Biomaterials: Fundamentals and Clinical Applications 2002.pdf · Biomaterials: Fundamentals and...

5th International Essen Symposium on

Biomaterials:

Fundamentals and Clinical Applications

Essen, October 9-11, 2002

Program and Abstracts

Biomaterials 2002: Fundamentals and Clinical Applications - 2 -

University of Essen PROGRAM

5th International Essen Symposium Essen, October 9-11, 2002 Biomaterials: Fundamentals and Clinical Applications Organized by the Working Group on Biomaterials and Tissue Compatibility of the University Essen In collaboration with the Graduate school "Reactivity in the Near-Surface Range" and the Working Group Biomaterials NRW e.V.


Welcome to the 5th Essen Symposium on Biomaterials The organizers extend a cordial welcome to all of the participants of the 5th Essen International Symposium on Biomaterials. We sincerely hope that you will have a pleasant stay in the City of Essen, which is celebrating its 1150th birthday this year. It is our believe that this symposium will form a platform for communicating your scientific results to the biomaterial community and will stimulate your research in the years to come. We are happy that the international character of the symposium could be expanded with over ten countries being represented at the symposium this year. The future of implants lies in their surface. This holds for metallic and non-metallic biomaterials. In the case of metals excellent bulk materials such as titanium/titanium alloys, cobalt chromium and stainless steels have been developed. Some of these bulk materials shed metal ions from their surfaces possibly eliciting allergic reactions. Otherwise, the surfaces of these materials show a high degree of natural self-passivation in the presence of oxygen giving them excellent empirical biocompatiblity. Nonetheless, very little is known about the actual surface chemistry of these metals or their specific reactivity in biological media. In recent years artificial metallic surfaces of high hydrophilicity onto which cyto-mediators or drugs were immobilized have been rationally developed. Such bioactive surfaces may slowly release their bio-load in vivo leading to implant protection or locally engineered tissue for enhanced integration. It is the aim of the Essen Symposia on Biomaterials to bring together leading researchers from around the world working on the cutting edge of biomaterials science and clinical implantology to discuss and develop novel approaches to implantological therapies for the welfare of millions of patients in the time to come.

Organizers: H.P. Jennissen M. Laub H. Rumpf Organizing Committee: D. Bingmann R. Erbel A. Fischer K. Jahnke F. Löer International Advisory Committee: R.B. Heimann (Freiberg) V. Hlady (Salt Lake City) D. Grönemeyer (Witten-Herdecke) S.G. Steinemann (Waldenburg) H. Uludag (Edmonton)


Proceedings Volumes of Previous Symposia The previous Symposia have been published in the International Journal Materialwissenschaft und Werkstofftechnik (Materials Science and Engineering Technology).

1st International Essen Symposium 1998 Proceedings (Guest editor: H.P. Jennissen): Materialwiss. Werkstofftech., Vol. 30, pp. 731-885 (1999)

2nd International Essen Symposium 1999 Proceedings (Guest editors: A. Fischer & H. Brauer): Materialwiss. Werkstofftech., Vol. 32, pp. 109-210 (2001)

3rd International Essen Symposium 2000 Proceedings (Guest editors: D. Bingmann): Materialwiss. Werkstofftech., Vol. 32, pp. 889-1008 (2001)

4th International Essen Symposium 2001 Proceedings (Guest editors: D. Bingmann): Materialwiss. Werkstofftech., in preparation (2002)

This years symposium will also be published in a proceedings volume of the scientific journal Materialwissenschaft und Werkstofftechnik (Materials Science and Engineering Technology). Abstracts can be submitted after the symposium. Deadline will be announced.


Sponsors and exhibitors We are most grateful to the following sponsors who have made this symposium possible. Scientific sponsors

Fördervereinigung für die Stadt Essen

Arbeitsgemeinschaft Biomaterialien NRW e.V.

Graduate school of the University of Essen "Reactivity in the Near-Surface Range"

FET (Zentralstelle für Forschungs- und Entwicklungstransfer), University of Essen

Industrial sponsors ATMOS MedizinTechnik GmbH & Co. KG, Lenzkirch

Fahrzeug-Werke LUEG AG/ Essen

Heraeus Kulzer GmbH

Stiftsquelle Johann Spielmann GmbH/ Essen

Stryker Trauma Science and Technology, Schoenkirchen

Exhibitor L.O.T. – Oriel GmbH & Co. KG, Darmstadt


Miscellaneous and social events Language: The official language of the symposium is English. All abstracts should be in this language. However lectures in German are also permitted. Localities: The conference venue is located at the University Essen - Audimax (S04 T01 A02). Slide and film Facilities are available for 24 x 26 mm slides, projection simultaneous projection of: two slides, overhead projection, VHS video and Powerpoint/ Acrobat presentation. Posters: Bulletin boards for poster display: 80 cm (wide) by 120 cm (high). Exhibition: University Essen - Audimax (S04 T01 A02). Social events: Reception by the Lord Mayor of Essen and Symposium dinner (October 9, 19:00) Special Symposium event (October 10, 19:00) - Villa Hügel: Exhibition "Sense and Sensuality - Flemish still life 1550 - 1670". After the exhibition dinner at the "Dampfbier" brewery. Tickets are available at the Symposium desk (32 Euro). Symposium Prof. Dr. H.P. Jennissen Secretary's Office: Mrs. Heidi Buballa Institut für Physiologische Chemie Universität Essen, Universitätsklinikum Hufelandstr. 55 D-45122 Essen Tel.: +49-201-723-4126 Fax.: +49-201-723-4130 E-Mail: [email protected] Symposium Audimax (S04 T01 A02) Secretary Desk Tel.: +49-201-183-4477 during the Fax: +49-201-183-4646 Symposium: Homepage of the http://www.biomaterials.uni-essen.de Symposium:


Wednesday, October 9, 2002

9:00 WELCOME

Plenary Lecture

H. P. Jennissen

9:15 Metallic Biomaterials

PROTEINS AT INTERFACES 10:00 – 11:20

S. Steinemann

Chairmen: V. Hlady, D. Klee 10:00

10:20

10:40

11:00

Protein Interactions with PEO Brushes

Protein Interactions with Heterogeneous Interfaces

Statistical Mechanical Modeling of Protein Adsorption

Surface Topography of BMP-2

V. Hlady, University of Utah, Salt Lake City

D. Britt, Utah State University, Logan

P. von Tassel, Wayne State University, Detroit

M. Laub, University of Essen

11:20 COFFEE BREAK CELLS AT INTERFACES

11:40 – 13:00

Chairmen: D. Brunette, S. Vukicevic 11:40

12:00

12:20

12:40

Regeneration Of Bone And Cartilage By Bone Morphogenetic Proteins (BMPs) And Cartilage-Derived Morphogenetic Proteins (CDMPs)

The Control of Cellular Responses by Biomaterial Topography

Cellular Motility on Implants

Biodegradable Hydrogel Implants Induce Cell Type Specific Responses

S. Vukicevic, University of Zagreb

D. Brunette, Uni- versity of British Columbia, Vancouver

L. Winkler, University of Essen

H. Hall, ETH Zürich

13:00 LUNCH


IMPLANT MATERIALS 14:00 – 15:40

Chairmen: A. Fischer, G. Bensmann 14:00

14:20

14:40

15:00

15:20

The Performance of Ni-free Stainless Steels for Medical Applications under Superimposed Stresses

Cobalt Chromium in Medical Applications

Entrapment of Wear Debris on Electro- chemically Microstructured Surfaces in a Metal-on-Metal Contact Situation

In Vitro Characterization of Micro- structured Titanium Implant Surfaces

Nuclear Magnetic Resonance (NMR) Studies on Plasma-Sprayed Hydroxy- Apatite Coatings: Influence of Bioinert Bond Coats on Phase Composition and Resorption Kinetics in Simulated Body Fluid

A. Fischer, University of Duisburg

A. Piotrowski, gb Implantat Technologie GmbH, Essen

R. Büscher, University of Essen

L. Scheideler, Universityof Tübingen

R.B. Heimann, Freiberg University

IMPLANT DESIGN AND SURFACE

MODIFICATIONS 15:40 – 16:20

Chairmen: H. Uludag, M. Wiemann 15:40 16:00

A Combinatorial Approach for Designing Synthetic Materials for Osteogenic Cell Differentiation: A Case Study with NiPAM Polymers Designed for RGD Grafting Biological Multi-layer Systems as Implant Surface Modification

H. Uludag, Edmonton University R. Willumeit, GKSS Research Center, Geesthacht

16:20 COFFEE BREAK


POSTER BREAKOUT SESSION 1 16:45 – 18:00

Chairmen: M. Laub, M. Schwarz 4 Minute Poster Exposés

Engineering with Nitinol: Characterisation and Optimisation Experimental Studies on the Interface Ingrowth Characteristics of Hydroxyapatite Coated Lumbar Intervertebral Implants Alumina Short Fibre Reinforced and Unreinforced Hydroxyapatite: Nano- and Microstructure Characterization of MD05 - A Bone Substitute Device Having Osteo- inductive and Osteoconductive Properties Tissue Reaction of Coronary Arteries after Implantation of Coated Stents with Anti-Inflammatory and Anti-Proliferative Drug Release First Analysis of Explanted Silicone Breast Implants Modification of Surfaces to Control Protein Adsorption and Cell Growth A Novel Type of Mechano-Protein with Promising Properties for Nanoscale Engineering Shear Strength of Experimental "Bone-Isoelastic" Titanium Alloys in the Ovine Femur

Importance on In-Vitro Biocompatibility Investigations by Nanocolloids from Metallic Wear in Implant Materials Therapy and Prophylaxis of Adhesion After Traumatic Right-sided Rupture of the Diaphragm - A Case Report

D. Aslanidis, @medical technologies, Belgium Y. Chen, University of Essen A. Dorner-Reisel, Freiberg University of Mining and Technology K. Hellerbrand, Scil Biomedicals, Martins- ried I. Karousssos, University of Essen A. Klocke, University of Aachen

M. Müller, Fraunhofer IGB, Stuttgart

W. Peters, University of Frankfurt (Main) A. Pingsmann, University of Essen L. Podleska, University of Essen T. Porté, Berufsge- nossenschaftliches Un- fallkrankenhaus Hamburg


Therapy and Prophylaxis of Periarticular Ossifications After Long-Term Ventilation - A Case Report Reducing Adhesions in Experimental Animal trials By an Antiadhesion - Foil - A Review Incorporation of Two Different Meshes for Hernial Surgery - Immunohisto- chemical and Ultrastructural Results - Porcine Heart Valve Interstitial Cells on Collagen Three-Dimensional Scaffolds: Characterization of Proteoglycans in the Newly Formed Extracellular Matrix

Structural Investigations of the Interaction of the Synthetic Peptide NK2 with Model Membranes

T. Porté, Berufsge- nossenschaftliches Un- fallkrankenhaus Hamburg T. Porté, Berufsge- nossenschaftliches Un- fallkrankenhaus Hamburg I. Schmitz, BG - Klinik Bergmannsheil, Bochum P. Vischer, Institut für Arteriosklerose- forschung, Münster R. Willumeit, GKSS Research Center, Geesthacht

18:00 End of Session 19:00 Reception by the Lord Mayor of Essen and

Symposium dinner

Address by: The Lord Mayor of Essen, Dr. W. Reiniger University Rector, Prof. Dr. K.-H. Jöckel Dean of Medical Faculty, Prof. Dr. H. Grosse-Wilde Presentation of 1st Young Scientist Award: Prof. Dr.-Ing. A. Fischer


Thursday, October 10, 2002

IMPLANT DESIGN AND SURFACE MODIFICATIONS 8:30 – 10:50

Chairmen: G. Fleminger/ R. Urban 8:30

8:50

9:10

9:30

9:50

10:10

10:30

Enhancement of Bone Growth by Coating of Osteoconductive Beta-Tricalcium Phosphate (Beta-TCP) with Recombinant Human Growth/Differentiation Factor-5 (rhGDF-5)

Covalent Surface Modelling of Medical Devices

A Bacterial TiO2-Binding Protein (TiBP) - Purification, Properties and Applications

Poly(vinylidenfluoride) as a Biomaterial in Bone Contact

Organization of Integrin Receptor Proteins in Response to the Material Surface Wettability

Surface Modification of a Porous TiO2/glass Ceramic

Adsorption and Desorption of BMP-2 and the Model Protein Ubiquitin on Hydrocarbon-Coated Metallic Surfaces

S. Pöhling, Scil Biomedicals GmbH, Martinsried

M. Keusgen, University of Bonn

G. Fleminger, Tel Aviv University

D. Klee, University of Aachen

G. Altankov, Bulgarian Acad. of Sci., Sofia

H.J. Erli, University of Aachen

H.P. Jennissen, University of Essen

10:50 COFFEE BREAK ADVERSE REACTIONS AND LOCAL

DRUG THERAPY 1 11:10 – 13:00

Chairmen: M. Morlock, G. Taeger 11:10 11:30

Micromotion at the Bone-Implant Interfaces Corrosion Products Generated from Interface Corrosion of Stainless Steel Implants

M. Morlock, Technical Univ. Hamburg-Harburg R. Urban, Rush-Presbyterian-St. Luke's Medical Center, Chicago


11:50

12:10

12:30

From Nickel-Interacting Proteins to Nickel-Reactive Human T-Cells

Porous Aluminia Coatings for Improved Bone Implant Interfaces

Comparison of Diamond-Like-Carbon and Ceramic Joint Bearings Articulating Against Polyethylene with Survivorship- Analysis

H.-J. Thierse, Max- Planck Institute for Immunobiology, Freiburg

P. Wilshaw, University of Oxford

G. Taeger, University of Essen

13:00 LUNCH

ADVERSE REACTIONS AND LOCAL DRUG THERAPY 2 14:00 – 15:20

Chairmen: J. Schierholz, L. Koole 14:00

14:15

14:25

14:35

14:50

15:00

Optimising Device Performance: the Drug- Device Interface from Development to Market

Novel Polylactide-Based Release Systems for Local Antibiotic Therapies

In Vitro Adherence and Accumulation of Staphylococcus Epidermidis RP 62 A and Staphylococcus M7 on Four Different Bone Cements

Controlled Release from the Polymer- Coated Surface of Medical Devices, Such as Wires, Coils and Catheter Tubes

Implant Related Risk Factors for Local Infection after Fracture Fixation

Different Materials to Repair an Incisional Hernias - Pro and Con

J. Schierholz, Research Center Caesar, Bonn

M. Schnabelrauch, Innovent Technologie- entw. e. V., Jena

D.P. König, Research Center caesar, Bonn

L. Koole, University of Maastricht

St. Arens, University of Bochum

M. Korenkov, University of Cologne

15:20 COFFEE BREAK


POSTER BREAKOUT SESSION 2 15:45 – 17:00

Chairmen: H. Rehage, R.B. Heimann 4 Minute Poster Exposés

A Laser Direct Writing Technique for Patterning of Organic Monolayers – A Fascinating Approach to New Biosensors ?! Dynamic Contact Angle Stability for Different Metal Surfaces Correlation of Particle Fluxes and Film Properties of Hard Carbon Coatings Electrochemical Studies of the Ad- sorption of Proteins on Conducting Surfaces Interaction of Natural and Synthetic Solutions with Concrete Materials Molecular Modelling Studies of the Interactions between Dystrophin and Beta-Dystroglycan Frost Dilatation and Pore System of Hardened Cement Paste under Different Storage Condition Biocompatibility of a Nickel-Free Steel (P2000) Assayed with Direct Metal Contact of Osteoblast-Like Cells Corrosion of Chemically Structured Metallic Surfaces Systemic Distribution of Cobalt and Chromium in Patients with Well Fixed and Loose Arthroplasties Langmuir-Blodgett Films of Nanosized Au55-Cluster Thin Films of BaTiO3 Prepared by R.F. Magnetron Sputtering

T. Balgar, University of Essen M. Chatzinikolaidou, University of Essen O. Filipov, University of Essen K. Gloddek, University of Aachen J. Krylova, University of Essen M. Leis, University of Essen A. Liebrecht, University of Essen M. Mölders, University of Essen A. Runiewicz, University of Essen N. Stais, University of Essen A. Vassiliev, University of Essen K. V. Reddy, University of Essen


Cytokine Expression of Human Donor Macrophages and Human THP-1 Leukaemia Macrophages after Challenge with Titanium Particles: Pharmacological Modulations Nickel-Specific Cytokine Production in Allergic Versus Non-Allergic Probands 3D-Reconstruction of Confocal Image Stacks: Visualisation of Live Cells in Bone Coating of Porous Bone Substitutes and of Metallic Prostheses with PALASEPT

Tissue Engineering on Natural, Biomaterial and Polymer Surfaces Adjusted to Laminar and Defined Gradient Hydrodynamics

M. Vendel, University of Essen M. Lindemann, University of Essen A. Roth, University of Applied Science (FH) Dortmund U. Gopp, Heraeus Kulzer GmbH & Co. KG, Wehrheim J. Wissler, ARCONS Applied Research, Bad Nauheim

17:00 General Poster Session 18:00 Presentation of Poster Award Prof. Dr. E. Winterhager,

Associate Dean of Research of the Medical Faculty of Essen

19:00 Special Evening Event with Dinner

Villa Hügel: Exhibition "Sense and Sensuality - Flemish still life 1550 - 1670" "Dampfbier" brewery


Friday, October 11, 2002 CELL COMMUNICATION AND CELL-

MATERIAL INTERACTIONS 9:00 – 10:20

Chairmen: D. Bingmann, F. Thévenod 9:00

9:20

9:40

10:00

Interactions of Osteoblastic and Other Cells with Bioactive Glasses In Vitro and In Vivo

Osteomalacia: Putative Role of Gap Junctional Dysfunctions in Bone Cells

Functional Significance of Gap Junctions for Growth and Differentiation of Bone Cells

Mechanisms of Cadmium Toxicity in the Kidney Proximal Tubule: A Tale of Traffic, Transport and Death

I. Silver, Bristol University

D. Bingmann, University of Essen

M. Wiemann, University of Essen

F. Thévenod, University of Manchester

10:20 COFFEE BREAK CLINICAL AND DENTAL APPLICATIONS

10:40 – 13:00

Chairmen: T. Kerschbaum, J. Wissler 10:40

11:00

11:20

11:40

12:00

Biomaterials for Ossicular Chain Reconstruction

A New Stapes Prosthesis Made of Titanium for the Surgical Treatment of Otosclerosis

Long-term Evaluation of Osseointegrated Implants ad modum Brånemark: Review and Results of our Clinic

Improvement of Mechanical Properties of Self Setting Calcium Phosphate Bone Cements with Several Metal Oxides Transcortical Test-Cylinders Implanted in Femurs of the Göttinger Minipig and Their Upgrading for a Gap Healing Model

A. Neumann, University of Essen

P. Dost, University of Essen

T. Kerschbaum, University of Cologne

U. Gbureck, University of Würzburg

M. Schwarz, University of Mannheim


12:20

12:40

Modified Cemented Stem Fixation in Hip Arthroplasty with Computer Based Analysis

Different Surface Materials for Osseointegration of Hip Arthroplasties in a Canine Model

B. Barden, University of Essen

M. Oldenburg, University of Essen

13:00 LUNCH

CLINICAL APPLICATIONS 14:00 – 15:40

Chairmen: P. Guggenbichler, M. Haude 14:00

14:20

14:40

15:00

15:20

Knochenmineral aus dem Labor: Mechanisch Stabiler Knochenersatz

Experimental and Clinical Results of Material Modifications with Nanosilver for Prevention of Central Venous Catheter Related Infections

Percutaneous In-Situ Coronary Venous Arterialization (PICVA)

Improved Intracoronary Imaging Techniques: A Clinician’s Perspective

First Experience with Intracoronary Thermography

M. Epple, Ruhr- University of Bochum

P. Guggenbichler, University of Erlangen

M. Haude, University of Essen

C. von Birgelen, University of Essen

A. Schmermund, University of Essen

15:40 INVITATION TO THE SYMPOSIUM 2003 D. Bingmann FAREWELL H.P. Jennissen


Posters ID-Number 01 Engineering with Nitinol: Characterisation and Optimisation

D. Aslanidis @medical technologies n.v., Nitinol Engineering (B)

02 Structural Investigations of the Interaction of the Synthetic Peptide NK2 with Model Membranes R. Willumeit, H. Kamusewitz, M. Schossig, H. Clemens GKSS Forschungszentrum, WFS (D)

03 Incorporation of Two Different Meshes for Hernial Surgery - Immunohistochemical and Ultrastructural Results - I. Schmitz, D. Weyhe, V. Zumtobel, K.-M. Müller BG - Klinik Bergmannsheil, Pathologie (D)

04 Shear Strength of Experimental "Bone-Isoelastic" Titanium Alloys in the Ovine Femur A. Pingsmann, C. Wüllenweber, A. Piotrowski Universitätsklinikum Essen, Klinik und Poliklinik für Orthopädie (D)

05 Surface Modification of Fine and Ultrafine Particles Affects Their Ability to Cause Inflammation: Mechanisms of Action P. Borm, C. Albrecht, A. Becker, G. Cakmak, D. Höhr, T. Shi, A. Knaapen, R. Duffin, R. Schins Institut für Umweltmedizinische Forschung GmbH (IUF), Particle Research Core (D)

06 Characterization of MD05 - A Bone Substitute Device Having Osteoinductive and Osteoconductive Properties K. Hellerbrand, P. Happersberger, S. Wank, A. Stich, B. Krämer, S. Lang, S. Pöhling, A. Schütz, U. Kohnert Scil Biomedicals, Biotechnologie (D)

07 Porcine Heart Valve Interstitial Cells on Collagen Three-Dimensional Scaffolds: Characterization of Proteoglycans in the Newly Formed Extracellular Matrix P. Vischer, E. Schönherr, M. Rothenburger, W. Völker Institut für Arterioskleroseforschung, Zellbiologie und Ultrastrukturforschung (D)

08 Alumina Short Fibre Reinforced and Unreinforced Hydroxyapatite: Nano- and Microstructure A. Dorner-Reisel, V. Klemm, G. Irmer, E. Müller Freiberg University of Mining and Technology, Institute of Ceramic Materials (D)

09 First Analysis of Explanted Silicone Breast Implants A. Klocke, D. von Heimburg, N. Pallua, B. Glasmacher RWTH Aachen, Institut für Biomedizinische Technologien, Helmholtz-Institut, Kryobiologie & Biomaterialien (D)


ID-Number 10 Coating of Porous Bone Substitutes and of Metallic Prostheses

with PALASEPT K.-D. Kühn, U. Gopp, S. Vogt, M. Schnabelrauch Heraeus Kulzer GmbH & Co. KG, Bereich Medizin (D)

11 Modification of Surfaces to Control Protein Adsorption and Cell Growth M. Müller, D. Hegemann, M. Müller, V. Sciarratta, C. Hoffmann, H. Brunner, C. Oehr Fraunhofer IGB, Grenzflächentechnologie und Materialwissenschaft (D)

12 A Novel Type of Mechano-Protein with Promising Properties for Nanoscale Engineering G. Noll, M. Knoblauch, D. Prüfer, A. van Bel, W. Peters J.W.Goethe-Universität, AK Kinematische Zellforschung (D)

13 Tissue Engineering on Natural, Biomaterial and Polymer Surfaces Adjusted to Laminar and Defined Gradient Hydrodynamics J. Wissler ARCONS Applied Research (D)

14 Therapy and Prophylaxis of Adhesion After Traumatic Right-sided Rupture of the Diaphragm - A Case Report Th. Porté, S. Strametz, C. Grimme, I. Burkard, Ch. Jürgens Berufsgenossenschaftliches Unfallkrankenhaus Hamburg (D)

15 Therapy and Prophylaxis of Periarticular Ossifications After Long-Term Ventilation - A Case Report Th. Porté, S. Strametz, C. Grimme, I. Burkard, Ch. Jürgens Berufsgenossenschaftliches Unfallkrankenhaus Hamburg (D)

16 Reducing Adhesions in Experimental Animal Trials by an Antiadhesion - Foil - A Review Th. Porté, S. Strametz, C. Grimme, I. Burkard, Ch. Jürgens Berufsgenossenschaftliches Unfallkrankenhaus Hamburg (D)

17 Tissue Reaction of Coronary Arteries after Implantation of Coated Stents with Inti-Inflammatory and Anti-Proliferative Drug Release I. Karoussos, H. Wieneke, O. Dirsch, Y. Ji, Y. Gu, U. Dahmen, R. ErbelUniversitätsklinikum Essen, Klinik für Kardiologie (D)

19 Importance on In-Vitro Biocompatibility Investigations by Nanocolloids from Metallic Wear in Implant Materials L.E. Podleska, G. Taeger, B. Schmidt, I. Tikhovski, A. Fischer, S. Ruchholtz Universitätsklinikum Essen, Klinik und Poliklinik für Unfallchirurgie (D)

20 Experimental Studies on the Interface Ingrowth Characteristics of Hydroxyapatite Coated Lumbar Intervertebral Implants Y.T. Chen, S.L. Liu, I. Michiels Universitätsklinikum Essen, Klinik und Poliklinik für Orthopädie (D)


ID-Number 21 Nickel-Specific Cytokine Production in Allergic Versus Non-

Allergic Probands M. Lindemann, J. Böhmer, M. Zabel, H. Grosse-Wilde Universitätsklinikum Essen, Institut für Immunologie (D)

22 Corrosion of Chemically Structured Metallic Surfaces A. Runiewicz, A. Fischer Universität Essen, Werkstofftechnik (D)

23 Interaction of Natural and Synthetic Solutions with Concrete Materials J. Krylova, M. Sulkowski, A.V. Hirner Universität Essen, Institut für Umweltanalytik, Fachbereich Chemie (D)

24 Molecular Modelling Studies of the Interactions between Dystrophin and Beta-Dystroglycan M. Leis, H. Kuhn, M. Laub, H.P. Jennissen Universität Essen, Physikalische Chemie (D)

25 Electrochemical Studies of the Adsorption of Proteins on Conducting Surfaces K. Gloddek, U. Simon RWTH Aachen, IAC (D)

26 A Laser Direct Writing Technique for Patterning of Organic Monolayers - A Fascinating Approach to New Biosensors ?! Th. Balgar, R. Bautista, N. Hartmann, E. Hasselbrink Universität Essen, Physikalische Chemie (D)

27 Frost Dilatation and Pore System of Hardened Cement Paste under Different Storage Conditions A. Liebrecht, M.J. Setzer Universität Essen, IBPM - Institute of Building Physics and Materials Science (D)

28 Cytokine Expression of Human Donor Macrophages and Human THP-1 Leukaemia Macrophages after Challenge with Titanium Particles: Pharmacological Modulations M. Vendel, C. Reiser, Y. Ding, B. Barden, S. Frede, F. Löer, J. Fandrey Universitätsklinikum Essen, Orthopädische Klinik und Poliklinik der Universität Essen (D)

29 Systemic Distribution of Cobalt and Chromium in Patients with Well Fixed and Loose Arthroplasties N. Stais, B. Barden, M. Sulkowski, F. Löer, A. Hirner Universitätsklinikum Essen, Klinik und Poliklinik für Orthopädie (D)

30 Langmuir-Blodgett Films of Nanosized Au55-Cluster A. Vassiliev, H. Rehage, G. Schmid Universität Essen, Institut für Physikalische Chemie (D)

31 Thin Films of BaTiO3 Prepared by R.F. Magnetron Sputtering K.V. Reddy, Z. Qiao, D. Mergel Universität Essen, Physics Department WG Thin Film Technology (D)


ID-Number 32 Correlation of Particle Fluxes and Film Properties of Hard Carbon

Coatings O. Filipov Universität Essen, Technische Physik (D)

33 The Immobilization of rhBMP-2 on Metals by Adsorption M. Chatzinikolaidou, H.P. Jennissen Universitätsklinikum Essen, Institut für Physiolog. Chemie/ Abtlg. Biochemische Endokrinologie (D)

34 Biocompatibility of a Nickel-Free Steel (P2000) Assayed with Direct Metal Contact of Osteoblast-Like Cells M. Mölders Universität Essen, Institut für Physiologie (D)

35 3D-Reconstruction of Confocal Image Stacks: Visualisation of Live Cells in Bone A. Roth, K. Melzer, K. Annacker (D)


ABSTRACTS AND MINIPOSTERS


LECTURES


GENERAL POSTERS


POSTERS GRADUATE SCHOOL

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