Cholestin®

Product Training Series

This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

New & Improved Cholestin®

• Cholestin contains policosanol, a novel ingredientextracted from beeswax

• Policosanol is clinically proven*– safe, effective, and well-tolerated

• Proprietary PoliSorb™ † softgel delivery• Convenient once-a-day dosage• Pharmanex is first to market in the US • Pharmanex has exclusive rights for the

network marketing channel

†Policor is a trademark of Hauser, Inc.

NCEP Cholesterol Guidelines

Classification of LDL, Total, and HDL Cholesterol (mg/dL)

LDL Cholesterol < 100 100-129 (+ 2+ RF) 130-159 (+ 0-1 RF) 160-189 > 190

OptimalNear or above optimalBorderline highHighVery High

Total Cholesterol < 200 200-239

> 240

DesirableBorderline highHigh

HDL Cholesterol < 40 > 60

LowHigh

From: Third report of the National CholesterolEducation Program Expert Panel, May 2001

NCEP Cholesterol Guidelines

Using NCEP guidelines,

about 65 million Americans

should make dietary and lifestyle changes

to maintain cardiovascular health

Cholestin® : Health Benefits

• Maintains existing normal cholesterol levels*– Total & LDL-Cholesterol

– HDL-Cholesterol

– LDL/HDL Ratio – Triglycerides

• Helps prevent oxidation of LDL cholesterol*

• Promotes normal blood fluidity*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

History of Policosanol

Early 90’s: Beeswax policosanol initially sourced in Cuba

Mid 90’s: Sugar cane policosanol suggested as more economical source Cuban government

Sugarcane policosanol clinically tested and commercialized in Cuba

Pedro P. Perez revives R&D work in US for beeswax policosanol

Perez teams up with top-quality pharmaceutical company; now supplier

2001: Pharmanex

launches Cholestin® - beeswax policosanol

Cholestin Composition

Primary Active Constituent:

• Policosanol from Beeswax (PolicorTM )†

– Novel ingredient - “Cholesterol Breakthrough”

– Extracted from white NF-grade beeswax (GRAS)

– Patent granted to supplier in October 2001 (for use, composition and process)

Pharmanex has been granted exclusivity for Network Marketing Channel

†Policor is a trademark of Hauser, Inc.

Standardization

• Guaranteed minimum 40% policosanol

• Reproducible fingerprint of 5 primary aliphatic long-chain alcoholsmV

0.00

10.00

20.00

30.00

40.00

50.00

60.00

Minutes2.00 4.00 6.00 8.00 10.00 12.00 14.00

C24 -

4.64

7C2

6 - 5.

012

C28 -

5.44

0 C30 -

5.93

7C3

2 - 6.

517

PoliSorb™ † Proprietary Delivery

• Policosanol delivery can be problematic:

– naturally a fat-soluble, waxy substance

– remains solid at body temperature

– tablets & capsules have poor dissolution

• Pharmanex PoliSorb™ proprietary delivery:

– overcomes solubility problems

– emulsified with lecithin phospholipids• natural cell membrane components

PoliSorb softgels have over 10 times better dissolution than policosanol capsules or tablets

†Policor is a trademark of Hauser, Inc.

Policosanol: Clinical Data

Policosanol (sugar cane wax), double-blind clinical trials:**• Blood lipids: 13 studies (total of 1,378 subjects)

• Platelet aggregation: 6 studies

• LDL-oxidation: 1 study

Policosanol from beeswax may be more effective:• Main constituent in sugar cane wax, octacosanol, is not very active in

rats (Kato S, Br J Nutr 1995;73:433)

Beeswax policosanol clinical trials:• Two open-label pilot studies

* Summarized in Healthcare Professionals Product Guide

Clinical Data - Summary

Research with policosanol has shown the following results (10-20 mg/day):*

• Benefits after 8-12 weeks, maximum effect evident after 12 months

• Excellent safety & side effect profile

* Summarized in Healthcare Professionals Product Guide

Policosanol Safety

Beeswax policosanol has excellent safety data:• Clinical data: few & mild side effects*

• Made from purified, white NF-grade beeswax

• GRAS (FDA-Approved) for food & drug use

* Summarized in Healthcare Professionals Product Guide

Drug Interactions

• No clinical reports of drug interactions*

• Preliminary contraindications:– high-dose aspirin therapy

– anticoagulants (warfarin, coumadin, etc.)

– discontinue within 2 weeks of surgery

* Summarized in Healthcare Professionals Product Guide

Summary

• Cholestin maintains existing normal cholesterol levels* • Provides 15 mg per softgel of policosanol• Policosanol is clinically proven• Proprietary PoliSorb™ softgel delivery• Convenient once-a-day dosage• Safe & well tolerated • Pharmanex is first to market in the US • Pharmanex has exclusive rights for the

network marketing channel

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.