Busselton Population Medical Research Foundation.
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Transcript of Busselton Population Medical Research Foundation.
Busselton Population Medical Research Foundation
Vancouver
Calgary
London
Where is Busselton?
The Shire of Busselton is the target population of the Busselton Health Study
Cross-sectional & longitudinal population health surveys, initiated in 1966 by Dr Kevin Cullen
Busselton Health Studies
AimsAs stated in 1966:
1. To study the prevalence of common diseases in an Australian community
2. To assess the range and variation of a large number of clinical and laboratory variables in a natural population
3. To provide a community service in the detection, treatment and prevention of disease and in the education of the population
4. To conduct longitudinal surveys for the study of risk factors related to health and disease
5. To study mortality from specific diseases in an Australian population and to define the usefulness of risk factors in predicting such mortality
Indiv iduals
(n = 12,537)
1966(n=3,394)
1969(n=3,680)
1972(n=3,885)
1975(n=3,635)
1978(n=4,006)
1981(n=3,940)
1967(n=1,614)
1970(n=1,598)
1973(n=1,489)
1977(n=556)
1987(n=1,120)
1990(n=3,880)
1992(n=1,120)
1994-5(n=5,715)
Deaths1966-2002
(n = 3,264)
Hospitaladmissions1973-2002
(n =85,294)
Current & prev iousaddresses
(n = 35,312)
Familyrelationships
(2,468 fam ilies;7,463 indiv iduals)
BHS DATABASE
Cancerregistrations
1982-2002
(n = 1,751)
C ross -sec tional surveys
Adults 18+ Children Adults 65+
2003/4(n=1,000)
2005/7(approx5,000)
F o llowupsurveys
1983(n=1,730)
Methods used in Busselton:1966 - 2007
Methacholine
Atopy
Airway Hyper-Responsiveness (AHR)
Respiratory Symptoms
FEV1 & FVC
Standardised Questionnaires
Spirometry
Bronchial challenges Histamine
Skin Allergy TestsDust mitesGrassesCat/dogMould
DatasetOver 16, 000 participants since 1966
Biological specimens• Sera• DNA
Physical data• Anthropometry• Lung Function• Atopy & allergy• Cardiovascular function• Mental health & cognition
Lifestyle & Behaviour• Nutrition• Alcohol & Tobacco use• Exercise
Mortality & Hospital Admissions• Linkage via WA Hospital Morbidity
Data System
Family data• 2000 families
Recent Projects Asthma Prevalence
Study (2005-07)
2929 adults1500 school-aged children
Burden Of Lung Disease (BOLD) (2007-08)
629 Busselton Adults > 40 yrs of age
Sleep-Disordered Breathing Study (2007- ongoing)
>800 adults
Obesity, Metabolic Syndrome, CVD Risk Study (2006-08)
500 children & adolescents 1200 adults
Current Projects The Busselton Diabetes Study (BDS) (2008 - 2009)
Regional comparision with Fremantle Diabetes Study (FDS II) 250 Diabetics and 250 age-matched controls
• Anthropometry• Biochemistry• Neurological assessments• Vision• Blood pressure• Brachial-Ankle Index• ECG• Spirometry• Oximetry• Sleep Apnoea• Diet & Nutrition• Quality of care• Lifestyle & well-being
Current Projects The Busselton Healthy Ageing Study (BHAS)
(Commencing 2009)
Multidisciplinary focus on diseases and factors common to ageing3000 “Baby Boomers” 45 – 64 year olds
• Anthropometry• DEXA scans – bone, muscle, fat• Cardiovascular profiling• Muscle strength & balance• Physical Activity• Eyes & vision• Ears & hearing• Respiratory function & health• Cognition• Diet & nutrition• Mental health & well-being• Biochemistry & DNA
Gene Chromosome location
Variation surveyed
Phenotype Assoc’n Population-analysis
Cases/controls
DPP10 2q14 SNPs Asthma Y A?B - TDT 244
CCR5 3p21 Δ32 Asthma N A/B - TDT 217
IL4 5q23 -589C/T Specific IgE HDM
Y Pop’n based 1004
LTA 6p21 Ncol int 1 Asthma Y ? 92/318
“ “ Haplotypes Asthma Y ? 179/825
TNF 6p21 -308G/A Asthma Y ? 92/318
“ “ Haplotypes Asthma Y Pop’n based 1004
HLA-DRB1
6p21 SNP alleles Total IgE Y Quant. phenot 1004
“ “ “ “ Y Aab. – Quant. phenotype
234
HLA 6p21 Haplotypes Asthma Y ? 179/825
NOD1 7p15 In/del int 9 Total IgE Y ? ?
FCER1B 11q12 Leu18//Leu183
AtopySPT/IgE
Y Pop,n based 1004
“ “ Gly237Glu SPT, IgE, BHR
Y ? ?
“ “ Rsalin 2 Asthma, total IgE
Y Quant. phenot 123
“ “ Rsalex 7 Total IgE, eos
Y Quant. phenot 121
PHF11 13q14 SNPs, haplotypes
Total IgE, asthma
Y ? ?
TCRA/D 14q11 VA8.1 IgE to Der p 2
Y Pop,n based 410, 426
Genetic Studies (Asthma and Allergy) Using Busselton Data – Association Studies - Cookson (London), Palmer and others.
BPMRF Investigators Clin Prof Bill Musk * Respiratory diseases
Assoc Prof Alan James* Respiratory diseases/ pulmonary physiology
Prof Mathew Knuiman* Biostatistician/epidemiologist
Prof Lyle Palmer* Genetic epidemiology
Assoc Prof Joseph Hung* Cardiovascular diseases
Adj Prof John Beilby * Laboratory scientist, cardiovascular studies
Dr Digby Cullen * Gastroenterology
Dr Tim Welborn Diabetes, obesity
Prof Timothy Davis* General medicine, diabetes
Adj Prof Nicholas de Klerk* Biostatistician/epidemiologist
Dr Peter Hollingsworth* Laboratory scientist, immunology
Dr Jennie Hui** Genetics
Dr Brendan McQuillan Cardiovascular diseases
Prof John Olynyk Gastroenterology, liver disease
Prof David Ravine* Medical genetics
Clin Assoc Prof John Walsh* Thyroid diseases
Dr Bu Yeap Endocrinology
Strengths:Numbers, Longitudinal + Cross-sectional,Phenotypes (Q, airway function, blood),
Family linkage.
Resources:Genotyping, Staff, Infrastructure (some).
Collaborative areas:Respiratory and Allergy, CVD, Diabetes
British Columbia
Western Australia