Cell Injury and the Pathogenesis of Human Disease (PATH 6266 )
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Transcript of Cell Injury and the Pathogenesis of Human Disease (PATH 6266 )
Cell Injury and the Pathogenesis of Human
Disease(PATH 6266)
“Cellular basis of disease”200 years of observation: organ and
microscopic
April 30 and May 2, 2012 Paul Boor M.D.
SUGGESTED READING(PATHOLOGIC BASIS OF DISEASE, 8th EDITION)
CHAPTER 1Cellular Response to Stress and Toxic Insult;
Adaptation, Injury, Death (pp 3-42)
CHAPTER 3Tissue Renewal, Repair, and Regeneration (pp
79-110)
Rudolph Virchow (1821-1902)
Cell Theory“Social Medicine”
Cell Injury – General Considerations
Numerous causes Biochemical events precede structural Duration and intensity of exposure important
(direct dose/response relationship) Injury may be TISSUE (or cell) specific Injury depends of ability of cells to respond,
resist, and repair injury
Cell Injury – Causes Hypoxia / Ischemia Physical (mechanical, heat, radiation) Chemical Biologic Agents Immunologic (host) reaction Genetic derangement Nutritional imbalance, deficiency
Cellular Degeneration
Sublethal, usually reversible forms of cellular injury unassociated with severe
cellular dysfunction.
Oxidative Stress and Cell Injury
Necrosis (or “Oncosis”) VS
Apoptosis
Types of Necrosis Coagulation Liquefactive Caseous “Fat” necrosis
Liquefactive Necrosis
Caseous Necrosis
“Fat” Necrosis
Key Words(Week 1 BBSC 6266)
Anatomy of the hepatic lobule; Cell: Hepatocyte, Kupffer cell, bile ductules; Acetaminophen; Cytochrome p450s; imines; Reactive oxygen species; reactive nitrogen
species; peroxynitrite; Adducts
Hepatic Injury: Regenerative Nodules
How to look at a slide
Recap