Andrea Galvis, MD 1 , 3 Ivan Ossma Gomez,MD MPH 1 , 2
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Long-Term Quantitative Analysis of Posterior Capsule Opacification After Implantation of Dual-Optic Accommodating IOLs Andrea Galvis, MD 1 , 3 Ivan Ossma Gomez,MD MPH 1 , 2 1 Fundación Valle del Lili Cali, Colombia 2 Universidad Industrial de Santander Bucaramanga, Colombia 3 Fundación Oftalmológica de Santander Bucaramanga, Colombia Authors are clinical investigators for the Synchrony Dual Optic Accommodating IOL
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Long-Term Quantitative Analysis of Posterior Capsule Opacification After Implantation of Dual-Optic Accommodating IOLs. Andrea Galvis, MD 1 , 3 Ivan Ossma Gomez,MD MPH 1 , 2 1 Fundación Valle del Lili Cali, Colombia 2 Universidad Industrial de Santander Bucaramanga, Colombia - PowerPoint PPT Presentation
Transcript of Andrea Galvis, MD 1 , 3 Ivan Ossma Gomez,MD MPH 1 , 2
Long-Term Quantitative Analysis of Posterior Capsule Opacification After Implantation of Dual-Optic Accommodating IOLs
Long-Term Quantitative Analysis of Posterior Capsule Opacification After Implantation of Dual-Optic Accommodating IOLs
Andrea Galvis, MD 1 , 3 Ivan Ossma Gomez,MD MPH 1 , 2
1 Fundación Valle del Lili Cali, Colombia2 Universidad Industrial de Santander Bucaramanga, Colombia3 Fundación Oftalmológica de Santander Bucaramanga, Colombia
Andrea Galvis, MD 1 , 3 Ivan Ossma Gomez,MD MPH 1 , 2
1 Fundación Valle del Lili Cali, Colombia2 Universidad Industrial de Santander Bucaramanga, Colombia3 Fundación Oftalmológica de Santander Bucaramanga, Colombia
Authors are clinical investigators for the Synchrony Dual Optic Accommodating IOLAuthors are clinical investigators for the Synchrony Dual Optic Accommodating IOL
Synchrony Dual Optic Synchrony Dual Optic Accommodating IOLAccommodating IOL
Fills the capsular bag
Designed to provide accommodation via forward movement of the anterior optic
Potential for movement could be impaired by capsule opacification
ACO
PCO
Fills the capsular bag
Designed to provide accommodation via forward movement of the anterior optic
Potential for movement could be impaired by capsule opacification
ACO
PCO
Galvis et al
Clinical Experience Clinical Experience SynchronySynchrony
Good unaided distance, intermediate and near visual function 1,2,3
Subjective and objective evidence of accommodative amplitude 4,5,6
Stability of over 2 years 1,2
Low PCO rates 7
Functional range of vision exceeding that of multifocals 8
Good unaided distance, intermediate and near visual function 1,2,3
Subjective and objective evidence of accommodative amplitude 4,5,6
Stability of over 2 years 1,2
Low PCO rates 7
Functional range of vision exceeding that of multifocals 8
1 Alarcon et al. ESCRS London 20062 Ossma et al. ASCRS San Francisco 20063 Beiko G. ESCRS London 20064 Ossma et al. ASCRS San Diego 20045 Galvis et al. ASCRS Washington 20056 Bohorquez et al. ESCRS London 20067 Galvis et al. ESCRS Berlin 20088 Ossma et al. ASCRS Chicago 2008
1 Alarcon et al. ESCRS London 20062 Ossma et al. ASCRS San Francisco 20063 Beiko G. ESCRS London 20064 Ossma et al. ASCRS San Diego 20045 Galvis et al. ASCRS Washington 20056 Bohorquez et al. ESCRS London 20067 Galvis et al. ESCRS Berlin 20088 Ossma et al. ASCRS Chicago 2008
Galvis et al
Rabbit Studies*Rabbit Studies*
*Werner et al. JCRS 2004; 1114-23 *Werner et al. JCRS 2004; 1114-23
Synchrony Plate Haptic IOL
Difference in PCO
Synchrony 0.714 ± 0.751
Plate haptic IOL 3.142 ± 0.899
Difference in PCO
Synchrony 0.714 ± 0.751
Plate haptic IOL 3.142 ± 0.899
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Study DesignStudy Design
Prospective Observational Analytical Study
3 Groups
Synchrony IOL Implantation (43 eyes)
Alcon SN60D3 (42 eyes)
Alcon SN60AT Implantation (54 eyes)
Prospective Observational Analytical Study
3 Groups
Synchrony IOL Implantation (43 eyes)
Alcon SN60D3 (42 eyes)
Alcon SN60AT Implantation (54 eyes)
Galvis et al
Study DesignStudy Design
Digital retroillumination photographs (3,6,12 and 24 months)
Evaluate incidence PCO
OSCA System
Evaluate incidence ACO
Photography grading one observer
Digital retroillumination photographs (3,6,12 and 24 months)
Evaluate incidence PCO
OSCA System
Evaluate incidence ACO
Photography grading one observer
Galvis et al
OSCAOSCA (Open Access Systematic Capsule (Open Access Systematic Capsule Assessment)Assessment)
¹ Aslam et al. BMC Ophthalmology 2005, 5:9
² Aslam et al. BMC Ophthalmology 2006, 6:30
³ Paton et al. BJO 2002, 86:1181-87
¹ Aslam et al. BMC Ophthalmology 2005, 5:9
² Aslam et al. BMC Ophthalmology 2006, 6:30
³ Paton et al. BJO 2002, 86:1181-87
Aslam et al. ¹-²-³
Based on texture analysis
Objective
Valid
Reliable
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Study PopulationStudy Population
SynchronSynchrony y
(n=43)(n=43)
SN60D3SN60D3(n=42)(n=42)
SN60ATSN60AT(n=54)(n=54) **
Age68.8 ± 5.4
68.5 ± 5.4
70.1 ± 5.6
p=0.55
Residual RefractionDefocus Equivalent
0.32 ± 0.153
0.22 ± 0.184
0.20 ± 0.157
p=0.48
* Kruskal Wallis Analysis of Variance
* Kruskal Wallis Analysis of VarianceGalvis et al
ResultsResults
Alcon SN6AD321.3 months postop
Alcon SN6AD321.3 months postop
Synchrony20.7 months postop
Synchrony20.7 months postop
Alcon SN60AT21.1 months postop
Alcon SN60AT21.1 months postop
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CLINICALLY SIGNIFICANT PCO
OSCA Score EvolutionOSCA Score
p=0.38p=0.27
p=0.83
Mann-Whitney Test
p=0.41
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Anterior Capsule OpacificationMonth 12
SynchronySynchronyn=43n=43
SN60D3SN60D3n=42n=42
SN60ATSN60ATn=54n=54
None - Mild 40(93.1%)
35(83.3%)
47(87%)
Moderate 3(6.9%)
7(16.7%)
6(11.1%)
Severe 0 0 1(1.9%)
Fisher’s Exact Test p=0.37
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ConclusionConclusion
Elements in design of Synchrony Dual Optic Accommodating Intraocular Lens
Minimize ACO
Minimize PCO
Synchrony Dual Optic Accommodating IOL
PCO Rates comparable to those of acrylic monofocal and multifocal IOLs
Elements in design of Synchrony Dual Optic Accommodating Intraocular Lens
Minimize ACO
Minimize PCO
Synchrony Dual Optic Accommodating IOL
PCO Rates comparable to those of acrylic monofocal and multifocal IOLs
Galvis et al
