Surgical management of Cerebral Aneurysms/media/files/providence or... · 2015-12-02 ·...
Transcript of Surgical management of Cerebral Aneurysms/media/files/providence or... · 2015-12-02 ·...
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Surgical management of Cerebral Aneurysms
by
Frederick Vincent
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No disclosure that would be a potential conflict of interest with this presentation
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Plan:.Epidemiology.Etiology.Histology of intracranial arteries.Location.Presentation of aneurysms.Conditions associated with aneurysms.Classic saccular aneurysm: pathogenesis, risk factors, vessel wall pathology, histopathology.Surgical approaches to aneurysms.Surgical technique.Cases of brain aneurysm
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Epidemiology
Difficult to estimate
Autopsy prevalence: 0.2 – 7.9% , it depends
Prevalence 5%
Ratio of ruptured: unruptured 5:3 to 5:6 (rough estimate is 1:1)
50% of these aneurysms rupture
Only 2% present during childhood
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Etiology
.Congenital predisposition (medial gap/muscular layer)
.Atherosclerotic or hypertensive
.Embolic: as in atrial myxoma
.Infectious (mycotic aneurysm)
.Traumatic
.Associated with other conditions
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Histology of intracranial arteries
• Intima (17%), media (52%) and adventitia (31%)
• Endothelium and subendothelial connective tissue
• Internal elastic lamina (mechanical strength) separates the I and M
• M consists of closely packed layers of smooth muscle cells surrounded by collagen and elastin fibers
• No external elastic lamina between M and Ad
• Ad is very thin
• Lower wall:lumen ratio
• Mean wall thickness 0.6 mm in the Basilar and 0.5 mm MCA
• Intradural arteries are surrounded by CSF remain in this state after entering the brain parenchyma (perivascular space/Virchow-Robin spaces)
• Ensheathed by “glia limitans” -> specialized layer of astrocytes
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Location
• Apex of branch points which is the site of max hemodynamic stress
• More peripheral do occur associated mycotic aneurysm or trauma
• Fusiform aneurysms more common in the VertBasilar system
• Dissecting aneurysm (categorized with arterial dissection)
• Saccular aneurysm locations• 85-95% in the carotid system: AcoA 30% p-com 25% MCA 20%
• 5-15% in the posterior ciculation: 10% basilar tip 5% vertebral
• 20-30% have multiple aneurysms
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Presentation
• Rupture• SAH
• Intracerebral hemorrhage 20-40%
• IVH 13-28%
• Subdural hematoma 2-5%
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opening in the subarachnoid space of the brain created by a separation of the arachnoid and pia matter
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Intraventricularhemorrhage• 13-28%
• Prognosis worse (64% mortality)
• The size of the ventricle is the most imp prognosticator
• Acom aneurysm -> rupture through the lamina termilalis -> anterior 3rd ventricle or lateral ventricle
• Basilar tip or carotid terminus aneurysm -> floor of the 3rd ventricle
• Distal PICA -> into the 4th ventricle via foramen of Luschka
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Other presentations
• Mass effect: giant aneurysm• Brainstem compression -> hemiparesis and cranial neuropathies
• Cranial neuropathies• Non-pupil sparing third nerve palsy Pcom
• Visual lost: • compressive optic neuropathy carotid ophthalmic aneurysm
• Chiasmal syndrome ophthalmic, acom, basilar tip
• Facial pain syndrome (ophthalmic/maxillary nerve distribution) intracavernous
• Intra or suprasellar aneurysm -> endocrine disturbance due to pituitary compression
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Other presentations
• Minor hemorrhage: warning or sentinel
• Small infarct or TIA: distal embolization
• Seizure: localized gliosis
• Headache without hemorrhage• acute (expansion, thrombosis or intramural bleed)
• > 2weeks irritation of overlying dura, mass effect -> increase ICP
• Incidental discovered (asymptomatic)
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Conditions associated with aneurysms
• Autosomal dominant polycystic kidney disease
• Fibromuscular dysplasia (abnormal growth within the wall )
• AVM
• Connective tissue disorders: Ehlers-Danlos type 4 (deficient collagen type 3), Marfan’s syndrome, pseudoxanthoma elasticum
• Multiple other family members with intracranial aneurysms
• Coarctation of the aorta
• Osler-Weber-Rendu syndrome (Hereditary hemorrhagic telangiectasia)
• Atherosclerosis
• Bacterial endocarditis
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Polycystic kidney disease
• Transmission is autosomal dominant
• Progressive chronic renal failure
• HTN is a common sequelae
• Prevalence of aneurysms with ADPKD is 10-30% around 15%
• Increased incidence, increased risk of rupture
• 10-20 fold increased risk of SAH compared to general population
• Average rate of rupture of incidental aneurysm is 2%/year
• Screening with MRA is beneficial
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Classic saccular aneurysm
• Focal outpouching of the wall
• Site of bifurcation
• Pointing in the direction of the blood flow
• Berry-like morphology
• Prevalence is 3.2% (for unruptured)
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Pathogenesis
• not completely understood
• Congenital disease (historically, assumption is incorrect, acquired)
• Caused by • hemodynamic stresses (luminal factors)
• Supported by preferred location (bifurcation) and increase association with arterial anatomical variants (agenesis, persistent anastomoses, asymmetry and fenestrations)
• defective vessel wall responses (abluminal factors)
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• Exogenous factors are associated with formation and rupture • Cigarette smoking
• Alcohol consumption
• Genetic foci associated with the development of aneurysms• Chromosomes 18q11.2, 10q24.32, 8q11.23-q12.1, 9p21.3
• Explain only up to 5% of familial risk of intracranial aneurysm
• The currently available genetic risk prediction tests are not well-established screening methods
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Risk factors for aneurysm formation and rupture• Female
• Increasing age
• HTN
• Tobacco smoking
• Excessive alcohol consumption
• Family history of aneurysm
• Polycystic kidney disease
• Previous SAH
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Vessel wall pathology
• Histopathological feature: disruption of the internal elastic lamina• Tears in IEL (induced by alteration of hemodynamic)• Smooth muscle cells
• can migrate into the intima• Proliferate -> myointimal hyperplasia (adaptive response)
• Endothelium composed of either,• near normal pattern of smooth and linearly organized endothelial cells• or irregular surface formed by increased endothelial-cell apoptosis and adhesion of
blood cells
• Media composed of dense or disorganized layers of smooth muscle cell or near absence of smooth muscle cells
• Adventitia composed of collagen fibers, may be stretched
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luminal subacute thrombus, a pattern of alternating thinning and thickening of the vessel wall, lack of
smooth muscle cells (arrows) in a large portion of the wall, and a mild infiltrate of adventitial lymphocytes
(arrowheads). loss of the internal elastic lamina
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Unruptured vs Ruptured aneurysm
• Unruptured aneurysm• Intact endothelium• Intact smooth muscle cell layers• Few macrophages and other inflammatory cells
• Ruptured aneurysm• Disrupted endothelium• A few smooth muscle cells• Diffuse invasion of macrophages and leukocytes
Aneurysm-wall inflammation is present before the rupture occurs and is not a result of the rupture
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Classification of aneurysms by their wall histopathology (structural changes)
• Orderly layers of smooth muscle and intact endothelium
• Disorganized layers of smooth muscle
• decreased numbers of smooth muscle cells and myointimalhyperplasia or organized thrombus
• Thin hypocellular wall and endothelial-cell apoptosis
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Microarray gene analysis
found differential gene expression profiles between healthy wall and aneurysm wall
• Increased expression of genes related to • Infiltration of inflammation cells• Complement activation• Apoptosis• Inhibition of re-endothelialization in the aneurysm wall
Both structural changes and an inflammatory response within the aneurysm wall seem to precede aneurysm rupture.
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Surgical approaches to aneurysms
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most common sitesof saccular aneurysms
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Lateral and superior view of common aneurysmson the supraclinoid portion of ICA
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Operative view of aneurysm sites on the ICA
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Fronto temporal (pterional) craniotomy
Used to expose aneurysms on theCircle of Willis
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Perforating arteries at common aneurysm sites
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Approach to PCOM
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Approach to PCOM
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Approach to MCA
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Microinstruments for microsurgery
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Blunt dissection vs sharp dissection
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Approach to ACOM
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Distal part of theAnterior cerebralartery
Interhemisphericapproach
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Common aneurysmSites in the posterior fossa
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Surgical technique
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-Indocyanine green: fluorescent dye-intra operative angiogram-intra operative doppler
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Cases of brain aneurysm
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Treament: coiling
The International Subarachnoid Aneurysm
Trial (ISAT) demonstrated that patients with
ruptured aneurysms rated by both the
neurosurgeon and the interventional
neuroradiologist as potential candidates for
therapy had lower morbidity, dependency
and mortality rates when treated with
endovascular coiling than when treated with neurosurgical clipping.
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First Coil3.5mm x 7.5 cm
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Repositioning of the first coil
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Second coil2mm x 1.5 cm
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Final resultAfter removing the microcatheter
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Pipeline
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What is Pipeline?
Flexible mesh like device
Bimetallic self expanding braid
25% platinum tungsten
75% cobalt chromium
48 strandsinterwoven in
standard pattern
30-35% surface coverage
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Low porosity
stent
Redirecting blood flow
Intra aneurysmal
stasis
Thrombosis within the aneurysm
Subsequent endothelialization
Excluded aneurysm
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Conclusion:
.Aneurysms are unique lesion
.Individualized mixture of geometry, size, location, relationship to surrounding
.lead to devastating morbidity and mortality:
high risk of rupture associated with
.posterior circulation and PCOM
. size> 7mm
.high aspect ratio or bottle neck
.irregular surface and daughter sac
.small parent artery
.Challenging to treat
.Many options to offer the patients