CbnÅ“rResearchcancerres.aacrjournals.org/content/51/19.toc.pdf · CbnÅ“rResearch VOLUME51â...
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CbnÅ“rResearch VOLUME 51 •¿ NUMBER 19 •¿ CNREA8 •¿ PP 5087-5448 CONTENTS§ Asterisks * preceding page numbers refer to studies using human-derived material. Perspectives in Cancer Research 5087 Platelet-derived Growth Factor in Autocrine Transformation. Bengt Westermark and Carl-Henrik Heldin. *5093 Antagonistic Effect of Aclarubicin on Daunorubicin-induced Cytotoxicity in Human Small Cell Cancer Cells: Relationship to DNA Integrity and Topoisomerase II. Peter Buhl Jensen. Palle Scheide Jensen. Erland J. F. Demant, Ellen Friche. Boe Sandahl S0rensen. Maxwell Sehested, Karsten Wassermann. Lars Vindel0v. Ole Westergaard, and Heine H0i Hansen. * 5 Kill Muscle-specific Gene Expression in Rhabdomyosarcomas and Stages of Human Fetal Skeletal Muscle Development. Patricia N. Tonin. Heidi Scrable. Hiroyuki Shimada, and Webster K. Cavenee. * 5107 Expression of Insulin-like Growth Factor I, Its Binding Proteins, and Its Receptor in Ovarian Cancer. Douglas Yee. Fernando R. Morales. Thomas C. Hamilton, and Daniel D. Von Hoff. *5113 Cyclin B Expression in HeLa Cells during the (.. Block Induced by Ionizing Radiation. Ruth J. Muschel, Hong BingZhang, George Iliakis, and W. Gillies McKenna. * 5118 Allelotype of Human Ovarian Cancer. Takaaki Sato, Hiroko Saito, Ryoji Monta. Sumiko Koi, Je H. Lee. and Yusuke Nakamura. 5123 Dietary Restriction Permits Normal Parturition and Lactation but Suppresses Mouse Mammary Tumor Virus Proviral Transcription Even after Mammary Involution. Robert W. Engelman. Yuka Fukaura, Nobuyuki Hamada. Robert A. Good, and Noorbibi K. Day. 5129 Differential Expression of the Normal and Mutated K-ras AlÃ-eles in Chemically Induced Thymic Lymphomas. Montserrat Corominas. Manuel Perucho, Elizabeth W. Newcomb. and Angel Pellicer. «i, *5134 Estimation of the Dividing Fraction and Potential Doubling Time of Tumors Using Cytochalasin B. Yuta Shibamoto and Christian Streffer. *5139 Hypoxie Fractions in Xenografted Human Colon Tumors. John T. Leith. Già Padfield. Lynn Faulkner, and Seth Michelson. *5144 Pharmacokinetics of Intravesical Mitomycin C in Superficial Bladder Cancer Patients. James T. Dalton, M. Guillaume Wientjes, Robert A. Badalament. Joseph R. Drago, and Jessie L-S. Au. 5153 Increase in Immunogenicity and Sensitivity to Natural Cell- mediated Cytotoxicity following in Vitro Exposure of MCA105 Tumor Cells to Ultraviolet Radiation. Mirsada Begovic, Ronald Herberman. and Elieser Gorelik. *5160 Different Energy Metabolism in Two Human Small Cell Lung Cancer Subpopulations Examined by "P Magnetic Resonance Spectroscopy and Biochemical Analysis in Vivo and in Vitro. Paul E.G. Kristjansen, Mogens Spang-Thomscn, and Bj0rn Quistorff. *5165 Characteristics of the Biphasic Action of Androgens and of the Potent Anti-proliferative Effects of the New Pure Antiestrogen EM-139 on Cell Cycle Kinetic Parameters in LNCaP Human Prostatic Cancer Cells. Yvan de Launoit. Raymonde Veilleux, Maurice Dufour, Jacques Simard, and Fernand Labrie. 5171 Frequent Allelic Losses and Mutations of the p53 Gene in Human Ovarian Cancer. Aikou Okamoto. Yuichi Sameshima, Shiro Yokoyama, Yoshiteru Terashima, Takashi Sugimura, Masaaki Terada, and Jun Yokota. """5177 Genetic Susceptibility to Squamous Cell Carcinoma of the Lung in Relation to Cigarette Smoking Dose. Kei Nakachi. Kazue Imai. Shin-ichi Hayashi. Junko Watanabe. and Kaname Kawajiri. *518I Multifactorial Mechanisms Associated with Broad Cross-Resist ance of Ovarian Carcinoma Cells Selected by Cyanomorpholino Doxorubicin. Derick H. M. Lau, Alexander D. Lewis, Mohamed N. Ehsan. and Branimir I. Sikic. *5188 Toxicity, Mutagenicity, and Mutational Spectra of /V-Ethyl-A'- nitrosourea in Human Cell Lines with Different DNA Repair Phenotypes. S. Maynard Bronstein. Judith E. Cochrane, Teresa R. Craft. James A. Swenberg. and Thomas R. Skopek. 5198 DNA Adducts of the Antitumor Agent Diaziquone. Ramesh C. Gupta, Achal Garg, Karen Earley, Satish C. Agarwal, Guy R. Lambert, and Stephen Nesnow. * 5205 Production of Neuromedin B and Neuromedin B Gene Expression in Human Lung Tumor Cell Lines. Carles Cardona. Pamela H. Rabbitts, Eliott R. Spindel, Mohammed A. Ghatei, Norman M. Bleehen, Stephen R. Bloom, and Julie G. Reeve. 5212 Effects of H-2Kb Gene on Expression of Melanoma-associated Antigen and Lectin-binding Sites on BL6 Melanoma Cells. Elieser Gorelik, Gilbert Jay. Misoon Kim. Vincent J. Hearing, Albert DeLeo, and J. Philip McCoy. Jr. "'"521') Measurement of 4-Aminobiphenyl-Hemoglobin Adducts in Lung Cancer Cases and Controls. Ainsley Weston. Neil E. Caporaso. Koli Taghizadeh. Robert N. Hoover. Steven R. Tannenbaum. Paul L. Skipper, James H. Resau, Benjamin F. Trump, and Curtis C. Harris. *5224 Biochemical Evidence That Glucocorticoid-sensitive Cell Lines Derived from the Human Leukemic Cell Line CCRF-CEM Ex press a Normal and a Mutant Glucocorticoid Receptor Gene. Lisa A. Palmer and Jeffrey M. Harmon. 5232 Alterations in Tumor Development in Vivo Mediated by Expres sion of Wild Type or Mutant p53 Proteins. Gad Shaulsky, Naomi Goldfinger, and Varda Rotter. § The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS. on April 19, 2018. © 1991 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Transcript of CbnÅ“rResearchcancerres.aacrjournals.org/content/51/19.toc.pdf · CbnÅ“rResearch VOLUME51â...
CbnÅ“rResearchVOLUME 51 •¿�NUMBER 19 •¿�CNREA8 •¿�PP 5087-5448
CONTENTS§
Asterisks * preceding page numbers refer to studies using human-derived material.
Perspectives in Cancer Research
5087 Platelet-derived Growth Factor in Autocrine Transformation.Bengt Westermark and Carl-Henrik Heldin.
*5093 Antagonistic Effect of Aclarubicin on Daunorubicin-induced
Cytotoxicity in Human Small Cell Cancer Cells: Relationship toDNA Integrity and Topoisomerase II. Peter Buhl Jensen. PalleScheide Jensen. Erland J. F. Demant, Ellen Friche. Boe SandahlS0rensen. Maxwell Sehested, Karsten Wassermann. LarsVindel0v. Ole Westergaard, and Heine H0i Hansen.
* 5 Kill Muscle-specific Gene Expression in Rhabdomyosarcomas and
Stages of Human Fetal Skeletal Muscle Development. Patricia N.Tonin. Heidi Scrable. Hiroyuki Shimada, and Webster K.Cavenee.
* 5107 Expression of Insulin-like Growth Factor I, Its Binding Proteins,
and Its Receptor in Ovarian Cancer. Douglas Yee. Fernando R.Morales. Thomas C. Hamilton, and Daniel D. Von Hoff.
*5113 Cyclin B Expression in HeLa Cells during the (.. Block Inducedby Ionizing Radiation. Ruth J. Muschel, Hong BingZhang, GeorgeIliakis, and W. Gillies McKenna.
* 5118 Allelotype of Human Ovarian Cancer. Takaaki Sato, Hiroko Saito,
Ryoji Monta. Sumiko Koi, Je H. Lee. and Yusuke Nakamura.
5123 Dietary Restriction Permits Normal Parturition and Lactation butSuppresses Mouse Mammary Tumor Virus Proviral TranscriptionEven after Mammary Involution. Robert W. Engelman. YukaFukaura, Nobuyuki Hamada. Robert A. Good, and Noorbibi K.Day.
5129 Differential Expression of the Normal and Mutated K-ras AlÃelesin Chemically Induced Thymic Lymphomas. MontserratCorominas. Manuel Perucho, Elizabeth W. Newcomb. and AngelPellicer.
«i,*5134 Estimation of the Dividing Fraction and Potential Doubling Time
of Tumors Using Cytochalasin B. Yuta Shibamoto and ChristianStreffer.
*5139 Hypoxie Fractions in Xenografted Human Colon Tumors. John
T. Leith. Già Padfield. Lynn Faulkner, and Seth Michelson.
*5144 Pharmacokinetics of Intravesical Mitomycin C in Superficial
Bladder Cancer Patients. James T. Dalton, M. GuillaumeWientjes, Robert A. Badalament. Joseph R. Drago, and JessieL-S. Au.
5153 Increase in Immunogenicity and Sensitivity to Natural Cell-mediated Cytotoxicity following in Vitro Exposure of MCA105Tumor Cells to Ultraviolet Radiation. Mirsada Begovic, RonaldHerberman. and Elieser Gorelik.
*5160 Different Energy Metabolism in Two Human Small Cell LungCancer Subpopulations Examined by "P Magnetic Resonance
Spectroscopy and Biochemical Analysis in Vivoand in Vitro. PaulE.G. Kristjansen, Mogens Spang-Thomscn, and Bj0rn Quistorff.
*5165 Characteristics of the Biphasic Action of Androgens and of thePotent Anti-proliferative Effects of the New Pure AntiestrogenEM-139 on Cell Cycle Kinetic Parameters in LNCaP HumanProstatic Cancer Cells. Yvan de Launoit. Raymonde Veilleux,Maurice Dufour, Jacques Simard, and Fernand Labrie.
5171 Frequent Allelic Losses and Mutations of the p53 Gene in HumanOvarian Cancer. Aikou Okamoto. Yuichi Sameshima, ShiroYokoyama, Yoshiteru Terashima, Takashi Sugimura, MasaakiTerada, and Jun Yokota.
"""5177 Genetic Susceptibility to Squamous Cell Carcinoma of the Lung
in Relation to Cigarette Smoking Dose. Kei Nakachi. Kazue Imai.Shin-ichi Hayashi. Junko Watanabe. and Kaname Kawajiri.
*518I Multifactorial Mechanisms Associated with Broad Cross-Resist
ance of Ovarian Carcinoma Cells Selected by CyanomorpholinoDoxorubicin. Derick H. M. Lau, Alexander D. Lewis, MohamedN. Ehsan. and Branimir I. Sikic.
*5188 Toxicity, Mutagenicity, and Mutational Spectra of /V-Ethyl-A'-
nitrosourea in Human Cell Lines with Different DNA RepairPhenotypes. S. Maynard Bronstein. Judith E. Cochrane, TeresaR. Craft. James A. Swenberg. and Thomas R. Skopek.
5198 DNA Adducts of the Antitumor Agent Diaziquone. Ramesh C.Gupta, Achal Garg, Karen Earley, Satish C. Agarwal, Guy R.Lambert, and Stephen Nesnow.
* 5205 Production of Neuromedin B and Neuromedin B Gene Expression
in Human Lung Tumor Cell Lines. Carles Cardona. Pamela H.Rabbitts, Eliott R. Spindel, Mohammed A. Ghatei, Norman M.Bleehen, Stephen R. Bloom, and Julie G. Reeve.
5212 Effects of H-2Kb Gene on Expression of Melanoma-associatedAntigen and Lectin-binding Sites on BL6 Melanoma Cells. ElieserGorelik, Gilbert Jay. Misoon Kim. Vincent J. Hearing, AlbertDeLeo, and J. Philip McCoy. Jr.
"'"521') Measurement of 4-Aminobiphenyl-Hemoglobin Adducts in Lung
Cancer Cases and Controls. Ainsley Weston. Neil E. Caporaso.Koli Taghizadeh. Robert N. Hoover. Steven R. Tannenbaum.Paul L. Skipper, James H. Resau, Benjamin F. Trump, and CurtisC. Harris.
*5224 Biochemical Evidence That Glucocorticoid-sensitive Cell LinesDerived from the Human Leukemic Cell Line CCRF-CEM Express a Normal and a Mutant Glucocorticoid Receptor Gene. LisaA. Palmer and Jeffrey M. Harmon.
5232 Alterations in Tumor Development in Vivo Mediated by Expression of Wild Type or Mutant p53 Proteins. Gad Shaulsky, NaomiGoldfinger, and Varda Rotter.
§The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS. Th± 8 One
N01Z-28D-28LZon April 19, 2018. © 1991 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
5238 Clonal Cosegregation of Tumorigenicity with Overexpression off-myc and Transforming Growth Factor-a Genes in ChemicallyTransformed Rat Liver Epithelial Cells. Lester W. Lee, VictoriaW. Raymond. Ming-Sound Tsao, David C. Lee, H. Shelton Earp.and Joe W. Grisham.
5245 Increased Survival after Treatments with Anticancer Agents ofChinese Hamster Cells Expressing the Human M, 27,000 HeatShock Protein. Jacques Huot. GaétanRoy. Herman Lambert.Pierre Chrétien,and Jacques Landry.
*5253 Human Carcinoid Cell Production of Panierino Growth Factors
That Can Stimulate Fibroblast and Endothelial Cell Growth.R. Daniel Beauchamp. Robert J. Coffey, Jr.. Russette M. Lyons,Elizabeth A. Perkett. Courtney M. Townsend. Jr., and Harold L.Moses.
*5261 Synergistic Effect of Nocardia rubra Cell Wall Skeleton andRecombinant Interleukin 2 for in Vivo Induction of Lymphokine-actirated Killer Cells. Kazuhiro Miyazaki, Kosei Yasumoto.Tokujiro Yano, Goro Matsuzaki, Keizo Sugimachi. and KikuoNomoto.
* 5266 IndividualSusceptibility to InducedChromosome Damage and Its
Implications for Detecting Genotoxic Exposures in HumanPopulations. John K. Wiencke. MargaretR. Wrensch. Rei Miike.and Nicholas L. Petrakis.
5270 Sequential Analyses of the Growth and Morphological Characteristics of Aberrant Crypt Foci: Putative Preneoplastic Lesions.E. A. McLellan. A. Mediine, and R. P. Bird.
O-
5275 Mechanisms of Resistance to Etoposide and Teniposide in Acquired Resistant Human Colon and Lung Carcinoma Cell Lines.Byron H. Long. Lotte Wang. Aurelio Lorico. Richard C. C. Wang.Michael G. Brattain. and Anna Maria Casazza.
*5284 Activation of Amino-a-carboline, 2-Amino-l-methyl-6-phenyl-imida/o[4,5-A|p>ridine, and a Copper Phthalocyanine CelluloseExtract of Cigarette Smoke Condensate by Cytochrome P-450Enzymes in Rat and Human Liver Microsomes. TsutomuShimada and F. Peter Guengerich.
* 5292 CD44 Splice Variants Confer Metastatic Behavior in Rats: Homologous Sequences Are Expressed in Human Tumor Cell Lines.Martin Hofmann, Wolfgang Rudy, Margot Zöller,Cornelia Tölg.Helmut Ponta. Peter Herrlich, and Ursula Günthert.
5298 Overcoming the Activity of Mammary Carcinoma SuppressorGene in Copenhagen Rats by v-l 1-rav Oncogene Transfer intoMammary Epithelial Cells in Situ. Bingcheng Wang, Wendy S.Kennan, Jane Yasukawa-Barnes, Mary J. Lindstrom, and MichaelN. Gould.
* 5304 Antiproliferative Activity of a Pregnancy Recognition Hormone,Ovine Trophoblast Protein-I. Carol H. Pontzer. Fuller W. Bazer.and Howard M. Johnson.
*5308 K-ras Activation in Premalignant and Malignant Epithelial Le
sions of the Human Uterus. Takayuki Enomoto. Masaki Inoue.Alan O. Perantoni. Gregory S. Buzard. Hiroshi Miki, OsamuTanizawa, and Jerry M. Rice.
*5315 Tumor Necrosis Factor Stimulates Epithelial Tumor CellMotility. Eliot M. Rosen. Itzhak D. Goldberg, David Liu, EvaSetter. Maribeth A. Donovan. Madhu Bhargava. Michael Reiss.and Barry M. Kacinski.
* 5322 Evidence for the Involvement of Transforming Growth Factor a
and Epidermal Growth Factor Receptor Autocrine Growth Mechanism in Primary Human Ovarian Cancers in Vitro. Ken-ichiroMorishige. Hirohisa Kurachi, Kyoka Amemiya. Yoshiko Fujita.Toshiya Yamamoto. Akira Miyake, and Osamu Tanizawa.
*5329 Folate-binding Protein Is a Marker for Ovarian Cancer. Ian G.Campbell, Tania A. Jones, William D. Foulkes, and JohnTrowsdale.
*5339 Prognostic Significance of Argyrophilic Nucleolar Organizer
Regions in Esophageal Carcinoma. Masaru Morita. HiroyukiKuwano. Hiroyuki Matsuda, Sunao Moriguchi, and KeizoSugimachi.
*5342 Increased Number of Accessible Sugar Epitopes Defined withMonoclonal Antibody AM-3 on Colonie Mucins Is Associatedwith Malignant Transformation of Colonie Mucosa. ChristophHanski. John Sheehan. Michael Kiehntopf. Birgit Stolze, HaraldStein, and Ernst-Otto Riecken.
«t.* 5348 Growth Inhibition of Oncogene-transformed Rat Fibroblasts by
Cocultured Normal Cells: Relevance of Metabolie CooperationMediated by Gap Junctions. Wolfgang Martin. GüntherZempel.Dieter Hülser,and Klaus Willecke.
5355 Prostratin, a Nonpromoting Phorbol Ester, Inhibits Induction byPhorbol 12-Myristate 13-Acetate of Ornithine Decarboxylase,Edema, and Hyperplasia in CD-I Mouse Skin. Zoltan Szallasiand Peter M. Blumberg.
' 5.U>1 Requirements for the Internalization of a Murine MonoclonalAntibody Directed against the HER-2/neu Gene Productc-ereB-2. Lisa A. Maier, Feng Ji Xu, Susan Hester. Cinda M.Boyer, Sara McKenzie. Arthur M. Bruskin, Yair Argon, andRobert C. Bast, Jr.
* 5370 Immortalization of Normal Human Bronchial Epithelial Cells by
Human Papillomaviruses 16 or 18. James C. Willey, AlberecBroussoud, Ambereen Sleemi. William P. Bennett. Peter Cerutti,and Curtis C. Harris.
Â¥5378 Regional Heterogeneity and Complementation in the Expressionof the Tumor-associated Glycoprotein 72 Epitopes in ColorectalCancer. R. Murare. L. Frati. R. Bei, F. Ficari. C. Valli, D. French,S. Mammarella. F. Caramia, G. Fegiz. and R. Mariani-Costantini.
* 5384 Experimental Studies and Preliminary Clinical Trial of Vinorel-bine-loaded Polymeric-Bioresorbable Implants for théLocalTreatment of Solid Tumors. Charles Fournier, Bernard Hecquet,Philippe Bouffard, Michel Vert, Armelle Caty. Marie-Odile Vilain,Luc Vanseymortier, Solange Merle, AnaïsKrikorian, Jean-LouisLefebvre, Alice Delobelle, and Lucien Adenis.
* 5392 Establishment of Epstein-Barr Virus-negative Diffuse Large Cell
Lymphoma Cell Line with an 8;22 Chromosomal Translocation.Ichiro Ichinose, Shuji Nakano, Koh-ichi Ohshima, Kenji Mitsugi.Keizo Anzai, Toshihiko Shida. and Yoshiyuki Nino.
5398 Induction of in Vitro Differentiation of Mouse Embryonal Carcinoma (F9) Cells by Inhibitors of Topoisomerases. KazuhiroKondo. Kazuhide Tsuneizumi, Toshio Watanabe, and MichioOishi.
*5405 Molecular Genetic Alterations in Superficial and Locally Ad
vanced Human Bladder Cancer. Joseph C. Presti, Jr., Victor E.Reuter, Teresa Galán.William R. Fair, and Carlos Cordon-Cardo.
")C54I(I Genetic Alterations of the p53 Gene Are a Feature of Malignant
Mesotheliomas. Richard J. Cote, Suresh C. Jhanwar. SteveNovick, and Angel Pellicer.
*5417 Chemotherapyand Chemosensitization of Transgenic Mice WhichExpress the Human Multidrug Resistance Gene in Bone Marrow-Efficacy, Potency, and Toxicity. Gerald H. Mickisch, ThomasLicht. Glenn T. Merlino. Michael M. Gottesman. and Ira Pastan.
Advances in Brief"5425 Antitumor Immune Response and Interleukin 2 Production In
duced in Colorectal Cancer Patients by Immunizationwith HumanMonoclonal Anti-Idiotypic Antibody. R. Adrian Robins, GavinW. L. Dentón, Jack D. Hardcastle. Eric B. Austin. Robert W.Baldwin, and Lindy G. Durrani.
on April 19, 2018. © 1991 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
' 5430 Major Alterations in the Nucleotide Structure of DNA in Cancer
of the Female Breast. Donald C. Malins and Russom Haimanot.
Letter to the Editor
5433 Correspondence re: O. C. A. Scott, Tumor Transplantation andTumor Immunity: A Personal View. Cancer Res., 51: 757-763,1991. M. J. Embleton. Reply by Oliver C. A. Scott.
Meeting Reports
5435 Developmental Genetics and Childhood Cancer: AACR SpecialConference in Cancer Research. Alfred Knudson. George F.Vande Woude, Stephen H. Friend. Webster K. Cavenee, andGarrett M. Brodeur.
5440 Workshop Report from the Division of Research Grants, NationalInstitutes of Health: The Role of Chromosome Rearrangements,Deletions, and Point Mutations in Cancer—APathology B StudySection Workshop. Harriet Isom. Geoffrey Kitchingman, PradipRoy-Burman. Nelson Fausto, and Martin Padarathsingh.
5445 AnnouncementsEighty-Third Annual Meeting of the AACRAACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRCalendar of Events
5448 Author Index
NOTE: AACR forms available in the back of this issue—•¿�Application for Active and Corresponding Membership•¿�Application for Associate Membership
Also available in the back of this issue—
GUIDELINES FOR SUBMITTING DISKS TOAACR PUBLICATIONS
on April 19, 2018. © 1991 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Cancer Research
VOLUME 51 •¿�NUMBER 19
CONTENTS Arranged by Subject Category
Perspectivesin CancerResearch
5087 Platelet-derived Growth Factor in Autocrine Transformation.Bengt Westermark and Carl-Henrik Heldin.
Advances in Brief
^5425 Antitumor Immune Response and Interleukin 2 Production In
duced in Colorectal Cancer Patients by Immunizationwith HumanMonoclonal Anti-Idiotypic Antibody. R. Adrian Robins, GavinW. L. Dentón, Jack D. Hardcastle, Eric B. Austin, Robert W.Baldwin, and Lindy G. Durrani.
A* 5430 Major Alterations in the Nucleotide Structure of DNA in Cancer
of the Female Breast. Donald C. Malins and Russom Haimanot.
BASIC SCIENCES
Biochemistry and Biophysics*5188 Toxicity, Mutagenicity, and Mutational Spectra of A'-Ethyl-A'-
nitrosourea in Human Cell Lines with Different DNA RepairPhenotypes. S. Maynard Bronstein, Judith C. Cochrane, TeresaR. Craft, James A. Swenberg, and Thomas R. Skopek.
Carcinogenesis
5123 Dietary Restriction Permits Normal Parturitionand Lactation butSuppresses Mouse Mammary Tumor Virus PrutiraiTranscriptionEven after Mammary Involution. Robert W. Engelman. YukaFukaura, Nobuyuki Hamada, Robert A. Good, and Noorbibi K.Day.
5129 Differential Expression of the Normal and Mutated K-ras AlÃelesin Chemically Induced Thymic Lymphomas. MontserratCorominas, Manuel Perucho, Elizabeth W. Newcomb. and AngelPellicer.
5198 DNA Adducts of the Antitumor Agent Diaziquone. Ramesh C.Gupta. Achal Garg, Karen Earley, Satish C. Agarwal, Guy R.Lambert, and Stephen Nesnow.
*5219 Measurement of 4-Aminobiphenyl-Hemoglobin Adducts in LungCancer Cases and Controls. Ainsley Weston, Neil E. Caporaso,Koli Taghizadeh, Robert N. Hoover, Steven R. Tannenbaum,Paul L. Skipper, James H. Resau, Benjamin F. Trump, and CurtisC. Harris.
5238 Clonal Cosegregation of Tumorigenicity with Overexpression ofc-myc and Transforming Growth Factor-a Genes in ChemicallyTransformed Rat Liver Epithelial Cells. Lester W. Lee, VictoriaW. Raymond. Ming-Sound Tsao, David C. Lee. H. Shelton Earp,and Joe W. Grisham.
^ 5266 IndividualSusceptibility to InducedChromosome Damage and Its
Implications for Detecting Genotoxic Exposures in HumanPopulations. John K. Wiencke, MargaretR. Wrensch, Rei Miike,and Nicholas L. Petrakis.
5355
5270 Sequential Analyses of the Growth and Morphological Characteristics of Aberrant Crypt Foci: Putative Preneoplastic Lesions.E. A. McLellan, A. Mediine, and R. P. Bird.
'5284 Activation of Amino-a-carboline, 2-Amino-l-methyl-6-phenyl-
imidazo[4,5-A]pyridine,and a Copper Phthalocyanine CelluloseExtract of Cigarette Smoke Condensate by Cytochrome P-450Enzymes in Rat and Human Liver Microsomes. TsutomuShimada and F. Peter Guengerich.
5298 Overcoming the Activity of Mammary Carcinoma SuppressorGene in Copenhagen Rats by \-H-ras Oncogene Transfer intoMammary Epithelial Cells in Situ. Bingcheng Wang, Wendy S.Kennan. Jane Yasukawa-Barnes, Mary J. Lindstrom, and MichaelN. Gould.
Prostratin, a Nonpromoting Phorbol Ester, Inhibits Induction byPhorbol 12-Myristate 13-Acetate of Ornithine Decarboxylase,Edema, and Hyperplasia in CD-I Mouse Skin. Zoltan Szallesiand Peter M. Blumberg.
Endocrinology
Characteristics of the Biphasic Action of Androgens and of thePotent Anti-proliferative Effects of the New Pure AntiestrogenEM-139 on Cell Cycle Kinetic Parameters in LNCaP HumanProstatic Cancer Cells. Yvan de Launoit, Raymonde Veilleux,Maurice Dufour, Jacques Simard, and Fernand Labrie.
Human Carcinoid Cell Production of Paracrine Growth FactorsThat Can Stimulate Fibroblast and Endothelial Cell Growth.R. Daniel Beauchamp. Robert J. Coffey, Jr., Russette M. Lyons.Elizabeth A. Perkett. Courtney M. Townsend, Jr., and Harold L.Moses.
"SI 65
5253
5153
5212
•¿�5261
5304
Immunology
Increase in Immunogenicity and Sensitivity to Natural Cell-mediated Cytotoxicity following in Vitro Exposure of MCA105Tumor Cells to Ultraviolet Radiation. Mirsada Begovic, RonaldHerberman. and Elieser Gorelik.
Effects of H-2Kb Gene on Expression of Melanoma-associatedAntigen and Lectin-binding Sites on Hid Melanoma Cells. ElieserGorelik, Gilbert Jay, Misoon Kim, Vincent J. Hearing, AlbertDeLeo, and J. Philip McCoy, Jr.
Synergistic Effect of Nocardia rubra Cell Wall Skeleton andRecombinant Interleukin 2 for in Vivo Inductionof Lymphokine-activated Killer Cells. Kazuhiro Miyazaki. Kosei Yasumoto,Tokujiro Yano, Goro Matsuzaki. Keizo Sugimachi, and KikuoNomoto.
Antiproliferative Activity of a Pregnancy Recognition Hormone,Ovine Trophoblast Protein-1. Carol H. Pontzer, Fuller W. Bazer,and Howard M. Johnson.
Requirements for the Internalizaron of a Murine MonoclonalAntibody Directed against the HER-2/neu Gene Productc-ereB-2. Lisa A. Maier, Feng Ji Xu, Susan Hester. Cinda M.Boyer, Sara McKenzie, Arthur M. Bruskin, Yair Argon, andRobert C. Bast, Jr.
* Indicates studies using human-derived material.
on April 19, 2018. © 1991 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
*5113
*5118
*5171
5232
*5292
*5308
*5329
*5348
5398
*5405
* 5410
Molecular Biology and Genetics
Cyclin B Expression in HeLa Cells during the <. Block Inducedby Ionizing Radiation. Ruth J. Muschel. Hong Bing Zhang. GeorgeIliakis, and W. Gillies McKenna.
Allelotype of Human Ovarian Cancer. Takaaki Sato. Hiroko Saito,Ryoji Morita. Sumiko Koi, Je H. Lee, and Yusuke Nakamura.
Frequent Alleile Losses and Mutations of thep53 Gene in HumanOvarian Cancer. Aikou Okamoto, Yuichi Sameshima. ShiroYokoyama, Yoshiteru Terashima. Takashi Sugimura, MasaakiTerada, and Jun Yokota.
Alterations in Tumor Development in Vivo Mediated by Expression of Wild Type or Mutant p53 Proteins. Gad Shaulsky, NaomiGoldfinger, and Varda Rotter.
CD44 Splice Variants Confer Metastatic Behavior in Rats: Homologous Sequences Are Expressed in Human Tumor Cell Lines.Martin Hofmann. Wolfgang Rudy. Margot Zöller.Cornelia Tölg.Helmut Ponta. Peter Herrlich, and Ursula Günthert.
K-rav Activation in Premalignant and Malignant Epithelial Lesions of the Human Uterus. Takayuki Enomoto, Masaki Inoue,Alan O. Perantoni, Gregory S. Buzard. Hiroshi Miki. OsamuTanizawa, and Jerry M. Rice.
Folate-binding Protein Is a Marker for Ovarian Cancer. Ian G.Campbell, Tania A. Jones. William D. Foulkes. and JohnTrowsdale.
Growth Inhibition of Oncogene-transformed Rat Fibroblasts byCocultured Normal Cells: Relevance of Metabolic CooperationMediated by Gap Junctions. Wolfgang Martin. GüntherZempel.Dieter Hülser,and Klaus Willecke.
Induction of in Vitro Differentiation of Mouse Embryonal Carcinoma (F9) Cells by Inhibitors of Topoisomerases. KazuhiroKondo, Kazuhide Tsuneizumi, Toshio Watanabe. and MichioOishi.
Molecular Genetic Alterations in Superficial and Locally Advanced Human Bladder Cancer. Joseph C. Presti. Jr.. Victor E.Reuter. Teresa Galán,William R. Fair, and Carlos Cordon-Cardo.
Genetic Alterations of the p53 Gene Are a Feature of MalignantMesotheliomas. Richard J. Cote, Suresh C. Jhanwar, SteveNovick, and Angel Pellicer.
Preclinical Pharmacology and Experimental Therapeutics3k* 5093 Antagonistic Effect of Aclarubicin on Daunorubicin-inducedCy-
totoxicity in Human Small Cell Lung Cancer Cells: Relationshipto DNA Integrity and Topoisomerase II. Peter Buhl Jensen. PalleScheide Jensen. Erland J. F. Demant, Ellen Friche, Boe SandahlSerensen, Maxwell Sehested. Karsten Wassermann. LarsVindel0v, Ole Westergaard. and Heine H0i Hansen.
A' 5ISI Multifactorial Mechanisms Associated with Broad Cross-Resist
ance of Ovarian Carcinoma Cells Selected by CyanomorpholinoDoxorubicin. Derick H. M. Lau, Alexander D. Lewis, MohamedN. Ehsan, and Branimir I. Sikic.
kU* 5245 Increased Survival after Treatments with Anticancer Agents of
Chinese Hamster Cells Expressing the Human M, 27,000 HeatShock Protein. Jacques Huot. GaétanRoy. Herman Lambert,Pierre Chrétien,and Jacques Landry.
5275 Mechanisms of Resistance to Etoposide and Teniposide in Acquired Resistant Human Colon and Lung Carcinoma Cell Lines.Byron H. Long, Lotte Wang, Aurelio Lonco, Richard C. C. Wang,Michael G. Brattain, and Anna Maria Casazza.
*
"5384 Experimental Studies and Preliminary Clinical Trial of V'inorel-
bine-loaded Polymeric Bioresorbable Implants for the LocalTreatment of Solid Tumors. Charles Fournier. Bernard Hecquet,Philippe Bouffard. Michel Vert. Armelle Caty. Marie-Odile Vilain.Luc Vanseymortier, Solange Merle, Anais Krikorian, Jean-LouisLefebvre, Alice Delobelle. and Lucien Adenis.
*5417 Chemotherapy and Chemosensitization of Transgenic Mice Which
Express the Human Multidrug Resistance Gene in Bone Marrow:Efficacy, Potency, and Toxicity. Gerald H. Mickisch. ThomasLicht, Glenn T. Merlino, Michael M. Gottesman. and Ira Pastan.
Tumor Biology
5100 Muscle-specific Gene Expression in Rhabdomyosarcomas andStages of Human Fetal Skeletal Muscle Development. Patricia N.Tonin. Heidi Scrable. Hiroyuki Shimada. and Webster K.Cavenee.
"!"51(1" Expression of Insulin-like Growth Factor I, Its Binding Proteins,
and Its Receptor in Ovarian Cancer. Douglas Yee. Fernando R.Morales. Thomas C. Hamilton, and Daniel D. Von Hoflf.
Estimation of the Dividing Fraction and Potential Doubling Timeof Tumors Using Cytochalasin B. Yuta Shibamoto and ChristianStreffer.
Hypoxie Fractions in Xenografted Human Colon Tumors. JohnT. Leith. Già Padfield. Lynn Faulkner, and Seth Michelson.
Different Energy Metabolism in Two Human Small Cell LungCancer Subpopulations Examined by "I1 Magnetic Resonance
Spectroscopy and Biochemical Analysis in Vivoand in Vitro. PaulE. G. Kristjansen. Mogens Spang-Thomsen, and Bj0rn Quistorff.
Productionof Neuromedin B and Neuromedin B Gene Expressionin Human Lung Tumor Cell Lines. Carles Cardona, Pamela H.Rabbitts. Eliott R. Spindel, Mohammed A. Ghatei, Norman M.Bleehen, Stephen R. Bloom, and Julie G. Reeve.
Biochemical Evidence That Glucocorticoid-sensitive Cell LinesDerived from the Human Leukemic Cell Line CCRF-CEM Express a Normal and a Mutant Glucocorticoid Receptor Gene. LisaA. Palmer and Jeffrey M. Harmon.
Tumor Necrosis Factor Stimulates Epithelial Tumor CellMotility. Eliot M. Rosen. Itzhak D. Goldberg, David Liu. EvaSetter, Maribeth A. Donovan, Madhu Bhargava. Michael Reiss.and Barry M. Kacinski.
5322 Evidence for the Involvement of Transforming Growth Factor aand Epidermal Growth Factor Receptor Autocrinc Growth Mechanism in Primary Human Ovarian Cancers in Vitro. Ken-ichiroMorishige. Hirohisa Kurachi. Kyoka Amemiya. Yoshiko Fujita.Toshiya Yamamoto. Akira Miyake. and Osamu Tanizawa.
*5342 Increased Number of Accessible Sugar Epitopes Defined withMonoclonal Antibody AM-3 on Colonie Mucins Is Associatedwith Malignant Transformation of Colonie Mucosa. ChristophHanski. John Sheehan. Michael Kiehntopf, Birgit Stolze. HaraldStein, and Ernst-Otto Riecken.
5378 Regional Heterogeneity and Complementation in the Expressionof the Tumor-associated Glycoprotein 72 Epitopes in ColorectalCancer. R. Muraro. L. Frati. R. Bei. F. Ficari. C. Valli. D. French,S. Mammarella, F. Caramia. G. Fegiz. and R. Mariani-Costantini.
5392 Establishment of Epstein-Barr Virus-negative Diffuse Large CellLymphoma Cell Line with an 8;22 Chromosomal Translocation.Ichiro Ichinose. Shuji Nakano. Koh-ichi Ohshima. Kenji Mitsugi.Keizo Anzai. Toshihiko Shida. and Yoshivuki Niho.
*5134
*5139
*5160
*5205
*5224
*5315
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Virology* 5370 Immortalization of Normal Human Bronchial Epithelial Cells by
Human Papillomaviruses 16 or 18. James C. Willey, AlberecBroussoud, Ambereen Sleemi, William P. Bennett, Peter Cerutti,and Curtis C. Harris.
CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS
Clinical
5144 Pharmacokinetics of Intravesical Mitomycin C in SuperficialBladder Cancer Patients. James T. Dalton, M. GuillaumeWientjes, Robert A. Badalament, Joseph R. Drago, and JessieL-S. Au.
5339 Prognostic Significance of Argyrophilic Nucleolar OrganizerRegions in Esophageal Carcinoma. Masaru Monta, HiroyukiKuwano, Hiroyuki Matsuda, Sunao Moriguchi, and KeizoSugimachi.
Epidemiológica!5177 Genetic Susceptibility to Squamous Cell Carcinoma of the Lung
in Relation to Cigarette Smoking Dose. Kei Nakachi. Kazue Imai,Shin-ichi Hayashi, Junko Watanabe, and Kaname Kawajiri.
Meeting Reports
5435 Developmental Genetics and Childhood Cancer: AACR SpecialConference in Cancer Research. Alfred Knudson, George F.Vande Woude, Stephen H. Friend, Webster K. Cavenee, andGarren M. Brodeur.
5440 Workshop Report from the Division of Research Grants, NationalInstitutes of Health: The Role of Chromosome Rearrangements,Deletions, and Point Mutations in Cancer—APathology B StudySection Workshop. Harriet Isom. Geoffrey Kitchingman. PradipRoy-Burman, Nelson Fausto, and Martin Padarathsingh.
5445 AnnouncementsEighty-Third Annual Meeting of the AACRAACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRCalendar of Events
5448 Author Index
NOTE: AACR forms available in the back of this issue—•¿�Application for Active and Corresponding Membership•¿�Application for Associate Membership
Letter to the Editor
5433 Correspondence re: O. C. A. Scott, Tumor Transplantation andTumor Immunity: A Personal View. Cancer Res., 51: 757-763,1991. M. J. Embleton. Reply by Oliver C. A. Scott.
Also available in the back of this issue—GUIDELINES FOR SUBMITTING DISKS TO
AACR PUBLICATIONS
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