ATB: MAKE A NEW LOGBOOK ENTRY “PROTEIN NETWORK PRACTICE 2” GET A SHEET FROM THE FRONT...
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Transcript of ATB: MAKE A NEW LOGBOOK ENTRY “PROTEIN NETWORK PRACTICE 2” GET A SHEET FROM THE FRONT...
• ATB: MAKE A NEW LOGBOOK ENTRY “PROTEIN NETWORK PRACTICE 2”
• GET A SHEET FROM THE FRONT COUNTER—1 PER PERSON
• PLANNER: DESIGN YOUR OWN NETWORK DUE FRIDAY
• CHECKUP/QUIZ ON FRIDAY• LOGBOOK CHECK AT END OF CLASS TODAY• IF YOU MISSED THIS MONDAY’S CHECKUP—
MAKE IT UP! IT TURNS INTO A ZERO AFTER FRIDAY
Lactose
Glucose
Lactase
Galactose
Key:
Metabolites
Enzyme reactions
Labrador (dog) pigmentation
Tyrosine Dopaquinone
Brown pigment
Black pigment
Yellow pigmenttyrosinase
TRP-2
TRP-1Boxes = metabolitesArrows = enzymes that change the metabolites
Phenylalanine
Homogentisicacid
Tyrosine
Tyramine
Thyroxine
Hydroxy-phenylpyruvate
Dopa
Dopamine
NoradrenalineAdrenaline
Dopaquinone Melanin
Phenylpyruvate
Maleyl-acetoacetate
Prephenate
1
2 4
35
6
2-amino-4-hydroxypterdine
(BLUE)
tetrahydroiopterin
biopterin(BLUE)
drosopterin(ORANGE)
sepiapterin(YELLOW)
isosepiapterin(YELLOW)
xanthopterin(GREEN-BLUE)
isoxanthopterin(VIOLET-BLUE)
Molecule A(colorless)
PTERIDINE PIGMENTS OMMOCHROMEPIGMENTS
Molecule B(colorless)
ommochrome pigment(BROWN)
31
5
4
6
2 9
7
8 10
In order to see pigments, they must be transported into specific areas of the eye cells. All the ommochrome and pteridine pigments use the same transport proteins (labeled as protein #10 on the network)
Color of fly is result of mixture of all pigments in network
Drosophila Eye Color Pigment Network
Wild Type Brown
Scarlet White
2-amino-4-hydroxypterdine
(BLUE)
tetrahydroiopterin
biopterin(BLUE)
drosopterin(ORANGE)
sepiapterin(YELLOW)
isosepiapterin(YELLOW)
xanthopterin(GREEN-BLUE)
isoxanthopterin(VIOLET-BLUE)
Molecule A(colorless)
PTERIDINE PIGMENTS OMMOCHROMEPIGMENTS
Molecule B(colorless)
ommochrome pigment(BROWN)
31
5
4
6
2 9
7
8 10
In order to see pigments, they must be transported into specific areas of the eye cells. All the ommochrome and pteridine pigments use the same transport proteins (labeled as protein #10 on the network)
Color of fly is result of mixture of all pigments in network
Drosophila Eye Color Pigment Network
Serotonin
• Serotonin is a molecule called a neurotransmitter used by cells in the brain to communicate
• Part of its function is to regulate emotions• Abnormally low amounts of serotonin in the
brain can cause depression
How is serotonin produced, and how can we use our understanding of it to treat depression?
Some enzymes involved in serotonin synthesisEnzyme: AAADSubstrate: 5-HTPProduct: serotonin
Enzyme: TPHSubstrate: tryptophanProduct: 5-HTP
Enzyme: MAOSubstrate: serotoninProduct: 5-HIAA
5-HIAA
5-HTP
Draw the enzyme pathway used to build serotonin
5-HIAA
5-HTP
TPH
AAAD
MAO
Tryptophan5-HIAA
5-HTPSerotonin