J.R.A.S. Vol. XXIX. No.3. July-Sept'08 pp.123-128

A COMPARATIVE STUDY ON PRAVALA MULABHAS2~fA AND PRAVALA SHAKHA

BHASMA IN AMLAPITTA

Himanshu S. Tiwari', B. Patgiri ' and P. K. Prajapati '

(Received on 29.08.20(6)

various preparations ofPravala (bothMula and Sliakh a ) liave been used inAmlapitta since ancient rime. P/'OI'(l/OMII/oand Pravato Shakh a are two differentspecies. Pravala Mula is Tubipora Musicaand Pravala Shakha is corallium rubrum.III this study two samples ofPravala Mil/aBhasma (Sarjika Kstiara [PM( S)B] andTandulikyu Swarasa Shodhita [PM(T)B j)and two samples of Praval a Sliakh aBhasma (Sarjika Kshara [PS(S)B] andTandulikya Swarasa Shodhita [PS(T)B /)were prepared according to authenticprocess. These all ./(1//1' Bhasma werestudied 10 evaluate the efl'icaC\' of the drugsin the Patients (!f Amlapitta (Hyperacidity).Results of studv suggest that the effect ofPravala Shaklta Sarjika Kshara ShodhitaBhasma [PS( S)B / \I'as better than (II/ threeOil different clinical pa rame t e rs likeAmlodgara. Avipuka, Doha, Chardi and

Slut/a in the patients ofAmlapitta.

Introduction

Pravala Mula and Pravala Shakhahave been traditionally used for variousmedicinal properties. These drugs areadministered in Mist rak richch a,Rajvakshma, Raktapitta. Ne t ra R og a,Opthalmic Ailments as Put apuk a,Amlapitta and Dalia, being used in the formof Churna and Bhasina. According to Dr.Nadkarni Pravala contains R3% ofCalcium Carbonate. Calcium Carbonatehas high neutralizing capacity, Its antacideffects are rapid in onset and relativelyprolonged in duration. Calcium carbonatehas been considered to he epitome of a non-systematic antacid.

In the stomach, it reacts with gastricacid to form calcium chloride

I. Chief Ayurvedic Physician, Multani Parmaceuticals Ltd. H-36, Conn aught Place,New Delhi. 2. Lecturer and 3. H,O,D., Dept. of R. S. and B. K., IPGT & RA, GujaratAyurvcd University, Jarnnagar (Gujarat)

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CaCOo + 2HCL ~ CaCI2 + Hp + CO2

In the intestine, CaCL2 reacts withbicarbonate to regenerate CaC01 Which isexcreted in feces.

CaCl2 + 2NaHC01~ CaC01 + 2 NaCI +Hp + CO2

The potency of an antacid is generallydefined in terms of its acid neutralizingcapacity (ANC), which is defined asnumber of mEq ofIN HCL that are broughtto pH 3.5 in 15 min. (or 60 min, in sometests) by a unit dose of a antacidpreparation. This takes into considerationthe equivalent weight of the compound aswell as the rate at which it dissolves andreacts with HCL.

The present clinical study wasdesigned to evaluate the comparativeefficacy of Pravala Mula Bhasma (twosamples) and Pravala Shakha Bhasma (twosamples) Shodhita by two different mediathat is Sarjika kshara and TandulikyaSwarasa in the patients of A mlap itta.

Reference of Pravala Mula Bhasmapreparations was taken from RasaTarangini (23/136). The amount of SarjikaKsh a ra to be taken was not clearlymentioned in the text, with the help ofAnukta Paribhasha it was taken in the samequantity of that of Pravala.

Materials and MethodsBased on the random distribution

clinical trial was carried out on 25 patientssuffering from classical signs andsymptoms of Amlapitta. Patients thus,selected grouped into PM(S)B, PM(T)B,PS(S)B and PS(T)B groups, each groupscontained 6 patients (minimum) and the

drug was administered in 500 mg capsulethrice daily with water for a period of 21days. Same dose and duration was appliedfor all the four samples. This dose is alreadymentioned in Rasa Tantra Sara EvamSiddha Prayoga Sangraha and Siddha YogaSangraha.

All these patients were kept onuniform diet and essential bio-chemicalinvestigations were done before and aftertreatment of all the four groups.

To evaluate the therapeutic responseof these drugs the parameter adopted onthe basis of improvement in, cardinal andassociated symptoms.

The effect of the treatment of thesefour drugs on the above parameters wasnoted. To know the improvement of meanof scores and mean differences before andafter treatment were calculated on 21 Sl day.Grading of the patients were done andgiven scores according to grades. As forexample in Amlodgara.Grade 0 : (Score - 0) :No Amlodgara at all.Grade 1 : (Score - 1) :Sometimes during the day.Grade 2 : (Score - 2) :Amlodgara of moderate severity butdoes not disturb the patients.Grade 3 : (Score - 3) :Sever Amlodgara disturbing the patients.Grade 4 : (Score - 4) :Small amount of fluid regurgitating frompatients mouth.

Result and Observation

The clinical effects of these four drugson different clinical parameters i.e. cardinal

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A COMPARATIVE STUDY ON PRAVALA .....

symptoms and associated symptoms havein Table I and Table II.

On statistical analysis as given in thetable, the clinical improvement in patientson above parameters were mostlysignificant at all level of treatment of thesefour drugs but highly significant in case ofdaha of all four drugs, while in Adhmana

Pravala Mula Sarjika Kshara ShodhitaBhasma [PM(S) B] was highly significant.The patients of all four groups appeared totolerate the preparations well and there wasno adverse effects in either groups.

But, percentage wise maximumimprovement was observed in PravalaShakha Sarjika Kshara Shodhita Bhasma

Effect of Pravala Mula Sarjika Kshara Sodhita Bhasma [PM(S) B] on cardinalsymptoms of 7 patients of Amlapitta

Cardinal Mean % X S.D. S.E. t PSymptoms B.T. A.T.

Amlodgara 1.86 0.43 76.88 1.43 0.97 0.37 3.87 <0.01Avipaka 2.00 0.71 64.50 1.28 0.75 0.28 4.50 <0.01Daha 2.86 0.43 84.97 2.43 0.53 0.20 12.02 <0.001Chhardi 1.14 2.09 74.56 0.86 0.90 0.34 2.52 <0.05Shula 1.43 0.43 69.93 1.00 1.00 0.38 2.64 <0.05

Effect of Pravala Mula Sarjika Kshara Shodhita Bhasma [PM(S)B] on associatedsymptoms of 7 patients of Amlapitta

Associated Mean % X S.D. S.E. t PSymptoms B.T. A.T.

Aruchi 1.29 0.43 66.66 0.86 0.69 0.26 3.29 <0.02Hrillasha 1.29 0.43 66.66 0.86 0.69 0.26 3.29 <0.02Gaurava 1.00 0.29 71.00 0.71 0.76 0.29 2.50 <0.05Angasada 1.29 0.29 77.52 1.00 0.82 0.31 3.24 <0.02Angamarda 1.00 0.43 57.00 0.57 0.53 0.20 2.83 <0.05Adhmana 2.29 0.43 81.22 1.86 0.69 0.26 7.12 <0.001A topa 2.00 0.43 78.50 1.57 0.78 0.29 5.28 <0.01Pipasa 2.14 0.71 66.82 1.43 0.79 0.37 3.87 <0.01

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Himanshu S. Tiwari et at.

Table-ICARDINAL SYMPTOMS

Parameters P/21 Days of Treatment

*Significant

PM(S) B PM(T) B PS(S) B

<0.01 * <0.05* <0.05*<0.01 * <0.05* <0.05*

<0.001 ** <0.001** <0.001**<0.05* <0.05* <0.05*<0.05* <0.05* <0.05*

**Highly Significant

PS(T) B

AmlodgaraAvipakaDahaChhardiShula

<0.05*<0.05*

<0.001 **<0.05*<0.05*

Table-IIASSOCIATED SYMPTOMS

Associated P/21 Days of Treatment

Symptoms PM(S) B PM(T) B PS(S) B PS(T) B

Aruchi <0.02* <0.05* <0.05* <0.05*Hrillasha <0.02* <0.01 * <0.05* <0.05*Gaurava <0.05* <0.05* <0.05* <0.05*Angasada <0.02 <0.05* <0.05* <0.05*Angamarda <0.05* <0.05* <0.05* <0.05*

Associated P/21 Days of Treatment

Symptoms PM(S) B PM(T) B PS(S) B PS(T) B

Adhmara <0.001 ** <0.05* <0.05* <0.05*Atopa <0.01 * <0.05* <0.05* <0.05*Pipasa <0.01 * <0.05* <0.02* <0.05*

*Significant **Highly Significant

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A COMPARATIVE STUDY ON PRAVALA .....

Table-IIIPercentage wise improvement in cardinal and associated sign and symptoms

Parameters PM(S) B PM(T) B PS(S) B PS(T) B

CardinalAssociated

75.3873.63

63.8356.45

83.6478.87

74.3662.07

IPS (S) B] i.e. 83.64% and 78.87% incardinal and associated symptoms.

'P' values of Pravala Mula [PM(S) Band PM (T) B] and Pravala Shakha rpS(S) B, PS (T) B] after treatment in thePatients of Amlapitta.

Discussion and Conclusion

The problem of Amlapitta is increasingthroughout the country. This is the burningproblem of the society of irregular andimproper food habits, busy and stressful lifestyle. Amlapitta is a very common diseasecaused Vidagdha Pitta with features likeAmlodgara, Hridadaha. Avipaka etc. Thereis need of special type of herbal or herbo-mineral formulations which produce

minimal side effects or any complicationsbut also improve all the symptoms relatedwith Amlapitta. Present study was designedto evaluate the efficacy of these herbo-mineral drugs (Pravala Mula Bhasma andPravala Shakha Bhasma) which may behelpful in treating the patients withoutproducing any side effects. At last, it maybe concluded that the effect of PravalaShakha Sarjika Kshara Shodhita Bhasmawas found better than the effect of otherthree Bhasma i.e. Pravala Mula Bhasma(Sarjika Kshara Shodhita and TandulikyaSwarasa Shodhita) and Pravala ShakhaTandulikya Swarasa Shodhita Bhasma inthe Patients of Amlapitta (hyperacidity) ondifferent clinical parameters.

Bhavaprakasa 1949

REFERENCES

Charak 1994

Bhavaprakasa by Shri Bhava Mishra, Hindicommentary by Brahmashanker Mishra(1949) 2nd Ed., Chukhambha SanskritSansthana, Varanasi.

Charak Samhita by Agnivesh revised byCharak and Dridhabala, Vidyotini Hindi com-mentary by Pt. Kashinath Shastri, Dr.Gorakhnath Chaturvedi, 20th Ed.,Chaukhamba Sanskrit Sansthana, Varanasi.

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Himanshu S. Tiwari et al.

Rasatarangini 2000

Sharangadhara 2002

Sushruta 1915

Vagbhata 1989

Rastarangini by Pranacharya Shri SadanandaSharma with Prasadini Sanskrit commentaryby Ayurvedacharya, Sh. Haridatta Shastri,Rasa Vijnana, Hindi Commentary by Pt.Dharmananda Shastri, 11th Ed., MotilalBanarasidas, Delhi.

Sharangadhara Samhita by Pt. SharangdharaAcharya, Dipika and Gudhartha Dipika ofAdhamala and Kashiram, 1ST Ed.,Chaukhambha Orientalia, Varanasi.

Susruta Samhita by of Sushrutacharya withNibandha Sangraha commentary of Dalhana,Edt. By Acharya Y. T., Nimay Sagar Press,Bombay.

Astbanga Sangraha (Hindi, Ayurveda ShastriLal Chanda), Vol 1-1965, II - 1988, III,Baidyanath Ayurveda Bhavan, Nagpur.

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