CbnœrResearchVOLUME 47 «NUMBER 24 •CNREA8 •PP 6425-6829

CONTENTSf

Asterisks # preceding page numbers refer to studies using human-derived material.

6425 Editorial. Peter N. Magee.

Perspectives in Cancer Research

6426 Heterogeneous DNA Damage and Repair in the MammalianGenome. Vilhelm A. Bohr, David H. Phillips, and Philip C.Hanawalt.

BASIC SCIENCES

*(i-U7 Effect of Polyamine Depletion by a-Difluoromethylornithine or(2R,5R)-6-Heptyne-2,5-diamine on Drug-induced TopoisomeraseH-mediated DNA Cleavage and Cytotoxicity in Human and Murine Leukemia Cells. Milorad Bakic, Diana Chan, Emil JFreireich, Laurence J. Marlon, and Leonard A. Zwelling.

* 6444 Effect of Intracellular Folate Concentration on the Modulation of5-Fluorouracil Cytotoxicity by the Elevation of Phosphoribosyl-pyrophosphate in Cultured Human KB Cells. Madeleine A. Kane.Eugene Roth, George Raptis, Carol Schreiber, and SamuelWaxman.

*645I Immunodetection and Modulation of Cellular Growth with Antibodies against Native Transforming Growth Factor-/?. JormaKeski-Oja, Russette M. Lyons, and Harold L. Moses.

* 6459 Enhancement of Antineoplastic Effects of Cisplatin by (alluminiiliAntagonists in Nude Mice Bearing Human Ovarian Carcinoma.Yoshihiro Kikuchi, Keibun Oomori, Isao Kizawa, Junko Hirata,Tsunekazu Kita, Munenori Miyauchi, and Koichi Kato.

6462 Treatment and Prophylaxis of Experimental Liver MétastasesofM5076 Reticulosarcoma with f»-Bis-neodecanoato-rra/u-.R,/?-l,2-diaminocyclohexaneplatinum(II) Encapsulated in Mnil¡lamellar Vesicles. R. Perez-Soler, A. R. Khokhar, and G. Lopez-Berestein.

6467 Murine Mammary Tumor Response to Hyperthermia and Radiotherapy Evaluated by in Vivo 3lP-Nuclear Magnetic Resonance

Spectroscopy. P. E. Sijens, W. M. M. J. Bovée,D. Seijkens, P.Koole, G. Los, and R. H. van Rijssel.

* 647-1 Production of Interleukin la-like Factor and Colony-stimulatingFactor by a Squamous Cell Carcinoma of the Thyroid (T3M-5)Derived from a Patient with Hypercalcemia and Leukocytosis.Kanji Sato, Yuko Fujii, Masayoshi Ono, Hitoshi Nomura, andKazuo Shizume.

6481 Nuclear Magnetic Resonance Analysis of Tumor Necrosis Factor-induced Alterations of Phospholipid Metabolites and pH in FriendLeukemia Cell Tumors and Fibrosarcomas in Mice. Franca Podo,Giulia Carpinelli, Massimo Di Vito, Massimo Giannini, EnricoProietti, Walter Fiers, Ion Gresser, and Filippo Belardelli.

*6490 Hydroxyurea-induced Cell Death as Related to Cell Cycle inMouse and Human T-Lymphoma Cells. Sven Skog, BernhardTribukait, Birgitta Wallström,and StafTan Eriksson.

6494 Dynamics of Generation of Antigen Loss Variants from LI 210Murine Leukemia Clones Detected by a Tumor-specific T-CellClone. Fumihiko Nagase, S. M. Jamshedur Rahman, TakashiYokochi, Kohei Kawashima, Ken-lchi Isobe, Tomoaki Yoshida,Ei-Ichi Nagura, and Izumi Nakashima.

* 6500 Abnormal Insulin-Receptor Down Regulation and Dissociation of

Down Regulation from Insulin Biological Action in Cultured Human Tumor Cells. Kathleen G. Mountjoy, Graeme J. Finlay, andIan M. Holdaway.

* 6505 Differential Collagen Biosynthesis by Human Neuroblastoma Cell

Variants. Yves A. DeClerck, Elizabeth T. Bomann, Barbara A.Spengler, and June L. Biedler.

6511 Prevention by Fructose-l,6-bisphosphate of Cardiac OxidativeDamage Induced in Mice by Subchronic Doxorubicin Treatment.Giuseppe Lazzarino, Anna Rita Viola, Luciano Mulieri, GiuseppeRotilio, and Irene Mavelli.

* tol7 Stimulation of c-myc Oncogene Expression Associated with Estrogen-induced Proliferation of Human Breast Cancer Cells. DonDubik, Thomas C. Dembinski, and Robert P. C. Shiu.

•^6522Hydroxyl Radical Production and Human DNA Damage Induced

by Ferric Nitrilotriacetate and Hydrogen Peroxide. Sumiko Inoueand Shosuke Kawanishi.

* 65 28 Antibody-guided Localization of Intraperitoneal Tumors following

Intraperitoneal or Intravenous Antibody Administration. GailRowlinson, Deborah Snook, Albert Busza, and Agamemnon A.Epenetos.

^6532 Detection of 1-jS-D-Arabinofuranosylcytosine Incorporation into

DNA in Vivo. D. Spriggs, G. Robbins, Y. Ohno, and D. Kufe.

6537 Modulation by Palmitoylcarnitine of Protein Kinase C Activation.Teruo Nakadate and Peter M. Blumberg.

6543 "P-Postlabeling Analysis of Aromatic DNA Adducts in Fish from

Polluted Areas. Bruce P. Dunn, John J. Black, and AlexanderMaccubbin.

6549 Differential Uptake of cis-Diamminedichloroplatinum(II) by Sensitive and Resistant Murine LI 210 Leukemia Cells. William R.Waud

* 6556 Expression of Antigens Associated with Small Cell Carcinoma of

the Lung on Hematopoietic Progenitor Cells. Edward D. Ball,Kristin A. Keefe, and Esther Colby.

6560 Inhibitory and Stimulatory Effects of Glucocorticoid on Androgen-induced Growth of Murine Shionogi Carcinoma 115 in Vivo andin Cell Culture. Daigo Hiraoka, Nobuyoshi Nakamura, YasukoNishizawa, Naomi Uchida, Shinzaburo Noguchi, KeishiMatsumoto, and Bunzo Sato.

6565 Avarol-induced DNA Strand Breakage in Vitro and in FriendErythroleukemia Cells. Werner E. G. Müller,Dusan Sladic,Rudolf K. Zahn, Karl-Heinz Bässler,Nikola Dogovic, HorstGerner, Miroslav J. Gasic, and Heinz C. Schroder.

* 6572 Monoclonal Antibody Technique for Detection of Estrogen Recep

tors in Human Breast Cancer: Greater Sensitivity and MoreAccurate Classification of Receptor Status Than the Dextran-coated Charcoal Method. Susan M. Thorpe.

*6576 Modulation of Human Hemopoietic Progenitor Cell Growth inVitro by Recombinant Human 0-Interferon. Shu-Jun Liu, Joao L.Ascensao, John D. Lutton, and Robin Lincoln.

t The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS.

on June 7, 2018. © 1987 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

* 6580 Mechanisms of Mitochondrial Photosensitization by the CationicDye, A^'-Bis(2-ethyl-l,3-dioxylene)kryptocyanine (EDKC):

Preferential Inactivation of Complex I in the Electron TransportChain. G. Ara, J. R. Aprille, C. D. Malis, S. B. Kane, L. Cincona,J. Foley, J. V. Bonventre, and A. R. Oseroff.

6586 Apparent DNA-binding Protein Specific for Cells Transformed byAvian Acute Leukemia Viruses. Stephen H. Benedict.

6590 donai Analysis of Radiation Leukemia Virus-induced Leukemicand Preleukemic Murine Cells. Yaacov Ben-David, Eitan Yefenof,and Moshe Kotler.

6595 Inhibitionof Proliferation of Normal, Preneoplastic, and Neoplas-tic Rat Hepatocytes by Transforming Growth Factor-/?.GordonK. Wollenberg, Esther Semple, Bette Ann Quinn, and M. AnthonyHayes.

*6600 Interleukin-2 Enhancement of Monoclonal Antibody-mediatedCellular Cytotoxicity against Human Melanoma. David H. Munnand Nai-Kong V. Cheung.

6606 Marked Synergism of Dimethylnitrosamine Carcinogenesis inRats Exposed to Cadmium. George G. Wade, Richard Mandel,and Hugues J-P. Ryser.

#<>ol4 Class 1 (Unique) Tumor Antigens of Human Melanoma: PartialPurification and Characterization of the FD Antigen and Analysisof a Mouse Polyclonal Antiserum. M. Jules Mattes, Francisco X.Real, Keiko Furukawa, Lloyd J. Old, and Kenneth O. Lloyd.

6620 Properties of a Plasma Membrane-associated Cathepsin B-likeCysteine Proteinase in Metastatic B16 Melanoma Variants. JurijRozhin, Donald Robinson, Melissa A. Stevens, Tamara T. Lah,Kenneth V. Honn, Randall E. Ryan, and Bonnie F. Sloane.

* 6629 Effect of Recombinant a-Interferon on the Expression of the bcr-abl Fusion Gene in Human Chronic Myelogenous Leukemia CellLines. D. Frank Andrews III, Jack W. Singer, and Steven J.Collins.

6633 Inhibition of 12-O-Tetradecanoylphorbol-13-acetate Induction ofOrnithine Decarboxylase Activity, DNA Synthesis, and TumorPromotion in Mouse Skin by Ascorbic Acid and Ascorbyl Palmi-tate. Robert C. Smart, Mou-Tuan Huang, Zheng Tao Han,Michael C. Kaplan, Antonino Focella, and Allan H. Conney.

6639 Immunotoxins to the Murine Transferrin Receptor: Intracavi-tary Therapy of Mice Bearing Syngeneic Peritoneal Tumors.Michael J. Björnand Gregory Groetsema.

* 6646 Cytogenetic Alterations Associated with the Acquisition of Dox-orubicin Resistance: Possible Significance of Chromosome 7 Alterations. Marilyn L. Slovak, Gerald A. Hoeltge, and Jeffrey M.Trent.

* 6653 Characterizationof Estrogen Receptor Messenger RNA in HumanBreast Cancer. P. J. Barrett-Lee,M. T. Travers, R. A. McClelland,Y. Luqmani, and R. C. Coombes.

* 6660 A New in l'ivo Model to Study Invasion and Metastasis of Human

Bladder Carcinoma. Thomas E. Ahlering, Louis Dubeau, andPeter A. Jones.

* 6666 Location of Genes Involved in Invasion and Metastasis on HumanChromosome 7. John G. Collard, Monique van de Poll, AnnehiekeScheffer, Ed Roos, Anton H. M. Hopman, Ad H. M. Geurts vanKessel, and Jacques J. M. van Dongen.

#6671 Induction of Malignant Subcutaneous Sarcomas in Hamsters bya Recombinant DNA Containing BK Virus Early Region and theActivated Human c-Harvey-ros Oncogene. Alfredo Corallini,Monica Pagnani, Paola Viadana, Paola Camellin, AntonellaCaputo, Pierluigi Reschiglian, Sonia Rossi, Giuseppe Altavilla,Rita Selvatici, and Giuseppe Barbanti-Brodano.

6678 Characterizationof Keratins from Rat Cervical Epithelial Cells inVivo and in Vitro. Thomas C. Wright, Jr.

6686 Differential Sensitivity of Tumor Targets to Liver Macrophage-mediated Cytotoxicity. Carol R. Gardner, Arthur J. Wasserman,and Debra L. Laskin.

6692 Ionizing Radiation as an Initiator: Effects of Proliferation andPromotion Time on Tumor Incidence in Mice. Deborah Jaffe andG. Tim Bowden.

#6697 Association between Expression of a Tumor-associated Carbohydrate Epitope and the Proliferativi'and Tumorigenic Activity of aHuman-Squamous Lung Cancer Cell Line and Epitope-positiveand -negative Sublines. Claus Due, HákanEriksson, Anne Sihm,and Lennart Olsson.

* 6705 Regulation of Growth and Differentiation of Human Keratinocytesby Type ft Transforming Growth Factor and Epidermal GrowthFactor. Michael Reiss and Alan C. Sartorelli.

* 6710 Characteristics of Cell Lines Established from Human ColorectalCarcinoma. Jae-Gahb Park, Herbert K. Oie, Paul H. Sugarbaker,Jerry G. Henslee, Tchaw-Ren Chen, Bruce E. Johnson, and AdiGazdar.

6719 Immunocytochemical Detection of Interaction Products of cis-Diamminedichloroplatinum(II) and cii-Diammine(l,l-cyclobu-tanedicarboxylato)platinum(II) with DNA in Rodent Tissue Sections. Philippe M. A. B. Terheggen, Ben G. J. Floot, EwaltScherer,Adrian C. Begg, Anne Marie J. Fichtinger-Schepman, and Leoden Engelse.

6726 Strong Promoting Activity of Reversible Uracil-induced Uro-lithiasis on Urinary Bladder Carcinogenesis in Rats Initiated withV-Butyl-Y-(4-hydro\yl>ulyl)nitrosaniini'. Tomoyuki Shirai,

Yoshiaki Tagawa, Shoji Fukushima, Katsumi Imaida, andNobuyuki Ito.

6731 Probable Free Radical Effects on Rat Liver Nuclei during EarlyHepatocarcinogenesis with a Choline-devoid Low MethionineDiet. Thomas H. Rushmore, Danny M. Chazarían,VenkatSubrahmanyan, Emmanuel Färber,and Amiya K. Ghoshal.

#6741 Mouse Monoclonal Antibodies to Human Epithelial Differentiation Antigens Expressed on the Surface of Ovarian CarcinomaAscites Cells. M. Jules Mattes, Katherine Look, Keiko Furukawa,Virginia K. Pierce, Lloyd J. Old, John L. Lewis, Jr., and KennethO. Lloyd.

6751 Role of Platelet Membrane in Enhancement of Tumor Cell Adhesion to Endothelial Cell Extracellular Matrix. David G. Menter,Bruce W. Steinert, Bonnie F. Sloane, Nancy Gundlach, ColeenY. O'Gara, Lawrence J. Marnett, Clement Diglio, Daniel Walz,

John D. Taylor, and Kenneth V. Honn.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

6763 Occupational Risks for Bladder Cancer among Men in Sweden.Hans S. R. Malker, Joseph K. McLaughlin, Debra T. Silverman,Jan L. E. Ericsson, B. J. Stone, Jan A. Weiner, Birgitta K. Malker,and William J. Blot.

6767 Chromosome Abnormalities in Malignant Lymphoma in Patientsfrom Saitama. Nobuo Maseki, Yasuhiko Kaneko, MasaharuSakurai, Masato Kurihara, Kazumi Sampi, Kayako Shimamura,and Shojiro Takayama.

6776 Phase I and Pharmacokinetic Study of Flavone Acetic Acid. DavidJ. Kerr, Stanley B. Kaye, James Cassidy, Christopher Bradley,Elaine M. Rankin, Lynne Adams, Albert Setanoians, TimothyYoung, Gordon Forrest, Michael Soukop, and Michel Clavel.

Continued

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6782 Phase I Clinical Study of the New Amino Acid-linked Nitrosourea,S 10036, Administered on a Weekly Schedule. David Khav.u.Francois Lokiec, Jean-Pierre Bizzari, Marise Weil, Laurent Meeus,Mustapha Sellami, Jacques Rouesse, Pierre Banzet, and ClaudeJacquillat.

6786 Biochemical Pharmacology of High Dose 1-0-D-Arabinofurano-sylcytosine in Childhood Acute Leukemia. Vassilios I. Avramis,Robert Biener, Mark Krailo, Jerry Finklestein, Lawrence Ettinger,Michael Willoughby, Stuart E. Siegel, and John S. Holcenberg.

6793 Immunocytochemical Detection of 1,25-Dihydroxyvitamin 1>>Receptor in Breast Cancer. Uta Berger, Patricia Wilson, Richard A.McClelland, Kay Colston, Mark R. Haussler, J. Wesley Pike, andR. Charles Coombes.

6800 Tumor Behavior in Transitional Cell Carcinoma of the Bladderin Relation to Chromosomal Markers and Histopathology. V.Ramesh Babu, Michael D. Lutz, Brian J. Miles, Riad N. Farah,Lester Weiss, and Daniel L. Van Dyke.

6806 Immunohistochemical Detection of the Placenta! Form of Gluta-thione 5-Transferase in Dysplastic and Neoplastic Human UterineCervix Lesions. Yuhko Shiratori, Yasushi Soma, HidetoshiMaruyama, Shigemi Sato, Atsushi Takano, and Kiyomi Sato.

6810 Inherent Sensitivity of Cultured Human Embryonal CarcinomaCells to Adducts of cis-Diamminedichloroplatinum(II) on DNA.Martin F. Pera, Frank Friedlos, Judith Mills, and John J. Roberts.

Meeting Report

6814 Strategies for Controlling Cancer through Genetics. Dilys M.Parry, John J. Mulvihill, Robert W. Miller, Kare Berg, andChristine L. Carter.

6818 Announcements

6819 Acknowledgment to Reviewers

6828 Author Index

NOTE: Advance registration form for 79th Annual Meeting of the American Association for Cancer Research available in the back ofthis issue.

on June 7, 2018. © 1987 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

Cancer Research

VOLUME 47 •NUMBER 24

CONTENTS Arranged by Subject Category

6425 Editorial. Peter N. Magee.

Perspectives in Cancer Research

6426 Heterogeneous DNA Damage and Repair in the MammalianGenome. Vilhelm A. Bohr, David H. Phillips, and Philip C.Hanawalt.

BASIC SCIENCES

Biochemistry and Biophysics

* h-444 Effect of Imracf llular Folate Concentration on the Modulation of5-Fluorouracil Cytotoxicity by the Elevation of Phosphoribosyl-pyrophosphate in Cultured Human KB Cells. Madeleine A. Kane,Eugene Roth, George Raptis, Carol Schreiber, and SamuelWaxman.

6467 Murine Mammary Tumor Response to Hyperthermia and Radiotherapy Evaluated by in Vivo 3lP-Nuclear Magnetic Resonance

Spectroscopy. P. E. Sijens, W. M. M. J. Bovée,D. Seijkens, P.Koole, G. Los, and R. H. van Rijssel.

6481 Nuclear Magnetic Resonance Analysis of Tumor Necrosis Factor-inducedAlterations of Phospholipid Metabolites and pH in FriendLeukemia Cell Tumors and Fibrosarcomas in Mice. Franca Podo,Giulia Carpinelli, Massimo Di Vito, Massimo Giannini, EnricoProietti, Walter Fiers, Ion Gresser, and Filippo Belardelli.

*f>522 Hydroxyl Radical Production and Human DNA Damage Inducedby Ferric Nitrilotriacetate and Hydrogen Peroxide. Sumiko Inoueand Shosuke Kawanishi.

6565 Avarol-induced DNA Strand Breakage in Vitro and in FriendErythroleukemia Cells. Werner E. G. Müller,Dusan Sladic,Rudolf K. Zahn, Karl-Heinz Bässler,Nikola Dogovic, HorstGerner, Miroslav J. Gasic, and Heinz C. Schröder.

* 6572 Monoclonal Antibody Technique for Detection of Estrogen Receptors in Human Breast Cancer: Greater Sensitivity and MoreAccurate Classification of Receptor Status Than the Dextran-coated Charcoal Method. Susan M. Thorpe.

Carcinogenesis

6537 Modulation by Palmitoylcarnitine of Protein Kinase C Activation.Temo Nakadate and Peter M. Blumberg.

6543 "P-Postlabeling Analysis of Aromatic DNA Adducts in Fish from

Polluted Areas. Bruce P. Dunn, John J. Black, and AlexanderMaccubbin.

6606 Marked Synergism of Dimethylnitrosamine Carcinogenesis inRats Exposed to Cadmium. George G. Wade, Richard Mandel,and Hugues J-P. Ryser.

6633 Inhibition of 12-O-Tetradecanoylphorbol-13-acetate Induction ofOrnithine Decarboxylase Activity, DNA Synthesis, and TumorPromotion in Mouse Skin by Ascorbic Acid and Ascorbyl Palmi-tate. Robert C. Smart, Mou-Tuan Huang, Zheng Tao Han,Michael C. Kaplan, Antonino Focella, and Allan H. Conney.

6692 Ionizing Radiation as an Initiator: Effects of Proliferation andPromotion Time on Tumor Incidence in Mice. Deborah Jaffe andG. Tim Bowden.

* Indicates studies using human-derived material.

6719 Immunocytochemical Detection of Interaction Products of t-i.v-Diamminedichloroplatinum(II) and c»-Diammine(l,l-cyclobu-tanedicarboxylato)platinum(II) with DNA in Rodent Tissue Sections. Philippe M. A. B. Terheggen, Ben G. J. Floot, Ewalt Scherer,Adrian C. Begg, Anne Marie J. Fichtinger-Schepman, and Leoden Engelse.

6726 Strong Promoting Activity of Reversible Uracil-induced Uro-lithiasis on Urinary Bladder Carcinogenesis in Rats Initiated withN-Butyl-yV-(4-hydroxybutyl)nirrosamine. Tomoyuki Shirai,Yoshiaki Tagawa. Shoji Fukushima, Katsumi Imaida, andNobuyuki Ito.

6731 Probable Free Radical Effects on Rat Liver Nuclei during EarlyHepatocarcinogenesis with a Choline-devoid Low MethionineDiet. Thomas H. Rushmore, Danny M. Chazarían,VenkatSubrahmanyan, Emmanuel Farber, and Amiya K. Ghoshal.

Endocrinology

:':i>474 Production of Interleukin la-like Factor and Colony-stimulating

Factor by a Squamous Cell Carcinoma of the Thyroid (T3M-5)Derived from a Patient with Hypercalcemia and Leukocytosis.Kanji Sato, Yuko Fujii, Masayoshi Ono, Hitoshi Nomura, andKazuo Shizume.

* 6500 Abnormal Insulin-Receptor Down Regulation and Dissociation ofDown Regulation from Insulin Biological Action in Cultured Human Tumor Cells. Kathleen G. Mountjoy, Graeme J. Finlay, andIan M. Holdaway.

"'•(i5!7Stimulation of c-myc Oncogene Expression Associated with Estrogen-induced Proliferation of Human Breast Cancer Cells. DonDubik, Thomas C. Dembinski, and Robert P. C. Shiu.

6560 Inhibitoryand Stimulatory Effects of Glucocorticoid on Androgen-induced Growth of Murine Shionogi Carcinoma 115 in Vivo andin Cell Culture. Daigo Hiraoka, Nobuyoshi Nakamura, YasukoNishizawa, Naomi Uchida, Shinzaburo Noguchi, KeishiMatsumoto, and Bunzo Sato.

Immunology

6494 Dynamics of Generation of Antigen Loss Variants from I 1210Murine Leukemia Clones Detected by a Tumor-specific T-CellClone. Fumihiko Nagase, S. M. Jamshedur Rahman, TakashiYokochi, Kohei Kawashima, Ken-Ichi Isobe, Tomoaki Yoshida,Ei-Ichi Nagura, and Izumi Nakashima.

:¡"6528 Antibody-guided Localization of IntraperitonealTumors following

Intraperitoneal or Intravenous Antibody Administration. GailRowlinson, Deborah Snook, Albert Busza, and Agamemnon A.Epenetos.

* t>55h Expression of Antigens Associated with Small Cell Carcinoma of

the Lung on Hematopoietic Progenitor Cells. Edward D. Ball,Kristin A. Keefe, and Esther Colby.

^6576 Modulation of Human Hemopoietic Progenitor Cell Growth inVitro by Recombinant Human /3-Interferon. Shu-Jun Liu, Joao L.Ascensao, John D. Lutton, and Robin Lincoln.

*6600 Interleukin-2 Enhancement of Monoclonal Antibody-mediatedCellular Cytotoxicity against Human Melanoma. David H. Munnand Nai-Kong V. Cheung.

on June 7, 2018. © 1987 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

#6614 Class 1 (Unique) Tumor Antigens of Human Melanoma: PartialPurification and Characterization of the FD Antigen and Analysisof a Mouse Polyclonal Antiserum. M. Jules Mattes, Francisco X.Real, Keiko Furukawa, Lloyd J. Old, and Kenneth O. Lloyd.

6686 Differential Sensitivity of Tumor Targets to Liver Macrophage-mediated Cytotoxicity. Carol R. Gardner, Arthur J. Wasserman,and Debra L. Laskin.

#6741 Mouse Monoclonal Antibodies to Human Epithelial Differentiation Antigens Expressed on the Surface of Ovarian CarcinomaAscites Cells. M. Jules Mattes, Katherine Look, Keiko Furukawa,Virginia K. Pierce, Lloyd J. Old, John L. Lewis, Jr., and KennethO. Lloyd.

Molecular Biology and Genetics* 6629 Effect of Recombinant a-Interferon on the Expression of the bcr-

abl Fusion Gene in Human Chronic Myelogenous Leukemia CellLines. D. Frank Andrews III, Jack W. Singer, and Steven J.Collins.

* 6653 Characterizationof Estrogen Receptor Messenger RNA in HumanBreast Cancer. P. J. Barrett-Lee,M. T. Travers, R. A. McClelland,Y. Luqmani, and R. C. Coombes.

Preclintcal Pharmacology and Experimental Therapeutics

#6437 Effect of Polyamine Depletion by a-Difluoromethylornithine or(2R,5R)-6-Heptyne-2,S-diamine on Drug-induced TopoisomeraseII-mediated DNA Cleavage and Cytotoxicity in Human and Murine Leukemia Cells. Milorad Bakic, Diana Chan, I mi! JFreireich, Laurence J. Marton, and Leonard A. Zwelling.

*6459

6462

*6490

6511

*6532

6549

*6580

6639

*6646

Enhancementof Antineoplastic Effects of Cisplatin by CalmodulinAntagonists in Nude Mice Bearing Human Ovarian Carcinoma.Yoshihiro Kikuchi, Keibun Oomori, Isao Kizawa, Junko Mirata,Tsunekazu Kita, Munenori Miyauchi, and Koichi Kato.

Treatment and Prophylaxis of Experimental Liver MétastasesofM5076 Reticulosarcoma with ci'j-Bis-neodecanoato-rrani-Ä,Ä-

l,2-diaminocyclohexaneplatinum(II) Encapsulated in Multilamel-lar Vesicles. R. Perez-Soler, A. R. Khokhar, and G. Lopez-Berestein.

Hydroxyurea-induced Cell Death as Related to Cell Cycle inMouse and Human T-Lymphoma Cells. Sven Skog, BernhardTribukait, Birgitta Wallström,and Staffan Eriksson.

Prevention by Fructose-l,6-bisphosphate of Cardiac OxidativeDamage Induced in Mice by Subchronic Doxorubicin Treatment. Giuseppe Lazzarino, Anna Rita Viola, Luciano Mulieri,Giuseppe Rotilio, and Irene Mavelli.

Detection of l-/3-D-Arabinofuranosylcytosine Incorporation intoDNA in Vivo. D. Spriggs, G. Robbins, Y. Ohno, and D. Kufe.

*6451

*6505

6595

6620

*6660

*6666

6678

*6697

*6705

*6710

6751

6586

6590

Differentia] Uptake of c»-Diamminedichloroplatinum(II)by Sensitive and Resistant Murine LI 210 Leukemia Cells. William R.Waud. *6671

Mechanisms of Mitochondria! Photosensitization by the CationicDye, Ar,7V'-Bis(2-ethyl-l,3-dioxylene)kryptocyanine (EDKC):

Preferential Inactivation of Complex I in the Electron TransportChain. G. Ara, J. R. Aprille, C. D. Malis, S. B. Kane, L. Cincotta,J. Foley, J. V. Bonventre, and A. R. Oseroff.

Immunotoxins to the Murine Transferrin Receptor: IntracavitaryTherapy of Mice Bearing Syngeneic Peritoneal Tumors. MichaelJ. Björnand Gregory Groetsema.

Cytogenetic Alterations Associated with the Acquisition of Doxorubicin Resistance: Possible Significance of Chromosome 7 Alterations. Marilyn L. Slovak, Gerald A. Hoeltge, and Jeffrey M.Trent.

6776

Tumor Biology

Immunodetection and Modulation of Cellular Growth with Antibodies against Native Transforming Growth Factor-0. JormaKeski-Oja, Russette M. Lyons, and Harold L. Moses.

Differential Collagen Biosynthesis by Human Neuroblastoma CellVariants. Yves A. DeClerck, Elizabeth T. Bomann, Barbara A.Spengler, and June L. Biedler.

Inhibition of Proliferation of Normal, Preneoplastic, and Neoplas-tic Rat Hepatocytes by Transforming Growth Factor-/8. GordonK. Wollenberg, EstherSemple, Bette Ann Quinn, and M. AnthonyHayes.

Properties of a Plasma Membrane-associated Cathepsin B-likeCysteine Proteinase in Metastatic B16 Melanoma Variants. JurijRozhin, Donald Robinson, Melissa A. Stevens, Tamara T. Lah,Kenneth V. Honn, Randall E. Ryan, and Bonnie F. Sloane.

A New in VivoModel to Study Invasion and Metastasis of HumanBladder Carcinoma. Thomas E. Ahlering, Louis Dubeau, andPeter A. Jones.

Location of Genes Involved in Invasion and Metastasis on HumanChromosome 7. John G. Couard, Monique van de Poll, AnnehiekeScheffer, Ed Roos, Anton H. M. Hopman, Ad H. M. Geurts vanKessel, and Jacques J. M. van Dongen.

Characterizationof Keratins from Rat Cervical Epithelial Cells inVivo and in Vitro. Thomas C. Wright, Jr.

Association between Expression of a Tumor-associated Carbohydrate Epitope and the Proliferative and Tumorigenic Activity of aHuman Squamous Lung Cancer Cell Line and Epitope-positiveand -negative Sublines. Claus Due, HâkanEriksson, Anne Siimi.and Lennart Olsson.

Regulation of Growth and Differentiation of Human Keratinocytesby Type ßTransforming Growth Factor and Epidermal GrowthFactor. Michael Reiss and Alan C. Sartorelli.

Characteristics of Cell Lines Established from Human ColorectalCarcinoma. Jae-Gahb Park, Herbert K. Oie, Paul H. Sugarbaker,Jerry G. Henslee, Tchaw-Ren Chen, Bruce E. Johnson, and AdiGazdar.

Role of Platelet Membrane in Enhancement of Tumor Cell Adhesion to Endothelial Cell Extracellular Matrix. David G. Menter,Bruce W. Steinert, Bonnie F. Sloane, Nancy Gundlach, ColeenY. O'Gara, Lawrence J. Marnett, Clement Diglio, Daniel Walz,

John D. Taylor, and Kenneth V. Honn.

VirologyApparent DNA-binding Protein Specific for Cells TransformedbyAvian Acute Leukemia Viruses. Stephen H. Benedict.

donili Analysis of Radiation Leukemia Virus-induced Leukemicand Preleukemic Murine Cells. Yaacov Ben-David, Eitan Yefenof,and Moshe Kotler.

Induction of Malignant Subcutaneous Sarcomas in Hamsters bya Recombinant DNA Containing BK Virus Early Region and theActivated Human c-Harvey-roìOncogene. Alfredo Corallini,Monica Pagnani, Paola Viadana, Paola Camellin, AntonellaCaputo, Pierluigi Reschiglian, Sonia Rossi, Giuseppe Altavilla,Rita Selvatici, and Giuseppe Barbanti-Brodano.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

Clinical

Phase I and Pharmacokinetic Study of Flavone Acetic Acid. DavidJ. Kerr, Stanley B. Kaye, James Cassidy, Christopher Bradley,Elaine M. Rankin, Lynne Adams, Albert Setanoians, TimothyYoung, Gordon Forrest, Michael Soukop, and Michel Clavel.

Continued

on June 7, 2018. © 1987 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

6782 Phase I Clinical Study of the New Amino Acid-linked Nitrosourea,S 10036, Administered on a Weekly Schedule. David Khayat,Francois Lokiec, Jean-Pierre Bizzari, Marise Weil, Laurent Meeus,Mustapha Sellami, Jacques Rouesse, Pierre Banzet, and ClaudeJacquillat.

6786 Biochemical Pharmacology of High Dose l-/3-D-Arabinofurano-sylcytosine in Childhood Acute Leukemia. Vassilios I. Avramis,Robert Biener, Mark Krailo, Jerry Finklestein, Lawrence Ettinger,Michael Willoughby, Stuart E. Siegel, and John S. Holcenberg.

6793 Immunocytochemical Detection of 1,25-Dihydro\y vitamin Di Receptor in Breast Cancer. Uta Berger, Patricia Wilson, Richard A.McClelland, Kay Colston, Mark R. Haussler, J. Wesley Pike, andR. Charles Coombes.

6810 Inherent Sensitivity of Cultured Human Embryonal CarcinomaCells to Adducts of cú-Diamminedichloroplatinum(II) on DNA.

Martin F. Pera, Frank Friedlos, Judith Mills, and John J. Roberts.

Epidemiological

6763 Occupational Risks for Bladder Cancer among Men in Sweden.Hans S. R. Malker, Joseph K. McLaughlin, Debra T. Silverman,Jan L. E. Ericsson, B. J. Stone, Jan A. Weiner, Birgitta K. Malker,and William J. Blot.

6767 Chromosome Abnormalities in Malignant Lymphoma in Patientsfrom Saitama. Nobuo Maseki, Yasuhiko Kaneko, MasaharuSakurai, Masato Kurihara, Kazumi Sampi, Kayako Shimamura,and Shojiro Takayama.

6800 Tumor Behavior in Transitional Cell Carcinoma of the Bladder inRelation to Chromosomal Markers and Histopathology. V.Ramesh Babu. Michael D. Lutz, Brian J. Miles, Riad N. Farah,Lester Weiss, and Daniel L. Van Dyke.

6806 Immunohistochemical Detection of the Placental Form of Gluta-thione S-Transferase in Dysplastic and Neoplastic Human Uterine

Cervix Lesions. Yuhko Shiratori, Yasushi Soma, HidetoshiMaruyama, Shigemi Sato, Atsushi Takano, and Kiyomi Sato.

Meeting Report

6814 Strategies for Controlling Cancer through Genetics. Dilys M.Parry, John J. Mulvihill, Robert W. Miller, Kare Berg, andChristine L. Carter.

6818 Announcements

6819 Acknowledgment to Reviewers

6828 Author Index

NOTE: Advance registration form for 79th Annual Meeting of the American Association for Cancer Research available in the back ofthis issue.

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1987;47:6425-6827. Cancer Res     47 (24 Part 1)

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