CNS pathology Third year medical students · 2019-02-20 · CNS pathology Third year medical...
Transcript of CNS pathology Third year medical students · 2019-02-20 · CNS pathology Third year medical...
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CNS pathologyThird year medical students
Dr Heyam Awad
2019
Lecture 13: CNS tumours 3/3
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meningioma
•Arise from arachnoid meningothelial cells.
•Arise in adults
•Attached to the dura
•Can be seen at external surfaces of the brain or within the ventricular system
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meningioma
•Majority: can be easily separated from brain, but some are infiltrative
•Behaviour: benign but infiltrative lesions recur
•Outcome depends on: size, location, histological grade
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Histological grades
•WHO I: (well diff) meningioma
•WHO II: atypical meningioma
•WHO III: anaplastic ( malignant ) meningioma
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Grade 1 meningiomas
•Well defined, dura based masses
•May compress but do not invade brain
•Can extend to overlying bone
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• Grade 1 meningiomas/ histological types
• •Syncytial: whorled clusters without visible cell membranes.
• •Fibroblastic: elongated cells and abundant collagen
• •Transitional: features of both, syncytial and fibroblastic
• •Psammomatous: numerous psammoma bodies
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syncitial
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fibroblastic
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pasammomatous
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Atypical meningioma WHO grade 2
•High cellularity
•Prominent nuclei
•High mitotic rate
•More aggressive than grade 1
•Recur
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Atypical meningioma
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Anaplastic meningioma
• Anaplastic meningioma WHO grade 3
•Highly aggressive
•Resemble sarcomas
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Primary CNS lymphoma
• Mostly: diffuse large B cell lymphoma.
•1% of intracranial tumors.
•Primary CNS lymphoma is the most common CNS neoplasm in the immunocompromised… in this situation they are almost always positive for EBV ((Epstein – Barr virus)
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CNS lymphoma
• Aggressive disease with poor prognosis
•Poor response to chemotherapy as compared to peripheral lymphomas
•Usually multiple nodules within the brain parenchyma
•Spreading outside the brain happens rarely and at late stages
•Peripheral lymphoma rarely spreads to the brain, if it does there is usually associated meningeal and CNS involvement.
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lymphoma
• Involves deep grey matter, white matter, cortex
•Periventricular spread is common
•Tumor nodules more defined than gliomas but less than metastases
•EBV positive tumors usually have extensive areas of necrosis
•Majority: diffuse large B cell lymphomas
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lymphoma: note the multiplicity of the lesions
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lymphoma
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Metastatic tumors
- ¼ to ½ of intracranial tumors
•Most common primary sites: lung, breast, melanoma, kidney and GIT.
•Form discrete well defined masses, can be multiple
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Paraneoplastic syndromes
•CNS and peripheral nerves can be affected in disseminated cancer as part of the paraneoplastic syndromes
•These include several manifestations including dementia, ataxia, sensory neuropathy and psychosis
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Familial tumor syndromes
•Inherited syndromes
•Mutations in several tumor suppressor genes
•Associated with increased risk of certain types of cancer
•2 syndromes with CNS involvement: Tuberous sclerosis and von Hippel - Lindou
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•Tuberous sclerosis
• Autosomal dominant
• Hamartmas and benign neoplasms in brain and other sites
• CNS tumors: cortical tubers and subependymal hamartomas
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• Tuberous sclerosis
•Cortical tubers: look like potatoes!!
•Tuber: thickened underground part of a stem
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• Cortical tubers : Hamartomas composed of haphazardly arranged large neurones.
• Mixture of glial and neuronal cells
• Cause seizures
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Tuberous sclerosis.. potatoes in the brain!
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• Subependymal tubers :Similar to cortical tubers
• Can cause hydrocephalus
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• Tuberous sclerosis/Extracerebral lesions
• renal angiomyolipoma,
• retinal glial hamartomas,
• pulmonary lymphangiomatosis
• cardiac rhabdomyoma
• cysts in liver, kidney , pancreas.
• skin lesions: angiofibroma, hypopigmented areas, thichened patches.
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•Von Hippel Lindau syndrome
• Autosomal dominant
• Mutation in VHL tumor supressor gene.
• Hemangioblastomas mainly in cerebellar hemispheres, retina.
• Cysts in pancreas, liver kidney
• Increase risk of renal cell carcinoma
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Summary of CNS tumoursMost common age most common
locationmain histologic criteria
Genetic mutations Prognosis Notes
Pilocytic astrocytoma Children Cerebellum Micro cystsRosenthal fiberslow cellularity
BRAF Excellent, grade I tumour
diffuse astrocytoma adults40-60
Cerebral hemispheres Astrocytic cells in fibrillary backgroundGFAP positive
IDH 1 or 2Mutation
Mean survival more than 5 years
to be called grade III: increased cellularity, mitosis and polymorphism.
Glioblastoma AdultsPrimary: over 55 yearsSecondary : younger: 50
cerebral hemispheres Necrosis, usually palisadingOR vascular proliferation
IDH mutated have better prognosis than IDH wild type
mean survival 15 months
Enhancing lesions on radiology.Can be primary (90% ) or secondary ( 10%)
oligodendroglioma Younger than astro40-50
white matter Rounded nuclei surrounded by a clear halo (fried egg appearance)
IDH PLUS 1p 19 q cpdeletion.
grade II: 10-20 years survivalgrade III : 5-10 years
grade III: same histological criteria of grade III astro
Ependymoma adults and children Adults: spinal cord<20 years: near fourth ventricle
True rosettes around empty spaces ( canals)Pesudoreosettes around blood vessels
better if resectableSpinal tumors easily resectable, so better prognosis than posterior fossa ones
Medulloblastoma Children Exclusively in the cerebellum
Primitive cells( small round blue cells)Homer Wright rosettes around neuropil
Myc : poor prognosisWNT: beter prognosis
grade IV tumorshighly aggressiveCan metastasise to bone
WNT mutation can be tested by B catenin stain.
meningioma Middle age Dura based lesions Meningeal cellsPsammoma bodies
generally goodDepends on grade
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