Cancer in Idaho: Data Update & Strategic Plan Objectives Idaho Cancer Policy Agenda Meeting April...

Cancer in Idaho: Data Update &

Strategic Plan Objectives

Idaho Cancer Policy Agenda MeetingApril 25, 2014

Chris Johnson, EpidemiologistCancer Data Registry of Idaho

[email protected]

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3 Handouts

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Cancer

• 100+ different diseases• Since 2008, #1 cause of death in Idaho

– About 22% of deaths are from cancer• In 2011 in Idaho:

7,263 new invasive cases

849 new in situ cases

2,559 cancer deaths

30% of those diagnosed this year will die of cancer within five years

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Leading Cause of Death by AgeIdaho 2012

• Cancer is the leading cause of death among age groups 45-54, 55-64 and 65-74

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Trends in Crude Mortality Rates, Idaho

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Why is Cancer the Leading Cause of Death in Idaho?

• Competing risks– Why are heart disease/stroke deaths down?

• “Statins and Smoking”– Decreases in blood cholesterol levels and

uncontrolled hypertension (risk factors), mostly through medication

– Improvements in medical treatments for blocked arteries, stroke

– Lower smoking rates in Idaho

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Cancer Risk Factors

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Levels of Disease Prevention

• Primary Prevention– Aims to prevent the disease from

occurring– Reduces incidence

• Secondary Prevention– After the disease has occurred but

before symptoms– Aims to find and treat disease early

• Tertiary Prevention– Goals are to improve treatment

outcomes, prevent complications

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Measures of cancer burden:

incidence, mortality,

YPLL

Colon & Rectum Cancer

Behavior: smoking, physical activity, diet, screening

Lung Cancer, Tobacco, other

Tobacco-related Cancers

Melanoma Breast Cancer

Lung Cancer/Smoking Constellation

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Lung Cancer

• Idaho 2011:– 838 new cases – 616 deaths

• By far the leading cause of cancer death among both men and women – Each year, more people die of lung cancer than

of colon, breast, and prostate cancers combined– Lung cancer has a poor prognosis; nearly 90%

of persons with lung cancer die of the disease

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Lung Cancer Risk Factors

• Smoking causes ~85% of lung cancer deaths• Radon – 2nd leading cause of lung cancer

– About 10% of lung cancer deaths– Leading cause of lung cancer among non-

smokers• Secondhand smoke• Asbestos, arsenic, chromium, nickel, other

substances in workplace• Air pollution, including diesel exhaust

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Smoking

• Accounts for at least 30% of all cancer deaths

• Population attributable risk varies by cancer site for other smoking-related cancers:

– Larynx– Oral Cavity– Nose and

Sinuses– Pharynx– Esophagus

– Stomach– Pancreas– Cervix– Kidney– Bladder– Ovary

– Colon & Rectum– AML

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Counseling & Interventions

• The USPSTF recommends that clinicians ask all adults about tobacco use and provide tobacco cessation interventions for those who use tobacco products.– Grade: A recommendation: there is high certainty

that the net benefit is substantial.

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USPSTF Screening Recommendation (Dec 2013)

• The USPSTF recommends annual screening for lung cancer with low-dose computed tomography (LDCT) in adults ages 55 to 80 years who have a 30 pack-year smoking history and currently smoke or have quit within the past 15 years.– Screening should be discontinued once a person has

not smoked for 15 years or develops a health problem that substantially limits life expectancy or the ability or willingness to have curative lung surgery.

• Screening cannot prevent most lung cancer–related deaths, and smoking cessation remains essential.

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Drilling Down into CCAI Strategic Plan Measures

2. Reduce the lung cancer death rate

6. Reduce the oropharyngeal cancer death rate

18. Decrease the proportion of adults aged 18+ who are current smokers

19. Reduce tobacco use by adolescents

23. Reduce the proportion of males who use smokeless tobacco

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Lung Cancer State Map

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Lung Cancer Trends - Idaho

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Lung Cancer Age-Specific Rates, Idaho, 2007-2011

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Variation and Disparities in Lung Cancer in Idaho

• Geographic• Race/ethnicity• Area-based SES measures

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County Maps of Smoking and Lung Cancer Incidence & Mortality

Smoking 11-12 Inc 07-11 Mort 08-12

1

2

3

4

5

7

6

Idaho

Owyhee

Lemhi

Custer

Valley

Elmore

Butte

Blaine

Cassia

Boise

Clark

Bonner

Ada

Shoshone

Bingham

Clearwater

CaribouPower

Fremont

Adams

Latah

Twin Falls

Bonneville

Oneida

Camas

Kootenai

Boundary

Washington

JeffersonGem

Benewah

Jerome

Lincoln

Bannock

Bear Lake

GoodingMinidoka

Lewis

Franklin

Nez Perce

Canyon

TetonMadison

Payette

1

2

3

4

5

7

6

Idaho

Owyhee

Lemhi

Custer

Valley

Elmore

Butte

Blaine

Cassia

Boise

Clark

Bonner

Ada

Shoshone

Bingham

Clearwater

CaribouPower

Fremont

Adams

Latah

Twin Falls

Bonneville

Oneida

Camas

Kootenai

Boundary

Washington

JeffersonGem

Benewah

Jerome

Lincoln

Bannock

Bear Lake

GoodingMinidoka

Lewis

Franklin

Nez Perce

Canyon

TetonMadison

Payette

1

2

3

4

5

7

6

Idaho

Owyhee

Lemhi

Custer

Valley

Elmore

Butte

Blaine

Cassia

Boise

Clark

Bonner

Ada

Shoshone

Bingham

Clearwater

CaribouPower

Fremont

Adams

Latah

Twin Falls

Bonneville

Oneida

Camas

Kootenai

Boundary

Washington

JeffersonGem

Benewah

Jerome

Lincoln

Bannock

Bear Lake

GoodingMinidoka

Lewis

Franklin

Nez Perce

Canyon

TetonMadison

Payette

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Smoking Prevalence, Idaho 2012

* In 2012, about 190,000 adult smokers in Idaho.

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Area-Based Measures

• Used methods based on Harvard School of Public Health Disparities Geocoding Project– Geocoded cancer incidence data– Used area-based socioeconomic measures

(ABSMs) to characterize both the cases and population

– Computed rates stratified by the area-based measure of socioeconomic status

– Ran multilevel models and will be showing the effects that were statistically significant

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Census Tract 2010Poverty

American Community Survey 2007-2011

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2

3

4

5

7

6

Idaho

Owyhee

Lemhi

Custer

Valley

Elmore

Butte

Blaine

Cassia

Boise

Clark

Bonner

Ada

Shoshone

Bingham

Clearwater

CaribouPower

Fremont

Adams

Latah

Twin Falls

Bonneville

Oneida

Camas

Kootenai

Boundary

Washington

JeffersonGem

Benewah

Jerome

LincolnBannock

Bear Lake

GoodingMinidoka

Lewis

Franklin

Nez Perce

Canyon

TetonMadison

Payette

Census Tracts 2010

Census_Tract_Poverty_ACS_0711

0% - <5% poverty

05% - <10% poverty

10% - <20% poverty

20% + poverty

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Census Tract 2010Uninsured

American Community Survey 2008-2012

1

2

3

4

5

7

6

Idaho

Owyhee

Lemhi

Custer

Valley

Elmore

Butte

Blaine

Cassia

Boise

Clark

Bonner

Ada

Shoshone

Bingham

Clearwater

CaribouPower

Fremont

Adams

Latah

Twin Falls

Bonneville

Oneida

Camas

Kootenai

Boundary

Washington

JeffersonGem

Benewah

Jerome

Lincoln

Bannock

Bear Lake

GoodingMinidoka

Lewis

Franklin

Nez Perce

Canyon

TetonMadison

Payette

Census Tracts 2010

Census_Tract_Uninsured_ACS_0812

<15% uninsured

15% - <25% uninsured

25% - <35% uninsured

35%+ uninsured

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Lung Cancer Incidence by Census Tract % Uninsured

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Potentially Averted Lung Cancer Cases, 2007-2011

Area Uninsured Status Person-Years Observed Expected Cases Percent<15% uninsured 1,588,827 606 606 - 0.0%15% - <25% uninsured 2,961,564 1,499 1,293 206 13.7%25% - <35% uninsured 2,123,378 1,320 1,022 298 22.5%35%+ uninsured 1,074,624 708 490 218 30.7%Total 7,748,393 4,133 3,412 721 17.4%

Expected counts = age-specific rates from low uninsured area applied to populations of other areas.

Uninsured Status-Related Population Attributable FractionLung & Bronchus Cancer Incidence, Idaho, 2007-2011

Case Counts Potentially Averted

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Lessening the Burden from Lung Cancer

• Primary Prevention– Don’t smoke!– Test for radon

• Secondary Prevention– LDCT among high risk population

• Tertiary Prevention– Ensure quality treatment

• Access to care• Concordant with guidelines (e.g. NCCN)• Clinical trials

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Using the Drill-Down Results

• Target geographic areas• Disparities by:

– Income– Education– Uninsured– LGBT

Colon & Rectum Cancer Constellation

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Colon & Rectum Cancer

• Idaho 2011:– 639 new invasive cases– 17 new in situ cases– 222 deaths

• Of cancers affecting both men and women, second leading cause of cancer death

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Colon & Rectum Cancer Risk Factors

• UK (2011) study estimates 54% of colon & rectum cancer cases are attributable to lifestyle factors:

Br J Cancer. 2011; 105(Suppl 2): S77–S81.

– Red and preserved meat consumption (21%)– Overweight and obesity (13%)– Low fiber diet (12%)– Alcohol (12%)– Tobacco (8%)– Physical inactivity (3%)– Other [infections, radiation] (4%)

• The percentages reflect the effect of removing one cause of cancer independently of other causes, and there is overlap, so the total is less than the sum

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USPSTF Recommendation (Oct 2008):

• The USPSTF recommends screening for colorectal cancer using fecal occult blood testing, sigmoidoscopy, or colonoscopy in adults beginning at age 50 years and continuing until age 75 years.– Grade: A recommendation – there is high

certainty that the net benefit is substantial.

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Colorectal Cancer Screening

• CDC: “If everyone aged 50 years or older had regular screening tests, at least 60% of deaths from this cancer could be avoided.”

• Colorectal cancer screening helps find precancerous polyps so they can be removed before they turn into cancer. In this way, colorectal cancer is prevented.

• Screening tests also can find colorectal cancer early, when the chance of cure is better.

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CCAI Strategic Plan ObjectivesPertaining to Colon & Rectum Cancer

• 5 – Mortality• 9 – Incidence• 15 – Late stage CRC among persons aged 50+• 16 – CRC Screening• 21 – Overweight• 22 – Physical activity

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Colon & Rectum Cancer State Map

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Colorectal Cancer ScreeningIdaho 2012, Ages 50-75

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Colon & Rectum Cancer Trends

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Colon & Rectum Cancer Incidence by Race/Ethnicity, 2007-2011

Race/Ethnicity Count Pop Rate Rate Ratio Ratio P-ValueNon-Hispanic White 2,872 6,623,464 39.2Hispanic (any Race) 97 848,174 32.7 0.83 0.120Black 9 74,451 31.8 0.81 0.662American Indian/Alaska Native 38 144,202 46.8 1.20 0.379Asian or Pacific Islander 26 126,108 31.7 0.81 0.332

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Colon & Rectum Cancer Incidence by Census Tract % Poverty

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Potentially Averted Colon & Rectum Cancer Cases, 2007-2011

Area Uninsured Status Person-Years Observed Expected Cases Percent0% - <5% poverty 528,593 161 161 - 0.0%5% - <10% poverty 2,015,643 770 654 116 15.0%10% - <20% poverty 3,905,375 1,639 1,386 253 15.5%20% + poverty 1,298,778 497 380 117 23.5%Total 7,748,389 3,067 2,581 486 15.8%

Expected counts = age-specific rates from low poverty area applied to populations of other areas.

Poverty Status-Related Population Attributable FractionColorectal Cancer Incidence, Idaho, 2007-2011

Case Counts Potentially Averted

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Lessening the Burden from Colon & Rectum Cancer

• Primary Prevention– Healthy diet, Healthy BMI, Physical activity– Don’t smoke

• Secondary Prevention– Colon & rectum cancer screening

• Tertiary Prevention– Ensure quality treatment

• Access to care• Concordant with guidelines (e.g. NCCN)• Clinical trials

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• Target geographic areas• Disparities by:

– Income– Education– Area-based SES

Breast Cancer Constellation

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Breast Cancer (Female)

• Idaho 2011:– 1,006 new invasive cases– 225 new in situ cases– 194 deaths

• Among Idaho women, breast cancer is:– the most common cancer (incidence)– 2nd most common for mortality

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Breast Cancer Risk Factors• Risk Factors you Cannot Change

– Aging – Race and ethnicity– Genetic risk factors

• 5-10% of breast cancers are hereditary• BRCA1 and BRCA2

– Family history• 15% of women who get breast cancer have a

family history; 85% do not.– Dense breast tissue– Certain other breast conditions (LCIS, DCIS,

atypical ductal or lobular hyperplasia) – Number of menstrual cycles– Previous chest radiation– Diethylstilbestrol exposure

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Breast Cancer Risk Factors

• Lifestyle-related factors– Birth control– Hormone therapy after menopause– Drinking alcohol– Being overweight or obese after menopause– Lack of physical activity

• Unclear factors– Chemicals in the environment– Tobacco smoke– Night work

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Idaho Breast Cancer Trends

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30% Reduction In Breast Cancer Mortality Since 1980s

• How much due to screening?– Goal is to treat cancer earlier, when a cure is

more likely• How much due to treatment?

– Adjuvant tamoxifen lowers breast cancer mortality by nearly a third in long term studies of women with ER+ breast cancers (about 75 percent of those diagnosed) • There were greater improvements in mortality

among women with ER+ than ER- tumors (SEER 1990-2003).

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Mammography Screening Recommendations

for Women at Average Risk

• Women at higher risk of breast cancer may need to be screened earlier and more often than other women.

American Cancer Society

National Cancer Institute

National Comprehensive Cancer Network

United States Preventive

Services Task Force

Every year starting at age 40

Every 1-2 years starting at age 40

Every year starting at age 40

Every 2 yearsAges 50-74

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JAMA Review – Pace & KeatingApril 2014

• 450 articles from 1960 to 2014 reviewed for evidence on the mortality benefit and chief harms of mammography screening.– Mortality benefit of mammography is “modest”

• 15% reduction of breast cancer mortality for women in their 40s, and 32% for women in their 60s.

– Risks of harm from screening are “significant”• Over 10 years of annual mammograms, 61% with

false-positive result.• 19% of cancers represent overdiagnosis

– Clinicians must focus on informed screening decisions based on individual risk of a breast cancer diagnosis.

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CCAI Strategic Plan ObjectivesPertaining to Breast Cancer

• 3 – Mortality• 11 – Late stage incidence rate ages 40+• 17A- Biennial mammogram 40+• 17B- Biennial mammogram 50-74

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Breast Cancer Mortality

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Breast Cancer Incidence

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Mammography ScreeningIdaho 2012, Females 40+

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Lessening the Burden from Breast Cancer

• Primary Prevention– Overweight and obesity, Physical activity

• Secondary Prevention– USPSTF – recommends biennial screening

mammography for women aged 50 to 74 years• Tertiary Prevention

– Ensure quality treatment• Access to care• Concordant with guidelines (e.g. NCCN)• Clinical trials

Melanoma of the Skin Constellation

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Melanoma of the Skin

• Idaho 2011:– 443 new invasive cases– 385 new in situ cases– 57 deaths.

• Melanoma is the 5th most common cancer in Idaho in terms of incidence and 14th most common site for cancer deaths.

• Unreported cases from in-office labs continues to be an issue for most states.– Meaningful Use 2 may help improve melanoma

reporting.

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USPSTF Recommendations:

• [2009] Not enough evidence to recommend for or against routine screening (total body examination by a doctor) to find skin cancers early.

• [2012] Recommends counseling children, adolescents, and young adults aged 10 to 24 years who have fair skin about minimizing their exposure to ultraviolet radiation to reduce risk for skin cancer.– Insufficient evidence to assess the balance of

benefits and harms of counseling adults older than age 24 years.

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CCAI Strategic Plan ObjectivesPertaining to Skin Cancer

• 8 – Mortality• 27 – Tanning appliances grades 9-12• 28 – Sunburn adults• 29 – Tanning appliances adults

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Melanoma of the Skin Mortality

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Melanoma of the Skin Incidence

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Melanoma of the Skin Trends

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Sunburn among Adults, Idaho 2012

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Sunburn among Adults, Idaho 2012

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Indoor Tanning among AdultsIdaho 2012

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Indoor Tanning among AdultsIdaho 2012

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Indoor Tanning among ChildrenIdaho 2013

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Lessening the Burden from Melanoma of the Skin

• Primary Prevention– Avoiding excessive sun exposure– Avoiding intense, intermittent, UV exposure– Preventing sunburns– Prompt self-referral to physician for changing nevi

• Secondary Prevention– USPSTF – not enough evidence to recommend

for or against routine screening• Tertiary Prevention

– Ensure quality treatment• Access to care, guidelines, clinical trials

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• Target geographic areas • Focus on the young and the affluent for sunburn

– Young females for indoor tanning

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Hospitals & Clinical Trials

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American College of SurgeonsCommission on Cancer (CoC)

Cancer Programs in Idaho (n=7)

• Eastern Idaho Regional Medical Center• Kootenai Medical Center• Portneuf Medical Center• Saint Alphonsus Regional Medical Center• St. Joseph Regional Medical Center• St. Luke's Magic Valley Medical Center• St. Luke’s Regional Medical Center/MSTI

– About 70% of Idaho resident cancer cases seen at one of these facilities

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Clinical Trial Enrollment

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The Future of Cancer in Idaho

• As Idaho’s population increases and we live longer, we can expect more cases of cancer and cancer deaths in the future

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Lessening the Burden• Primary Prevention – Decreases Incidence

– Don’t smoke! Test for radon– Obesity & physical activity– Skin cancer prevention– Vaccinations for Hep B and HPV

• Secondary Prevention - Screening– Breast– Colorectal– Lung

• Tertiary Prevention - Ensure Quality Treatment– Access to care, Clinical trials– Concordant with guidelines (e.g. NCCN)

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