China Chemical & Pharmaceutical Group Overvie · Sedative, hypnotics & tranquilizers Electrolytes &...

China Chemical & Pharmaceutical GroupOverview

Agenda

CCPG Vision and Core Value

Company Presentations

Global Business Development

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CCPG Family

CCPC Vision and Core Value

Vision

To be the Most Trusted Healthcare Enterprise in the Greater China Area

Core Value

Enthusiasm, Innovation, Care, Health

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CCPG Family

CCPG Organization Chart

Chunghwa Yuming Healthcare Co., Ltd. (CYH), Taiwan. Medical product and food supplement marketing & sales

Chunghwa Biomedical Technology Co. Ltd. (CBT), Taiwan. Non-medical product marketing & sales and senior home care services.

Suzhou Chunghwa Chemical & Pharmaceutical Industrial Co., Ltd.(SCCPC), China. Generic drug R&D, manufacturing, marketing and sales

Chunghwa Chemical Synthesis & Biotech Co., Ltd. (CCSB), Taiwan, USA. Chemical & biological API R&D, production, marketing and sales

China Chemical & Pharmaceutical Co. (CCPC), Taiwan. The mother company. Generic drug R&D, and manufacturing

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CCPG Family

China Chemical & Pharmaceutical Co., Ltd. (CCPC)

Profile

Founded in 1952 The first public listed pharmaceutical Co. in

Taiwan Stock Exchange. The first generic pharmaceutical company

in Taiwan to meet GMP(1984) & cGMP(2001) guidelines The first Taiwan pharmaceutical company

invested in China (1993) One of the largest contract manufacturers

for human pharmaceutical & animal health products in Taiwan

CCPC Headquarters and Manufacturing Plants

Taipei

Hsinfong

Taichung

Tainan

Headquarters

Hsinfong Plant IHuman Products

Tainan plant I Animal Health products

Tainan Plant IIHuman Pharmaceuticals Taichung Plant

Penicillin Products

Tainan plant IIICephalosporin Products

Research andDevelopment Center

Hsinfong Plant IIImmunosuppressant

Products

CCPC Product Forms

Product lines include

Tablets

Capsules

Injection

Solutions

Ointments

Veterinary products

Premixes, additives

CCPC Major Products

Anti-infective drugs

Cardiovascular agents

Hypolipedemics

Remedies for peptic ulcer

Anti-pyretics & analgesics

Anti-diabetic agents

Anti-tussives & expectorants

Anti-histamines

Remedies for asthma

Anti-fungal and anti-viral agents

Sedative, hypnotics & tranquilizers

Electrolytes & hemodialysis preparations

Vitamin preparations

Animal health products

CCPC Business Development Strategy

Maximize short and long term revenues

Further strengthen pipelines A fully vertically integrated pharmaceutical company

Development of niche generics into global markets

Application of CCPC unique controlled-release technology of drug delivery system for niche product development

Reinforce Organizational capabilities Product portfolio optimization

Global contract manufacturing business

How can CCPC drive growth, whilst building and defending it’s existing product portfolio?

Pharmaceutical Research Institute

Pharmaceutical Research Institute

Formulation Research Laboratory

Special Project Laboratory

Analytical Research Laboratory Production

Technology Development

Laboratory

1. Osmotic Pump Device2. Matrix Device3. Repeated-Release Device4. Delayed-Release Device5. Modified-Release Device6. Multiple-Layer Device7. Orally Disintegrating Tablet Device

Technological Platform 1. 2.

3. 4. 5.

6. 7.

CCPC Drug Delivery System Platform

Osmotic Pump (Tablet)

Matrix (Tablet)

Repeated-Release (Tablet)

Delayed-Release (Pellet)

Modified-Release (Pellet)

Multiple-Layer (Tablet)

Orally Disintegrating Tablet

CCPC Niche Product DevelopmentApplication of CCPC unique controlled-release technology of drug delivery system for niche product development

Delayed-ReleaseDevice

CCPC Drug

Delivery System Platform

Nifecardia*(Nifedipine)

Xadosin*(Doxazosin)

Zotan*(Tamulosin)

Rafax*(Venlafaxine)

Setizin-CP 12(Cetirizine/Pseudoephedrine)

Vantydin 12*(Fexofenadine/Pseudoephedrine)

Finska LP 24(Loratadine/Pseudoephedrine)

Taquidine*(Lansoprazole)

Finska LP 12*(Loratadine/Pseudoephedrine)

Naposin(Naproxen)

Trenfylline*(Pentoxifylline)

Glicron*(Gliclazide)

Glibudon*(Metformin)

Arizole*(Aripiprazole)

Zotan*(Tamulosin)

Olan*(Olanzapine)

* BE indicated Global MKT Contract

CCPC Collaborators

Exclusive Agent

Distributor

Contract manufacturer

R&D collaborator

Chunghwa Yuming Healthcare Co., Ltd. (CYH)

Profile

CYH is100% owned by CCPC Marketing and sales of human

pharmaceutical products and functional foods Agency for multinational

pharmaceutical Actively looking for export/import

and license-in/out business opportunities

CYH Business Strategy

Prescription products CCPC products

License-in products

OTC products CCPC products

License-in products

Medical Equipments Omron

Functional Foods Homart

Keep Revenues and Profit Growing

Chunghwa Biomedical Technology Co., Ltd. (CBT)

Profile

CBT is100% owned by CCPC Founded in March, 2006 CBT is 100% owned by CCPC Marketing and sales of consumer,

skin care products and health foods Providing non-medical senior

homecare services

Suzhou Chung-Hwa Chemical & Pharmaceutical Industrial Co., Ltd. (SCCPC)

Profile

CYH is100% owned by CCPC Established in April,1993 Total investment: US $60 Million Location: Suzhou Hi-Tech,

Industrial District, Suzhou, China GMP Plant : 45,000 square meters

SCCPC Capabilities

Qualification GMP in 2014

Annual production capacity Powder Injection: 60,000,000 vials Tablet: 1,800,000,000 tablets Capsule: 1,800,000,000 capsules Granule:400,000,000 sachets Disinfection Solution for Contact Lenses:

10,000,000 bottles Mouth Wash Solution: 8,000,000 bottles

R&D 8-10 new products annually

Contract research and manufacturing

Marketing, distribution and promotion

SCCPC is a Generic Pharmaceutical Co.

Product Category

Antibiotics (Cefalosporins mainly)

Hypolipidemics

Gastrointestinal drug

Gynaecological drug

Antipyretics

Hypoglycomics

Antidepressant

Disinfection solution for contact lenses

Antiseptic solution

Chunghwa Chemical Synthesis & Biotech Co., Ltd. (CCSB)

Profile Founded in 1964 First registered and one of the largest bulk

pharmaceutical chemical manufacturers in Taiwan First Taiwan FDA approved plant (1984)

Turning Points in 1997 Formed the New Management Team in 1997 Invested US$ 20 million to construct 4 cGMP Plants for Synthetic Products 2 cGMP Plants for Biotechnology Products

Established US Sales Office-Pharmaports in 2000 Products Developing both synthetic & biotech products Participate new drug development and contract

manufacturing Global Market Oriented with Emphasis on U.S.A., Europe, Japan

Initial public offering on December 20, 2010 Obtain the necessary land for plant expansion in 2012

CCSB cGMP InspectionsYear Authorities Products

2005 USFDA Pravastatin

2006 TFDA Prindopril Erbumine

2007 KFDA Methocarbamol

2008 NIPTFDA

TrandolaprilRapamycin

2009 German AuthorityTFDA

PravastatinMethocarbamol, Pravastatin

2010 TFDA Tacrolimus, Mycophenolate Mofetil

2011 USFDA Mycophenolate Mofetil, Tacolimus/SD20, Dexbrompheniramine Maleate

2012 German AuthorityTFDA

PravastatinFluconazole, Mataxalone, Rapamycin

2013 PMDA Tacrolimus

R&D Product Pipeline

Rapamycin Products under Investigation

Everolimus Rosuvastatin: Antihyperlipidemics

Caspofungin Entecavir: Antiviral Drug

Micafungin Carfilzomib: Anti-Cancer Drug

Ethyl Icosapentate Ingenol Mebutate: Anti-Cancer Drug

CCSB is a Niche Pharmaceutical API Company

DMF List

DMF 8625 Dexbrompheniramine Maleate

DMF 13080 Methocarbamol

DMF 14234 Guaifenesin

DMF 14235 Pravastatin Sodium

DMF 17399 Rapamycin

DMF 17573 Trandolapril

DMF 18494 Mycophenolate Mofetil

DMF 18985 Tacrolimus

DMF 22430 Olopatadine HCl

DMF 23213 Tacrolimus SD20

DMF 23434 Metaxalone

DMF 23435 Mycophenolate Sodium

DMF 24372 Mycophenolate Mofetil HCl

DMF 26271 Ethyl Icosapentate

DMF 26819 Everolimus Pre-Mix

DMF 27216 Everolimus

CCSB Product Categories

Why CCSB?

Over 45 years of bulk API manufacturing experience

US, Europe and Japan Health Authorities approved cGMP facilities for synthesis & biotech APIs

Fully cGMP trained and experienced personnel

Strong R&D support

Proven records for cost effective and on-time delivery of contract manufacturing from lab to commercial scales

Good communication skills & prompt response

Pilot Plant Reactor Feeding Tank Fermentor

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CCPG Family

Vertical Integration (API & Finished Dosage Form)CCPC is an Integrated Pharmaceutical CompanyNiche and Innovative Product Development

API Formulation Production Marketing & Sales

China Chemical & Pharmaceutical Group Overvie · Sedative, hypnotics & tranquilizers Electrolytes &...

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Transcript of China Chemical & Pharmaceutical Group Overvie · Sedative, hypnotics & tranquilizers Electrolytes &...