Chapter 4 Integumentary System Human Anatomy and Physiology.
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Transcript of Chapter 4 Integumentary System Human Anatomy and Physiology.
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Chapter 4Chapter 4Integumentary SystemIntegumentary System
Human Anatomy and Physiology
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Integumentary SystemIntegumentary System
Composed of – skin – Sweat glands– Oil glands– Hairs– Nails
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FunctionsFunctions
Protection against– Damage– Ultraviolet radiation– Desiccation (drying out)
Aids in temperature regulation Aids in excretion of urea and uric acid Synthesizes Vitamin D
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Structure of SkinStructure of Skin Skin composed of two kinds of tissue that are firmly
connected to each other– Epidermis– Dermis
If these two layers separate, a blister forms. Deep to dermis is the subcutaneous tissue (hypodermis) –
not actually considered a layer of skin– Made of adipose tissue– Anchors the skin to underlying organs
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Structure of SkinStructure of Skin
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EpidermisEpidermis Made of stratified
squamous epithelium that can keratinize (become hard and tough)
Avascular – no blood supply of its own
Composed of five layers called strata– Stratum basale– Stratum spinosum– Stratum granulosum– Stratum lucidum– Stratum corneum
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Layers of EpidermisLayers of Epidermis Stratum basale
– Deepest cell layer– Only epidermal cells that receive
adequate nourishment via diffusion of nutrients from the dermis
– Constantly undergoing cell division
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Layers of EpidermisLayers of Epidermis
Cells move up to the next layer, Stratum Spinosum
Then, Stratum Granulosum where they start to become flatter, increasingly full of keratin and finally the cells die
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Layers of EpidermisLayers of Epidermis
Stratum Lucidum– present where the skin
is hairless and extra thick, palms of hands and soles of feet
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Layers of EpidermisLayers of Epidermis
Stratum Corneum– Outermost layer– 20-30 cell layers thick, ¾ of the epidermal thickness– Composed of dead cell remnants, completely filled
with keratin Keratin waterproofs skin
– Totally new epidermis every 25 to 45 days
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MelaninMelanin Pigment that ranges in
color from yellow to brown to black
Produced by melanocytes found in the stratum basale
When skin exposed to sunlight, melanocytes produce more melanin and tanning occurs
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MelaninMelanin
forms a protective umbrella over the cells’ nuclei which shields DNA from the damaging effects of the UV radiation
Freckles and moles are seen where melanin is concentrated in one spot
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DermisDermis
Made of dense connective tissue
Two major regions:– Papillary layer– Reticular layer
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Dermis – Papillary LayerDermis – Papillary Layer
– Upper layer– Contain dermal
papillae Uneven
fingerlike projections which indent the epidermis
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Dermis – Papillary LayerDermis – Papillary Layer
Furnish nutrients to the epidermis
Provide fingerprints
Contain pain receptors: Meissner’s corpuscles
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DermisDermis
Reticular layer– Deepest skin
layer
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Dermis – Reticular LayerDermis – Reticular Layer
– Contains blood vessels, hair
follicles, sweat and oil glands
Rich nerve supplydeep pressure
receptors: Pacinian corpuscles
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Dermis – Reticular LayerDermis – Reticular Layer
Contains:
–Collagen: responsible for toughness and attracts and binds water to help hydrate the skin
–Elastic fibers: give skin elasticity
• Decreases with age causing wrinkles
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Dermis and Body Dermis and Body TemperatureTemperature
Blood vessels Sweat secretion
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Skin ColorSkin Color Three pigments:
1. Melanin amount and kind – yellow, black, or brown
2. Carotene Orange-yellow pigment found in carrots and other
orange, deep yellow or leafy green vegetables
3. Amount of oxygen bound to hemoglobin Hemoglobin is the pigment in blood cells – gives
the crimson color – rosy glow
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Appendages of the SkinAppendages of the Skin
Exocrine Glands– release secretions to
the skin surface via ducts
– Two groups: Oil glands
(sebaceous glands) Sweat glands
Hair and Hair Follicles Nails
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Sebaceous GlandsSebaceous Glands
Oil glands Found all over skin
except palms and soles Produces sebum
– Lubricant that keeps skin soft and moist
– Contains chemicals that kill bacteria
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Sebaceous Gland ProblemsSebaceous Gland Problems
Whitehead: blocked by sebumBlackhead: If sebum dries it darkensAcne: active infectionIncreased secretion during adolescence
cause skin problems
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Sweat GlandsSweat Glands
More than 2.5 million per personTwo types:
– Eccrine glands– Apocrine glands
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Eccrine Sweat GlandsEccrine Sweat Glands
More numerous Found all over body Produce sweat that
pours through pores Regulate body heat
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SweatSweatSweat is a clear secretion that is made of
– water– salts– vitamin C– traces of metabolic wastes like ammonia, urea, uric acid,
and lactic acid (lactic acid attracts mosquitos)
Acidic (pH 4 to 6 )– Inhibits growth of bacteria
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Apocrine sweat glandsApocrine sweat glands
Located mostly in axillary and genital areasDucts empty into hair folliclesBreakdown of secretion by skin bacteria
produces musky odor.
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HairsHairs
Millions all over bodyServe protective functionHairs lost most of usefulness because we
have other means of keeping warm unlike the early humans.
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Hair AnatomyHair Anatomy
Produced by hair follicle
Flexible epithelial surface
Root: part of hair enclosed in the follicle
Shaft: part of hair projecting from the surface
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Why do my hairs stand on end?Why do my hairs stand on end?
Arrector pili – Muscles that connect
each side of the hair follicle to the dermal tissue
– When these muscles contract, the hair is pulled upright, causing “goose bumps”
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NailsNails
Visible part is called nail body
Root is hidden by cuticle
Nail bed changes color with blood flow change
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Tissue RepairTissue Repair
Tissue injury stimulates inflammatory response.
Wound healing (tissue repair) occurs two ways– Regeneration– Fibrosis
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RegenerationRegeneration
Replacement of destroyed tissue by the same kind of cells
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FibrosisFibrosis
Repair by dense connective tissue by the formation of scar tissue
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Overview of Steps for Tissue Overview of Steps for Tissue RepairRepair
1. blood escapes from dermal blood vessels, and blood clot soon forms
2. blood clot and dried tissue fluid form a scab protecting the area blood vessels send out
3. branches and fibroblasts migrate into the area
4. fibroblasts produce new connective fibers, scab sloughs off
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Steps of tissue healingSteps of tissue healing
Capillaries allow fluid rich in clotting proteins and other substances to seep into injured area from the bloodstream.
Leaked clotting proteins construct a clot, which stops loss of blood, holds wound together. This prevents bacteria from spreading to surrounding tissues.
Clot exposed to air, dries and hardens, forming scab
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Steps of Tissue HealingSteps of Tissue Healing
Granulation tissue forms– Delicate pink tissue composed largely of
capillaries that grow into damaged area from undamaged blood vessels.
– Contain phagocytes that dispose of blood clot and fibroblast (connective tissue cells) that make collagen fibers (scar tissue) to permanently bridge the gap.
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Steps of Tissue HealingSteps of Tissue Healing
Surface epithelium begins to regenerate and makes its way across the granulation tissue just beneath the scab, which then detaches.
Final result : fully regenerated surface epithelium that covers the scar.
Scar can be visible or invisible.
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Keloid ScarsKeloid Scarsresult of an overly
aggressive healing process
extend beyond the original injury
may affect mobilityPossible treatments
include surgical removal, or injections with steroids
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Contracture scarsContracture scars If your skin has been
burned, you may have a contracture scar, which causes tightening of skin that can impair your ability to move; additionally, this type of scar may go deeper to affect muscles and nerves.
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Hypertrophic scarsHypertrophic scars
Raised and red scars that are similar to keloids, but do not breach the boundaries of the injury site.
Possible treatments can include injections of steroids to reduce inflammation.
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Acne ScarsAcne Scars If you've had severe
acne, you probably have the scars to prove it.
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FYI……FYI……
Epithelial Tissue regenerate easily.Connective tissue including bone regenerate
easily as well.Skeletal Muscle regenerates poorly, if at all.Cardiac Muscle and Nervous tissue are
replaced only by scar tissue.
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Imbalances of the SkinImbalances of the Skin
Infections and Allergies– Athlete’s Foot– Boils and Carbuncles– Cold Sores– Contact dermatistis– Impetigo– Psoriasis
Burns– 1st degree– 2nd degree– 3rd degree
Skin Cancer– Basal cell carinoma– Squamous cell carcinoma– Malignant melanoma
ABCD RULE
Other Disorders– Erythema– Pallor– Jaundice– Decubitus ulcer– bruises
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Infections and AllergiesInfections and Allergies Athlete’s Foot:
– itchy fungal infection of the toes
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Infections and AllergiesInfections and Allergies
Boils and Carbuncles: – inflammation of hair
follicles and sebaceous glands
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Infections and AllergiesInfections and Allergies
Cold Sores: – fever blisters; small
fluid filled blisters that itch an sting, caused by herpes simples infection
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Infections and AllergiesInfections and Allergies
Contact dermatitis: – itching, redness, and
swelling of the skin, progressing to blistering
– Caused by exposure of the skin to chemicals like poison ivy that provoke allergic responses
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Infections and AllergiesInfections and Allergies
Impetigo– Pink, water-filled raised
lesions that develop a yellow crust and eventually rupture
– Causes by a highly contagious staphylococcus infection
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Infections and AllergiesInfections and Allergies Psoriasis
– Chronic condition characterized by reddened epidermal lesions covered with dry, silvery scales
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BurnsBurns
Tissue damage and cell death caused by intense heat, electricity, UV radiation (sunburn), or certain chemicals (acids)
When the skin is burned, two life threatening problem result:
1. Dehydration
2. Infection
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11stst threat: Dehydration threat: Dehydration
The body loses fluids containing proteins and electrolytes
This can lead to a shutdown of the kidneys and circulatory shock
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22ndnd threat: Infection threat: Infection
Leading cause of deathBurned skin is sterile for about 24 hours,
but after that pathogens easily invade and multiply rapidly
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Rule of NinesRule of Nines Divides the body area into 11 areas, each accounting
for 9 percent of the total body surface, plus 1% surrounding the genitals
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BURNS
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BurnsBurns
1st degree– Only the epidermis is
damaged– Becomes red and
swollen– Not usually serious and
generally heal in two to three days without any special attention
– sunburn
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BurnsBurns 2nd degree
– Involve injury to the epidermis and the upper region of the dermis
– Skin is red and painful and blisters appear
– Re-growth of the epithelium can occur
– No permanent scars result if care is taken to prevent infection
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BurnsBurns 3rd degree
– Destroy the entire thickness of the skin
– Appears gray-white or blackened
– Nerve endings are destroyed so the burn is not painful
– Regeneration is not possible
– Skin grafting must be done to cover the underlying exposed tissues
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BurnsBurns
Considered critical if any of the following conditions exists:– 1. Over 25 % of the body has 2nd degree burns– 2. Over 10% of the body has 3rd degree burns– 3. Any third-degree burn of the face, hands, or
feet
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Skin CancerSkin Cancer
Most skin tumors are benign and do not spread
Some are malignant (cancerous) and tend to invade other parts of the body
Skin cancer is the most common type of cancer in the body
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Basal Cell CarcinomaBasal Cell Carcinoma Least malignant and most
common Full cure rate in 99% of
patients
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Squamous Cell CarcinomaSquamous Cell Carcinoma
Believed to be sun-induced
If it is caught early and removed surgically, good chance of complete cure
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Malignant MelanomaMalignant Melanoma Cancer of the melanocytes Accounts for 5% of skin cancers Often deadly – 50% survival rate Usually appears as a spreading
brown to black patch that metastasizes rapidly to surrounding lymph and blood vessels
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ABCD RuleABCD Rule
Asymmetry: the two sides of the pigmented spot of mole do not match
Border Irregularity: The borders of the lesion are not smooth but exhibit indentations
Color: the pigmented spot contains areas of different colors
Diameter: the spot is larger than 6 mm in diameter (size of pencil eraser)
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JaundiceJaundiceAn abnormal yellow
skin tone usually indicates a liver disorder in which excess bile pigments are absorbed into the blood, circulated throughout the body, and deposited in body tissues.
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Decubitus ulcerDecubitus ulcer
Restriction of blood supply to the skin results in cell death, and if severe or prolonged, ulcers.
Occur in bedridden patients who are not turned regularly
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BruisesBruises
Reveal sites where blood has escaped from the circulation and has clotted in the tissue spaces
Hematoma: clotted blood massAn unusual tendency to bruising may
signify a deficiency of vitamin C in the diet or hemophilia