators . . 320

PAUL H. SATO. Synthesis of Ascorbic Acid in Guinea Pigs by an Implanted Dialysis BagContaining L-Gulonolactone Oxidase 326

SHORT COMMUNICATIONVINCENZO BARONE, FRANCESCO LELJ AND NIN0 RUSSO. Conformational Analysis of N-

($-Acetoxyethyl)Pyridinium Ion: Comparisons with Acetyicholine 331

NUMBER 3, NOVEMBER 1980

E. M. BROWN, M. F. ATFIE, S. REEN, D. G. GARDNER, J. KEBABIAN AND G. D.AURBACH. Characterization of Dopaminergic Receptors in Dispersed Bovine Parathy-roid Cells 335

GREGORY A. WEILAND, KENNETH P. MINNEMAN AND PERRY B. MOLINOFF.Thermodynamics of Agonist and Antagonist Interactions with Mammalian f3-Adrener-gic Receptors 341

DE-MAW CHUANG, WILLIAM J. KINNIER, LEN FARBER AND ERMINI0 COSTA. A Biochem-ical Study of Receptor Internalization during /3-Adrenergic Receptor Desensitization inFrog Erythrocytes 348

JAMES N. DAVIS, EDWARD OLENDER, WENDY MAURY AND ROBERT MCDANIEL. a-Ad-renergic Regulation of Cholinergic Responses in Rat Parotid Acinar Cells 356

GEORGES VAUQUELIN AND MICHAEL E. MAGUIRE. Inactivation of /3-Adrenergic Receptorsby N-Ethyhnaleimide in 549 Lymphoma Cells. Agonist Induction of Functional Recep-tor Heterogeneity 362

ISA0 MORISHIMA, W. JOSEPH THOMPSON, G. ALAN R0BIS0N AND SAMUEL J. STRADA. Lossand Restoration of Sensitivity to Epinephrine in Cultured BHK Cells: Effect of Inhib-itors of RNA and Protein Synthesis 370

JOSEPH J. ERDOS AND MICHAEL E. MAGUIRE. Independent Desensitization of /3-Adrener-

gic Receptor-Regulated Magnesium Transport and Cyclic AMP Accumulation 379C. E. SPIVAK, B. WITKOP AND E. X. ALBUQUERQUE. Anatoxin-a: A Novel, Potent Agonist

at the Nicotinic Receptor 384

RUDIGER SCHULZ, MICHAEL WUSTER, HEINZ KRENSS, AND ALBERT HERZ. Lack of Cross-

Tolerance on Multiple Opiate Receptors in the Mouse Vas Deferens 395

RYUNG-SOON (SONG) KIM, FRANK S. LABELLA, HILDA ZUNZA, FEDERIKA ZUNZA, AND JOHNF. TEMPLETON. Progesterone Derivatives that Bind to the Digitalis Receptor: Struc-tare-Activity Relationships 402

EDWARD J. PAVLIK AND BENITA S. KATZENELLENBOGEN. The Stability of the Uterine

Estrogen Receptor when Complexed with Estrogens or Antiestrogens 406

CHARLES E. SPIVAK AND DERMOT B. TAYLOR. Ion Exchange between Agonists and

Inorganic Ions at the Acetyicholine Receptor of Torpedo californica 413

ANITA KOBER AND INGVAR SJOHOLM. The Binding Sites on Human Serum Albumin for

Some Nonsteroidal Antiinfiammatory Drugs 421

VINCENT E. GROPPI, JR. AND EDWARD T. BROWING. Norepinephrine-Dependent ProteinPhosphorylation in Intact C-6 Glioma Cells. Analysis by Two-Dimensional GelElectrophoresis 427

II�ZE DUCIS AND VICTOR DISTEFAN0. Evidence for a Serotonin Uptake System in IsolatedBovine Pinealocyte Suspensions 438

ILZE DUCIS AND VICTOR DISTEFANO. Characterization of Serotonin Uptake in IsolatedBovine Pinealocyte Suspensions 447

SHERYL BALDWIN, LEMONT B. KIER AND DONALD SHILLADY. Approximate MolecularPotentials of Mescaline Analogues in a Study of Similarities to 5-Hydroxy-tryptamine 455

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ALESSANDRO AGRESTI, FRANCA BUFFONI, JOYCE J. KAUFMAN AND C�iu.�oPETRONGOLO. Structure-Activity Relationships of Eseroline and Morphine: Ab InitioQuantum-Chemical Study of the Electrostatic Potential and of the Interaction Energywith Water 461

PER 0. SEGLEN AND PAUL B. GoiwoN. Effects of Lysosomotropic Monoamines, Diamines,Amino Alcohols, and Other Amino Compounds on Protein Degradation and ProteinSynthesis in Isolated Rat Hepatocytes 468

J. S. CHARNOCK, R. A GIBSON, E. J. MCMURCHIE AND J. K. RAISON. Changes in the

Fluidity of Myocardial Membranes during Hibernation: Relationship to Myocardial

Adenosinetriphosphatase Activity 476

ROBERT I. GLAZER AND KATHLEEN D. HARTMAN. Evidence that the Inhibitory Effect ofAdenosine, but Not Cordycepin, on the Methylation of Nuclear RNA is Mediated by S-Adenosyihomocysteine Hydrolase 483

JAN M. WOYNAROWSKI AND TERRY A. BEERMAN. Inhibition of DNA Replication in HeLa53 Cells by Macromomycin-I, an Antitumor Protein Antibiotic 491

SHU-JING C. WEI, BEATRICE P. CHEN AND JERRY M. RICE. Comparative Effects ofMethyl- and Ethylnitrosourea on DNA Directing Cell-Free DNA-Dependent Synthesisof/1-Galactosidase 494

RUSSELL T. KAWAHATA, CHARLES A. HOLMBERG, BENNIE I. OSBURN, LINDA F. CHUANGAND RONALD Y. CHUANG. Effect of 6-Mercaptopurine Ribonucleotides on DNA-Dependent RNA Polymerase Activity 503

PAUL J. PREIDECKER, KRISHNA C. AGRAWAL, ALAN C. SARTORELLI AND E. COLLEEN

MooRE. Effects of the Ferrous Chelate of 4-Methyl-5-Amino-1-FormylisoquinolineThiosemicarbazone (MAIQ-1) on the Kinetics of Reduction of CDP by RibonucleotideReductase of the Novikoff Tumor 507

SALVATORE J. CARADONNA AND YUNG-CHI CHENG. The Role of Deoxyuridine Triphos-phate Nucleotidohydrolase, Uracil-DNA Glycosylase, and DNA Polymerase a in theMetabolism of FUdR in Human Tumor Cells 513

WILLIAM R. GRECO AND MAIRE T. HAKALA. Biochemical Pharmacology of Lipophilic

Diaminopyrimidine Antifolates in Mouse and Human Cells in Vitro 521

CECILIA SCHELIN, ANDERS TUNEK, BENGT JERSTROM AND BENGT JERGIL. IrreversibleBinding of Isolated Beno[a]pyrene Metabolites to Specific Rat Liver MicrosomalProteins 529

G. B. CORCORAN, J. R. MITCHELL, Y. N. VAISHNAV AND E. C. HORNING. Evidence thatAcetaminophen and N-Hydroxyacetaminophen Form a Common Arylating Intermedi-ate, N-Acetyl-p-Benzoquinoneimine 536

LELAND W. K. CHUNG AND HAIYEN CHAO. Neonatal Imprinting and Hepatic CytochromeP-450. I. Comparison ofTestosterone Hydroxylation in a Reconstituted System betweenNeonatally Imprinted and Nonimprinted Rats 543

EDWARD BRESNICK, BRUCE HASSUK, PAUL LIBERATOR, WAYNE LEVIN AND PAUL E.THOMAS. Nucleolar Cytochrome P-450 550

C. ROLAND WOLF, WILLARD G. HARRELSON, JR., WOLFGANG M. NASTAINCZYK, RICHARD

M. PHILPOT, B. KALYANARAMAN AND RONALD P. MASON. Metabolism of Carbon

Tetrachioride in Hepatic Microsomes and Reconstituted Monooxygenase Systems andIts Relationship to Lipid Peroxidation 553

JAMES S. FELTON, JEANNE N. KETLEY, WILLIAM B. JAKOBY, ANTERO AITI0, JOHN R. BENDAND DANIEL W. NEBERT. Hepatic Glutathione Transferase Activity Induced byPolycycic Aromatic Compounds. Lack of Correlation with the Murine Ah Locus . . . . 559

HENG H. LIEM, URSULA MULLER-EBERHARD AND ERIC F. JOHNSON. Differential Induc-tion by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin of Multiple Forms of Rabbit MicrosomalCytochrome P-450: Evidence for Tissue Specificity 565

ALAN POLAND, IVAN MAK, EDWARD GLOVER, RODNEY J. BOATMAN, FRANK H. EBETINOAND ANDREW S. KENDE. 1,4-Bis[2-(3,5-Dicbloropyridyloxy)]Benzene, a PotentPhenobarbital-like Inducer of Microsomal Monooxygenase Activity 571

M. C. P0IRIER, G. M. WILLIAMS AND S. H. YUSPA. Effect of Culture Conditions, Cell Type,and Species of Origin on the Distribution of Acetylated and Deacetylated Deoxygua-nosine C-8 Adducts of N-Acetoxy-2-Acetylaminofluorene 581

SUZANNE E. PATTON, GERALD M. ROSEN AND ELMER J. RAUCKMAN. Superoxide Produc-tion by Purified Hamster Hepatic Nuclei 588

EDWARD PEREZ-REYES AND RONALD P. MASON. Electron Spin Resonance Study of theAutoxidation of 6-Aminodopamine 594

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DERMOT M. F. COOPER, CONSTANTINE L0ND0S AND MARTIN RODBELL. Adenosine Recep-tor-Mediated Inhibition of Rat Cerebral Cortical Adenylate Cyclase by a GTP-Depend-ent Process 598

PAUL R. ORTIZ DE MONTELLANO, KENT L. KUNZE AND BRUCE A. MIC0. Destruction ofCytochrome P-450 by Olefins: N-Alkylation of Prosthetic Heme 602

RONALD W. HoLZ. Correlation of the Effects of Bretylium, Guanethidine, and N,N-Diiso-propyl-N’-Isoamyl-N’-Diethylaminoethylurea (P-286) on the H� Electrochemical Gra-dient across the Chromaffin Granule Membrane and on Chromaffin Granule Function 606

AUTHOR INDEX FOR VOLUME 18 611

CUMULATIVE SUBJECT INDEX FOR VOLUMES 17-18 616

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Molecular Pharmacology Volume 18, Number 1, July 1980

CONTENTS

G. BARBIN, J. M. PALACIOS, E. RODERGAS, J. C. SCHWARTZ AND M. GAR-BARG. Characterization of the High-Affinity Binding Sites of [3H]Histamine in RatBrain . . . . . . . . . 1

PATRICK KITABGI, CLAUDINE PouS’rls, CLAUDE GRANIER, JURPHAAS VAN RIETSCHOTEN,JEAN RIVIER, JEAN-LOUIS MORGAT AND PIERRE FREYCHET. Neurotensin Binding toExtraneural and Neural Receptors: Comparison with Biological Activity and Structure-Activity Relationships . . . 11

GILLES WAKSMAN, JEAN-PIERRE CHANGEUX AND BERNARD P. ROQUES. Structural Re-quirements for Agonist and Noncompetitive Blocking Action of Acyicholine Derivativeson Electrophorus electricus Electroplaque . . . . 20

CHARLES R. MANTIONE AND ISRAEL HANIN. Further Characterization of Human RedBlood Cell Membrane Cholinergic Receptors . . . . 28

GEORGE T0MLINS0N, BULENT MUTUS AND IAN MCLENNAN. Modulation of Acetylcholin-esterase Activity by Peripheral Site Ligands . 33

ALAN R. P. PATERSON, EDA Y. LAU, EWA DAHLIG AND CAROL E. CASS. A Common Basisfor Inhibition of Nucleoside Transport by Dipyridamole and Nitrobenzylthioinosine? 40

SUMIO SHIMA, YO5HIK0 KAWASHIMA, MASANAO HIRAI AND MIKI0 ASAKURA, with thetechnical assistance of HIR0SHI KOUYAMA. Effects of Androgens on Isoproterenol-Sensitive Adenylate Cyclase System of the Rat Prostate 45

ELIZABETH A. DUELL. Adenosine-Induced Alterations in the Adenosine 3’:5’-Monophos-phate Levels in Mammalian Epidermis . . . . . . . 49

WU-HSIUNG HUANG AND AMIR ASKARI. Ouabain-Induced Changes in the Tertiary andthe Quaternary Conformations of (Na� + K�)-Activated Adenosine Triphosphatase 53

GEORGINA M. NEMECEK, JACK N. WELLS AND REGINALD W. BUTCHER. Inhibition ofFibroblast Cyclic AMP Escape and Cyclic Nucleotide Phosphodiesterase Activities byXanthines . . . . . 57

JOHN N. KooN’rZ AND WESLEY D. WICKS. Cytotoxic Effects of Two Novel 8-SubstitutedCyclic Nucleotide Derivatives in Cultured Rat Hepatoma Cells . . . . 65

J. AD0LF0 GARCIA-SAINZ AND JOHN N. FAIN. Effect of Adrenergic Amines on Phospha-tidylinositol Labeling and Glycogen Synthase Activity in Fat Cells from Euthyroid andHypothyroid Rats . . . . . . . . . . . . . . 72

MICHAEL R. HANLEY, C. M. LEE, LYNNE M. JONES AND ROBERT H. MICHELL. SimilarEffects of Substance P and Related Peptides on Salivation and on PhosphatidylinositolTurnover in Rat Salivary Glands 78

KAM-YEE Y. PANG, LEON M. BRASWELL, LARRY CHANG, TOBY J. SOMMER AND KEITH W.MILLER. The Perturbation of Lipid Bilayers by General Anesthetics: A QuantitativeTest of the Disordered Lipid Hypothesis 84

W. G. WAGGONER, JOHN MCDERMED AND H. J. LEIGHTON. Presynaptic Regulation ofTyrosine Hydroxylase Activity in Rat Striatal Synaptosomes by Dopamine Analogs 91

DAVID S. DUCH, MARK P. EDELSTEIN AND CHARLES A. NICHOL. Inhibition of Histamine-Metabolizing Enzymes and Elevation of Histamine Levels in Tissues by Lipid-SolubleAnticancer Folate Antagonists . . . . 100

EWAN J. T. CHRYSTAL, RONALD L. KOCH AND PETER GOLDMAN. Metabolites from the

Reduction of Metronidazole by Xanthine Oxidase 105

(continued)

Published bimonthly by Academic Press, Inc., 111 Fifth Avenue, New York, N.Y. 10003

1980: Volumes 17-18. Price per volume: $65.00 U.S.A.; $74.50 outside U.S.A.

All prices include postage and handling. -Information regarding personal subscription rates may be obtained by writing to the Publisher.

All correspondence and subocription orders should be addressed to the office of Publishers111 Fifth Avenue, New York, N.Y. 10003.

Send notices of change of address to the office of the Publishers at least 6-8 weeks in advance.

Please include both old and new addresses.

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Copyright © 1980 by The American Society for Pharmacology and Experimental Therapeutics

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CONTENTS (Cont’d)

JOYCE A. ARMSTRONG, GERALD S. MARKS AND PAUL W. ARMSTRONG. Absence of Metab-olite Formation during Nitroglycerin-Induced Relaxation of Isolated Blood Vessels . . . 112

PETER J. WIRTH, ERIK DYBING, CHRISTER VON BAHR AND SNORRI S. THORGEIRS-SON. Mechanism of N-Hydroxyacetylarylamine Mutagenicity in the Salmonella TestSystem: Metabolic Activation of N-Hydroxyphenacetin by Liver and Kidney Fractionsfrom Rat, Mouse, Hamster, and Man 117

PAUL R. ORTIZ DE MONTELLANO AND BRUCE A. MIC0. Destruction of Cytochrome P-450

by Ethylene and Other Olefins 128RADHEY S. GUPTA, JIRI J. KREPINSKY AND LOUIS SIMINOVITCH. Structural Determinants

Responsible for the Biological Activity of (-)-Emetine, (-)-Cryptopleurine, and (-)-Tylocrebrine: Structure-Activity Relationship among Related Compounds 136

SHORT COMMUNICATIONS

I. R. NEILSON, M. A. SINGER AND G. S. MARKS. Association between the Membrane-Fluidizing Properties and Porphyrin-Inducing Activity of Alfaxolone and Related

Steroids 144

AWNI M. SARRIF, HIR0SHI TONE, PETER V. DANENBERG AND CHARLES HEIDELBER-

GER. The Incorporation of Trifluorothymidine into Calf Thymus DNA in a Cell-FreeSystem Does Not Lead to Chain Termination 148

SUZANNE E. PATTON, GERALD M. ROSEN, ELMER J. RAUCKMAN, DOYLE G. GRAHAM,BARBARA SMALL AND DANIEL M. ZIEGLER. Hamster Hepatic Nuclear Mixed-FunctionAmine Oxidase: Location and Specific Activity 151

ERRATUMVolume 16, Number 3, November, 1979: Ingvar Sj#{246}holm, Bo Ekman, Anita Kober, Ingrid

Ljungstedt-P#{227}hlman, Birgitta Seiving, and Torgny Sj#{246}din,“Binding of Drugs to HumanSerum Albumin: XI. The Specificity of Three Binding Sites as Studied with AlbuminImmobilized in Microparticles,” pp. 767-777 157

Copyright © 1980 by The American Society for Pharmacology and Experiment Therapeutics

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No part of this publication may be reproduced or transmitted in any form or by any means, electronic

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1980 articles are the same as those shown for current articles.

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