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2010

T H E S I G N A T U R E E V E N T  of Gabrielle's Angel Foundation, the   Angel Ball, has become so

popular it is now a yearly event! Cipriani Wall Street will once again serve as the backdrop for

this black-tie gala, so mark your calendars for Thursday, October 21, 2010! You won’t want to

miss this year’s  Angel Ball  as the Foundation honors the lead guitarist of one of the world’s

most celebrated rock bands, U2’s The Edge and his wife, director, choreographer and dancer,

Morleigh Steinberg; COTY, Inc. Chief Executive Officer, Bernd Beetz for his incredible work

in support of blood cancer research through COTY's DKMS Foundation; and Sean Parker,

Managing Partner of the Founder’s Fund and creator of online music sharing site Napster and

Facebook Causes. We expect this event to sell out very quickly so, only a limited number of 

individual tickets at $1,500.00 will be available. Table levels begin at $15,000.00, so reserve your

seats early this year! Continental Airlines will serve as the Official   Angel Ball  Airline for the

fourth year in a row with Inez Weinstein Special Events handling all reservations (212-254-6677).

As always, the  Angel Ball will showcase A-list celebrities and the best live musical performances

in town! So, save the date: Thursday, October 21st. We look forward to sharing a magical night

with you!

Angel Ball Slated for October 2010

InspirationsA Newsletter from Gabrielle’s Angel Foundation for Cancer ResearchSUMMER 2010 | VOLUME 17

G A B R I E L L E ’ S A N G E L F O U N D A T I O N A N N O U N C E S  new grants totaling $2.7 million as it

continues its mission to fund the best junior investigators working in cancer research today.

Twelve of the nation’s leading young scientists receive $75,000.00 per year to sustain their labs

and further solidify their research careers. Dr. Stephen D. Nimer, Chief of Hematology at

Memorial Sloan-Kettering Cancer Center and Chairman of the Foundation’s Medical Advisory

Board reaffirmed that only the ‘crème de la crème’ are chosen for these three-year Medical

Research Awards.

Due to the overwhelming success of the  Angel Ball  2009, ten conventional and two integrative

(complementary) medicine grants were selected from the over 80 applicants.  The Shulamit

 Benjamini Sandberg Research Grant was established in memory of Foundation sponsor Lorraine

Schwartz’s mother. Additional monies partially funded another of these projects in memory of 

two ardent Foundation supporters, Jeffrey Steiner and Alan Beeber, as raised by their families.

These twelve promising scientists hail from the nation’s leading research centers including Fox

Chase Cancer Center, St. Jude Children’s Research Hospital, Dartmouth Medical School and

the University of Texas Southwestern Medical Center.

With over $13 million distributed to date through the generous support of Gabrielle’s Angel

Foundation donors and sponsors, these Medical Research Awards give hope to young scientists

and the cancer patients they seek to cure.

 For information on our twelve new grantees, please see page 3.

Foundation Announces $2.7M in New Grants

 Leonard & Evelyn Lauder, Honoree Thomas C. Quick & Jennifer Hudson, Angel Ball 2009

CO-FOUNDERS

Denise Rich

Philip Aouad

BOARD OF DIRECTORS

Deborah Dunsire, M.D. Millennium Pharmaceuticals, Inc.

Star JonesTelevision Personality, Author & Attorney

Patricia Quick Philanthropist

Thomas C. Quick First Palm Beach Properties, Inc.

Frank RellaTrine Corporation

Michèle Rella Director

Daniella Rich Kilstock Director

Ilona Rich Schachter Director

Paul Schindler, Esq.Greenberg Traurig, LLP 

Lorraine E. Schwartz Lorraine E. Schwartz, Inc.

Donald M. TorescoToresco Enterprises, Inc.

Erin Zammett Ruddy Author & Magazine Columnist

MEDICAL ADVISORY BOARD

Chairman Stephen D. Nimer, M.D. Memorial Sloan-Kettering Cancer Center

Barrie R. Cassileth, Ph.D. Memorial Sloan-Kettering Cancer Center

Curt I. Civin, M.D.University of Maryland School of Medicine

 James R. Downing, MDSt. Jude Children’s Research Hospital

Carl H. June, M.D.University of Pennsylvania

 Jerome E. Groopman, M.D. Harvard Institute of Medicine

 Janet D. Rowley, M.D., D.Sc.The University of Chicago

Rainer Storb, M.D. Fred Hutchinson Cancer Research Center

 Jeffrey D. White, M.D.

 Bethesda, Maryland

Cheryl L. Willman, M.D.University of New Mexico Cancer

 Research & Treatment Center

FOUNDATION STAFF

 Jennifer Ranieri Director

Christa Justus Development

136 East 57th Street

Suite 1704

New York, NY 10022

tel  (646) 861-2033

fax (646) 781-9355web  gabriellesangels.org 

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Gabrielle’s Angel Foundation, a 501(c)(3) non-profit organization, proudly funds leading junior investigators

whose work represents cutting-edge scientific research in both conventional and integrative disciplines

which focus on prevention, treatment and quality of life issues of leukemia, lymphoma and other related

cancers. To date, the Foundation has awarded over $13 million in Medical Research Awards making it one

of the largest non-governmental sources of grant support to blood cancer researchers in the nation.

Helen Keller noted, “Although the world is full of suffering, it is full also of the overcoming of 

it.” I believe this with all my heart. My life has been an incredible journey from motherhood to acareer in music to my commitment to a cause that means the world to me. In 1996, my daughter,

Gabrielle, a 27-year-old actress and Hodgkin’s lymphoma survivor, developed acute myeloge-

nous leukemia (AML). In remission for the second time, she needed a bone marrow transplant

and I was the perfect match. AML eventually took my beloved Gabrielle’s life but not her spirit,

which lives on in the work of the organization her sisters and I created in her memory, Gabrielle’s

Angel Foundation for Cancer Research. It was Gabrielle’s last wish to help spare others the

suffering she had endured. We believed the best way to honor her memory was to turn our grief 

into a positive force for others.

Gabrielle’s Angel Foundation funds cutting-edge science in both mainstream research as well as integrative and complementary

medicine which focus on prevention, treatment and quality of life issues of leukemia, lymphoma and related cancers. These are

the country’s most promising young investigators just starting their labs. Our grantees have gone on to obtain federal NIH funding

published papers, become heads of research institutions, and filed patents on their discoveries. They are Howard Hughes Medica

Institute Early Career Scientists, Leukemia & Lymphoma Special Fellows and on Stand Up 2 Cancer’s Dream Team—just a few examplesof the brilliant minds being funded by Gabrielle’s Angel Foundation! The inspiration is in the numbers and in the many lives this

research touches: over $13 million awarded to 60 of the country’s best and brightest, making Gabrielle’s Angel Foundation one of the

largest non-governmental sources of grant support to blood cancer researchers in the nation.

Gabrielle believed that life is a quest, something to be lived out loud and celebrated. So, each year we host an incredible party, ou

signature gala, The Angel Ball, to celebrate life while raising money for these amazing scientists. I am so thankful to all of my friends

in the entertainment industry who, for one very special autumn night, gather together with a common wish—to eradicate cancer in

our lifetime.

I know in my heart Gabrielle would be so proud of all the Foundation has accomplished. We have been approved two years in a row

as one of the Independent Charities of America’s “Best in America” charities for upholding our commitment to our donors and

sponsors to meet and maintain the highest standards of accountability. 75 cents of every dollar raised by Gabrielle’s Ange

Foundation directly funds these future leaders of cancer research who continue to push the boundaries of what is possible.

As a songwriter, I understand the healing power of music and its ability to touch the deepest parts of us. I believe that from grie

and tragedy something new can emerge which makes the world a better place and allows us to remember those we have lost. Cance

has taken my mother, my sister and my daughter from me, but not my resolve to make a difference. As we approach our fifteenth

year, I remain more hopeful than ever for new advancements, a breakthrough, even a cure. I feel strongly that Gabrielle’s vision and

strength of spirit continue to light the path of Gabrielle’s Angel Foundation every step of the way. I believe that what we do together

can create miracles.

P U B L I S H E R ’ S N O T E :   Gabrielle’s Angel Foundation President & Co-Founder Denise Rich recently signed on as a Contributing

Columnist at Tonic.com, a digital media company dedicated to promoting the good that happens around the world each day. Tonic.com

shares the stories of people and organizations that are making a difference by inspiring good in themselves and others. Her first article

was published online in March. Visit Tonic.com regularly for future articles.

A Daughter’s Wishby Denise Rich

(reprinted from Tonic.com)

Our Mission Statement

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Patrick Brown, M.D. Johns Hopkins, Sidney Kimmel Comprehensive Cancer Center-----------------------

 Investigating promoter hypermethylation in the biology of  MLL-rearranged leukemia, and as a novel target for therapy-----------------------

“I chose the field of cancer research because mypatients’ courage inspires me to look for ways tomake cancer treatment work better.”

 Jianjun Chen, Ph.D.The University of Chicago-----------------------

The role and targets of APL-specific miRNAs in leukemogenesis-----------------------

“As a young investigator, I believe that the supportfrom Gabrielle’s Angel Foundation should have asignificant influence on my career development.”

Patricia Ernst, Ph.D. Dartmouth Medical School-----------------------

Targeting MLL-Cofactor Interaction to Selectively Block Mixed Lineage Leukemia-----------------------

“I chose the field of cancer research because mypostdoctoral mentor passed away with cancer whileI worked at Dana Farber, making me realize forhow much we know, we still don’t know enough toprevent and treat most cancers.”

Paul J. Galardy, M.D. Mayo Clinic Rochester-----------------------

 Exploring the role of UCHL1 in leukemia and lymphoma-----------------------

“The support of Gabrielle's Angel Foundation comesat a time when it is very difficult to survive as aphysician-scientist. [This] support provides criticalfunds that will allow my research to further developand for me to explore other avenues of interest incancer biology. This award is immensely importantto my career development.”

Ross L. Levine, M.D. Memorial Sloan-Kettering Cancer Center-----------------------

Genomic characterizations of myeloproliferative neoplasms-----------------------

“…there is a real need to improve our understandingof leukemia biology so we can improve outcomes

for our patients.”

Kirsten Ness, P.T., Ph.D.St. Jude Children’s Research Hospital-----------------------

Vibration Intervention for Bone Enhancement in ChildhoodCancer Survivors-----------------------

“Cancer survivors face unique challenges (includingpotential problems with movement and fitness) asthey age….”

 Jeffrey C. Rathmell, Ph.D. Duke University Medical Center-----------------------

 Bcl-2 Family Proteins as Metabolic Targets in Leukemia-----------------------

“Cancer impacts everyone’s lives in one way oranother…Looking at cancer cell metabolism gives usa new avenue to potentially treat a wide variety of cancers. We hope our efforts will make a difference.”

 Jennifer Rhodes, Ph.D. Fox Chase Cancer Center-----------------------

 In Vivo Regulation of Myeloid Cell Development and Leukemia-----------------------

“I find it interesting that the fundamental processesgoverning normal cell development are oftenderegulated in cancer. What are the key factors? Itis both my curiosity and the importance of this field

that drive me to do cancer research.”

Ulrich Steidl, M.D., Ph.D. Albert Einstein College of Medicine-----------------------

 Identification of Functionally Critical Transcriptional TargetGenes in Stem Cells in AML & MDS-----------------------

“There is still no curative treatment options availablefor many patients, …therefore, I felt that leukemiaresearch is critically needed for the discovery of fundamentally novel approaches to ultimately cureleukemia.”

Richard T. Williams, M.D., Ph.D.

St. Jude Children’s Research Hospital-----------------------

Systematic, High-Throughput Developmental Therapeutics in High-Risk ALL-----------------------

“My father succumbed to metastatic melanomawhen I was a child and I know that seeded my desireto make a positive impact as an adult.”

Peiying Yang, Ph.D. MD Anderson Cancer Center-----------------------

 Fish oil (n-3 fatty acids) and non-Hodgkin lymphoma-----------------------

“This funding makes it possible to explore the potentialof using dietary interventions for the prevention ortreatment of cancer.”

Chengcheng (Alec) Zhang, Ph.D.University of Texas Southwestern Medical Center-----------------------

 Ex Vivo expansion of hematopoietic stem cells for cord bloodand allogeneic transplantations-----------------------

“This funding… gives me confidence in supportingmy own research and offers me the freedom topursue new and risky projects.”

 For more information on these research projects, visit

www.gabriellesangels.org 

Our 2009 Medical Research Award Grant Recipients

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Co-Founder Hosts Fashion FeteWith Americana Manhasset

Americana Manhasset, Long Island’s premiere luxury shopping

destination, brought their exquisite merchandise to Denise

Rich’s Manhattan residence for a preview of the summer’s

newest fashions. Fortunately for guests, the rainy April after-

noon gave way to sunshine that filled that apartment. The

break in the weather coupled with an amazing 25% of all pro-

ceeds going to the Foundation afforded attendees the perfect

incentives to spend. Guests were encouraged to ‘sip, shop and

splurge’ and through their generosity, the Foundation received

over $72,000 for cancer research. Haute couture stalwarts Dior,

Etro, Fendi, Frette, Hirshleifer’s, Louis Vuitton, Prada, and

Spring Flowers beautifully displayed their wares while a select

list of supporters nabbed the latest high-end items for their

summer jaunts. The Director of Americana’s VIP Personal

Shopping Services, Danielle Merollo and Marketing Director,

Rebecca Hollander organized the festive afternoon with cater-

ing provided by Mary Giuliani Catering & Events and parting

gifts by Zegna, Hermès and others. Americana Manhasset has

long supported Gabrielle’s Angel Foundation through their

Champions for Charity® event. Last year’s holiday promotion

netted the Foundation over $15,000. With the ongoing and very

generous support from Americana Manhasset President

Deirdre Costa Major and its Owner, Frank Castagna, Gabrielle’s

Angel Foundation looks forward to future events with an

organization whose philanthropic reach knows no bounds.

 For more information, please visit:

www.championsforcharity.org & ww.americanamanhasset.com

1. Happy shoppers, Allison Lutnick & Marcy Lehrman

2. Americana Manhasset’s Danielle Merollo with hostess Denise Rich & Erica Reid

3. Long Island vintner, Cynthia Rosicki

4. Queen of the New York comedy scene, Caroline Hirsch

5. Gabby DeMatteis & her mom, Lynn DeMatteis love their new Vuitton!

6. Supporters Jennifer Fischer & Michele Herbert

7. Etro’s colorful wares on display

8. Americana Manhasset President, Deirdre Costa Major with Denise Rich

9. Foundation Board member Lorraine E. Schwartz & her sister, Ofira Sandberg 

10. Fendi President of North America, Stacy Sharp Van Praagh came by for a visit

11. The Louis Vuitton leather goods section was a hit!

12. Natalie Cole tries on a beautiful scarf with the help of an Americana employee

Foundation Highlights 2010...

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7

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Photos: Amber De Vos/PatrickMcMullan.com

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Board of DirectorsExpands to IncludeProminent Philanthropists

Gabrielle’s Angel Foundation is thrilled

to announce the expansion of its Board of 

Directors to include three individuals

committed to helping further the reach and

the mission of the Foundation. The newest

members of Gabrielle’s Angel Foundation’s

Board of Directors include (left to right)

celebrity jeweler and longtime sponsor of 

the  Angel Ball, Lorraine E. Schwartz; 2009

 Angel Ball  honoree, Thomas C. Quick of First Palm Beach Properties, Inc.; and his

sister, also a 2009 honoree, philanthropist

Patricia Quick. All three of these outstanding

humanitarians have demonstrated unwavering

loyalty and generosity to Gabrielle’s Angel

Foundation, and each of them remains

committed to making a difference in the

lives of others through their considerable

charitable endeavors. In its ongoing quest

to increase the awareness for the need

for cancer research, Gabrielle’s Angel

Foundation gratefully welcomes Lorraine,

Tom and Tricia to the Board!

Foundation Announces Angel Ambassador

“Survivor: Africa” winner, Ethan Zohn,

knows the true meaning of adventure.

So, it’s no surprise that after being

diagnosed with a rare form of cancer,CD 20+ Hodgkins Lymphoma, and living

to tell the tale, that he continues his

crusade to help make a difference in the

lives of others. A self-proclaimed “soccer

crazy, cancer crusher and big dreamer,”

Ethan has agreed to speak out on behalf of 

Gabrielle’s Angel Foundation as an “Angel

Ambassador.” As an “Angel Ambassador,”

Ethan will share the latest Foundation

news through his vast reach in the media

andspeak from his experienceas a cancer

survivor. He will also attend various

Foundation functions throughout the

year to impress upon a wider audience the

urgent need for funding cancer research.

His charitable work speaks for itself. After winning “Survivor: Africa” in

2001, Ethan Co-Founded Grassroots Soccer, a nonprofit organization

that trains professional soccer players to teach African children, through a

tailor-made curriculum, about HIV/AIDS prevention. His desire to change

the world extends to other charities, as well, including America Scores and

the Elizabeth Glazer Pediatric AIDS Foundation. Ethan has been recognized

for his philanthropic efforts by the International Association of Physicians

in AIDS Care, received the Heroes Among Us Award from the Boston

Celtics and many others. He works with the Alliance for Global Conser-

vation to raise awareness of the links between international conservation

and treatments for deadly diseases and, like Co-Founder Denise Rich,

Ethan pens a column for Tonic.com.

Gabrielle Rich Aouad believed that “Life is an adventure, a quest…” Ethan

Zohn lives his life with the passion and drive befitting a true survivor. His

many accomplishments speak to the limitless possibilities one committed

individual can attain. Gabrielle’s Angel Foundation is very grateful to have

this “inspired philanthropist” on its team!

 Follow Ethan on Twitter @EthanZohn or visit him online: www.ezohn.com

“...Since being diagnosed with CD20+

Hodgkins Lymphoma and joining thiselite club that no one asks to belong to...I quickly found, once you’re in, it’s like afamily that doesn’t judge, a communitythat welcomes you with open arms,a village that renews itself through thestrength of numbers.”

ETHAN ZOHN, Angel Ball 2009

“If we didall that wewere truly

capable of,we wouldastoundourselves.”

THOMAS EDISON

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1. Jay Sean rocks the house

2. Andrew Warren & friends

3. Cupcakes courtesy of Crumbs Bake Shop

4. DJ PS1

5. Runway fashion showPhotos: Eugene Mim/PatrickMcMullan.com

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Teens Raise $70,000 for Foundation!

York Prep Junior, Andrew Warren, and a committee of his high-school friends rallied

the troops for the second “Teens Making a Difference” on Friday, May 7th raising an

incredible $70,000.00 for Gabrielle’s Angel Foundation. Sponsored by Rocawear and

espace, the event drew over 300 New York-area high school students dressed to the

nines and ready for a good time.

The excitement began on the red carpet where the teens mingled with celebrities such

as Tinsley Mortimer and Jules Kirby (“High Society”), Mark Indelicato (“Ugly Betty”),

Broadway star Orfeh (Legally Blonde) and Sports Illustrated model Esti Ginsberg.

They munched on delicious donated treats from Pop Burger, Sant Ambroeus, and

Serafina and desserts by TLC’s The Cake Boss and Crumbs while Serendipity 3 served

up their signature frozen hot chocolate. Student DJ Mac Petrycki opened for DJ PS1

who then handed over the spinning duties to DJ Enferno. The DJs kept the dance floor

packed and the crowd went wild when Cash Money/Universal Artist Jay Sean got upand rocked the house with three of his hit singles.

Andrew’s proud parents, longtime Foundation supporters Marcy & Michael, pitched in

with party preparations to help make the event a success. Other parents whose help

was invaluable in the planning and execution were Michael Cohen of the Trump

Organization and Jan Planit who, with student committee member Danielle Brizel, put

on an amazing fashion show. Professional models, including Calvin Klein newbie

Grayson Vaughn, strutted the runway in clothes by Michael Kors, Jill Stuart, Anlo,

Shoshanna, Elizabeth and James, Unk and Will, Calvin Klein, Cynthia Rowley and

more. Foundation Board member, Daniella Rich Kilstock and her husband, Richard

stopped by in support of the event to thank everyone for their efforts. At night’s end,

guests went home with gift bags, underwritten by the Shiboleth family, which included

products from KLS Cosmetics, Neutrogena, Tommy Hilfiger, Pop Chips, Rocawear and

more. The teens’ enthusiasm inspired everyone involved to create another memorablenight for cancer research. Gabrielle’s Angel Foundation has faith that this next generation

of philanthropists will carry on the tradition of giving back as they truly showed what

it means to make a difference in the lives of others.

GABRIELLE’S ANGEL FOUNDATIONWOULD LIKE TO THANK THE FOLLOWINGFOR THEIR GENEROUS SUPPORT:

Food and Beverage underwritten by: Aquaforte

Water, Carlo’s Bake Shop, Crumbs, Pop Burger,

Sant Ambroeus, Serafina, Serendipity 3

Giftbags Courtesy of: The Shiboleth Family

Contents Courtesy of:  Elizabeth Grant

Cosmetics, i[2]y Foundation, KLS Cosmetics,

Neutrogena, Pop Chips, Rocawear, Sephora,

Tommy Hilfiger

Transportation Courtesy of: The Schwartz Family

Security donated by: Mike Zimmet LLC

Fashion Show by: Jan Planit, Planit Management,

LLC, One Model Management, Q Models,

DNA Men, Alice +Olivia, Anlo, Calvin Klein,Cynthia Rowley, Elizabeth & James, Jill Stuart,

Maglia, Michael Kors, Shoshanna, Unk & Will

Stylist: Nikki Diamond

Fashion Assistant: Remy

Hair: Jemma Muradiam & Arte Salon at

Rona Represents

Makeup: Hope Choman

Music Courtesy of: DJ Enferno, DJ PS1, Mac Petrycki

Event Head: Andrew Warren

Co-Chair Committee: Danielle Brizel, Olivia Davis,

Katie Fraguela, Chloe Greisman, Natalie Jackson,

Gaia Matisse, Katie Resnick, Annabel Schwartz,

Karen Shiboleth

Committee Members: Alexa Eshaghian, Allegra

Bliken, Anna Novogratz, Ariella Haase, Avery

Singer, Bella Chartuni, Blayne Planit, Carolina

Bouzan, Chloe Goutal, Elizabeth Hilfiger, Gabe

Iello, Gaby Novogratz, Gaetano Guarducci, Hayley

Helene, Isabella Trent, Jen Alper, Julian Taffel,

 Juliana Hatkoff, Kate Yellin, Kerri Arfa, Leah

Bardwill, Lucille Agapova, Madison Brill, Maggie

Sachs, Makenzie Moon, Molly Brill, Nell Blagg,

Nicole Butler, Nicole Slaine, Rebecca Cher,

Samantha Cohen, Sammy Zaits, Serena Liegey,

Sophie Curtis, Stephanie Rosenfeld, Yael Ginzburg

Special Thanks to: Seth Greenberg, Marcy &

Michael Warren, Jan Planit, Michael Cohen,

Lynne Patton, Larry Goldfarb, Barry Rosenthal,

Amanda Lens and the entire staff at espace.

More 2010 Highlights...

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Grantee Shaves Head in Support of Pediatric Cancer Patients

Dr. Alex Huang has a mission—to find a cure for childhood cancer. That’s why, for the second year in a

row, this 2007 Foundation grantee showed solidarity with his young patients by shaving his head and all

for a very good cause. In conjunction with Team UH Rainbow Babies & Children’s Hospital, Dr. Huang

& his colleagues at Case Western Reserve joined the thousands of volunteers participating in the St.

Baldrick’s Foundation St. Patrick’s Day shave to show compassion for these children who typically lose

their hair during treatments. The Rainbow Babies & Children's Hospital Team, with seventeen participants,

raised nearly $19,000 earning them the honor of #1 Team in the City of Cleveland. Dr. Huang led them

in fundraising by bringing in over $4000. His lab will continue to accept donations through the end of  June with all proceeds directly benefiting their research.  As of press time, St. Baldrick’s Foundation

experienced a record-breaking year raising over $19.3 million for childhood cancer research.   In the

United States, more children die of childhood cancer than any other disease. As a physician, Dr. Huang

works tirelessly so that there will come a day when he can follow the sentence “Your child has cancer…”

with the words “We have a cure.” As a parent, Dr. Huang prays for the success of this mission every day.

To make a donation to Dr. Huang’s team or for more information on his research, visit www.huanglab.com

Foundation Grantee Awarded Million DollarGrant from NIH

2007 Foundation Grantee, James C. Mulloy, Ph.D.of Cincinnati Children’s Hospital Medical Center

and his colleague Yi Zheng, Ph.D. recently received a

five-year award totaling $1.04 million from NIH’s

National Cancer Institute for their grant entitled

“Targeting CDC42 in Leukemia Stem Cells.” The

scientists are part of the Cancer and Blood Diseases

Institute at Cincinnati Children’s and its division of 

Experimental Hematology/Cancer Biology.

Dr. Mulloy’s research has shown that human blood stem cells can be induced to

make leukemia upon introduction of a leukemia oncogene into these cells. His

laboratory developed a novel mouse model of acute myeloid leukemia (or

AML), one of the first models that use human cells rather than mouse cells to

produce leukemia. Dr. Mulloy's discovery heralded a significant advance for thefield of leukemia biology, since the signals that are important in mouse cancer

can be different from the signals needed for human cancer. With funding from

Gabrielle's Angel Foundation, his laboratory has used this model system to test

novel therapeutic approaches targeted to the key events that occur during the

development of leukemia.

According to the press release from Cincinnati Children’s, the focus of Dr.

Mulloy’s NIH-NCI studies (research into CDC42) “… involves a protein that

normally is crucial to cell adhesion, survival and migration. Scientists have

learned that under certain conditions CDC42 stimulates development of disease

initiating cells in bone marrow and leukemia stem cells, which they believe can

fuel prolonged disease, relapse and mortality.” Ultimately, the goal of Dr.

Mulloy’s newly funded research is to develop a new therapeutic strategy for

targeting CDC42 to eliminate leukemia stem cells in bone marrow for leukemiasthat are resistant to conventional chemotherapies.

“We’re really excited about this novel approach to cancer therapy,” remarked

Mulloy on this five-year grant. “We expect that inhibition of CDC42 will pro-

mote the release of leukemia stem cells from the bone marrow and make them

more susceptible to chemotherapy.” He emphasized the important role his 2007

grant from the Foundation played in these discoveries stating, “The funding

from Gabrielle’s Angel Foundation gave me the flexibility to put some resources

into these other studies. I want to thank you again for investing in me and my

work. It really does make a difference.” Gabrielle’s Angel Foundation wishes Dr.

Mulloy and his team continued success in their efforts to find better treatments

for those living with AML.

New Addition toMedical Advisory Board

Gabrielle’s AngelFoundation for

Cancer Research

proudly welcome

Carl H. June, M.D

to its Medical

Advisory Board.

 June, the Director

of Translational

Research at the Abramson Cancer Center

at the University of Pennsylvania and an

investigator with the Abramson Family

Cancer Research Institute, joins the

Foundation’s team of nine of the nation’s

top scientific researchers. Dr. Junemaintains a research laboratory that studie

various mechanisms of lymphocyte

activation as they relate to immune

tolerance and adoptive immuno-therapy.

He has co-authored more than 250 peer-

reviewed publications and is the recipient

of numerous awards, including the Frank

Brown Berry Prize in Federal Medicine

(1997), the William Osler Award (2002),

and the Bristol-Myers Squibb Freedom to

Discover Award (2005—2009). Dr. June

currently serves as President of the Clinica

Immunology Society. After graduating

from the Naval Academy in Annapolis,Maryland, and Baylor College of Medicine

in Houston, Texas, Dr. June completed his

graduate training in immunology at the

World Health Organization in Geneva,

Switzerland. He then went on to pursue

postdoctoral training in transplantation

biology and medical oncology at the Fred

Hutchinson Cancer Research Center in

Seattle, Washington. Gabrielle’s Angel

Foundation considers Dr. June a valuable

and exceptional addition to its team.

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News in Brief 

 ANGE L BRACELETS SP ECIA L!Catherine M. Zadeh wants to help change the

world one bracelet at a time. Luckily for

Foundation supporters, her unique creation

made expressly for Gabrielle’s Angel

Foundation is available for purchase now at

half the price! “Gabrielle’s Angel Bracelet,”

part of her “Live and Let Live” campaign, isa beautiful sterling silver wing design set

elegantly on a simple black cord. Normally

retailing for $100.00, the Foundation is

making available limited quantities for $50.00

All proceeds help to fund the cutting-edge

research projects for which Gabrielle’s

Angel Foundation is known. To order you

or your loved one this exquisite expression

of hope, please call the Foundation

directly at (646) 861-2033.

EVERY NOTE COUNTS!In conjunction with the Memorial Sloan-Kettering Cancer Center’s Integrative

Medicine Department, Gabrielle’s Angels Music Therapy team brings the

healing power of music to oncology patients and their families (Inspirations

Volume 16, Winter 2009). This amazing group of trained therapists brings

hope and comfort to patients at their bedside and in pre-surgical settings. The

buttons worn in this photo use the Foundation’s purple and red colors and read,

“Brought to you by Gabrielle’s Angels and the MSKCC Music Therapy Program.”

The Foundation proudly supports this vital service. (Left to right) Taryn Thomas

(piano keyboard), Holly Mentzer (harp), Karen Popkin (guitar), Alessandro

Ricciarelli (guitar), Candia Bouzioti (djembe), Kate Beever (barred percussion).

Find us, Follow us, Become a Fan

Gabrielle’s Angel Foundation has a

Facebook Fan Page and a

Twitter feed @CureCancerNow!

Get up-to-the-minute news from

Gabrielle’s Angel Foundation online!

www.gabriellesangels.org

Did you know…

10 of our Foundation grantees were previously awarded

American Society of Hematology Young Scholar Awards?

“Somewhere, something incredible is waiting to be known.”CARL SAGAN