Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs...

73
Aortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014

Transcript of Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs...

Page 1: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Aortic Aneurysm

Medical vs Surgical

Marian Soat RN MSN CCNS CCRN

Clinical Nurse Specialist

November 2014

Objectives

bull Discuss aortic aneurysm and the natural history of an aneurysm

bull Explain the pathophysiology of an aortic aneurysm

bull Discuss the difference between medical management and surgical interventions

bull Identify nursing considerations

Cleveland Clinic Heart and

Vascular Institute

bullHospital Tower

bull 288 Hospital Beds

bull 110 Critical care

Beds

Aortic Aneurysm

Definition

bull Permanent localized dilation of the aorta that is at least 50 larger in diameter than a normal aorta

bull The word aneurysm comes from the Greek aneurysma meaning a widening

wwwuthtmcedu

Aortic Aneurysm

bullEstimated 15 - 2 million people in the

US have an aortic aneurysm

bullThe primary cause of 10597 deaths

bullContributing cause in more than

17215 deaths

httpwwwcdcgov

Aortic Aneurysm

bull About two-thirds of people who have an aortic

aneurysm are male

bull The US Preventive Services Task Force

recommends that men aged 65 ndash 75 years who

have ever smoked

ndashShould be screened via ultrasound for abdominal

aortic aneurysms even if they have no symptoms

httpwwwcdcgov

Common Sites

bullThoracic Aortic

aneurysm ~ 19

bullThoracic

Abdominal Aorta

~ 2

Common Sites

bullAbdominal Aortic

aneurysm ~ 65

bullAbdominal Aortic

aneurysm

associated with

iliac ~ 13

Thoracic Aortic Aneurysms

bull Men and women are equally likely to

get thoracic aortic aneurysms

bull Thoracic aortic aneurysms are

usually caused by hypertension

bull May develop in individuals inherited

connective tissue disorders such as

Marfan syndrome

Thoracic aortic aneurysm

bull Signs and symptoms can include

ndash Sharp sudden pain in the chest or

upper back

ndash Shortness of breath

ndash Trouble breathing or swallowing

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 2: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Objectives

bull Discuss aortic aneurysm and the natural history of an aneurysm

bull Explain the pathophysiology of an aortic aneurysm

bull Discuss the difference between medical management and surgical interventions

bull Identify nursing considerations

Cleveland Clinic Heart and

Vascular Institute

bullHospital Tower

bull 288 Hospital Beds

bull 110 Critical care

Beds

Aortic Aneurysm

Definition

bull Permanent localized dilation of the aorta that is at least 50 larger in diameter than a normal aorta

bull The word aneurysm comes from the Greek aneurysma meaning a widening

wwwuthtmcedu

Aortic Aneurysm

bullEstimated 15 - 2 million people in the

US have an aortic aneurysm

bullThe primary cause of 10597 deaths

bullContributing cause in more than

17215 deaths

httpwwwcdcgov

Aortic Aneurysm

bull About two-thirds of people who have an aortic

aneurysm are male

bull The US Preventive Services Task Force

recommends that men aged 65 ndash 75 years who

have ever smoked

ndashShould be screened via ultrasound for abdominal

aortic aneurysms even if they have no symptoms

httpwwwcdcgov

Common Sites

bullThoracic Aortic

aneurysm ~ 19

bullThoracic

Abdominal Aorta

~ 2

Common Sites

bullAbdominal Aortic

aneurysm ~ 65

bullAbdominal Aortic

aneurysm

associated with

iliac ~ 13

Thoracic Aortic Aneurysms

bull Men and women are equally likely to

get thoracic aortic aneurysms

bull Thoracic aortic aneurysms are

usually caused by hypertension

bull May develop in individuals inherited

connective tissue disorders such as

Marfan syndrome

Thoracic aortic aneurysm

bull Signs and symptoms can include

ndash Sharp sudden pain in the chest or

upper back

ndash Shortness of breath

ndash Trouble breathing or swallowing

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 3: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Cleveland Clinic Heart and

Vascular Institute

bullHospital Tower

bull 288 Hospital Beds

bull 110 Critical care

Beds

Aortic Aneurysm

Definition

bull Permanent localized dilation of the aorta that is at least 50 larger in diameter than a normal aorta

bull The word aneurysm comes from the Greek aneurysma meaning a widening

wwwuthtmcedu

Aortic Aneurysm

bullEstimated 15 - 2 million people in the

US have an aortic aneurysm

bullThe primary cause of 10597 deaths

bullContributing cause in more than

17215 deaths

httpwwwcdcgov

Aortic Aneurysm

bull About two-thirds of people who have an aortic

aneurysm are male

bull The US Preventive Services Task Force

recommends that men aged 65 ndash 75 years who

have ever smoked

ndashShould be screened via ultrasound for abdominal

aortic aneurysms even if they have no symptoms

httpwwwcdcgov

Common Sites

bullThoracic Aortic

aneurysm ~ 19

bullThoracic

Abdominal Aorta

~ 2

Common Sites

bullAbdominal Aortic

aneurysm ~ 65

bullAbdominal Aortic

aneurysm

associated with

iliac ~ 13

Thoracic Aortic Aneurysms

bull Men and women are equally likely to

get thoracic aortic aneurysms

bull Thoracic aortic aneurysms are

usually caused by hypertension

bull May develop in individuals inherited

connective tissue disorders such as

Marfan syndrome

Thoracic aortic aneurysm

bull Signs and symptoms can include

ndash Sharp sudden pain in the chest or

upper back

ndash Shortness of breath

ndash Trouble breathing or swallowing

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 4: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Aortic Aneurysm

Definition

bull Permanent localized dilation of the aorta that is at least 50 larger in diameter than a normal aorta

bull The word aneurysm comes from the Greek aneurysma meaning a widening

wwwuthtmcedu

Aortic Aneurysm

bullEstimated 15 - 2 million people in the

US have an aortic aneurysm

bullThe primary cause of 10597 deaths

bullContributing cause in more than

17215 deaths

httpwwwcdcgov

Aortic Aneurysm

bull About two-thirds of people who have an aortic

aneurysm are male

bull The US Preventive Services Task Force

recommends that men aged 65 ndash 75 years who

have ever smoked

ndashShould be screened via ultrasound for abdominal

aortic aneurysms even if they have no symptoms

httpwwwcdcgov

Common Sites

bullThoracic Aortic

aneurysm ~ 19

bullThoracic

Abdominal Aorta

~ 2

Common Sites

bullAbdominal Aortic

aneurysm ~ 65

bullAbdominal Aortic

aneurysm

associated with

iliac ~ 13

Thoracic Aortic Aneurysms

bull Men and women are equally likely to

get thoracic aortic aneurysms

bull Thoracic aortic aneurysms are

usually caused by hypertension

bull May develop in individuals inherited

connective tissue disorders such as

Marfan syndrome

Thoracic aortic aneurysm

bull Signs and symptoms can include

ndash Sharp sudden pain in the chest or

upper back

ndash Shortness of breath

ndash Trouble breathing or swallowing

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 5: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Aortic Aneurysm

bullEstimated 15 - 2 million people in the

US have an aortic aneurysm

bullThe primary cause of 10597 deaths

bullContributing cause in more than

17215 deaths

httpwwwcdcgov

Aortic Aneurysm

bull About two-thirds of people who have an aortic

aneurysm are male

bull The US Preventive Services Task Force

recommends that men aged 65 ndash 75 years who

have ever smoked

ndashShould be screened via ultrasound for abdominal

aortic aneurysms even if they have no symptoms

httpwwwcdcgov

Common Sites

bullThoracic Aortic

aneurysm ~ 19

bullThoracic

Abdominal Aorta

~ 2

Common Sites

bullAbdominal Aortic

aneurysm ~ 65

bullAbdominal Aortic

aneurysm

associated with

iliac ~ 13

Thoracic Aortic Aneurysms

bull Men and women are equally likely to

get thoracic aortic aneurysms

bull Thoracic aortic aneurysms are

usually caused by hypertension

bull May develop in individuals inherited

connective tissue disorders such as

Marfan syndrome

Thoracic aortic aneurysm

bull Signs and symptoms can include

ndash Sharp sudden pain in the chest or

upper back

ndash Shortness of breath

ndash Trouble breathing or swallowing

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 6: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Aortic Aneurysm

bull About two-thirds of people who have an aortic

aneurysm are male

bull The US Preventive Services Task Force

recommends that men aged 65 ndash 75 years who

have ever smoked

ndashShould be screened via ultrasound for abdominal

aortic aneurysms even if they have no symptoms

httpwwwcdcgov

Common Sites

bullThoracic Aortic

aneurysm ~ 19

bullThoracic

Abdominal Aorta

~ 2

Common Sites

bullAbdominal Aortic

aneurysm ~ 65

bullAbdominal Aortic

aneurysm

associated with

iliac ~ 13

Thoracic Aortic Aneurysms

bull Men and women are equally likely to

get thoracic aortic aneurysms

bull Thoracic aortic aneurysms are

usually caused by hypertension

bull May develop in individuals inherited

connective tissue disorders such as

Marfan syndrome

Thoracic aortic aneurysm

bull Signs and symptoms can include

ndash Sharp sudden pain in the chest or

upper back

ndash Shortness of breath

ndash Trouble breathing or swallowing

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 7: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Common Sites

bullThoracic Aortic

aneurysm ~ 19

bullThoracic

Abdominal Aorta

~ 2

Common Sites

bullAbdominal Aortic

aneurysm ~ 65

bullAbdominal Aortic

aneurysm

associated with

iliac ~ 13

Thoracic Aortic Aneurysms

bull Men and women are equally likely to

get thoracic aortic aneurysms

bull Thoracic aortic aneurysms are

usually caused by hypertension

bull May develop in individuals inherited

connective tissue disorders such as

Marfan syndrome

Thoracic aortic aneurysm

bull Signs and symptoms can include

ndash Sharp sudden pain in the chest or

upper back

ndash Shortness of breath

ndash Trouble breathing or swallowing

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 8: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Common Sites

bullAbdominal Aortic

aneurysm ~ 65

bullAbdominal Aortic

aneurysm

associated with

iliac ~ 13

Thoracic Aortic Aneurysms

bull Men and women are equally likely to

get thoracic aortic aneurysms

bull Thoracic aortic aneurysms are

usually caused by hypertension

bull May develop in individuals inherited

connective tissue disorders such as

Marfan syndrome

Thoracic aortic aneurysm

bull Signs and symptoms can include

ndash Sharp sudden pain in the chest or

upper back

ndash Shortness of breath

ndash Trouble breathing or swallowing

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 9: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Thoracic Aortic Aneurysms

bull Men and women are equally likely to

get thoracic aortic aneurysms

bull Thoracic aortic aneurysms are

usually caused by hypertension

bull May develop in individuals inherited

connective tissue disorders such as

Marfan syndrome

Thoracic aortic aneurysm

bull Signs and symptoms can include

ndash Sharp sudden pain in the chest or

upper back

ndash Shortness of breath

ndash Trouble breathing or swallowing

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 10: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Thoracic aortic aneurysm

bull Signs and symptoms can include

ndash Sharp sudden pain in the chest or

upper back

ndash Shortness of breath

ndash Trouble breathing or swallowing

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 11: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms highest

prevalence

bull Abdominal aortic aneurysms

ndash More common in men

ndash Among people aged 65 years and older

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 12: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Abdominal Aortic Aneurysms

bull Abdominal aortic aneurysms may be

caused by atherosclerosis

bull Symptoms include

ndash Throbbing or deep pain in back or side

ndash Pain in the lower half of the body

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 13: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Natural History

bull Aortic aneurysm will

expand with eventual

rupture

bull Some aneurysms

remain stable for

long periods of time

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 14: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Natural History

bullSome aneurysms

enlarge quickly

bullRate of growth of

aneurysm is

unpredictable

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 15: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pathophysiology of Aortic

Aneurysm

bullThe underlying cause is

unknown in many

individuals

bullAtherosclerosis may

cause aneurysms

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 16: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pathophysiology of Aortic

Aneurysm

bull Family clusters are suggestive of a genetic

predisposition

bull Hypertension

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 17: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Marfan Syndromebull A disorder discovered in 1896

by a French doctor named Antoine Marfan

bull Symptomsndash Tall

ndash Long narrow face

ndash Long arms and legs

bull About 200000 Americans suffer from this disease

bull The disease is usually hereditary

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 18: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pathophysiology of Aortic

AneurysmbullDegeneration of the arterial media

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 19: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pathophysiology of Aortic

Aneurysm

bullArterial media is made

up of collagen and

elastin

bullCollagen and elastin are

fibrous protein

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 20: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pathophysiology of Aortic

Aneurysm

bullCollagen

Responsible for the

mechanical

strength of vessel

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 21: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pathophysiology of Aortic

Aneurysm

bullElastin

Provides elasticity

to the vessel and

allows it to double

in diameter

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 22: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pathophysiology of Aortic

Aneurysm

bullThere is no

evidence that

elastin is

synthesized in

adult life

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 23: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pathophysiology of Aortic

AneurysmbullElastin has half

life of 40-70 yrs

bullElastin in normal

vessel ~ 36

bullElastin in

aneurysmal

vessel ~ 8

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 24: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Rates of Rupture

bulllt 40 cm = low

bull40 - 49 cm = 5

bull50 - 59 cm = 25

bull60 - 69 cm = 35

bullge 70 cm = 75

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 25: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Indications for Medical

Intervention

bull Lower risk for

rupture

bull lt 40 cm ndash annual

US and CT scan

bull 45 ndash 5 cm ndash

semiannual US and

CT

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 26: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Indication for Repair

bull 55 ndash 60 cm consider

elective repair

bull Increase in diameter

by more than 05 cm

within 6 month interval

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 27: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Research

bull Two trials comparing EVAR to observation

for AAA lt55 cm

ndashFound no significant long-term differences

between AAA repair and medical management

bull In spite of the lower mortality rate

associated with EVAR

ndashThere appears to be no advantage to elective

EVAR repair for small and medium-sized

aneurysms

Endovascular repair compared with surveillance of aortic aneurysms Ouriel et al

Positive Impact of Endovascular Options for treating Aneurysms Early (PIVOTAL)

Vasc Surg 2010 May51(5)1081-7Epub 2010 Mar 20

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 28: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Research

bull The randomized trials were comprised

predominately of men

bull For women a lower threshold of 5 cm may be

justified for elective repair of asymptomatic

AAA

ndashDue to the higher rate of rupture in women

compared with men for AAA of the same diameter

Should abdominal aortic aneurysm be managed differently in women

AULederle FASOScand J Surg 200897(2)125

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 29: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Rapid Aneurysm Expansion

bull Earlier repair for rapid aneurysm

expansion

ndash gt05 cm in six months

bull Some data suggest that rapidly expanding

AAAs are more likely to have symptoms

bull Rapid expansion may represent instability

of the aortic wall and may be a sign of

impending aortic rupture

Clinical features and diagnosis of abdominal aortic aneurysm

uptodatecomm

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 30: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Therapies to Limit Aortic Expansion

bullThe likelihood that an aneurysm will

expand or rupture is influenced by a

number of factors including

ndash Aneurysm diameter

ndash Rate of expansion

ndash Gender

ndash Ongoing smoking

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 31: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Patient Age

bull Younger patients with AAA with a long life expectancy

will likely require repair at some point in their lives

bull The likelihood of needing surgery in the future for

medium-sized aneurysms (40 to 55 cm) is 50

percent at three years 60 to 65 percent at five years

and 70 to 75 percent at eight years

bull Older patients often die from associated illnesses prior

to expansion of the aneurysm to a size that would

indicate a need for repair

bull Continued observation in older patients may be

warranted for AAA that exceeds 55 cm

Systematic review repair of unruptured abdominal aortic aneurysm

Kane et al Intern Med 2007146(10)735

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 32: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pharmacologic Therapies

bull Many pharmacologic therapies aimed at

limiting AAA expansion and preventing

rupture have been tried

bull No pharmacologic therapy has been

proven successful at achieving these goals

bull Not recommended to implement any of the

pharmacologic therapies discussed for the

sole purpose of treating AAA

wwwuptodatecomcontentsmanagement-of-asymptomatic-abdominal-aortic-aneurysm

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 33: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Cardiovascular Risk Reduction

bull Current multidisciplinary guidelines regard

AAA as a coronary heart disease

equivalent and recommend aspirin

bull There is no evidence to suggest that ASA

contributes to AAA expansion or rupture

bull Statins are recommended to reduce the

progression of atherosclerosis

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 34: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

bull Beta blocker therapy has a role in

managing patients with AAA

bull Beta blockers have not been clearly shown

to reduce aneurysm expansion rates

bull Two large trials found no significant

differences in AAA expansion rates in

patients receiving beta blockers compared

with those who did not

Uncertain Benefit of Beta-Blockers

Propranolol Aneurysm Trial Investigators J Vasc Surg 200235(1)72

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 35: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

ACE inhibitors and ARBs

bull A number of clinical studies have associated

reduced rates of expansion or rupture with the

use of angiotensin-converting-enzyme

inhibitors and Angiotensin II Receptor Blockers

bull Patients taking ACE inhibitors were significantly

less likely to present with ruptured aneurysm

compared with those who were not on ACE

inhibitors

Angiotensin-converting enzyme inhibitors and aortic rupture a population-based

case-control study Hackam DG Lancet 2006368(9536)659

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 36: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Other Antihypertensives Agents

bull Diuretics and calcium channel blockers

have also been studied for their effects on

AAA expansion

bull Calcium channel blockers

ndashNo significant differences

bull Diuretics appear to have no impact on

expansion rates

Abdominal aortic aneurysm expansion risk factors and time intervals for surveillance

Brady AR Circulation 2004110(1)16

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 37: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Potentially Beneficial Therapies

bullSmoking cessation ndash Cigarette smoking is the risk factor most strongly

associated with

ndash Aneurysm formation

ndash Aneurysm expansion

ndash Aneurysm rupture

ndash Is the most important modifiable risk factor in patients

with AAA

bullExercise ndash Higher levels of physical activity are associated with a

lower risk of cardiovascular morbidity and death

uptodatecommanagement-of-asymptomatic-abdominal-aortic-aneurysm

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 38: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Medical Intervention

bull Do not let HR go less than 60

bull Keep BP less than 16090

bull Call for

ndash Systolic BP greater than 160

ndash Systolic BP less than 90

ndash Diastolic BP greater than 90

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 39: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pharmacologic Intervention

bull Hydralazine 10 mg

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure

ndashSBP greater than 140 OR DBP greater

than 90

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 40: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pharmacologic Intervention

bull Metoprolol 10 mg injection (LOPRESSOR)

bull Route INTRAVENOUS

bull Freq EVERY 2 HOURS AS NEEDED

bull PRN Reasons Give for blood pressure of

bull PRN Comment SBP greater than 140 OR DBP

greater than 90 if HR greater than 60

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 41: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Pharmacologic Intervention

bull Metoprolol tartrate (short acting) 125 mg tab(s)

(LOPRESSOR)

bull Admin Amount 1 tablet (1 times 125 mg tablet)

bull Route ORAL

bull Freq 2 TIMES DAILY

bull Admin Instruction HOLD FOR SBP lt 110 OR HR lt 60

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 42: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Indication for Repair

bullWhen risk of

rupture is greater

than risk of

surgery

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 43: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Indication for Repair

bullWhen patient is

symptomatic

bull2000 lives could

be saved if the

aorta is repaired

before rupture

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 44: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bull Institution and

physician

dependant

bullOpen repair is

more invasive

bullEVAR is less

invasive

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 45: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Open Repair or Endovascular

Aneurysm Repair (EVAR)

bullOpen repair for younger and healthier

patients

bullEVAR for older and more debilitated

patients

bullAnatomic considerations

bullPatient preference

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 46: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Open Surgical Technique

bullMedian sternotomy

for ascending aorta

and arch

bullLeft thoracotomy

for descending aorta

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 47: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Open Surgical Technique

bullAorta is cross clamped

bullDiseased portion of aorta is replaced with a Dacron or Teflon graft

bullGraft is sewn into place

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 48: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Open Repair

bullRecovery is similar to

cardiac surgical

procedure

bullAdmitted to ICU for

1-3 days

bullRapid assessment in

the ICU is performed

by the nurse

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 49: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Open Repair

bull If aortic valve is

involved bradycardia

or heart block may

occur

ndashInflammation

ndashTrauma

ndashSutures close to the

conduction system

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 50: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Open Repair

bullHypotension occurs often during

the first 12 hours after surgery

ndash As the patient warms

ndash As systemic vascular resistance

decreases to normal levels

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 51: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Morbidity and Mortality Rates

bull Individuals more likely to experience serious

perioperative complications

ndash Patients with coronary artery disease

ndash Cigarette smokers with significant chronic

obstructive pulmonary disease

ndash Arrhythmias

ndash Pneumonia

ndash Older patients

ndash Female patients

ndash Renal dysfunction

m

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 52: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Surgical Complications

bull Myocardial

infarction

bull Perioperative

bleeding

bull Graft infection

bull Renal failure

bull Colon ischemia

bull Wound infection

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 53: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Surgical Outcomes

bullOpen surgical

repair has a 30 day

mortality rate of

4-12

bullGrafts are durable

for 20-30 years

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 54: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Endovascular Aneurysm Repair

EVAR

bullEndo ndash within + Vascular ndash vessel

bullMinimally invasive technique

bullEVAR grafts have been used to

repair thoracic and abdominal

aneurysms

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 55: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Endovascular Aneurysm Repair

EVAR

bullUse a metal stent covered with graft

material

bullThe stent is deployed inside the aorta

and held in place with metal hooks or

barbs

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 56: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Endovascular Aneurysm Repair

EVAR

bullTransvascular

approach

bullFemoral incision

bull Insertion of a

bypass conduit

or endograft

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 57: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Advantages of an Endovascular Repair

bullGood short term morbidity

and mortality rates

bullPatients who are too ill for

conventional surgery can be

considered for EVAR

bullBenefit is greatest for high risk

patients

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 58: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Endovascular Aneurysm Repair

EVARbullThe stent graft

create a new

lining within the

aneurysm sac

bullReduce pressure

in the sac and

protect from

ruptureBefore and after endovascular thoracic aortic aneurysm placement

photo courtesy of Joseph Bavaria MD

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 59: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Advantages of an Endovascular

Repair

httpwwwcodavisut

bullDecrease amount

of total blood loss

bullDecrease in

incidence of

cardiac and

respiratory events

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 60: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Advantages of an Endovascular

Repair

bull Increase in

patient

satisfaction and

comfort levels

bullDecrease in total

hospital stay

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 61: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Complications of Endovascular Repair

bullDamage to blood vessels or organs

bullDurability of endograft uncertain

bullPotential for graft migration

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 62: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Complications of Endovascular

Repair

bull Endoleak

Endoleak is defined

as a persistent blood

flow outside the

lumen of the graft and

into the aneurysm

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 63: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Spinal Complications

bull May cause paralysis

bull Due to hypotension

bull Due to inflammation

bull Hemorrhage

bull Fluctuations in BP

bull Decreased spinal

perfusion

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 64: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Open Surgery vs Endovascular

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 65: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Nursing Considerations

Management of

Complications

bullEvaluate

bullCirculation

bullEdema

bullLimb occlusion due to blockage of a blood vessel

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 66: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Nursing Considerations

Management of Complications

bull Temperature of extremities

bull Pulses

bull Color of extremities

bull Capillary refill

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 67: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Summary

bullNatural history of an aneurysm

bullPathophysiology of aortic aneurysm

bullMedical management of aortic aneurysm

bullDifference between an open aneurysm

repair and endovascular repair

bullNursing considerations

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 68: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Questions

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient

Page 69: Aortic Aneurysm Medical vs Surgical - Cleveland Clinic · PDF fileAortic Aneurysm Medical vs Surgical Marian Soat RN, MSN, CCNS, CCRN Clinical Nurse Specialist November 2014. Objectives

Conclusion

bullTake your knowledge and skill

combine it with your compassion and

give all to your patient