Cole - PDF

Connection, compassion, and the genome Evolution, the moral philosopher?

Steve W. Cole, Ph.D.

Lonely

Integrated

Social isolation

78 131

Inflammation

Immunoglobulin G1 production Type I interferon antiviral response

Cole et al., Genome Biology, 2007

Low SES Social loss / anticipated bereavement Post-traumatic stress Cancer diagnosis Social threat Loneliness Social instability Chronic stress Low social rank Caregiving for seriously ill Depression

Early life low SES

Cole et al., Proc National Acad Sci USA, 2011

Irwin & Cole, Nature Reviews Immunology, 2011

Lonely

Integrated

How not to live


How should we live?

What is the nature of true happiness?

Eudaimonic Hedonic

How often do you feel happy? How often do you feel satisfied?

Short Flourishing – Hedonic Life has direction and meaning? Grow and become a better person?

Short Flourishing – Eudaimonic How often do you feel sad? How often do you feel depressed?

CES-D

CESD

-‐3

-‐2

-‐1

0

1

2

3

Hedonic Eudaimonic

Eudaimonic

Hedonic

IL1A IL1B IL6 IL8 TNF PTGS1 PTGS2

IGJ IGLL1 IGLL3 CD19

GBP1 IFI16 IFI27 IFI27L1 IFI27L2 IFI30 IFI35 IFI44 IFI44L IFI6 IFIH1 IFIT1 IFIT1L IFIT2 IFIT3 IFIT5

IFITM1 IFITM2 IFITM3 IFITM4P IFITM5 IFNB1 IRF8 IRF2 IRF7 MX1 MX2 OAS1 OAS2 OAS3 OASL

Hedonic Eudaimonic

Hedonic

Eudaimonic

What is good?

What is bad?

Collaborators Barb Fredrickson & PEP Lab John Cacioppo, Louise Hawkley, Bob Rose Steve Suomi, Jim Heckman, Gabriella Conti Greg Miller, Edith Chen Susan Lutgendorf, Anil Sood John Sheridan, Nicole Powell John Capitanio, Erica Sloan Mike Irwin, Patti Ganz, Julie Bower Margaret Kemeny, Jerry Zack Teresa Seeman, Andrew Fuligni

Support HopeLab Foundation NCI CA116778, CA110793, CA109298 NIAID AI33259, AI36554, AI49135, AI52737 NIA AG107265, AG033590, AG34679 NIMH MH00820, MH15750 NCRR RR020645 NINR NR012899 MacArthur Foundation James Pendleton Charitable Trust Santa Fe Institute for Complex Systems Norman Cousins Center

Social instability

MR.31MR.44MR.43MR.41MR.55PR.47PR.40PR.37PR.35

IFIT1--- AMBPLOC719243LOC707854LOC707854---LOC720683------LOC719654LOC722730LOC715108IFIT2LOC695344--- ---LOC697200GBP1LOC693768LOC702381IFIT2LOC700208LOC695344IFITM3LOC708344------ MX1--- MNP1ALOC713715--- LOC698943---LOC696808LOC695344LOC702540LOC712753---LOC693427LOC710518---GBP1LOC700141CYP3A5LOC710740LOC705416------ ---GBP1LOC720006---GBP1GBP1---LOC574122LOC574146LOC710518LOC710518--- MAMU-DQB1GZMB--- ---LOC710518LOC714584BDKRB2LOC707116LOC713232GBP1--- ------TLR5LOC694847IRF7LOC705096LOC707359------ LOC713232--- --------- LOC716043---IFITM3--------- ------IFI27---MAMU-ALOC704850---LOC702540---LOC694699--- CD82---LOC693838LOC710740LOC705298ST3GAL4LILRBCLOC694225NKG7---LOC710350--- ---LOC695437 /// LOC705266---MX2--- LOC722130LOC708852LOC713485---LOC697235LOC701433---DYSFLOC714427------LOC717665IL15LOC695323LOC722305CLIC5LOC700653SP100LOC695560TKTL1LOC717218IRAK3SERPINA1LOC700486LOC704994LOC707236MX2LOC697235--- LOC693954--- MAMU-DQB1IL15LOC693567C1QASLC11A1--- LOC700993LOC694871--- ---SLC11A1--- POLR1DLOC693768LTB4RLOC695612LOC693954---LOC711291--- LOC694699LOC710706F2RL1LILRA2 /// LILRAB /// LILRAC /// LOC722780------ LOC708383---LOC716337---SERPINA1LOC722774------ ------LOC694225LOC695158LOC712977LOC718307GLULIGKV1-5--- LOC697656LOC705568LOC705670GBP1LOC716978LILRBC---LOC706221--- LOC712046LRP2LOC696824 /// LOC703106 /// LOC703892 /// LOC713723 /// LOC719483 /// LOC719702 /// LOC720309 /// LOC720330 /// LOC720342 /// LOC720369 /// LOC720696 /// LOC723284 /// LOC723473 /// MAMU-A /// MAMU-B /// MAMU-B18 /// MAMU-I---LOC694502------LOC694684--------- LOC695612TREM1--- LOC697718LOC711743SLC11A1------ LOC717799DDIT4--- ------PRDM1LOC693532LOC697835LOC705554WARSCOL15A1FOSL2FES---GSN LOC714968--- --------- LOC704216KLRF1LOC716161LOC710216KIR3DL12LOC716161LOC701759BIKLOC722305CD14LY96LOC701826LOC710267LILRABLOC698947------ LOC711743IFITM3--- LOC700632---CYTH4---LOC719654LOC695612------IGHG1 /// LOC711303------ LOC694871LOC713191APBB2---UPP1LOC701234ANXA3KLRC3LOC710375ITGA2BKLHL2--- ------LOC693532LRP2UPP1KLRC3---NOTCH4LOC712358LOC696549GADD45BKLRC3---EFHD2HMGCL---AOAHCCL5DDX58LOC715924---LOC714584---LOC574145--- LOC707687LOC709760--- TLR4---LOC698947GKLOC718993NCF1---LOC711743CYP3A5---LOC694225LOC699497LOC711746--- LOC719654LOC696050DAPP1SLC31A2LOC705061LOC696549LOC708852---LOC574146--------- LOC697977LOC711303---PLA2G7--- LOC722564LOC694240LOC712342LOC721138LOC715767NCF1LOC712466APBB2LOC574145---LOC693660--- ---LOC711743ATP5BLOC705700LPL LOC699236IDO1--- LOC717799SIGLEC5--- LOC695734LOC703083--- LOC711746GADD45BLOC711746LOC700215LOC710650LOC708602LOC705865--- LOC696345---LOC722311LOC697857------ MDM2------ LOC715516LOC707383DGKGLOC715071LOC710384LOC711079TNFRSF1BTNFSF13BLOC704355GPR87--- LOC694684---LOC703777LOC702406LOC695092--- ------LOC708948---LOC710986GPR153CTSD--- LOC701101LOC706221--- CTBP2 /// LOC705737LOC710864--- LOC714931LOC703028TLR6LOC708852------ LOC717811---LOC719412KIR2DL4 /// KIR3DH5GADD45BLOC701759------ LOC707033---SGSHLOC707336---LOC719595---MDM2LOC706642FPR2---TBX21LOC696060--- WARSGOT2--- ---RXRA--- LOC698683------ CLEC7ALOC719301LOC712466FFAR2---LTB4RSYKLOC717038---GADD45ATLR4------LOC574145---PTAFRSAT1LOC698953FGR--- LOC713191---LOC698917------ ---RRP22LOC703901LOC710909LOC721106LOC712342LOC704667LOC701759--- MSRALOC707395LOC699977RALBLOC703083LOC711784LOC712282LOC719260NCF1LOC698953--- ---IL15--- ------LOC713630LOC698947PSG2--- LOC715967DUSP5LOC693759LOC709790LOC710986LOC715767LOC719127LOC718868SHC2---LOC720016---LOC697235LOC698683SLC7A11---LOC713436EIF2S1CMASLOC713453---LOC700476LOC698247------ LOC700074---LOC717492LOC695219LOC711940--- ---CMAS--- ---LOC700365LOC654415LOC697652MSH2RAB11FIP2LOC707390--- MED6---LOC712712------NAALAD2LOC716189LOC698329--- TMPO---LOC693281---LOC715074LOC707873------ LOC698974LYZLOC704367------RCHY1---ADD3GYPA---CAPN2LOC710951GSTA1---LOC715410LOC696961--- ---LOC708226BIRC3LOC696772---LOC697490---MAP1BPB1 LOC695224---LOC703452LOC701837LOC709702LOC706456------ ---LOC710611LOC718651LOC709962------ PLEKHG1LOC713173LOC715660ZC3H13LOC707992LOC698247ADSSTIMM17ALOC701890LOC710951--- GNESATB1--- LOC707119LOC717473--- LOC717679LOC721420PROSC--------- ZYG11B---LOC715437LOC716755LOC719983GPAMLOC714008--- LOC695544LOC716408TRB@LOC710176------ LOC700505RHOBTB1TBC1D19---LOC706314LOC696883BCOR---LOC696756RCHY1--- LOC696131---ATF1LOC695826EXOC5--- LOC696945LOC717294LOC713415LOC710580LOC706541--- LOC714059LOC696756SEC24A---TNFAIP3ZNF195---LOC709008---LOC694760--- SAR1A---LOC702568---RWDD3--- ------LOC704154GPAMLOC694043--------- LOC713236------ LOC700708PIGKLOC700198LOC695147------ ------LOC720204---RBL2---LOC704667LOC716820DOCK10---LOC709656---MKI67IP--- ---ARL4C--- LOC714761LOC722107LOC717518LOC694298--- DLD---TTC3LOC706563ITGA6BIRC3XGLOC703367 /// ZDHHC4CGB8LOC701340LOC714480RPS6KB1---LOC706873--- ---LOC705946---CCR7LOC708734---LOC697319--- TRB@LOC695153LOC699509BXDC2LOC713463PDE7A------ZC3H13LOC705480LOC700709LOC693565LOC703693--- LOC694909LOC693663CDC37LOC696004LOC696091FN1 ---LOC718554--- LOC694500SENP7LOC702550LOC710966---GSTT1---LOC696416---LOC699511--- LOC695453LOC694351--- LOC697232---LEO1LOC722935---LOC704695LOC709960LOC705480DDX20LOC703458SATB1LOC708808---LOC697095CAMK4LOC704301LOC705611ZMYND11------ ZNF146LOC705346--- ------LOC695606---LOC715471------LOC714764LOC708871 /// LOC709304SMC3--- ---LOC707664XCL1---LIMA1LOC711071------ATP1B1---LOC704451EXOSC3LOC695399--- LOC701669LOC711975LOC696006---LOC700869LOC711280---LOC710966--- LOC711066LOC698759--- LOC695606H1F0LOC722004------ ---LOC705788--- ------DYRK2LOC709483---LOC710942------LOC712825ITPR1--- LOC703373LOC694190--- LOC694961LOC704624--- ------LOC722528LOC696606LOC712125--- LOC700222LOC704513LOC710690------ LOC697740LOC715927--- LOC717092ADD3LOC708812LOC709585---ZNF226LOC696416LOC702135--- SLC26A2---LOC701522---MGST1ZXDB------ ---KIAA0562LOC714761---LOC700118--- ------LOC701555---LOC704292--- RCHY1------ ---LOC696086---LOC721789--- LOC717280LOC715927LOC717589ZNF141LOC708691--- ---LOC706229CAMK4IGKV1-5 /// LOC720225LOC710457--- LOC721394LOC705491---LOC712568LOC697718---LOC717824LOC698632SUCLA2---LOC713436LOC704362LOC715526LOC710290---LOC704221PTTG1------ LOC694159LOC710951--- LOC703458LOC706456LOC694723 /// LOC718160---LOC704412--- LOC697206------ ------CSPG5------ ---LOC703456LOC694817---CD5LLOC702385LOC693270LOC701919--- ZXDBLOC699511LOC695429------LOC716408---EXPH5LOC704248---LOC713831LOC697813---LOC705228LOC717288------ --------- ---LOC704037--- LOC698337--- ---LOC705093KLF4LOC712825LOC712079--- ---LOC702158LOC697577LOC707195---LOC701837---RAB11FIP2LOC711063LOC704412--- ------CD8B---LOC707388LOC718091LOC698785LOC710276LOC702516LOC704916CTGFLOC703326---LOC705946--- ---ME2 SLC27A2LOC703152LOC714223LOC700843CYTH1LOC715015AXIN2LOC705551LOC712125LOC708226PRMT6--- ------LOC701038LOC703018--- ---ITGA6IL8 MYCLOC704916LOC715683------LOC702705---LOC693428--- LOC700747LOC717288LOC716475------LOC715357---LOC710744LOC708094------ LOC716949------ LOC707560LOC693803LOC696407------LOC717228------MGST1LOC707743LOC710361------LOC698329LOC696756---LOC711787---LOC710319LOC698904LOC704667---ZNF397--------- LOC710080LOC695437--------- LOC708930------ GPR183LOC718408--- LOC702307------ LOC700615---PDE6ADYRK2C16orf70LOC706873FZD10SFRS5FOSLOC696063--- ------LOC716013ZC3H13LOC695780NDFIP2---LOC713460--- ITGA6PDE7A---LOC696021--- ---CEP290--- --------- ---LOC699255LOC711386LOC701218LOC703567LOC699418LOC708226LOC712754POLR1CLOC706531--- ---HIPK2LOC702153---LOC706836LOC719284LOC711501---LOC705093---LOC711141--- LOC715974--- LOC711302HMGCS2LOC693850LOC714786------ LOC698275---LOC712403---LOC709540--- LOC709901---LOC701889------ LOC715511LOC704412LOC695193LOC703781---LOC702775---LOC700750--- ------LOC715357---LOC695437 /// LOC705266LOC702846LOC722567POLR1CLOC699196LOC711501--- CPA3------ --------- WIF1LOC711141--- --------- ---PF4ARL4CFCER1ALOC695437 /// LOC705266LOC708902LOC702878--- --------- EGR2---LOC712338---------

Mother reared

Peer reared

717 521

Inflammation

Immunoglobulin G1 production Type I interferon antiviral response

CTRA – conserved transcriptional response to adversity


Cole et al., Proc National Acad Sci USA, 2011

Cole - PDF

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