Chapter 8: Sampling, Standardization & Calibration
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Transcript of Chapter 8: Sampling, Standardization & Calibration
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Chapter 8: Sampling, Standardization & Calibration
CHE 321: Quantitative Chemical AnalysisDr. Jerome Williams, Ph.D.
Saint Leo University
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Overview
• Standardization & Calibration• Sensitivity & Detection Limits
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Standardization & Calibration
• Calibration determines relationship between analyte response & analyte concentration.
– Accomplished using chemical standards.
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Standardization & Calibration
• Comparison with Standards
– Direct comparison (Colorimeters & Titrations)
– External Standard Calibration (Least Squares Method)
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Figure 8-9 p172
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Figure 8-10 p172
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Table 8-1 p175
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Table 8-2 p177
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Table 8-3 p178
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Fig 8-9, p.195
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Standardization & Calibration
• Errors in External Standard Calibration
– Blanks are used to correct for many calibration errors.
– Ideal blank contains everything except the analyte.– Solvent blank or reagent blank more practical.
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Standardization & Calibration
• Minimizing Errors in Analytical Procedures
– Multivariate Calibration– Saturation, Matrix Modification, & Masking– Internal Standard Methods– Standard Addition Methods
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Sensitivity & Detection Limits
• Be familiar with the following terms
– Analytical & Calibration Sensitivity– Detection Limit– Linear Dynamic Range– Control Chart (including UCL, LCL)– Statistical Control– Validation & GLP
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Figure 8-14 p187
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Figure 8-15 p189
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p189
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p189
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Figure 8-16 p190
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Suggested Problems
• HW Set 7: 8.1, 8.2, 8.3, 8.17, 8.26