PEPTIC ULCERS
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Transcript of PEPTIC ULCERS
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PEPTIC ULCERSGastroenterologyUniversity of PretoriaPretoria Academic HospitalObedy Mwantembe04 May, 2004
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Definition – Peptic Ulcer An ulcer in the
Lower oesophagus Stomach Duodenum Duodenum
Acute or Chronic
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Ulcer or Erosion Muscularis Mucosae Duodenal Ulcer
Oesophageal ulcers Small bowel ulcers
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Epideomiology Up to 10-12% in one’s life time
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Duodenal Ulcer Male:Female 5-2:1 90% H.pyroli
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Gastric Ulcer Male:Female 2:1 Up to 70% h. pyroli
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AETIOLOGY Helicobacter Pyroli
Age 12 nearly 100% Europe 30-40% DU – 90% GU – 70%
Non-Steroidal anti-inflammatory drugs (NSAIDs) Inhibit cyclo-oxygenase activity
Reduce formation of protective PGE
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AETIOLOGY Heredity
DU closer than GU especially if below 20y
Blood Group O Smoking
GU than DU Difficult healing
Stress ulcers
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AETIOLOGY Acid-pepsin and acid Vs Defensive factors (Gastric mucosal
barrier) No ulcer No acid (Pernicious
Anaemia) Too much acid – severe
ulcerations
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CHRONIC ULCER 90% in lesser curve within antrum
or at junction between body and antral mucosa (stomach)
Duodenal ulcers 1st part 50% anterior wall
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THE CLINIC Recurrent abdominal pain
Epigastrium Related to food Episodic
History a questionable indicator of the presence of an ulcer
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Topics of Discussion State the main ideas you’ll be
talking about
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Topic One Details about this topic Supporting information and
examples How it relates to your audience
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Topic Two Details about this topic Supporting information and
examples How it relates to your audience
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Topic Three Details about this topic Supporting information and
examples How it relates to your audience
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Real Life Give an example or real life
anecdote Sympathize with the audience’s
situation if appropriate
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What This Means Add a strong statement that
summarizes how you feel or think about this topic
Summarize key points you want your audience to remember
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Next Steps Summarize any actions required of
your audience Summarize any follow up action
items required of you