Chem2999 Chem3998 2020 - UNSW Chemistry · 2019. 10. 8. · UoC of second year subjects OR 36 UoC...
Transcript of Chem2999 Chem3998 2020 - UNSW Chemistry · 2019. 10. 8. · UoC of second year subjects OR 36 UoC...
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OVERVIEW OF UNDERGRADUATE RESEARCH PROGRAMS CHEM2999 & CHEM3998
This booklet provides details of the CHEM2999 and CHEM3998 courses, in which students undertake an authentic short research project under the direction of a Chemistry academic member of staff taking advantage of UNSW's world-class researchers and research facilities. Student engage directly with academics and their research group, becoming involved with the group's regular activities such as group meetings, while learning important research and transferable graduate skills prized throughout academia, industry and business.
Both courses require a WAM of at least 65 and are offered in all three terms and in summer. Enrolment occurs every term.
CHEM2999 – Special Project in Chemistry
This course is most suitable for students in their second year with only first-year Chemistry background. It provides an early introduction to the university research environment. A particular focus of this course is communicating the complex research topic to a scientifically-literate non-expert audience.
CHEM3998 – Advanced Special Project in Chemistry
This course provides a more sophisticated introduction to the university research environment than CHEM2999 with a more complex project that utilises the skills and knowledge obtained by students in their early undergraduate degree. Students thus need to have completed at least 18 UoC of second year subjects OR 36 UoC of Level II Science or Engineering Courses to take this course.
These courses are designed to pave the way into Honours. However, you can most certainly undertake Honours without these courses.
For summer term research, students will need to find an appropriate academic who will be available for this period.
For each course a 1 hr fortnightly session is allocated but will be used as required for training, skills development, reflection and cohort building.
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Typical deadlines for Chem2999 and Chem3998
Term 1
Online form submitted by Wednesday Week 10 Term 3, the year preceding
Enrolments will occur on during the exam weeks of Term 3 or after the release of results depending on the WAM check
Term 2
Online form submitted by Wednesday Week 10 Term 1
Enrolments will occur on during the exam weeks of Term 1 or after the release of results depending on the WAM check
Term 3
Online form submitted by Wednesday Week 10 Term 2
Enrolments will occur on during the exam weeks of Term 2 or after the release of results depending on the WAM check
Summer Term
Online form submitted by Wednesday Week 10 Term 3
Enrolments will occur on during the exam weeks of Term 3 or after the release of results depending on the WAM check
ASSESSMENT
Both courses are pass/fail.
Both courses require attendance to an hourly weekly meet-up. This is a key component of the revised courses. It will enable students to build stronger supportive peer networks, discuss research careers and culture. It will provide an opportunity to practice short informal presentations to a non-specialist audience. Most importantly, these meetings will facilitate students in developing a high level of meta-cognition of the technical and transferable skills they are developing during their research placement, essential when applying for PhD positions and jobs in the future.
Both CHEM2999 and CHEM3998 requires the submission of a scanned copy of the laboratory notebook (or equivalent) and an excel spreadsheet (summarising activity) in Week 5 and Week 10 of each Term. Submission of a final report is required in Week 11 of each Term. Feedback is provided the week after each submission.
The two courses will be distinguished by the standard of research expertise that students must demonstrate to successfully pass this course, along with a different focus area in the final report: CHEM2999 students focus on contextualising their research while CHEM3998 students focus on identifying fruitful future directions of their research.
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7
CHEM2999 & CHEM3998
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11
ON/OFF catalytic activities. One example are spiropyran molecules, which act as ‘photoacids’, being switched between stable acidic and non-acidic states using light stimulus. Photoacids based on spriopyran may be directly incorporated into molecular and supramolecular systems for applications in stimulus-responsible switching with applications ranging from synthetic catalysis to in-situ drug release. New photoacidic molecules are required which are suitable for building into larger structures and membranes, and the tuning their photoswitching properties will be studied using a combination of spectroscopic techniques.
Skills: organic synthesis, multidimensional NMR spectrometry, mass spectrometry
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(c) Novel ruthenium(II) complexes
Ruthenium(II) complexes are extremely useful complexes with applications ranging from energy storage and light harvesting, to catalysis and drug applications. This project will develop new types of chiral ruthenium(II) complexes which are responsive to their environments to allow these useful properties to be controlled by external stimuli (eg, temperature, chemical reagents, light, redox etc).
Skills: organic and inorganic synthesis, multidimensional NMR spectrometry, mass spectrometry, X-ray crystallography, cyclic voltammetry, X-ray crystallography, photophysical measurements
(d) Molecular rotors
(in collaboration with A/Prof. Jason Harper)
Being able to control motion at the molecular level is a fundamental challenge facing science. Nature uses controlled molecular motion, so called ‘molecular machines’ to control virtually every process in biology. So far, chemists use molecular machines to control nothing! This project involves the synthesis of molecular ‘rotors’ with a ‘propeller’ which can spin spontaneously when appropriate energy is supplied.
Skills: Organic synthesis, multidimensional NMR spectrometry
(e) …or other projects tailored to your interests!
1. Yang, J.; Bhadbhade, M.; Donald, W. A.; Iranmanesh, H.; Moore, E. G.; Yan, H.; Beves, J. E. Chem. Commun. 2015, 51, 4465-4468.
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13
breast cancer cell lines. The project will make use of new methods for oxygen tolerant polymer synthesis on microtitre plates that we have recently developed in order to prepare these libraries at low volume and high throughput.[2]
The project will involve the synthesis of several chain transfer agents required to generate the different polymer architectures, the synthesis of peptides for receptor binding, and subsequent polymerisation and polymer analysis by NMR, GPC and associated techniques. Screening of biological activity will be performed in collaboration with Dr Adam Gormley at Rutgers University in the USA, and there is the possibility of visiting his lab in the middle of the year to perform some of this work if you so choose.
(b) Stabilisation of glucose oxidase enzymes in nanocapsules (with Prof. Martina Stenzel)
Despite their extensive use in a range of synthetic, biosensing, and therapeutic applications, enzymes are often highly unstable to heat, pH, and the presence of organic solvents. However, several recent studies have shown that it is possible to protect enzymes against degredation by such environmental factors by encapsulating them within nanocapsules.[3,4]
We recently developed a new methodology for encapsulation of glucose oxidase (GOx) inside a type of nanoparticle known as a polyion complex (PIC) micelle. This gives excellent control over the structure of the nanoparticle, and allows us to crosslink the shell surrounding the enzyme to impart mechanical stability to the enzyme. In this project we will incorporate sugars such as trehalose, mannose, glucose and fructose, which have been shown to have a stabilising effect on enzymes,[3] into our enzyme nanoparticles and compare their effects on enzyme stability. This will be done by first polymerising the sugars into the polymer backbone and then assembling them into the core of the PIC micelle. Enzyme activity will be monitored after exposure to a range of solvent, thermal, and other environmental stresses.
The project will involve controlled polymer synthesis and self-assembly techniques to prepare the enzyme nanocapsules, characterisation by light scattering and electron microscopy, and the use of enzyme activity assays to measure their activity under a range of environmental stresses.
1) J. Lemke, S. von Karstedt, J. Zinngrebe and H. Walczak, Cell Death Differ., 2014, 21, 1350–64.
2) R. Chapman, A. J. Gormley, M. H. Stenzel and M. M. Stevens, Angew. Chemie Int. Ed., 2016, 128, 4576–4579; R. Chapman, A. J. Gormley, K. Herpoldt and M. M. Stevens, Macromolecules, 2014, 47, 8541–8547.
3) A. Beloqui, S. Baur, V. Trouillet, A. Welle, J. Madsen, M. Bastmeyer, G. Delaittre; Small, 2016, 12, 1716–1722
4) E. M. Pelegri-O’Day, S. J. Paluck and H. D. Maynard, J. Am. Chem. Soc., 2017, 139, 1145-1154; R. J. Mancini, J. Lee and H. D. Maynard, J. Am. Chem. Soc., 2012, 134, 8474–9.
Preparation of single enzyme nanogels. Adapted from Beloqui et al [3]
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FIELD ng (F10) w.edu.au
MISTRY
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20
Alternative Bridging Groups for Organometallic Polymers
The majority of alkyne-bridged organometallic polymers use linear aromatic spacer units, such as 1,4-diethynylbenzene, as the bridge between metal centres. Non-aromatic bridges such as 1,12-diethynyl-p-carborane (C6H12B10) have been described as “3D aromatic systems”. We are interested in the effect of aromatic bridges, as well as non-aromatic bridges such as 1,3-diethynylbenzene, on the chemical and electrochemical behaviour of organometallic polymers.
(b) The Organometallic Chemistry of Carbon Dioxide
Carbon dioxide reacts with many organometallic compounds to give products in which the CO2 is incorporated into the metal complex. A greater understanding of the ways in which CO2 binds and reacts with metal compounds may provide new ways to capture CO2 and utilise this wasted and environmentally dangerous compound.
Our previous work has focused on the stoichiometric insertion of CO2 into metal-hydride and metal-carbon bonds, to give metal formates and acetates, respectively. There have been many reports in the literature of catalytic activation of CO2 to yield formic acid (by hydrogenation), acrylates (by reaction of CO2 with ethylene), and carbonates (by reaction of CO2 with epoxides). We are interested in exploring the ability of novel iron(II) and ruthenium(II) complexes that we have prepared in the lab to catalytically activate CO2.
(c) The Chemistry of ‘CP3’ Complexes
We have recently developed a new type of polydentate ligand for transition metals, which binds to metal centres using three phosphorus donors and an anionic carbon donor. To date, we have only explored the chemistry of this ligand on ruthenium(II). We anticipate that this ligand will form complexes with a wide range of transition metals, and are particularly interested in investigating the synthesis and catalytic properties of new rhodium and iridium complexes.
Selected publications from the group:
1. L. D. Field, A. M. Magill, T. K. Shearer, S. J. Dalgarno, M. M. Bhadbhade, Eur. J. Inorg. Chem., 2011, 23, 3503-3510.
2. L. D. Field, P. M. Jurd, A. M. Magill, M. M. Bhadbhade, Organometallics, 2013, 32, 636-642.
3. O. R. Allen, L. D. Field, A. M. Magill, K. Q. Voung, M. M. Bhadbhade, S. J. Dalgarno, Organometallics, 2011, 30, 6433-6440.
4. L. D. Field N. Hazari, H. L. Li, Inorg. Chem., 2015, 54, 4768-4776.
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A PROF. L
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r Richard
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24
magnetic nannanoporesarefit is the nolves develo
our models
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ganisation of metastasis, eate the 3D ture). In the pk that stabilispes of enzymmaterials de in collaborat
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uids are saltss but outcomear solvents. we have alre control reacs and kineticect can be re opportunity
cs simulationng reaction y
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ECHANIS
derstanding compasses ed can changecluding bioory, there is exs, reaction ki
n organic rProf. Anna C
elow 100°C.ns in ionic liqof this projeed and to us
me. The proof these resud for studentnew methodsmore synthemising isolat
hydrocarbProf. Lawren
ant to be plareactivity of tems relative
nvolve synthenetic studies
25
STIC AND
how organicexamining he how a rea
rganic, synthxtensive oppinetics, synth
reactions: gCroft, Univer
. They havequids are ofteect is to extese this knowloject would lts, along wits with more s for followinetic aspects, tion. That is,
bons: diffence Scott, Bo
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A/PRL
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PHYSICA
processes hhow structuraction proceeetic, analytic
portunity for hesis and mo
getting the rsity of Nott
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ng reaction p by focussin to get the re
erent reacoston Colleg
Yet the synmatic systemaromatics an
ctivity of syste the reactivity
ROF. JASLevel 2, Da385 4692 E:
AL ORGAN
happen and al features ids. This kno
cal and envicollaboration
olecular dyna
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replacemenedly different erstanding o
monstrate thag NMR speorganic and e physical anrogress and g on designi
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NIC CHEM
what affectsin both the owledge canronmental c
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nts for volatile to those in tof ionic liquidat ionic liquidectroscopy to analytical cnd analytical undertake ming new ioni
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Cl, AlCl3M, -78oC l
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MISTRY
s reaction reagents
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For recent
1. R. R. H574 & JChemPl
2. S. R. D
3. N. Kons
4. R. R. Het al., Phy2017, 15,
Catalysis us
ocyclic carbes are effectivject aims to r
ng any solveulk, electron the opportu systems; ths. The ultima
Solvent-sol(in collaborDr Leigh Ald
e previously nd the compuids and whlvents. This ple compounolvents for aements of ken to highlige a better unood solubilityes into ionic l
t examples of o
Hawker et al., OJ. Phys. Org. ClusChem 2017,
. George et al.,
standaras et al.
awker et al., Chys. Chem. Chem 5556; S. T. Kea
sing N-heter
enes, have sve for some relate structu
ent effects – ics, heteroat
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ute interacration with Ddous, King’s
made use ofponents of any certain rea project aimsnds and simua given solutesolubility anght key solutnderstandingy giving us thliquids – and
our work in the a
Org. Biomol. ChChem. 2018, 31
82, 449; Butler
Org. Biomol. C
., ChemistrySel
hem. Commun.m. Phys. 2018, aveney et al., J
rocyclic carb
ignificant roleprocesses b
ure and chemthis requires
toms). Alonge various ch
n vary from be able to ra
ctions in Dr Ron Haines College, &
f molecular dn ionic liquid;actions proces to extend tulations – whe. In order nd moleculae-solvent inte of what inte
he opportunit these could
above areas se
em. 2018, 16, 3, DOI: 10.1002r et al., J. Phys
Chem. 2015, 13
lect, 2017, 2, 71
. 2018, 54, 22920, 16558; W.
J. Phys. Chem.
26
benes: unde
es in organobut not for otmical propertis a series ofg with makinharacterisatiosimple screeationally cho
ionic liquies, UNSW; P
& Prof. Bill P
dynamics sim; this can be eed faster othis and to mhich ionic liquto do this b
ar dynamicseractions. Teractions arety to 'design' then be mad
ee:
3453, Org. Biom2/poc.3862; S. Ts. Org. Chem. 2
3, 9035 & 10745
18; M. H. Dunn
96 & J. Phys. OrE. S. Hart et al B. 2016, 120, 1
erstanding s
- and organohers; the origes of carbenf chosen car
ng the precuron techniqueening of cataose an NHC
ds: can wProf. Anna C
Price, Wester
mulations to u used to expn moving to
model - both uid would be oth physical
s would be The outcome e required to appropriate de!
mol. Chem. 20T. Keaveney et018, 31, DOI: 1
5 & Polycycl. A
et al., J. Org. C
rg. Chem. 2018l., ChemPlusCh12687 & ChemP
structure/act
ometallic catagin of this is es to catalyt
rbenes that vrsors to the cs and to undalysts throug catalyst for a
we design Croft, Univerrn Sydney U
understand inlain why ben
17, 15, 6433; Ct al., Pure Appl0.1002/poc.38
rom. Compd. 2
Chem. 2017, 82
8, 31, DOI: 10.1hem 2018, 53, 3PhysChem 201
ctivity relatio
alysis, howevs not well undtic efficacy, avary in one carbenes, thdertake evalgh to detailea given proce
better sorsity of Nott
University)
nteractions benzene is so s
ChemPlusCheml. Chem. 2017,19 & 2016, 29,
2016, 36, 897.
2, 7324.
1002/poc.3862;348 & Org. Biom16, 17, 3853.
onships3
ver some derstood.
along with way only is project uation of
ed kinetic ess.
olvents?4 tingham;
etween a soluble in
m 2016, 81, 89, 745 & 700.
J. J. Black mol. Chem.
We devemany pgroup). Tour expeinclude, physical include ato comeassumed (a)
To furthefor sevedynamicmolecula (b)
reorganialso pla
Getting to th
elop and approcesses inThis enableserimental col but are not organic chean experime and chat abd, and you w
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catalysis, solvwork closelyent. The folloer ideas youed with valua
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as anti-cancores. In this p free energyn transport, a
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27
Le
UTATIONAL
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sign of Luke Hunter)
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28
affinities of sqxperiments.
Solvation Ml-known “var
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ondensed phs a longstandnal procedurd thermodyn2016, 120, uch as continolecules imf their compfor specific sfor simple or would like to
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mplicitly are putational effolvents, and rganic (e.g. So investigate
quantum mecmodelling solv
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molecules. T
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eterocyclic c(with NguyeA/ProHarpe
odel structurThe insights here are opps.
This work
amework ver, such much of
ng robust on phase J. Phys.
proximate that treat
popular they are are very ns. In this statistical QM/MM ementary
carbenes Dr. Vinh en and
of Jason er)
re-activity provided ortunities
Fluocan conf
In thbioafluor
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orine is a sma have a drformation, anhe Hunter gactive molecrinated molec
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Fine-tuningpeptides are riety of diseae two major d-to-tail cyclise shapes of cproject, we aproblems. Ted amino a blocks.
rators: Prof Mky Avery
Next-genera proteases a
ce-specific mcycles of seV, and thus we are des
s. The key s at very p distribution o
rators: A/Prof
FL
all atom that ramatic impand binding affroup, we are
cules. We cocules that we
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the shapes promising leases includinlimitations ofsation is oftencyclic peptideare using flu
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Maria Kavalla
ation enzymare enzymes manner. Aspaeveral diseas they are psigning a neis to incorpo
precise locatof the activat
f Renate Grif
LUORINE
packs a big act on molefinity for protee harnessingollaborate ee create.
search areas
of cyclic peead compoung cancer anf cyclic peptidn inefficient; es to optimisuorine chemi
to synthesh are valua
aris, A/Prof S
me inhibitorsthat cleave o
artic proteaseses includingotential drugw class of aorate fluorinetions, in ordted intermedi
ffith, Dr Junm
29
IN MEDIC
punch. Whenecular propeein targets. g such effec
extensively to
s within the
eptides nds for the nd malaria. des: (i) their (ii) it is difficu
se their targeistry to solvesise stereosable shape-c
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NIC CHEM
nic moleculesetabolic stab
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NTER ng (F12) w.edu.au
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s, fluorine bility, 3D
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e/hypnotic ac-rape” drug.of GHB’s
e’s conformamany differenwe are creatrable activity
rator: Prof Ma
Molecular Vunprecedenis a commo
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ult for tumouwith a slowe
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novel treatmcause of deatoptions are pproach. We natural hypoitude-chambeage-control mel understans hypoxia res
ole Jones, A/
undesirableyrate (GHB)nds to neuro previously b
ments incluunately howctivity, which We believeeffects can ational flexibnt neurotransting conform while editing
ary Collins, D
Velcro: creatnted ways n disease thy is the princ is limited bynventional d
A and weld thr cells to repr developme
aham Ball, A
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ment for stroth and disabiextremely li
e’re developoxia protectiver-in-a-pill”), mode after a nding of thesponse.
/Prof Renate
e activity out is a molec
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wever, GHB has led to ite that the be attribut
bility, which asmitter recepationally-rest
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Dr Junming H
ting new mo
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he two strandpair. This wilnt of drug res
A/Prof Larry W
hers within thther techniquase peptide s
30
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ping drugs tve mechanis which will stroke. The e proteins t
Griffith
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ptors. In this tricted fluorin
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oaming” reactnough energyforming unexs and to exp
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31
LASER PR
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models to test
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addition/lossc fuels, in bobuilt reactortion, will be m
ct the weakne have discohis Honours pk out the chossibility.
ed compounds to the chloroead use in cont environme
eric lifetimes rs of times gre990s and willgently needee. This projeced to be almo
the atmosp
key intermedreactions. O
ep in the “proospheric ceduce the fully oxidize
or increase y and leading
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r example:
attack on atmtracting H tohe OH-adduestigate eithohexene) anm and probed electronic sal step in atm
s from commoth cases mar to make itmass selecte
nesses in atmovered that project, you wemical mech
ds (collaboratofluorocarbonommercial proental drawbacranging from
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ct can be tailoost exclusive
here and co
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molecular ed products the MW, g to harmful ng of either rpenes) or toluenes) is eral projects
mospheric spo form H2O acted radicals
her a typicad react it witd using laserstructure of t
mospheric pro
on fuels andaking radicalt gain or lod and probed
32
mospheric chmany carbowill make mehanism and
tion with Chrins (CFCs) anoducts, but wck: they abso
m decades to rbon dioxide
r centuries. Tand the pathwored to have
ely experimen
ombustion (C
pecies: OH and a radicas have beenl biogenic cth OH. The er spectroscopthe radical processing of t
d biofuels: Hs. In this pr
ose H. Thed by laser sp
hemistry of Honyls are a easurementsimportance.
ris Hansen): Hnd hydrochlowith no ozoneorb infrared licenturies. Th (CO2). Thes
Their atmosphways by whic a significant ntal in nature
Collaborator
can attack l, or adding n scarcely mcompound (eensuing OH-apy to determroduct. This wthese compo
Hydrogen atoroject you we resulting pectroscopy.
H2 before wesource of H
s of H2 produ Collaborat
Hydrofluorocorofluorocarboe depletion poght very strohis leads to gse compoundheric chemistch these spe computation, or anywher
r: Tim Schm
unsaturated across a -b
measured in e.g. -pinenadducted or aine where thwill provide tunds.
ms can be loill choose suradical, the
e reach this H2 when expuction from a tion with atm
carbons (HFCons (HCFCsotential. How
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midt)
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gained by nd use a ediate in
BIOI
Inspired chemistrof our wchemicaand biolcellular i1) Dev2) Use
syntOur worchemistr It wouldprojects
(a) J. Kruzic
Hydrogeremodeldynamicof stimulare inveresponseforce. WchemistrRecentlyhydrogeHorizonsconjugatand chelinkages
(b) biomate
3D printformulatprolongeobserved
INSPIRED
by biologicary to mimic th
work is motival cues (extraogical cues dentity, fate elop model s the output frthetic organork is necessary, materials
d be great tos:
Mechanochc, Mech. Eng
els in tissue led, and und
c chemistry inli-responsive
estigating chee to stimuli iWe are parry can be moy, we demonl facilitated rs 2016). Thistion tag, and emistry of ss that we are
Directing therials (w/ Pro
ing of cells ation, segregaed printing, d in nature.
D MATERI
al materials, he physical avated by a dacellular matr(paracrine anand function
synthetic platrom 1 to des
oids, model tuarily interdisc fabrication (b
o work with
hemical funcg.)
are viscoeladergo dynamn the laborat
e motifs, or seemical linkagncluding: temrticularly intodulated thronstrated howreaction withs approach represents asoft material interested in
he chemistrof. J. Gooding
and tissues iation of diff
and difficu New metho
ALS, TISS
we integrateand chemicadynamic modrix compositiond juxtacrine. Our broad atforms for celign clinically umours, tissuciplinary; honbioprinting, li
Honours stu
ctionalisatio
astic materiamic changes tory most ofteecondary polges in hydromperature, pHerested in ough applied force-induce an appropris amenablea new route ts. There ar investigating
ry/architectug)
s limited by ferent cell tulty recreatindologies to q
33
SUE ENGI
e nano- andl properties o
del of the mion), physica
e signals) guaims are to: ll biology res relevant biomue repair andnours studenthography), a
udents on th
n of hydrog
als that are in chemistryen involves ilymerization gels that areH, enzymaticapproaches compressioed bond ruptriate acceptoe to patterninto modifying re several og.
ure of 3D e
issues with ctypes, cell vng complexquickly fabri
LT: 9385 46
INEERING
d micro- fabrof the cell anicroenvironml cues (geomides mechan
earch and himaterials tha
d replacemennts will gain and cell and
he following
gels (w/ Prof
continuouslyy. Recreatingincorporationroutines. Wee dynamic inc activity and where the
on or tensionture in a dis
or molecule wng virtually a the mechaniother dynam
extruded so
complex bioiviability duri
x architecturcate cell-lad
DLevel 7, Hilm666 E: k.kilia
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rication technnd tissue mic
ment where thmetry, mechanochemical s
gh-throughpuat direct a funnt). practical exmolecular bi
g
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y g n e n d e . ulfide linked within the many molecule cs
mic
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DR. KRIS Kmer Buildinan@unsw
ANOCHEM
niques with croenvironmehe interplay
anics and topsignalling to
ut drug devenctional outco
xperience in ology techniq
poly(ethylenaterial (Fig. with the ap
ompression ruptent reaction with
Extrusion of celd alginate (Adv
KILIAN ng (E10) .edu.au
MISTRY
synthetic ent. Much between
pography) influence
elopment. ome (e.g.
synthetic ques.
ne glycol) 1; Mater.
ppropriate
tures disulfides h acceptor
ll-laden chemicv. Mater., 2015)
for
cally )
tissue sttissue ecomposimicrofluico-culturwithin a
(c)
Cells inphysiolomechanmicroenvdevelopereversibmechanEnabledduring oAdv. Hesimple pdirectionwith revnanoparmicroenv
(d) Stenzel)
Our inteprogresstumour colonizahydrogeof thesestate (Ficells arecauses oof our therapeuin need exploringcell typeJunmin Lee, Mer
Joshua M. Grolm
Amr A. Abdeen, (19), 2536-2544.
Junmin Lee, Am
tructures witengineering. ition (Fig. 2;idics will be ere formulatio3D bulk poly
Magnetoact
n vivo interogical and ics and mvironments ed a compoly modulatedics—to stud by the dyn
osteogenesisealth. Mater. permanent mns in this proversible bonrticles withinvironment fo
Synthetic tu
erests in cesion and me
microenviroation. We mils and were a
e micro-tumoigure 4; Natue believed toof suffering in
model sysutic developmof students g spatiotemp
es. redith N. Silberstein, Amr
man, Douglas Zhang, And
Junmin Lee, N. Ashwin B.
r A. Abdeen, Kathryn L. W
h well-defineWe are exp Advanced Memployed to
ons for transly(ethylene gly
tive hydroge
ract with mpathologica
matrix presin the labor
osite magnetod across thedy temporal amic reversi where stiffe 2016). Thesagnets, whic
oject involvesnds (e.g. H-n the hydror therapeutic
umours for c
ellular “plastietastasis is onment thaicroengineereable to uncovrs in orchest
ure Materials be the root n cancer. Oustems into ment on patieincluding: neporal uptake
r A. Abdeen, Sang Yup K
drew M. Smith, Jeffrey S.
Bharadwaj, Randy H. Ew
Wycislo, Timothy M. Fan,
ed segregateploring the eMaterials 20 establish graation to a 3D
ycol) hydroge
els to drive c
matrices thatal processesentation. Hatory has poactive mate
e full spectrurelationship
bility, we disening guides se materials
ch will broades: 1) the inve-bonding in gel framewo
c developmen
cancer nano
city” has lea conseque
at promote ed small pover an intrigutrating the ac 2016). This cause of rec
ur vision for thautonomous
ent derived cew hydrogel of nanopart
im, and Kristopher A. Kili
Moore, and Kristopher A
woldt, and Kristopher A. K
and Kristopher A. Kilian,
34
ed populationextrusion of m015). By incoadients of mD printer to el.
cell and tiss
t are dynaes governedHowever, rproved challeerial—where um of physios in cell-mascovered crit lineage spe can be ada
en the use ofestigation of
polysacchaork, and 3)nt.
omedicine d
ed us to caence of dyn intravasatiopulations ofuing role for gctivation of a is importantcurrence andhe future of ts tissue-mimcells. We havchemistry anticles, integra
ian, Mechanochemical fu
A. Kilian, Rapid 3D extrus
Kilian, Magnetoactive hyd
, Interfacial geometry dict
ns has the pmultiple hydorporating chultiple cell bidirect write t
sue engineer
amic, with md by chanrecreating tenging. We stiffness ca
ologically releatrix interacttical time pe
ecification (Fapted to muf this techniqustiffening anrides), 2) c) establishin
development
ncer, wherenamic interacon, extravaf melanoma geometry at ta cancer stet because thed metastasisthis work is thmetic architve several nend fabricationation of mult
nctionalization of disulfide
ion of synthetic tumor mic
rogels for temporal modu
tates cancer cell tumorige
potential to brogel materia
hemical handnding ligandsthe cell-laden
ring
many nging these have
an be evant tions.
eriods ig. 3; ltiple hydrogue to virtually
nd softening covalent tethg a 3D ma
t (w/ Prof. M
e we believections in theasation andcells across
the perimetem cell (CSCese CSC-like
s, the primaryhe integrationtectures, foew directionsn techniquestiple differen
e linked hydrogels, Mater
croenvironments, Advanc
ulation of stem cell activity
enicity, Nature Materials,
Fig. iron Hea
be transformaals of tissuedles in the ps. We aim ton extruded h
gel systems, y any laboratin hydrogel
hering of iroagnetoactive
M.
e e d s
er C) e y n
or s s, nt
rials Horizons, 2016, 3, 44
ced Materials, 2015, 27 (3
ty, Advanced Healthcare
2016, 15, 856-862.
3. Cancer cell particles in a h
alth. Mater., 201
Fig. 4. Incurvaturethe activstem-likeMater., 2
ational to e-mimetic polymers, o develop hydrogels
and use tory. New materials on oxide e tumour
47-451
37), 5512-5517
Materials, 2016, 5
adherent to hydrogel (Adv. 16)
nterfacial e will guide ation of a
e state (Nat. 2016)
Climate considerthe fact fluctuatesource rstorage
I am opsystem. principleexpectin
Please f
It would
(a) RechUniversi
Aluminiutheoreticdevelopienergy tproved dmultivalecapacity
Based oreversibis unlockand batt
changes, der utilising ene that sustain
es all the timranging fromapplications
pening a newOur researc
es to developng to conduct
feel free to co
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on preliminaryle Al-ion inteking the full ptery enginee
Leve
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w research ch project wilp advanced t interdisciplin
ontact me if y
o work with H
Al-ion Batter
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y and unpublercalation thropotential of reering. Based
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ossil fuels, austainable rey sources arnt advances ectronic devile resources
group whichl combine syenergy storanary researc
you need any
Honours stu
ries – (In co
undant elem8056 mAh mes utilising aldevelopmentectrode mateis accompan
lished resultsough electrocechargeable d on the larg
35
718, Scien
VANCED E
and global wesources, incre highly ab in lithium-ioices to elect will become
h focuses onynthetic chemage devices, h and establ
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ment in the EmL–3) on accluminium offt of Al-ion berial that canied by signi
s, we envisiochemical pro AI-ion batterge selection
nce and En
ENERGY
arming havecluding wind undant, the
on battery tetric vehicles. increasingly
n developingmistry, electro in particularish collabora
rmation.
he following
with Prof. J.
Earth’s crustcount of its mers a golden
batteries has n reversibly ificant structu
on that redox-ocesses. Theries, by comb and synthe
DR. DOngineering B
E: dongju
MATERIA
e encouragedpower and ssupply of schnology ha In the future important.3
next-generaochemistry, ar, rechargeabations with oth
projects:
Fraser Stod
t. (ref) It hasmultiple redon opportunity not reachedintercalate A
ural changes
-active compe overarchingbining syntheetic versatilit
ONG JUNBuilding (Sun.kim@unsw
ALS CHEM
d scientific ssolar energy
sustainable rave enabled e, developin
ation energyand materialsble batteriesher research
ddart at Nort
s one of theox states.4 Ty for deliverind a stage yeAl-ions, becs, resulting in
pounds couldg goal of thisetic organic cty of various
N KIM EB, E8) w.edu.au
MISTRY
society to . Despite esources a power g energy
y storage s science . We are
h groups.
hwestern
e highest Therefore, ng a high et. It has ause the n a rapid
undergo program chemistry s organic
moleculestarting
Figure 1compariscompounthe cationresulting
(b) Lith
The Lithapplicatideliverinof activenanostrudissoluti
1. Huggins R. Ad
2. Armand M. &
3. Choi J. W. & A
4. Elia G. A., et a
5. Kim D. J., et a
6. Moon S., et al
es5, the redopoint for dev
. (a) Theoreson between nd. Upon discnic chloroalum in the formatio
hium Sulphu
hium–Sulphuon on accou
ng long cyclee material ducture electroon of polysu
dvanced batteries: Materi
Tarascon J.-M. Building b
Aurbach D. Promise and
al. An overview and future
al. Redox-active macrocyc
l. Encapsulated monoclin
ox-active comeloping affor
etical volumetLi-ion and A
harging, the mminates, whichon of tetracoo
r Battery – (
ur system isunt of its hig life mainly d
during redox ode as well lphides throu
ials science aspects. Spr
better batteries. Nature 4
reality of post-lithium-ion
e perspectives of aluminu
cles for organic recharge
ic sulfur for stable cycling
mpounds baserdable large-s
ric and specAl-ion batteriemacrocycle is h were genera
ordinated alum
(In collaborat
s a promisigh theoreticadue to the for processes. as encapsul
ughout the ba
inger Science & Business
51, 652–657 (2008).
batteries with high energ
um batteries. Adv. Mater.
able batteries. J. Am. Ch
g of li–s rechargeable bat
36
ed rechargeascale energy
cific capacity es. (c) Electr reduced to itated by the a
minium comple
tion with Prof
ng high-peral specific crmation of so In this projlates sulphurattery cycling
s Media, 2008.
gy densities. Nat. Rev. Ma
28, 7564–7579 (2016).
hem. Soc. 139, 6635–664
tteries. Adv. Mater. 25, 65
able AI-ion bay storage app
of Li-ion anrochemical res semiquinon
asymmetric cleex.
f. Do Kyung
rformance bapacity.6 Ho
oluble polysuject, we willr within the e
g process.
ater. 1, 16013 (2016).
3 (2017).
547-6553 (2013).
atteries couldplications.
d Al-ion battedox of quinoe state. Followeavage of dia
Kim at KAIST
attery candiowever, it ha
lphides3, whl design a 1electrode, in
d provide a p
teries. (b) Baone-based mwed by interaluminium hex
T)
idate for laras come up hich results in1-dimensiona order to pre
promising
attery cell acrocyclic
acting with xachloride,
rge-scale short on
n the loss al hollow event the
The maibioactivesystemsVery ofte analoguebiologicaresearchmolecula
(a) Quorum
The emedevelop availableorganic vivo antnovel aninhibit tpathwayinteractiorepresenresistancheterocy
New sca(in collab
The majmoleculaminimizilimitationease wicentral moleculaon biphfunctioni
in focus of te moleculess. Such chemen such dive syntheses nes. The acal activity anh is multi-disar modelling
DESIGN AN Sensing Inh
ergence of m novel classee in this arsynthesis, mtimicrobial sntagonists ofthe regulatoys of bacteriaon using the nts a non-grce. In particyclic compou
affolds for anboration with
ority of convar targets. Hng unwanten of antibioticith which reaim of this ar antimicrobhenyl scaffoing of the me
S
the researchs. Naturally micals are uerse moleculnot only provccess to vad mode of asciplinary in and biologic
ND SYNTHEShibitors
multi-drug rees of antimicrea focussin
molecular modscreening. Tf bacterial si
ory quorum a, and will m X-ray crystarowth inhibitiular, this pronds with anti
timicrobial di Prof. David
ventional antiHaving very w
d side effeccs targeting aesistance ca
project is tbial peptide (Solds, which embranes of
SYNTHET
undertaken produced csed to medies are produvide access rious structuction, and of nature and al screening.
SIS OF NOV
esistance in crobials for thng on a codelling, and iThis project ignalling path
sensing comodel the real structures ion strategy oposal will inimicrobial ac
iscovery StC Black)
biotics used well-defined tcts. Howevea single rece
an be develoto design nSMAMP) mim disrupt thf the bacteria
37
Level 7,
TIC ORGA
in my groupchemicals ariate interactiuced only in to sufficienturally-relatedffers opportu involves a .
VEL ANTIMIC
common huhe treatmentombination oin vitro and iwill develo
hways, whicommunicatioeceptor-liganof bacterial s that is lessnvestigate th
ctivity.
today share targets, thesr, a major eptor is the oped. The ovel small mics based he normal al cell, and
PRO, Science a
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p is the discre of fundaons across minute quant quantities od analogues unities to dev
combination
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Hydrophobigroups
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allows full velop new then of syntheti
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HN
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NAL CHEM
development ortance in bf biological hor innovativelecules but aassessmenterapeutic leaic organic c
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O
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UMAR ing (E8) w.edu. au
MISTRY
of novel biological hierarchy. e organicalso their t of their ads. The hemistry,
need to ojects are
asR. This t of drug of novel
n specific electivity,
CationicGroup
OOH
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Small An(In collab
The rapithe neepeptidesbactericiaction isaims to susing a microscoremarkastructurein self-astudied f
(b) (in collab
Cancer ion a gloaltered mto most glucose blocks fodioxide (cancer cmoleculeof this pcompou
(c) (in collab
Myelodyblood cea conseqCurrentlyazacytidreduce suppresslimited benvironmactivity acancer c
nsequence ass resistance
ntimicrobial Pboration with
id emergenced for deves (AMPs) areidal properties predominansynthesize avariety of tecopy and fluo
ably versatilees. Functionaassembly intofor their local
DEVELOPINboration with
is a major buobal scale. Ametabolism o normal cells for non-oxidor cell divisio(CO2) in mitocell glucose me that increas
project is to gnds will be e
NOVEL CYTboration with
ysplastic syndell productionquence of boy, the front-ine (AZA), wtumour formsor genes. Hby their highments. The aand drug-likecell lines, and
llow the devee mechanism
Peptides h Dr Adam M
ce of bacterialopment of e a diverse aes. AMPs acntly attributeda series of smchniques incorescence m
e materials walisation of tho hydrogels lisation and/o
NG ANTICAN Dr Kyle Hoe
urden of diseA hallmark feof glucose cos, cancer cedative purpoon (lipid, DN
ochondria. Thmetabolism tses glucose generate newvaluated for
TOSINE ANA Dr Ashwin U
drome (MDSn in the boneone marrow f-line treatmewhich acts amation in pHowever, theh cytotoxicity
aim of this proe properties. Td their mecha
elopment of s used by ba
artin)
al resistancealternative
array of natuct via non-recd to their fac
mall AMPs ancluding suppomicroscopy. which can she N-terminucomposed oor transporta
NCER COMPehn, BABS, U
ease, affectineature of neompared to nlls use a greses including
NA and protehe goal of thito be more lioxidation and
w derivatives anticancer a
ALOGUES AUnnikrishnan
S) is a group marrow. Patfailure and p
ent of such as a DNA mart through use of the cy, as well aoject is to geThe new comanism of actio
38
antimicrobiaacteria agains
e to current aanti-infective
urally-occurriceptor interaccially amphipnd elucidate orted lipid bilSmall amphelf-assemble
us of these sof long, entwtion across t
POUNDS THUNSW)
ng the lives oearly all cancnon-canceroueater proporg the produein), rather tis proposal iske that of nod selectively with enhancctivity in vari
AS ANTI-CANn)
of cancer ditients diagnorogression todisease is t
methyltransfer the increacurrently devas their poornerate a varimpounds willon.
l agents withst other antib
antibiotics fure strategiesng moleculections. Their
philic structurtheir mechanlayers (tBLMhiphilic shorte into a varishort peptideswined fibres. he bacterial c
HAT ACTIVA
f tens of millcer cells is tus cells. Relation of incomction of buildthan oxidativs to develop on-cancerous kills cancer ced activity aous cancer c
NCER AGEN
iseases that osed with MDo acute myelthe cytosinerase (DNMTse expressi
veloped inhibr bioavailabiiety of new cy be evaluate
h enhanced abiotic types.
rther increas. Antimicrobs that posse mechanism re. This projenisms of acti
M), atomic fort peptides aiety of elegas with aromaThe modifiecell membran
TE GLUCOS
ions their ative ming ding
ve pathways anticancer m
s cells. We hcells in vitro
and drug-likecell lines.
NTS
affects normDS often die aoid leukaem
e analogue, ) inhibitor thon of tumo
bitors has beelity and stabytosine derivd for antican
activity and t
ses bial ess of ect ion rce are ant atic groups ced peptides wne.
SE OXIATIO
that producmolecules tha
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mal as ia. 5-
hat our en bility in physvatives with encer activity i
N
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Educatospecificateachingdifficultiebased re Are youdifferenyou:
(a)
As part oexpandintested laconcepts
You will following
(b)
Technologreatly entertainalready developilearning
ors have proally in chemisg to provide aes students esearch.
u interested nce on the w
Effects of th
of the excitinng on similaaboratory skis by complet
have the opg research qu
Do students Are studentsDoes this asIs the blende
Developmen
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ning way to lexist [5] bu
ing gamifica in Chemistry
gressed signstry [1-3], hoan outstandilearning che
in doing resway we edu
hreshold/ma
ng new chanar changes lls. In this noting hurdle ta
pportunity to uestions that
study differes more effectssessment med (online an
nt of online
panded the pning and inclearn potentit are not yetion aspectsy then you co
nificantly in towever there ng educationemistry enco
search in chucate our st
astery learni
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engage witht may influenc
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possibilities crease efficially boring o
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39
the past 50 is still muchnal experiencounter using
emical eductudents? Th
ing
year chemiste award-win
ment studentsne lessons to
h this excitince future dire
shold assessng and applybetter unders
ce) material m
activities
of where teaiencies in teor repetitive cd into the cu-based appsved in some
LT: 9385
years in unh to discoverce at UNSW
g modern tec
cation? Do yhe following
ry a novel asning undergs must show o receive a p
ng and innovections of un
sments compying the thresstanding of tmore helpful
aching can geaching [4]. content. Somurriculum at s and resea exciting proj
DR. Level 1, Da5 4708 E: k.
CHEMICA
nderstanding r, develop an. We hope tochnologies b
you aspire to projects m
ssessment mraduate labo complete knass in the co
vative projectdergraduate
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go. When us Game-base
me apps speUNSW. If yrching their ects in this fi
KIM LAlton Buildinlapere@unsw
CAL EDUC
how studennd implemeno address thbacked by e
o make an immay be just
method is beioratory prog
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t by focussin teaching:
tional modelsdge?
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sed effectiveed apps pro
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PERE ng (F12) w.edu.au
CATION
nts learn, t into our
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mpactful right for
ing used, gram that threshold
ng on the
s?
ely it can ovide an chemistry rested in student’s
40
(c) Have your own idea(s)?
If you have your own idea for a project that aligns with our philosophy then we would like to hear from you. Get in contact with me and we can discuss your project idea(s).
References
1. M. M. Cooper and R. L. Stowe, “Chemistry Education Research—From Personal Empiricism to Evidence, Theory, and Informed Practice,” Chem. Rev., vol. 118, no. 12, pp. 6053–6087, 2018.
2. N. Reid, “A scientific approach to the teaching of chemistry. What do we know about how students learn in the sciences, and how can we make our teaching match this to maximise performance?,” Chem. Educ. Res. Pract, vol. 9, no. 1, pp. 51–59, 2008.
3. V. Talanquer and J. Pollard, “Let’s teach how we think instead of what we know,” Chem. Educ. Res. Pract., vol. 11, no. 2, pp. 74–83, 2010.
4. M. K. Seery, “Harnessing technology in chemistry education,” New Directions in the Teaching of Physical Sciences, vol. 0, no. 9, pp. 77–86, 2013.
5. “New app a game changer for chemistry education - RMIT University.” [Online]. Available: https://www.rmit.edu.au/news/all-news/2017/jun/new-app-a-game-changer-for-chemistry-education. [Accessed: 21-Aug-2018].
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46
would learn how to synthesize molecules, and multiple techniques including how to run reactions in solution and on solid phase. In this project you would learn how to synthesize molecules utilizing solution and solid phase chemistry. You will learn how to run proton and 2-D NMR, LCMS, and column chromatography. You will also have the opportunity to learn how biological assays work on your compounds, including cell death, cell permeability, protein level analysis via western blots, protein folding assays, and protein expression.
(c) Developing prodrugs: a general approach for building cell permeable drug molecules
This project will involve the synthesis of prodrugs that can enter cells and where masking groups are cleaved in cell lysate revealing the active molecule. The approach for this project will involve the incorporation of masking polar side chains with methyl groups, which are easily removed upon cell entry via enzymes. Prodrugs will also incorporate N-methyls on the backbone amide bonds and D-amino acids, both modifications disrupt intramolecular hydrogen bonds within a macrocycle and change the orientation of the side chains in such a way as to improve cell permeability. The prodrug molecules will also include asparagines, where these side chain amides increase transport across the cell membrane. In this project you would learn how to synthesize molecules utilizing solution and solid phase chemistry. You will learn how to run proton and 2-D NMR, LCMS, and column chromatography. You will also have the opportunity to learn how biological assays work on your compounds, including cell death, cell permeability, protein level analysis via western blots, protein folding assays, and protein expression.
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51
mediate the phosphorylation. This work originated from earlier work on the synthesis of a natural product. Variolin B is a member of a unique class of marine alkaloids isolated from an extremely rare Antarctic sponge. It is no longer available from its natural source. The Morris group have devised a synthesis of variolin B that has restored access to the material and allowed further biological studies to be carried out. From this work it has been established that variolin B is a potent kinase inhibitor and represents an important scaffold for the development of kinase inhibitors. A range of analogs have been developed that are more selective inhibitors of certain kinases, as well as have better properties (such as solubility).
Our recent publication (ACS Chem. Biol., 2017, 12, 825) describes how we have developed a new class of kinases inhibitor that selectively inhibits the kinase SRPK1 and has led to the identification of a series of molecules that are currently being developed as a treatment for aged macular degeneration, in collaboration with Exonate.
The Morris group is focused on developing selective inhibitors of the various RNA slicing kinases (the CLKs, DYRKs and SRPKs), with appropriate drug-like properties so they can be used as chemical probes to help understand the role these important kinases have on biological systems. A combination of synthesis and structure-based drug design is used to do this work, with students able to use Schrodinger and Cresset software to aid their design work.
(c) Developing the AAL(S) Scaffold for Therapeutic Applications (collaborations with Assoc Prof Nigel Turner (SOMS), Prof Alaina Ammitt (UTS), Dr Nikki Verrills/Dr Matt Dun (Newcastle)
Ceramide synthase (CerS) and protein phosphatase 2A (PP2A) are two enzymes that play a critical role in the regulation of multiple cellular signalling processes. The malfunctioning of these two enzymes has been found to have implications in diseases such as cancer, diabetes, asthma and neurological diseases including Alzheimer’s disease and stroke. Little is known about the biological mechanism of these enzymes and in particular, how they cause such diseases. To gain insight into these biological processes, the CerS and PP2A binders, FTY720 and AAL(S), will be used to explore the binding site of both enzymes and allow the identification of chemical probes which can be used to develop an understanding of the biological mechanisms of these complex diseases.
Development of the AAL(S) scaffold will allow for analog production which along with key biological testing will provide key information towards revealing the biochemical pathways and proteins involved regulating both enzymes at a molecular level. With Prof Ammitt, work is focused on using these molecules for the development of therapeutics for the treatment of asthma, whereas with Asoc Prof Turner we are developing molecules to elucidate the role of CerS in fat metabolism (see Turner et al, Nature Communications, 2018, 9: 3165 | DOI: 10.1038/s41467-018-05613-7)
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MISTRY
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53
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54
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USUAL CULES
ocatalytic
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55
compound family. Due to the donating ability of the two nitrogen atoms, the exocyclic C-C double bond is very electron-rich and strongly polarized. This interesting feature of NHOs offers multinucleophilic reactivity over the ketene aminal frameworks.[6] Due to the strong nucleophilicity of the -carbon, NHOs can act as strong Lewis/Bronsted bases.[7-9] This project will focus on synthesizing a family of NHOs, estimating their basicity and applying them as organocatalysts to promote environmentally friendly chemical processes. Students are encouraged to discuss with Vinh in person about this project.
(c) Project NTV3 - Tropylium-Based Host-Guest (collaboration with A/Prof Pall Thordarson) This project will explore the potential of tropylium-bearing systems in host-guest chemistry in collaboration with A/ProfPall Thordarson’s group. The electron-deficient nature of tropylium moiety makes it particularly attractive for the bindingand sensing of small and medium-sized biologically importantanions such as chloride, phosphate and carbonates. Wepropose the synthesis of tropylium-based macrocycles (see figure) as the starting point for this project, which will representa new platform in supramolecular chemistry. Please also see Thordarson’s Honours projects for more details.
References [1] D. J. M. Lyons, R. D. Crocker, M. Blümel, T. V. Nguyen,* Angew. Chem. Int. Ed. 2017, 56, 1466-1484. http://dx.doi.org/10.1002/anie.201605979
[2] T. V. Nguyen,* A. Bekensir, Org. Lett. 2014, 16, 1720-1723. http://dx.doi.org/10.1021/ol5003972 [3] T. V. Nguyen,* M. Hall, Tetrahedron Lett. 2014, 55, 6895-6898. http://dx.doi.org/10.1016/j.tetlet.2014.10.100 [4] T. V. Nguyen,* D. J. M. Lyons, Chem. Commun. 2015, 51, 3131-3134. http://dx.doi.org/10.1039/C4CC09539A
[5] Demelza J. M. Lyons, Reece D. Crocker, Dieter Enders, Thanh V. Nguyen,* Green Chem. 2017, in press (DOI = 10.1039/C7GC01519D). http://dx.doi.org/10.1039/C7GC01519D
[6] R. D. Crocker, T. V. Nguyen,* Chem. Eur. J. 2016, 22, 2208-2213. http://dx.doi.org/10.1002/chem.201503575
[7] M. Blümel, J.-M. Noy, D. Enders, M. H. Stenzel, T. V. Nguyen,* Org. Lett. 2016, 18, 2208-2211.
http://dx.doi.org/10.1021/acs.orglett.6b00835
[8] M. Blümel, R. D. Crocker, J. B. Harper, D.Enders, T. V. Nguyen,* Chem. Commun. 2016, 52, 7958-7961.
http://dx.doi.org/10.1039/c6cc03771b
[9] Ugur Kaya, Uyen P. N. Tran, Dieter Enders, Junming Ho, Thanh V. Nguyen,* Org. Lett. 2017, 19, 1398–1401. http://dx.doi.org/10.1021/acs.orglett.7b00306
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Bis-β-diketon
ample cryptop
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irectly.
We are modificatranslatio(a) Devehard tis
Repairinchallengsignificanegativeis to decustom-dare varioceramic high-temimpossib
(b) Nano
Cardiovaglobally.ability ofengineeregeneracardiomytissue emechanstimulateregion.
(c) Synt
Unlike oquantummetallic oxidativeDNA, caThey offhaving n
interested ination techniquon. elopment ofsue defects
ng large bonege and sunt socio-e
ely affect quaevelop a 3Ddesign synthous 3D prin scaffolds.
mperature sinble for incorp
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ascular disea In case of mf damaged hring offers ation, by yocytes. Thengineered pical strengthe formation
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other inorganm dots, mag
nanoparticlee lesions, dealcium phospfer several anon-toxic deg
n design, syues for tissue
f a technolos without usi
e defects remboptimal ou
economic ality of life. T
D printing prhetic bone gting techniquHowever, th
ntering after poration of bio
cardiac pat
ases are themyocardial inheart tissue is
promising combinin
e aim of this patch that prh, and bioacof new vasc
rous calcium
nic nanocarrnetic nanopa
es that increaecrease cell
phates are theadvantages ogradation pro
BIOMAREGE
ynthesis and e engineerin
ogy for 3D ping sintering
mains a majoutcomes carepercussionhe aim of thocess to fab
graft. Currenues for fabrihese scaffolprinting that omolecules s
tches for tre
e leading caufarction, the s severely lim
strategies g biomateproject is to ovides optimctivity for ceculature, and
m phosphate
iers such asarticles, silicase mutation viability ande safest cateover other naoducts, excel
60
ATERIALSENERATIO
characterisag and regen
printing of pg; ink optim
r surgical an have ns and is project bricate a tly, there ication of lds need makes it such as grow
eatment of m
use of death regenerationmited. Tissue
for cardiacerials and fabrication a
mal structureells that cand facilitate o
e nanopartic
s carbon naca nanoparticn frequency, d induce daegory of biomanoparticles llent biocomp
Level 7, H
S DESIGNON (with S
ation of biomerative medi
porous bioaisation
wth factors an
myocardial in
h n e c d a , n oxygen and n
cles for drug
notubes, cles and produce mage to
materials. such as patibility,
DR. IMAHilmer Build
E: iman.ro
N FOR SKEScientia Pro
materials andcine with an
ctive ceram
nd drugs.
nfarction
nutrient trans
g delivery ap
AN ROOding (E10), oohani@unsw
ELETAL Tof. Justin G
d developing emphasis o
mics for trea
sfer to the d
pplications
OHANI Rm735 w.edu.au
TISSUE Gooding)
g surface on clinical
tment of
damaged
in vivo acalcium in the fnanomeof poros
(d) Fabcomposantimicr
Bioactiveand regebond to bioactivein termsquite chsintered aim of composiinto 3D c
(e) Devenginee
There isIdeally, tsimilar tointerconattachmevascularMoreoveoxygen producinporous cdoes nostrong p
(f) Bioacas a cue
Incorporfor direcengineecalcium enhanceany groosteoart
and in vitro sphosphate n
field that hadicine. The aity to be able
brication ansition melrobial prope
e glasses haenerate osse host bone ae glasses has of numberhallenging to without crysthis project
ition that hasconstructs w
veloping a ering.
s a current nthe structure o that of trabnected poreent, proliferisation ander, porous sttransfer that
ng porous mconstructs mot resemble torous scaffo
ctive ion dee for stem ce
ration of therct stimulationring strategiphosphate
e chondrogenowth factor thritis.
tability, and nanoparticlesas impeded aim of this pre to uptake su
nd in vitrolt-derived erties.
ave been useeous defectsand stimulateave been lagr of commer design a gstallisation but is to fabrs antimicrobiaithout or min
facile tech
need for bett of the synth
becular bone,es. This is eration, and formation tructure facilt are key fa
materials suchade by suchthe trabeculalds that mimi
elivery by caell differenti
rapeutic ionsn of cells is ies. The aimnanoparticle
nic differentir and a p
pH depende in porous anthe applicat
roject is to syubstantial am
characteribioactive
ed in the clins due to theie new bone ging behind rcial productglass composut also remaicate a newal property aimal crystallis
hnique to f
ter bone graetic graft sho, highly porouessential fo
d migratio of new litates nutrie
actors for heh as polyme methods sh
ar bone. Theics the trabec
alcium phosiation.
into the struan attractivem of this ses doped wation of stem
possible tre
61
ent solubility. nd non-agglotion of this ynthesis calcmounts of bio
isation of glasses
nical practiceir unique abgrowth. How other biocerts worldwidesition that c
ains bioactivew bioactive and can be fosation.
fabricate h
aft substituteould be us with or cell n for tissue.
ent and ealth cell meer sponge mhow either lowe aim of projecular structur
phate nano
ucture of bioe approach fstudy is to with specific m cells withoatment me
Despite all oomerated formcategory ofium phospha
omolecules.
novel with
e to fill ility to wever, ramics e. It is an be e. The
glass ormed
ighly porou
s to regener
etabolism. Tethod, robocw mechanicaect is to estare of bone at
particles
materials for tissue fabricate ions to out using thod for
of these advam has been a materials i
ate nanoparti
us ceramic
rate disease
There are vacasting or exal strength orablish a facile complex ana
antages, synan ongoing cn drug delivcles with hig
cs for bone
ed or damag
ariety of metxtrusion prinr a pore struce method toatomical sha
nthesis of challenge very and h degree
e tissue
ed bone.
thods for ting. The cture that produce
apes.
My reseapplicatirenewabdetection
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Light froBut, to gneglect tthe bandefficiencreached harnessewavelen
Recentlyorganic concentrrange of
(b)
One stracollectorSuch syluminesc
When liisotropictowards reabsorproles of reduce improvebe possorientatio
earch group ons ranging
ble energy. On schemes, v
Photochem
om the sun generate a pthat part of thd gap. Such
cy of solar ce 25%). Photed to congth light, inc
y, we havepolymer andrate the absof nanostructu
New Materia
ategy to slasr. However, ystems are cence solar c
ght falls oncally. About solar cells ption effects.f absorption
reabsoments have sible by cleon of transit
M
investigatesg from studyOur principavacuum cham
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reaches us photovoltagehe spectrum a strategy lells to abouttochemical unvert long reasing the p
applied Pd dye-sensitorption of lighured architect
als for Lumi
sh the cost ousually such expensive concentrator
n a slab of 75% of this on the edg. We will cou and emissiorption. been shown ever design ion dipole m
MOLECULA
s how moleying radicals al tools are fmbers and m
version for Im
as a contine in a solar c with photon imits the ene 33% (UNSW
upconversionwavelength
photocurrent
UC to amoized solar ceht and increatures incorpo
nescence S
of solar enerh systems re
and cumb is promising
material co light is trapge of the suple fluoresceon, and Further
by us to of the
moments.
62
Level 5,
AR SPEC
ecules intera and ions ofemtosecond
mass spectrom
mproved So
uous spectrcell, we usu energies beergy conversW Si cells hn (PUC) canh into sho of the device
orphous silicells. But, effase upconveorating biomim
Solar Concen
rgy is to useely on geombersome, an way to do th
ontaining fluopped in the slab. Until nent dyes to
PROF, Science a
T: 04 39 3
TROSCOP
act with lighof astrophysid and nanosmeters.
olar Energy C
um. ually elow sion ave be
orter e.
con, ficiencies arersion efficienmetic light ha
ntration (wit
e a small aremetric concennd cannot chis using pas
orophores, lslab by tota
now, such slight-absorbi
. TIMOTnd Enginee86 109 E: sc
PY AND S
ht, and the cal and atm
second laser
Conversion
e still too lowncies, we arearvesting ma
th A/Prof. Pa
ea of solar cntration of suconcentratedsive molecul
ight is absoal internal resystems havng nanomate
THY SCHering Buildchmidtim@g
SOLAR EN
consequencmospheric intrs, with soph
w for applicae currently exaterials.
all Thordars
cell and a launlight usingd diffuse ligles.
orbed but reeflection, anve been plaerials to sep
HMIDT ing (E8) mail.com
NERGY
ces, with terest, to histicated
ation. To xploring a
on)
rge solar g mirrors. ght. The
e-emitted d guided
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63
(c) Laser Spectroscopy of Isolated Radicals and Ions (with Prof. Scott Kable)
The new Molecular Photonics Laboratory houses sophisticated lasers and equipment with which we can discover new transient chemical species of importance in the gas phase chemistries of our atmosphere and the interstellar medium.
Atmospheric Radicals
One of the greatest scientific challenges of our time is to understand the complex chemistry of the atmosphere. Plants and human activity are responsible for >1000 Tg (1012 kg) of volatile organic compounds being emitted into the atmosphere each year. These molecules are processed into less volatile compounds which then find their way into secondary organic aerosols, which are a major natural impactor on public health and climate. In this project, we will develop laser-based spectroscopic methods to detect and characterize intermediates formed on the way from the plant to the aerosol particle.
Interstellar Molecules and Ions
As stars die, they eject complex organic molecules into the interstellar medium, where they live out millennia before being incorporated into new stars and planetary systems. These organic molecules are the seeds of life, but, as yet, we do not know the chemical make up of the interstellar medium from which planetary systems are formed.
Using a star as a lamp, we can peer into this medium using telescopes by observing molecular absorption spectra. However, despite there being hundreds of nibbles taken out of the visible stellar spectra of stars occluded by diffuse clouds, only a few molecules have been unambiguously detected by their visible spectra. The unidentified features are known as the diffuse interstellar bands, and are the longest standing mystery in astrophysical spectroscopy.
In this project, we will develop techniques to capture the spectra of isolated, never-seen-before aromatic cations which the leading candidates for carrying the DIBs, and (hopefully) solve this long standing problem.
(d) Advanced Spectroscopy for Complex Functional Materials (with Dr Dane McCamey, School of Physics)
Complex functional materials are employed in a range of applications, the development of which is motivated by the future technological needs of society. Organic solar cells, organic light emitting diodes and organic electronics all employ materials characterized by a complex relationship between morphology and function which can only be elucidated by advanced spectroscopic techniques.
Combining lasers and magnetic resonance, we will develop and apply new advanced spectroscopic techniques to complex functional materials, revealing the dynamical behaviour of charge carriers and excited states.
We their
We and elec
Our solid
It would
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Sodium-temperaconducti
chemically tur physical prouse a combi neutron d
ctrochemical goal is to fud oxide fuel c
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Towards the
ion batteriesmitations hav
and energyar sodium-ionharacterising
yte materials.and affo
ion battery te-scale energble power soof the followr component
electrode ma
electrodes prns for lithium will be synthtery performa
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une the atomoperties suchnation of tec
diffraction (aand impedanlly characteri
cells, and the
o work with H
e next gene
s are ubiquitoe restricted
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ordable rooto provide sgy storage frources. Stud
wing parts of in idealized
aterials
rovide the so-ion batterieshesized and ance. We areprove perform
ing ceramics0C). This pemperature.
S
mic arrangemh as energy shniques to ch
at the Austnce analysis,ise materials
en characteris
Honours stu
ration of bat
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om-temperatuufficient powom intermitte
dents will wof a battery abatteries.
ource of the s. Here, new characterizee working tomance.
s or glassy-cproject works
64
T
OLID STA
ment (crystal storage capaharacterise otralian Sync and electron
s, place themse how they
udents on th
tteries: Sod
daily lives, e.use in appli
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and p a ure wer ent ork and
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ATE AND
structure) ofacity, ionic coour materialschrotron ann microscopy
m into real-wowork in these
he following
ium-ion batt
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s and represntaining trans
mine the relatfolding layer
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R. NEERDa
4 E: neeraj.sh
MATERIA
f solid state nductivity or , including bud ANSTO),y. orld devices se devices.
projects:
teries
hones and lauiring highertarget new b
sent the largsition metal otionship betwred electrod
be excellenterials with s
RAJ SHAlton Buildinharma@unsw
ALS CHEM
materials to thermal exput not limited solid stat
such as batte
aptop compur power, e.gbattery chem
gest cost anoxides, phospween crystal de materials
t electrolytessufficient so
ARMA ng (F12) w.edu.au
MISTRY
enhance ansion.
d to X-ray te NMR,
eries and
uters, but g. electric istries, in
d energy phates or structure
s in order
s at high odium-ion
Negative
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(b)
The majfor billiontear on b(e.g. in material costs. Innegativedue to groups o(e.g. –Ctypically voids anstates. Ssynthesicontrollavoids of in order to produ
(c) phase e
Safety isadvantagthe ionicespecialapproximconductipreventito the cproject lcharacteto study will shed
(d)
Dependidesigned
e electrode m
e electrodes r lithium-ion
e electrodes be enable the
Tuning neg
ority of matens of dollars both moving optics, coat that neithern order to ae thermal exp
transverse or cooperativCN- or WO6
feature larnd cations wiSo why not s tool? In t
ably insert L the NTE mato tune the cce ZTE mate
Improving sevolution
s an importages to the hc conductivitly under am
mately 1000ivity of the eng further de
crystal structuithium-ion an
erized. Impor the formatio
d light on the
Other proje
ing on your d. Please co
materials
are the leas batteries shand underst
e next genera
ative therma
erials expand per year in parts (e.g. intings, electror expands n
achieve this, pansion (NTEvibrations o
ve rotations 6). These mrge crystalloth variable ouse a battethis project Li and Na iterials, via a
cooperative rerials.
solid-state e
ant aspect ohighly flammaties of solid-
mbient condit0C as the electrolyte. Ievelopment aures adoptednd oxide-ion rtantly, variabon (from star formation pr
cts
interests, onsult with Ne
st investigatehow poor petanding their ation of devic
al expansion
d during heatmaintenancen aircraft gasonics). If a znor contracts the oppositE) is a propeof atom of units
materials ographic xidation
ery as a we will nto the battery, otations
electrolytes
f high poweable liquid e-state compotions. At the
operating tn both examand use of thd by the eleconducting mble temperatrting reagentsrocesses and
ther solid steeraj for furth
65
ed componenerformance limitations tces.
n to produce
ting via therme, re-manufas turbines), azero thermals upon heatite extreme oerty exhibited
by underst
r batteries. Uelectrolytes thounds are g
e other extretemperatures
mples, electrhese technoloectrolytes anmaterials wilture time-ress) of these iod optimal con
tate projectsher details.
nt in a sodiumin sodium-io
towards reve
e zero therm
mal expansiocture and re
and componel expansion ing, this couof materials d by a small
anding thei
Using a solidhat are comgenerally loweme, solid os are esseolyte ionic cogies. The io
nd how they l be synthes
solved neutroonic conduct
nditions requi
, e.g. makin
m-ion batteryon batteries. ersible sodium
mal expansio
on and this pplacement co
ents that are (ZTE) mate
uld dramaticaare considegroup of ma
r formation
d-state electmercially ava
wer than thexide fuels cntially deter
conductivity ionic conducti
evolve with ized and the
on powder ditors under vared for synth
ng new supe
y and the com By developm insertion/e
on materials
process is resosts due to w designed to
erial can be ally reduce ered in this aterials predo
characteris
trolyte has sailable. Unfoe liquid councells often oprmined by tis a critical ivity is direct temperature
eir ionic condiffraction willaried conditiohesis.
erconductors
mpounds ping new extraction
s
sponsible wear and be static made, a industrial project -
ominantly
stics and
significant ortunately nterparts, perate at the ionic hurdle in ly related e. In this ductivities be used ons. This
, can be
The druginclu– thedete
In oprepdisc
It would
(a)
time withstudying
(b)
Carbohyscientificcommunsignal trTo improof a ligathe recotowards
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delivery of dg delivery hauding polymee core holds
ermines the inur group, we
paration to teuss their dru
d be great to
Imitating vir
h microscopg cell uptake
Drug carrier
ydrates havec communitynication evenransmission aove the distrnd (e.g. carbognition of m the improv
ent nanoparttriblock terpo
NANOPA
drugs can beave typically ers. In our gro the drug, manteraction wie work on difesting these pg delivery pr
o work with H
ruses with p
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rs inspired b
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nts, includingand infectionribution of drbohydrate anmalignant ce
ved treatmen
ticles prepareolymers
SC
ARTICLES
e improved by sizes belowoup, we syntainly anti-canth cells. fferent aspecparticles on croblems.
Honours stu
polymers: Le
Mnsswbqngndk
s such as A
by nature: N
a hot topic fo to the myria: cellular rec
n by pathogeugs in a biol
nd peptide taells), could nt of cancer
ed from
66
CIENTIALevel 7,
AND TAI
y packaging w 100 nm athesize varioncer drugs, w
cts starting frcancer cell li
udents on th
earning from
Most drug cnanoparticlessuccessful nstructures. Ewith its wormbioactive groquick entry. nanoparticlesgain more nanoparticlesdifferent softkey parame
AFM to evalu
Nanoparticle
for research ad number ocognition, inflens displayedlogical syste
argeted therabe an impor and other
A PROF. , Science a
T: 9385 4
LORED P
the drug intond can be pus polymers
while the she
rom organic sines. We hav
he following
m the succes
carriers descs. Interestnano-objectsExample is thm-like morphoups that allo In this pros that will si
understands into cells,tness as we ter. The stuate the prop
es with suga
within the f biological lammation, d by them. m, the use
apeutics for ortant step diseases.
MARTInd Enginee4656 E: m.s
OLYMERS
o nanoparticprepared usi to create corll makes the
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ss of viruses
cribed in litetingly, natu, viruses, h
he by now wehology. In adow fast recogoject, we wilmulate the sding of th we will ma have found
udent will theperties of the
ar antennae
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INA STEering Buildstenzel@unsw
S FOR CATREAT
cles. Nanopaing various re-shell nano particles so
polymer nanwith clinicians
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ENZEL ing (E8) w.edu.au
ANCER TMENT
rticles for materials oparticles luble and
noparticle s and we
spherical highly elongated bola virus ses carry host and elongated ruses. To of these rticles of
ould be a nd some le before
es with ncer
Synthesare prepactive pothese na
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NanoparThey cacells in influencecellular growing Howevetumour tumorigecolleaguKilian hacancer ssurfacesphenotyuptake differencto target
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When blmicellesaggregasharp tHowevestructurenanoparaffect thare excunderstaproject ycan evemathemhttp://ain
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various immr, these cellwhere canc
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Learning mration with Dr
lock copolym, it is wide
ate has a cortransition ber, we do noe is and howrticle. Thesehe biological cellent tools and why diffeyou would spen spend a datical mo
nse.edu.au/g
olymers has by direct RA
ese nanoparinteract with
of nanopart
uickly taken as vehicle toway. A lot
size and ohis knowledgmortal cances do not reser cells mayd in with cachool of ched a model thand cells of en geometries on of these icles by varction of nano
m cells or me
more about r Chris Garve
mers self-assely assumedre-shell strucetween bothot know whaw much watee propertiesactivity. Smathat provid
erent nanopapend some tiday at the Aodelling. Srad_students
been one ofAFT polymerrticles will bebiological me
icles with ca
up by canceo deliver druis known abther paramege was gaier cells in tsemble cell fy display enncer stem cemistry, A/Pat allows us nhanced tumsuch as coilsmodels with
rious phenotoparticles andtastatic cells
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semble into d that the cture with a h phases. at the real er is in the s however all angle neue more inforticles behavme at ANST
Australian SyStudents s2/honours_s
67
f our core acrization of ge loaded withedia such as
ancer stem
er cells. ugs into bout the eters on ined by the lab. found in nhanced cells. My Prof Kris to grow
morigenicity os and stars r
h nanoparticltypes simultd help us ide.
re of nanopTO
utron scatterormation. Onve differently TO and learnynchrotron inare eligibscholarships
ctivities over lycomonomeh anti-cancer proteins
cells Collabo
on an engineresulting in tes allows us
taneously. Tentify what ty
particles –
ring (SANS) nce we und and why som and apply th
n Melbourne.ble to .
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oration with A
eered surfaceumour tissues to evaluate
This can helypes of nano
Scattering
and small aderstand theme of them dhe technique Prerequisiteapply for
years. The st-functionaliwe like to le
A/Prof Kris K
e. Cells are ge with a steme the rate olp us evaluaoparticles are
analysis at
angle X-ray se structure, do not perfore. If time pere is some inr a sc
polymers zation of
earn how
Kilian
grown on m-cell-like of cellular ating the e suitable
ANSTO
scattering we also
m. In this mits, you nterest in holarship
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Over theapproaccoordinaorderingrange of
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This resfaced infacile stoexcellentuning theffectiveshown h
Quantum
Magneticrole to ppretty usfascinatiunderstawhen disingle cembeddideal maquantum
up focuses onhallenges fa
ues that incluis the notion
mple inter-moes in order to
d be great to
Metal organ
e last 20 yehes that hav
ation compou and immenf molecular g
and storing
search projecn industry - orage of gaset host materheir propertiee gas-selectihere.
m phenomen
c materials hplay in quantseful at secung therefor
and the behamensionalitychains (1D) ed into a no
aterials in whm confinemen
n making anacing us todaude X-ray an of hierarchicolecular inteo deliver new
o work with H
nic framewo
ears, inorganve reinvigoraunds or MOFse composituests, openi
molecules -
ct is specificeffective sepeous fuels surials for smaes MOFs canve membran
na in magneti
have revolutioum computinuring notes tre that weaviour of sucy is constrain or sheets on-magnetic ich to study t
nt.
MAT
d understanday: energy, nd neutron scal emergen
eractions; wew materials di
Honours stu
rks (MOFs):
nic chemistryated the subFs. These toional flexibiling up many
how to sele
cally targetedparations of uch as H2. Hall moleculesn become efnes such as
ic materials
onised the wng; they haveto the fridge e still do ch materials, ned. MOFs (2D) of m matrix, mathe effects of
68
TERIALS
ding new mawater and scattering in tt properties
e aim for a isplaying nov
udents on th
coordinatio
ry has takenbject – one aopologically bty, along witpotential app
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A/PL
T: 938
CHEMIST
aterials that asustainabilitytruly multi-diand complexgreater und
vel properties
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on chemistry
n on board area showingbeautiful matth structural plications.
molecule ove
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s MOFs makH4 or H2. Bge vessels oelecting MO
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PROF. JLevel 1, Da85 4672 E: j
TRY AT TH
are often focy. We makesciplinary proxity - the worerstanding os.
projects:
y of the 21st
a number og particular terials displayrigidity; they
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d use informnal aid for ce
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ve spectrum ng inelastic n
JOHN STlton Buildinj.stride@unsw
HE NANOS
cused on some use of a rojects. Key rld around usof these fund
t century
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mation and haenturies and
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TRIDE ng (F12) w.edu.au
SCALE
me of the range of to these s derives damental
epts and polymeric ng range osts for a
ave a key are even
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controlling thelifetimes, i.e.
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wski, Adam D. Martin, Albility in the three-dimensiwski, Adam D. Martin an 140, 2869-2874.
blished. To eeloped for uPMX53 will p
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73
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pramolecular systems, CAtwood, Jonathan W. Steust 2017, 28-35. M. Sagnella, Maria Kava
hem, 2017, 82, 383-389. mes in Redox-Responsi
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75
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76
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