bone-tec 2017International

Bone-Tissue-Engineering Conference

12 - 14 October 2017

Venue: Wappenhalle ICM, Munich, Germany

Conference Chair: Prof. Martijn van Griensven

Klinikum rechts der Isar Technische Universität München

ear participants of bone-tec 2017!

Bone and the adjacent structures are fascinating tissues for many different disciplines. The bone-tec conference is bring-ing all these disciplines together since 2008. The beauty of bone-tec is that both clinicians and scientists are discussing together and presenting their views on scaffolds and matri-ces for musculoskeletal engineering, drug delivery systems, growth factors and gene therapy, cells and cell-based thera-pies, immune system and musculoskeletal tissue regenera-tion, bone regeneration, cartilage, ligament and tendon en-gineering, regeneration of musculoskeletal interfaces, novel strategies to musculoskeletal regeneration: bioreactors and cell printing technologies, clinical applications and hurdles of clinical translation.

The first conferences of bone-tec were held in Hannover, the working place of Dr. Karl-Heinz Schuckert, the initiator of bone-tec. In 2013, bone-tec was hosted in Singapore (Prof. Teoh) and in 2015 in Stuttgart (Prof. Schenke-Layland). Cut-ting edge state-of-the-art translational and basic science will be presented alongside clinical studies. This will partly be presented by invited speakers and yourself from 26 countries all over the world.

Besides the science, Munich also offers a great venue for the hours outside the conference. Munich has a roaring night-life and it is worth coming earlier or stay longer to see much of a rich cultural heritage, do shopping or go to the mountains, which are nearby.

We welcome you in Munich for bone-tec 2017!

With our best regards

Prof. Martijn van Griensven, MD, PhD Congress President bone-tec 2017

Assist. Prof. Elizabeth Rosado Balmayor, PhDProgram Chair bone-tec 2017

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bone-tec 2017

International Bone-Tissue-Engineering Conference

bone-tec 2017 is endorsed by:

Congress Venue of bone-tec 2017

Wappenhalle ICM Munich Konrad-Zuse-Platz 8, 81829 Munich, Germany

Congress President bone-tec 2017:

Prof. Martijn van Griensven, MD, PhD

Program Chair bone-tec 2017:

Assist. Prof. Elizabeth Rosado Balmayor, PhD

Honorary Chair bone-tec 2017:

Dr. Karl-Heinz Schuckert, MD, DDS, PhD

Congress Secretariat bone-tec 2017:

Marina UngerFritz Seidl, MA, MBA

Scientific Board bone-tec 2017:

Prof. Martijn van Griensven, MD, PhD (Germany)Prof. C. James Kirkpatrick, MD, PhD, DSc (Germany)Dr. Karl-Heinz Schuckert, MD, DDS, PhD (Germany)Prof. Swee-Hin Teoh, PhD (Singapore)Prof. Katja Schenke-Layland, PhD (Germany)Prof. Fergal O‘Brien, PhD (Ireland)Prof. Peter C. Johnson, MD (U.S.A.)

Event:

The number of participants is limited to 200.The CME certification of bone-tec 2017 has been re-quested from the Bavarian Medical Association (Bayeri-sche Landesärztekammer).

bone-tec 2017

International Bone-Tissue-Engineering Conference

Thursday, 12 October 2017

12:30 - 13:45

Registration

13:45 - 14:00

Opening SessionChairs: M. van Griensven, E. Rosado Balmayor, K.-H. Schuckert

14:00 - 15:50

Scientific Session 1 - Bioinspired Calcium Phosphates for Bone Tis-sue Regeneration Chairs: P. Hatton and B. Lotz

14:00 - 14:20

In vitro evaluation of biocompatibility in 2D- and 3D- culture systems and potential mechanism of action of nanohydroxyapaptite pastesA. Crawford

14:20 - 14:30

Nanotechnology to create instructive microenviron-ments for bone repairO. Castano

14:30 - 14:40

Antibacterial silver-doped nanoscale hydroxyapati-te to address clinical needs in dental and orthopa-edic surgeryC. Wilcock

14:40 - 14:50

Osteoinductive properties of nanostructured HA- functionalized gelatin scaffolds in relation to en-dogenous or human mesenchymal stromal cellsA. Parrilli

14:50 - 15:00

Single-dose local administration of teriparatide with a octacalcium phosphate collagen composite en-hances bone regeneration in a rodent critical-sized calvarial defectS. Kamakura

15:00 - 15:10

Settable, weight-bearing nano-hydroxyapatite-poly-urethane bone grafts in a sheep tibial plateau defect modelL. Boller

15:10 - 15:30

The manufacture of nanoscale calcium phosphates: bioinspired & versatile medical devices for bone tis-sue regenerationP. Hatton

15:30 - 15:50

20 Years Bone Tissue Engineering, what we expec-ted and what we achievedK.-H. Schuckert

15:50 - 16:20

Visit of the Poster Exhibition and the Industry Exhi-bition / Coffee Break

bone-tec 2017

International Bone-Tissue-Engineering Conference

16:20 - 17:50

Scientific Session 2 - Electrical Stimulation of Orthopaedic Tissues

Chairs: S. Cartmell and S. Waters

16:20 - 16:40

Micro-invasive direct current stimulation - a new electroceutical treatment for soft tissue injuries in sports medicineA. Molsberger

16:40 - 17:00

Combination of bone tissue engineering and elec-trical stimulation approaches, in vitro and in vivo studies L. Leppik

17:00 - 17:20

Use of Electrical Stimulus for Bone Tissue Enginee-ringS. Cartmell

17:20 - 17:40

Mathematical models for tissue engineeringS. Waters

17:40 - 17:50

Conductive nano-topographies for MSC chondroge-nesis under the stimulation of pulsed electric-mag-netic fields (PEMFs)Y. Wu

17:50 - 18:40

Guided Poster Session

Chairs: F. O‘Brien, P. ten Dijke, A. Motta, A. Nüssler

Friday, 13 October 2017

08:30 - 10:00

Scientific Session 3 - Additive Biomanufacturing: Finding Parity in Disparity in Research

Chairs: P. Poh and D. Valainis

08:30 - 08:50

Mathematical optimization for bone scaffolds in a time-evolution modelP. Dondl

08:50 - 09:10

Evolution of bone scaffolds’ design – from conventi-onal to additive manufacturing of scaffoldsP. Poh

09:10 - 09:20

Fabrication of osteoconductive implants via stere-olithography for personalised bone reconstruction P. Evdokimov

09:20 - 09:30

Manufacture of PHBV scaffolds by selective laser sintering S. Diermann

09:30 - 09:40

Patient-specific implant made by stereolithography for orbital floor regeneration O. Guillaume

09:40 - 10:00

Frontiers in 3D-printed scaffolds bone tissue engi-neering and bioreactor technology S.-H. Teoh

bone-tec 2017

International Bone-Tissue-Engineering Conference

10:00 - 10:30

Visit of the Poster Exhibition and the Industry Exhi-bition / Coffee Break

10:30 - 12:00

Scientific Session 4 - Tissue Engineering of Cartilage, Tendon, Liga-ment and Tissue Interfaces

Chairs: S. Font Tellado and C. Evans

10:30 - 10:50

Recent Advances on Nature Inspired Tissue Engi-neering Strategies for the Regeneration of Musculo-skeletal TissuesR. L. Reis

10:50 - 11:00

Characterization of textile silk fibers for tendon tis-sue engineering applicationsS. Chiera

11:00 - 11:10

Heparin-based TGF-β2 and GDF5 release from bi-phasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineeringS. Font Tellado

11:10 - 11:20

Comparison of human cell populations on murine tendon repair F. Dyrna

11:20 - 11:30

Generation of non-condensing mineralized cartilage discs for zonal constructs S. Diederichs

11:30 - 11:40

Artificial Tissue Cutter - Creation of standardized cartilage defects to study influence of defect depth on regeneration in an osteochondral ex vivo model A. Schwab

11:40 - 12:00

Novel methods to make fibroin scaffolds C. Migliaresi

12:00 - 13:00

Lunch Break

13:00 - 13:30

Visit of the Poster Exhibition and the Industry Ex-hibition

13:30 - 15:00

Scientific Session 5 - Novel Developments in Musculoskeletal Engi-neering

Chairs: S. Diederichs and E. Amann

13:30 - 13:50

Differentiation of induced pluripotent stem cells to-ward mesenchymal stromal cells – new perspecti-ves for standardized cellular therapy?W. Wagner

13:50 - 14:00

Local androgen/bisphosphonate combination treat-ment to enhance bone healingJ. Gossen

bone-tec 2017

International Bone-Tissue-Engineering Conference

14:00 - 14:10

The in vivo compatibility, integration and regenera-tion of a decellularised porcine bone scaffold in an ovine modelH. Fermor

14:10 - 14:20

Endochondral bone regeneration in a xenogeneic setting D. Gawlitta

14:20 - 14:30

Molecular beacon nanotechnology in osteogenic differentiation of human and ovine mesenchymal stem cells T. M. Randau

14:30 - 14:40

Development of a perfuseable on-chip microvas-cular network for the study of pericytes migration and plasticity in response to bone healing related signals A. Pereira

14:40 - 15:00

Disease modelling of multiple epiphyseal dysplasia (MED) using pluripotent stem cells S. Kimber

15:00 - 15:30 Visit of the Poster Exhibition and the Industry Exhi-bition / Coffee Break

15:30 - 17:20

Scientific Session 6 - Gene Therapy and Growth Factors for Musculo-skeletal Engineering

Chairs: E. Rosado Balmayor and A. Lang

15:30 - 15:50

Gene transfer approaches to improving bone healingC. Evans

15:50 - 16:00

BMP2 cmRNA induced osteogenesis on human stem cells and accelerated bone formation in vivoW. Zhang

16:00 - 16:10

Transcript-activated matrix for bone regenerationC. Plank

16:10 - 16:20

Generation of a custom designed hMSC for engi-neering of osteoinductive bone graftsT. Klein

16:20 - 16:30

IGF-1 enhances the osteogenic activity of BMP-6 in vitro and in vivoG. Rico-Llanos

16:30 - 16:40

Influence of BMP2, BMP6, TGF-β1, TGF-β3 and pTHrP combinations and timing on chondrogenesis of AMSC in 3D collagen gelR. Tomys

bone-tec 2017

International Bone-Tissue-Engineering Conference

16:40 - 17:00

Fibrodysplasia ossificans progressive (FOP): in vit-ro model and its application for identification of new therapeutic agentsP. ten Dijke

17:00 - 17:20

Scaffold based delivery of biomolecules for enhan-ced bone repairF. J. O’Brien

18:30 - 22:00 Gala Dinner at Hofbräukeller Wiener Platz, Munich(Innere Wiener Straße 19, 81667 Munich / for direc-tions, please see the last page of the program)

Saturday, 14 October 2017

08:30 - 10:00

Scientific Session 7 - Bone Healing Promoting Environments and Inflammation

Chairs: E. Engel and M. Haffner-Luntzer

08:30 - 08:50

Engineered BMP-2 based systems for efficient rege-neration of bone critical-size defectsC. Gonzalez-Garcia

08:50 - 09:00

Metabolite monitoring and shear stress distribu-tions in bone tissue engineering scaffolds cultured in flow perfusion bioreactorsV. Sikavitsas

09:00 - 09:10

New possibilities for treating musculoskeletal infec-tionsM. Hanschen

09:10 - 09:20

Bovine col I-based scaffold inhibits bone healing in a mouse-osteotomy-model - time to rethink delivery systemsA. Lang

09:20 - 09:30

Release of RHO-inhibiting C3 toxin from a protein-DNA hybrid hydrogel for targeted osteoclast inhibi-tionA. Kovtun

bone-tec 2017

International Bone-Tissue-Engineering Conference

09:30 - 09:40

The immunological milieu of fracture hematoma du-ring therapeutic hypothermia - results from a porci-ne model of combined traumaK. Horst

09:40 - 09:50

TNF-β: a new inflammatory cytokine in articular chondrocytesC. Buhrmann

09:50 - 10:00

Cytorich: a novel anti-inflammatory/catabolic and regenerative autologous blood-derived product for osteoarthritis treatmentI. Brokhman

10:00 - 10:30 Visit of the Poster Exhibition and the Industry Exhi-bition / Coffee Break

10:30 - 12:00

Scientific Session 8 - Natural Origin Scaffolds for Musculoskeletal Engineering

Chairs: W. Bonani and S. Schneider

10:30 - 10:50

Nature-derived materials and strategies for bone tis-sue engineeringA. Motta

10:50 - 11:00

Gelatin and fibroin silk scaffolds for bone regene-rationS. Schneider

11:00 - 11:10

Building blocks for bone tissue engineering: a co-culture system for vascularization of hydrogelsN. Cagol

11:10 - 11:20

Subtotal meniscal reconstruction using an opti-mised silk fibroin scaffoldS. Klose

11:20 - 11:30

Adipose derived mesenchymal stem cells differenti-ate layer specific into osteoblasts or chondrocytes on a chitosan three-layered scaffoldE. Amann

11:30 - 11:40

Biofunctionalised polymer implants for in situ re-pair of traumatic and early osteoarthritic cartilage defectsA. Crawford

11:40 - 12:00

Advanced acrylic bone cements with antibiotic loa-ded compounds. A new approach for the local treat-ment of infections associated to implants.J. San Román

12:00 - 12:30 Visit of the Poster Exhibition and the Industry Exhi-bition / Coffee Break

bone-tec 2017

International Bone-Tissue-Engineering Conference

12:30 - 14:00

Scientific Session 9 - Cell-Based Approaches to Musculoskeletal Engineering

Chairs: S. Ehnert and W. Zhang

12:30 - 12:50

Simulating skeletal regeneration in vitro: fact or fan-tasy?C. J. Kirkpatrick

12:50 - 13:00

Cell-based therapy for treatment of large bone de-fects in Frankfurt: history, status and future per-spectivesD. Henrich

13:00 - 13:10

Analysis of MSCA-1 and CD146 subpopulations from cranial periosteal tissueF. Umrath

13:10 - 13:20

Silicon oxynitride breath figure coatings for enhan-ced interfacial adhesion and osteogenesisC. Carlomagno

13:20 - 13:30

TGF-β1 damages osteoblasts‘ primary cilia (mecha-nosensors) in a HDAC6-dependant mannerS. Ehnert

13:30 - 13:40

Fractionated human adipose tissue as a native con-struct for the generation of a bone organ by endo-chondral ossificationJ. Guerrero

13:40 - 13:50

Mini-bone-3D co-culture system of osteoblasts and osteoclastsV. Häussling

13:50 - 14:00

Smart nanosensors for cell labelling and imaging in tissue engineeringC. Xu

14:00 - 14:15 Closing SessionChair: M. van Griensven

bone-tec 2017

International Bone-Tissue-Engineering Conference

Invited and Keynote Speakers:

Prof. Dr. Sarah Cartmell, PhDManchester, United Kingdom

Dr. Aileen Crawford, PhD Sheffield, United Kingdom Prof. Dr. Peter ten Dijke, PhDLeiden, The Netherlands

Prof. Dr. Patrick Dondl, PhDFreiburg, Germany

Prof. Dr. Christopher Evans, DScRochester, Minnesota, US

Dr. Cristina Gonzalez-GarciaGlasgow, United Kingdom

Professor Paul V. Hatton, BSc, PhD, FIMMMSheffield, United Kingdom

Prof. Dr. Susan Kimber BA, MA, PhDManchester, United Kingdom

Prof. Dr. Dr. C. James Kirkpatrick, MD, PhD, DSc Mainz, Germany

Dr. Liudmilla Leppik, PhDFrankfurt, Germany

Prof. Dr. Claudio Migliaresi, PhDTrento, Italy

Prof. Dr. Albrecht Molsberger, MDDüsseldorf, Germany Prof. Dr. Antonella Motta, PhDTrento, Italy

Prof. Dr. Fergal O‘ Brien, PhDDublin, Ireland

Dr. Su Ping Patrina Poh, PhDMunich, Germany

Prof. Dr. Rui Reis, PhD, DSc, hc MD, FBSE, FTERMGuimarães, Portugal

Prof. Dr. Julio San Román, PhDMadrid, Spain

Dr. Karl-Heinz Schuckert, MD, DDS, PhDHannover, Germany

Prof. Dr. Swee-Hin Teoh, PhDSingapore

Prof. Dr. Dr. Wolfgang Wagner, MD, PhDAachen, Germany

Prof. Dr. Sarah Waters, PhDOxford, United Kingdom

Scientific Review Board:

Sònia Font Tellado, MSc

Prof. Dr. Dr. Martijn van Griensven, MD, PhD

Prof. Dr. Dr. C. James Kirkpatrick, MD, PhD, DSc

Prof. Dr. Fergal O‘ Brien, PhD

Dr. Su Ping Patrina Poh, PhD

Assist. Prof. Dr. Elizabeth Rosado Balmayor, PhD

Prof. Dr. Katja Schenke-Layland, PhD

Dr. Karl-Heinz Schuckert, MD, DDS, PhD

Prof. Dr. Swee-Hin Teoh, PhD

bone-tec 2017

International Bone-Tissue-Engineering Conference

Bronze Sponsors:

Sponsors:

Location Plans:

Wappenhalle (Congress Venue)Konrad-Zuse-Platz 8, 81829 Munich, Germany

Hofbräukeller (Gala Dinner)Innere Wiener Straße 19, 81667 Munich, Germany

Klinikum rechts der Isar Technische Universität München