CancerManagementinMan:Chemotherapy, …978-90-481-9704-0/1.pdf · Rosalia DeNecochea-Campion Moores...
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Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures
Transcript of CancerManagementinMan:Chemotherapy, …978-90-481-9704-0/1.pdf · Rosalia DeNecochea-Campion Moores...
Cancer Management in Man: Chemotherapy,Biological Therapy, Hyperthermiaand Supporting Measures
Cancer Growth and Progression
Volume 13
Founding Editor
Hans E. Kaiser†, D. Sc.
Series Editors
Aejaz Nasir, M.D., M.Phil., FCAPDepartment of Interdisciplinary Oncology-Pathology,Moffit Cancer Center & Research Institute,Tampa, FL, U.S.A.
Timothy J. Yeatman, M.D.Professor of Surgery,Executive Vice President Translational Research,President & Chief Scientific Officer M2Gen,Moffit Cancer Center & Research Institute,Tampa, FL, USA
For further volumes:http://www.springer.com/series/5721
Cancer Managementin Man: Chemotherapy,Biological Therapy,Hyperthermiaand Supporting Measures
Edited by
Boris R. MinevMoores UCSD Cancer Center and UCSD Division of Neurosurgery,
University of California San Diego (UCSD), La Jolla, CA, USA
Genelux Corporation, San Diego Science Center, San Diego,
CA 92109, USA
123
EditorBoris R. MinevMoores UCSD Cancer Center and UCSD
Division of NeurosurgeryUniversity of California San Diego
(UCSD)3855 Health Sciences Drive 082092093-0820 La JollaCA, USA
and
Genelux CorporationSan Diego Science CenterSan Diego, CA [email protected]
ISBN 978-90-481-9703-3 e-ISBN 978-90-481-9704-0DOI 10.1007/978-90-481-9704-0Springer Dordrecht Heidelberg London New York
© Springer Science+Business Media B.V. 2011No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or byany means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without writtenpermission from the Publisher, with the exception of any material supplied specifically for the purpose ofbeing entered and executed on a computer system, for exclusive use by the purchaser of the work.
Cover illustration: Tumor therapy with vaccinia virus. Mice were i.v. injected with a single dose(1 × 107 pfu per mice) of the light-emitting oncolytic vaccinia virus GLV-1h68 (row 2–4) or PBS control(row 1) 30 d after breast tumor cell implantation. Bright field photographs (left column), GFP fluorescenceimages (middle column), and immunohistochemical analyses of expression of GLV-1h68-encodedβ-galactosidase (right column) in tumors were done 14 (row 2), 28 (row 1 and 3), and 56 d (row 4) aftervirus or PBS injection. Two weeks after virus injection, strong fluorescence of GFP was seen in tumorswith a volume of ∼1400 mm3. An additional 2 wk later, a much reduced GFP fluorescence was observedat tumor size of ∼480 mm3 in the same mouse. After 56 d, no GFP fluorescence was seen in the tumorwhich was ∼180 mm3 in size. β-galactosidase activity was detected concomitant with light emission andwas completely eliminated as light emission was extinguished.
Printed on acid-free paper
Springer is part of Springer Science+Business Media (www.springer.com)
Dedicated to Professor Hans E. Kaiser, an unforgettable mentor,colleague and friend.
Boris R. Minev
Contents
Part I Chemotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1 Plant-Derived Natural Products as Anticancer Agents . . . . . . . . 3David G.I. Kingston
2 The Vinca Alkaloids . . . . . . . . . . . . . . . . . . . . . . . . . . . 25Nicole Coufal and Lauge Farnaes
3 Taxanes and Epothilones in Cancer Treatment . . . . . . . . . . . . 39Edward F. McClay
4 Alkylating Agents . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61Laurent Gate and Kenneth D. Tew
5 Anthracyclines and Anthracenediones . . . . . . . . . . . . . . . . 87Nicole Coufal and Lauge Farnaes
6 Topoisomerase I Inhibitors – The Camptothecins . . . . . . . . . . 103Michael Newton, Gene Wetzstein, and Daniel Sullivan
7 Folate Antagonists . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125Alex Ko
8 Platinum Complexes for the Treatment of Cancer . . . . . . . . . . 145David Roberts, Peter J. O’Dwyer, and Steven W. Johnson
9 Hormonal Therapy in Cancer . . . . . . . . . . . . . . . . . . . . . 165Soe T. Maunglay, Julia A. Cogburn, and Pamela N. Munster
10 Effects of Cancer Chemotherapy on Gonadal Function . . . . . . . 191Angela R. Bradbury and Richard L. Schilsky
11 Targeting the Tumor Microenvironment for EnhancingChemotherapy in Hematologic Malignancies . . . . . . . . . . . . . 215Luis A. Crespo, Xinwei Zhang, and Jianguo Tao
Part II Biological Therapy . . . . . . . . . . . . . . . . . . . . . . . . . 235
12 Cytokines in the Treatment of Cancer . . . . . . . . . . . . . . . . . 237Adrian Bot
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viii Contents
13 Antibody-Based Therapies for Solid Tumors . . . . . . . . . . . . . 245Satish Shanbhag and Barbara Burtness
14 Cancer Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257Stephanie Schroter, Melanie Hayden, Wenxue Ma,Nellia Fleurov, Neha Rahan, and Boris R. Minev
15 Adoptive Immunotherapy of Cancer Using AutologousLymphocytes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285Yoshiyuki Yamaguchi, Riki Okita, Akiko Emi,Katsuji Hironaka, Makoto Okawaki, Takuhiro Ikeda,Masahiro Ohara, Ichiro Nagamine, and Jun Hihara
16 Oncolytic Virotherapy of Cancer . . . . . . . . . . . . . . . . . . . 295Nanhai G. Chen and Aladar A. Szalay
Part III Other . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 317
17 Protein Kinase Inhibitors . . . . . . . . . . . . . . . . . . . . . . . . 319Daanish Hoda and Adil Daud
18 Inhibitors of Tumor Angiogenesis . . . . . . . . . . . . . . . . . . . 331Anaadriana Zakarija and William J. Gradishar
19 Transcatheter Management of Neoplasms . . . . . . . . . . . . . . 341Christos S. Georgiades and Jean-Francois Geschwind
20 Tumor Stem Cells: Therapeutic Implications of a ParadigmShift in Multiple Myeloma . . . . . . . . . . . . . . . . . . . . . . . 349Neil H. Riordan, Thomas E. Ichim, Famela Ramos,Samantha Halligan, Rosalia De Necochea-Campion,Grzegorz W. Basak, Steven F. Josephs, Boris R. Minev,and Ewa Carrier
Part IV Hyperthermia . . . . . . . . . . . . . . . . . . . . . . . . . . . . 363
21 Induced Hyperthermia in the Treatment of Cancer . . . . . . . . . 365Bert Hildebrandt, Johanna Gellermann, Hanno Riess,and Peter Wust
Part V Supporting Measures . . . . . . . . . . . . . . . . . . . . . . . . 379
22 Hematologic Support of the Patient with Malignancy . . . . . . . . 381Thomas A. Lane
23 Current Status of Bone Marrow Transplantationfor Treatment of Cancer . . . . . . . . . . . . . . . . . . . . . . . . 407Edward D. Ball, Asad Bashey, Ewa Carrier,Januario E. Castro, Peter Holman, and Thomas A. Lane
24 Pain Management in Cancer Patients . . . . . . . . . . . . . . . . . 437Hrachya Nersesyan, Jeffrey J. Mucksavage, Eljim Tesoro,and Konstantin V. Slavin
Contents ix
25 Management of Nausea and Vomiting in Cancer Patients . . . . . . 453Rudolph M. Navari, Paula P. Province, and Steven D. Passik
26 Nutrition in the Management of the Cancer Patient . . . . . . . . . 473Cheryl L. Rock
27 Predictive Value of IFN-γγγ-Induced Indoleamine2,3-Dioxygenase (IDO) Expression in Cancer Patients . . . . . . . . 495G. Brandacher, A. Amberger, K. Schroecksnadel,R. Margreiter, and Dietmar Fuchs
Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 509
Contributors
A. Amberger Department of General and Transplant Surgery, Tyrolean CancerResearch Institute, Innsbruck Medical University, Innsbruck, Austria,[email protected]
Edward D. Ball Department of Medicine and Moores UCSD Cancer Center,La Jolla, CA 92093-0960, USA, [email protected]
Grzegorz W. Basak Department of Hematology, Oncology and Internal Diseases,Medical University of Warsaw, Warszawa, Poland, [email protected]
Asad Bashey Department of Medicine and Moores UCSD Cancer Center, La Jolla,CA 92093-0960, USA, [email protected]
Adrian Bot Scientific Management, MannKind Corporation, Valencia, CA 91354,USA, [email protected]
Angela R. Bradbury Department of Medicine, Fox Chase Cancer Center,Philadelphia, PA 19111, USA, [email protected]
G. Brandacher Department of General and Transplant Surgery, Tyrolean CancerResearch Institute, Innsbruck Medical University, Innsbruck, Austria,[email protected]
Barbara Burtness Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia,PA 19111-2497, USA, [email protected]
Ewa Carrier Moores UCSD Cancer Centre, San Diego, CA, USA,[email protected]
Januario E. Castro Department of Medicine and Moores UCSD Cancer Center,La Jolla, CA 92093-0960, USA, [email protected]
Nanhai G. Chen Genelux Corporation, San Diego Science Center, San Diego, CA,USA, [email protected]
Julia A. Cogburn Department of Interdisciplinary Oncology, H. Lee MoffittCancer Center, Experimental Therapeutics and Breast Medical Oncology, 12902Magnolia Dr, Tampa, FL 33612, USA
Nicole Coufal UCSD Department of Medicine, 9500 Gilman Drive, La Jolla, CA92093, USA, [email protected]
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xii Contributors
Luis A. Crespo Hematopathology and Laboratory Medicine, University of SouthFlorida College of Medicine, H. Lee Moffitt Cancer Center and Research Institute,12901 Magnolia Drive, Tampa, FL 33612, USA
Adil Daud Department of Medicine, Division of Hematology Oncology,University of California, 1600 Divisadero Street, San Francisco, CA 94010, USA,[email protected], [email protected]
Rosalia DeNecochea-Campion Moores UCSD Cancer Centre, San Diego, CA,USA, [email protected]
Akiko Emi Department of Surgical Oncology, Research Institute for RadiationBiology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-Ku,Hiroshima 734-8553, Japan
Lauge Farnaes UCSD Department of Medicine, 9500 Gilman Drive, La Jolla, CA92093, USA, [email protected]
Nellia Fleurov Moores UCSD Cancer Center, La Jolla, CA 92093-0820, USA,[email protected]
Dietmar Fuchs Department of Biological Chemistry, Biocenter, InnsbruckMedical University, Innsbruck, Austria, [email protected]
Laurent Gate INRS, 54000 Nancy, France
Johanna Gellermann Klinik für Strahlenheilkunde, Campus Virchow Klinikum,Charité Universitätsmedizin Berlin, Humboldt-Universität, D-13344 Berlin,Germany, [email protected]
Christos S. Georgiades Division of Vascular and Interventional Radiology,Department of Vascular and Interventional Radiology, The Johns Hopkins Hospital,Baltimore, MD 21287, USA, [email protected]
Jean-Francois Geschwind Division of Vascular and Interventional Radiology,Department of Vascular and Interventional Radiology, The Johns Hopkins Hospital,MD, Baltimore 21287, USA
William J. Gradishar Division of Hematology/Oncology, Robert H. LurieComprehensive Cancer Center, Northwestern University, Feinberg School ofMedicine, 676 N. St. Clair, Suite 850, Chicago, IL 60611, USA,[email protected]
Samantha Halligan Moores UCSD Cancer Centre, San Diego, CA, USA,[email protected]
Melanie Hayden Moores UCSD Cancer Center, La Jolla, CA 92093-0820, USA,[email protected]
Jun Hihara Department of Surgical Oncology, Research Institute for RadiationBiology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-Ku,Hiroshima 734-8553, Japan
Bert Hildebrandt Medizinische Klinik für Hämatologie und Onkologie, CampusVirchow Klinikum, Charité Universitätsmedizin Berlin, Humboldt-Universität,D-13344 Berlin, Germany, [email protected]
Contributors xiii
Katsuji Hironaka Department of Surgical Oncology, Research Institute forRadiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-Ku,Hiroshima 734-8553, Japan
Daanish Hoda Division of Hematology Oncology, Department of Medicine,University of California, 1600 Divisadero Street, San Francisco, CA 94010, USA
Peter Holman Department of Medicine and Moores UCSD Cancer Center,La Jolla, CA 92093-0960, USA, [email protected]
Thomas E. Ichim Medistem Inc, San Diego, CA, USA, [email protected]
Takuhiro Ikeda Department of Surgical Oncology, Research Institute forRadiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-Ku,Hiroshima 734-8553, Japan
Steven W. Johnson Department of Hematology/Oncology, University ofPennsylvania, Philadelphia, PA 19104, USA, [email protected]
Steven F. Josephs Therinject LLC, San Diego, CA, USA,[email protected]
David G.I. Kingston Department of Chemistry, M/C 0212, Virginia PolytechnicInstitute and State University, Blacksburg, VA 24061, USA, [email protected]
Alex Ko UCSD Department of Medicine, 9500 Gilman Drive, La Jolla, CA 92093,USA, [email protected], [email protected]
Thomas A. Lane UCSD Transfusion Services and Stem Cell Processing Lab,Moores UCSD Cancer Center, La Jolla, CA 92093-0960, USA, [email protected]
Wenxue Ma Moores UCSD Cancer Center, La Jolla, CA 92093-0820, USA,[email protected]
R. Margreiter Department of General and Transplant Surgery, Tyrolean CancerResearch Institute, Innsbruck Medical University, Innsbruck, Austria
Soe T. Maunglay Department of Interdisciplinary Oncology, H. Lee MoffittCancer Center, Experimental Therapeutics and Breast Medical Oncology, 12902Magnolia Dr, Tampa, FL 33612, USA
Edward F. McClay Melanoma Research Center, Pacific Oncology andHematology Associates, San Diego, CA, USA, [email protected],[email protected]
Boris R. Minev Moores UCSD Cancer Center and UCSD Division ofNeurosurgery, La Jolla, CA 92093-0820, USA; Genelux Corporation, San DiegoScience Center, San Diego, CA 92109, USA, [email protected]
Jeffrey J. Mucksavage Department of Pharmacy Practice, University of Illinois atChicago, 833 South Wood Street, Chicago, IL 60612, USA
Pamela N. Munster Department of Interdisciplinary Oncology, H. Lee MoffittCancer Center, Experimental Therapeutics and Breast Medical Oncology, 12902Magnolia Dr, Tampa, FL 33612, USA, [email protected]
xiv Contributors
Ichiro Nagamine Department of Surgical Oncology, Research Institute forRadiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-Ku,Hiroshima 734-8553, Japan
Rudolph M. Navari Department of Medicine, Indiana University School ofmedicine South Bend, South Bend, IN 46617, USA, [email protected]
Hrachya Nersesyan Illinois Neurological Institute, OSF Saint Francis MedicalCenter, 530 N.E. Glen Oak Avenue, Peoria, IL 61637, USA, [email protected]
Michael Newton Department of Clinical Pharmacy, West Virginia UniversitySchool of Pharmacy and Mary Babb Randolph Cancer Center, Morgantown, WV26506, USA
Peter J. O’Dwyer Department of Hematology/Oncology, University ofPennsylvania, Philadelphia, PA 19104, USA
Masahiro Ohara Department of Surgical Oncology, Research Institute forRadiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-Ku,Hiroshima 734-8553, Japan
Makoto Okawaki Department of Surgical Oncology, Research Institute forRadiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-Ku,Hiroshima 734-8553, Japan
Riki Okita Department of Surgical Oncology, Research Institute for RadiationBiology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-Ku,Hiroshima 734-8553, Japan
Steven D. Passik Sloan Kettering Cancer Center, Cornell University School ofMedicine, New York, NY, USA
Paula P. Province Walther Cancer Research Center, University of Notre Dame,South Bend, IN 46617, USA
Famela Ramos Medistem Inc, San Diego, CA, USA, [email protected]
Neha Rahan Moores UCSD Cancer Center, La Jolla, CA 92093-0820, USA,[email protected]
Hanno Riess Medizinische Klinik für Hämatologie und Onkologie, CampusVirchow Klinikum, Charité Universitätsmedizin Berlin, Humboldt-Universität,D-13344 Berlin, Germany
Neil H. Riordan Medistem Inc, San Diego, CA, USA, [email protected]
David Roberts Department of Hematology/Oncology, University of Pennsylvania,Philadelphia, PA 19104, USA
Cheryl L. Rock Department of Family and Preventive Medicine, and CancerPrevention and Control Program, School of Medicine, University of California, SanDiego, CA, USA, [email protected]
Richard L. Schilsky Department of Medicine, University of Chicago MedicalCenter, Chicago, IL 60637, USA, [email protected]
Contributors xv
K. Schroecksnadel Department of Biological Chemistry, Biocenter, InnsbruckMedical University, Innsbruck, Austria
Stephanie Schroter Moores UCSD Cancer Center, La Jolla, CA 92093-0820,USA, [email protected]
Satish Shanbhag Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia,PA 19111-2497, USA, [email protected]
Konstantin V. Slavin Section of Functional and Stereotactic Neurosurgery,Department of Neurosurgery, University of Illinois at Chicago, 912 South WoodStreet, Chicago, IL 60612, USA, [email protected]
Daniel Sullivan Experimental Therapeutics Program and Department of Blood andMarrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute,Tampa, FL 33612, USA, [email protected]
Aladar A. Szalay Genelux Corporation, San Diego Science Center, San Diego,CA 92109, USA; Rudolf Virchow Center for Experimental Biomedicine, Institutefor Biochemistry and Institute for Molecular Infection Biology, University ofWürzburg, Würzburg, Germany; Department of Radiation Oncology, Rebecca andJohn Moores Comprehensive Cancer Center, University of California, San Diego,CA, USA, [email protected]
Jianguo Tao Hematopathology and Laboratory Medicine, University of SouthFlorida College of Medicine, H. Lee Moffitt Cancer Center and Research Institute,12901 Magnolia Drive, Tampa, FL 33612, USA, [email protected]
Eljim Tesoro Department of Pharmacy Practice, University of Illinois at Chicago,833 South Wood Street, Chicago, IL 60612, USA
Kenneth D. Tew Department of Pharmacology, Medical University SouthCarolina, 173 Ashley Ave, Charleston, SC 29466, USA, [email protected]
Gene Wetzstein Malignant Hematology Program and Department of Pharmacy,H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Peter Wust Klinik für Strahlenheilkunde, Campus Virchow Klinikum, CharitéUniversitätsmedizin Berlin, Humboldt-Universität, D-13344 Berlin, Germany
Yoshiyuki Yamaguchi Department of Surgical Oncology, Research Institute forRadiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-Ku,Hiroshima 734-8553, Japan, [email protected]
Anaadriana Zakarija Division of Hematology/Oncology, Robert H. LurieComprehensive Cancer Center, Northwestern University, Feinberg School ofMedicine, 676 N. St. Clair, Suite 850, Chicago, IL 60611, USA,[email protected]
Xinwei Zhang Hematopathology and Laboratory Medicine, University of SouthFlorida College of Medicine, H. Lee Moffitt Cancer Center and Research Institute,12901 Magnolia Drive, Tampa, FL 33612, USA
