Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne...

8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis

1/31

Lelcror kg gkxdlc`nm`n oe hckk` kg xlpr`~xoef le` lgpnx oemlclpoke n}ykr~xn

Rykerkx1

Xnrnlxbm clhkxlpkx1

Y%K% Hk} =002699 LW QnorpPmn Enpmnxcle`r

P *2< == =77 8= 99oegkIpek%pxorjncoke%ecvvv%pxorjncoke%ec

Yxnrnepnx1

@x% L%A% Jcnoeeoanem~or


2/31

Oepxk`~bpoke

Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg rnx~d lch~doele` oe hckk`

MYCB$DR dnpmk` `nwnckydnep gkxdlc`nm`n oe hckk`

Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr

K~pcoen


3/31

Gkxdlc`nm`n -GL/ or r~rynbpn` kg hnoef lrrkbolpn` vopm cn~jndol%

Ykrrohcn dnbmleord1 GL nepnxr pmn hckk` lgpnx oemlclpoke le` or lhcn pk xnlbm pmnhken dlxxkv%

GkxdlBlxn xn|~nrpn` PEK Pxorjncoke pk oewnrpoflpn vmnpmnx GL ble nepnx pmnhckk` rpxnld wol oemlclpoke%

GL or le ne`kfnek~r bkdyk~e` vopm l bkebnepxlpoke kg 8$2 df+C oe hckk` le` mlrl rmkxp mlcg cogn%

Pmn dkrp kbb~xxoef n}ykr~xn xk~pn gkx GL or oemlclpoke% Yxnwok~r oemlclpoke rp~`onr

mlwn rmkve ek xlorn` GL cnwnc oe pmn hckk` kg n}ykrn` leodlcr%

Oepxk`~bpoke -


4/31

Oepxk`~bpoke -8/

Lrr~dypoke1 nopmnx GL bleekp nepnx pmn hckk` wol oemlclpoke kx hckk` bkebnepxlpoker

xnp~xe pk pmnox ymrokckfoblc wlc~n wnx glrp -ek bkebnepxlpoke oebxnlrn `npnbplhcn/%

PEK Pxorjncoke `nwnckyn` l ekwnc# rneropown dnpmk` gkx rncnbpown `npnbpoke kgn}kfnek~r GL oe hckk`%

Pk `orpoef~orm n}kfnek~r GL le` ne`kfnek~r GL op vlr `nbo`n` pk n}ykrn xlpr pk


5/31

Oepxk`~bpoke

Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg rnx~d lch~doe

le` oe hckk`



K~pcoen


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Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg RL -


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Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg RL -8/

Gxnn GL oe pmn yxnrnebn kg hkwoen rnx~d lch~doe -HRL/1

Pmn bkebnepxlpoke kg GL vlr df+C

Pmn bkebnepxlpoke kg HRL vlr 0> f+C oe ymrokckfoblcrlcoen

Pmn do}p~xnr vnxn oeb~hlpn` gkx 80 mk~xr

Lp p49 pmn xnbkwnx vlr ==. le` fxl`~lcc `nbxnlrn` pk6>. lgpnx 80$mx oeb~hlpoke%

45 ^y pk 8>. kg pmn GL hoe`r pk HRL


8/31

Xnbkwnx kg GL gxkd l >% f+C HRL oe @YHR%

Podn f+C


Lp p49 pmn xnbkwnx vlr ?>. vopm XR@ 3 0. le` vlrrpocc 5?9. lgpnx 80$mx oeb~hlpoke%

45 GL mlx`c hoe`r pk XRL -3 >./


10/31

Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg RL ->/

Gxnn GL oe pmn yxnrnebn kg m~dle rnx~d lch~doe -MRL/1

Pmn bkebnepxlpoke kg GL vlr < le` /

Pmn bkebnepxlpoke kg MRL vlr 0> f+C


Lp p49 pmn xnbkwnx vlr 66. vopm XR@ 3 >. le` vlr>9. lgpnx 80$mx oeb~hlpoke%

45 ^y pk >9. kg pmn GL hoe`r pk MRL


11/31

Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg RL -7/

ên}ynbpn`c# pmnxn or l òggnxnebn oe GL hoeòef hnpvnne HRL#

XRL le` MRL

Hoeòef oe`nyne`nep kg GL bkebnepxlpoke

XRL mlx`c hoe`r GL# HRL ~y pk 8>. le` MRL ~y pk >9.

Ykrrohcn n}yclelpoke1

Rpx~bp~xlc oggnxnebnr# lcpmk~fm pnxpolx rpx~bp~xn or mofmc

bkernxwn` @oggnxnep ykrppxlerclpokelc dkògoblpoker


12/31

Gxnn gkxdlc`nm`n oe hckk` -6/

Pmn GL bkebnepxlpoke oe hclej xlp hckk` yclrdl vlr ckv% Pmn GLbkebnepxlpoke oe hclej hckk` yclrdl le` mndkcrlpn rcofmpc `nbxnlrn`

`~xoef df+C GLle` oeb~hlpn` gkx < mx lp XP%

Gkxpogon` GL vlr xnclpownc rplhcn oe hckk` yclrdl%

Gkxpogon` GL bkebnepxlpoke xlyo`c `nbxnlrn` oe mndkcrlpn%

Lgpnx gkxpogoblpoke kg vmkcn hckk`# ek gxnn GL vlr `npnbpn` oe hckk` yclrdl

kx mndkcrlpn% GL rnndr pk xlyo`c dofxlpn pk pmn xn` hckk` bnccr le` hn`nfxl`n`+hk~e` d~bm glrpnx pmle pmn lcxnl` yxnrnep ne`kfnek~r GL%


13/31

Oepxk`~bpoke


le` oe hckk`



K~pcoen


14/31

Lelcpoblc bmlccnefn1 GL or le ne`kfnek~r bkdyk~e`% N}kfnek~r

le` ne`kfnek~r GL rmk~c` hn `orpoef~ormn`%

Rkc~poke

Clhncn`


15/31

Yxkykrn` dnpmk`1 `nxowlpoqlpoke vopm @EYM le` MofmYnxgkxdlebn Co|~o` Bmxkdlpkfxlym Dlrr Rynbpxkdnpx -MYCB$

DR/ lgpnx mn}len n}pxlbpoke% @nyxkpkelpn` GL$@EYM -d+q 89?/`nxowlpown vocc hn `npnbpn`%

MYCB$DR

MYCB$DR dnpmk` `nwnckydnep gkxdlc`nm`n oe hckk` -8/


16/31

Pk `orpoef~orm n}kfnek~r le` ne`kfnek~r GL oe hckk` pmn orkpkyob

xlpok kg pmn `nyxkpkelpn` @EYM `nxowlpown -d+q 89?+8


17/31

Lelcpoblc bmlccnefn1 GL or xlyo`c dnplhkcoqn` le`+kx xlyo`c hoe`r

pk GL$lbbnypkxr oe hckk` 45 ckv xnbkwnx

Rkc~poke

N}ynxodneplc yxkbn`~xn vlr kypodoqn` 45 @nxowlpoqlpoke vopmoe 2doe~pnr

Ckv xnbkwnx bk~c` ekp hn rkcwn` bkdycnpnc# xnynlplhocop vlrkypodoqn`1

Glrp le` xnynlplhcn rldycn yxnylxlpoke -en}p pk n}ykrn`xlpr/ Orkpkyob `orpxoh~poke or ekp lggnbpn` h xnbkwnx



18/31

Lelcpoblc bmlccnefn1 rneropowop 45 n}kfnek~r -clhncn`/ GL rmk~c`

hn `npnbpn` lr rneropownc lr ykrrohcnRkc~poke

L``opoke kg


19/31


Xnbkwnx gxkd ymrokckfoblc rlcoen vlr hnpvnne =? le` ?2. lp le` 6?. lp


20/31


Goelc dnpmk`1

L`` 899 c vmkcn hckk` pk >99 c N@PL rkc~poke -lepo$bklf~cleple` mndkcror/

L`` 899 c mndkcrlpn pk > dc 8#0$@EYM rkc~poke oe lbnpkeopxocnbkeploeoef ynxbmckxob lbo`

Xnlbp gkx doe lp XP le` wkxpn}

Bnepxog~fn $0> . lp 8$7 df+C cnwnc vopm

XR@ 3 6.%

@~n pk fkk` xnynlplhocop dnpmk` or r~oplhcn gkx |~lepoplpown lelcror


21/31

Oepxk`~bpoke


le` oe hckk`



K~pcoen


22/31

Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr - dc 8#0$@EYM rkc~poke oe lbnpkeopxocn

bkeploeoef ynxbmckxob lbo`Xnlbp gkx doe lp XP le` wkxpn}

Bnepxog~fn


23/31

Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr -8/

Dnpmk` wlco`lpoke rnp ~y -orkpkyob òrpxoh~poke/1

$Orkpkyob òrpxoh~poke `npnxdoen` gkx 7 òggnxnep xlpr1 . bkego`nebn oepnxwlc1 8 }


24/31



25/31


Dnpmk` wlco`lpoke rnp ~y -GL |~lepogoblpoke oe hckk`/1

Coenlx blcohxlpoke b~xwn 8%>$8>9 f+C -x 5 9%??7/ Xnbkwnx GL 2>$0>.

Xnynlplhocop 3 6. gxkd ne`kfnek~r 7 df+C gkxpogoblpoke cnwnc

Ckv xnbkwnx xngcnbpr ldk~ep kg gxnn GL oe hckk`# ek bkxxnbpoke

Blcohxlpoke b~xwn GL$@EYM -MYCB$DR/

9%9N*99

8%9N*9>

2%9N*9>

0%9N*9>

>%9N*9>

7%9N*9>

9 >9 9 299

Bkebnepxlp oke GL$@EYM# n}yxnrrn` lr GL -f+C/

Ynljlxnld+q89?4589?-lxhopxlxy

~e

opr/


26/31

Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr ->/

Dnpmk` wlco`lpoke rnp ~y -Rplhocop GL oe hckk` n}pxlbp/1

@~xoef rpkxlfn lp 8$


27/31


Oemlclpoke rp~` rnp ~y1

Ryxlf~n @lvcn xlpr -


28/31


Xnr~cpr1

Pmn lox bkebnepxlpoke vlr lr n}ynbpn`% Pndynxlp~xn vlr 88%8B -R@ 0%9 . -R@ 2%>/%

Pmn `npnxdoen` orkpkyob xlpokr `o` ekp `oggnx rofeogoblepc gxkdwlco`lpoke rnp -


29/31

Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr -=/

Xnr~cpr1

Pmnxn vlr ek oebxnlrn oe hckk` GL bkebnepxlpoke `~xoefn}ykr~xn% Pmn kwnxlcc dnle `npnxdoen` bkebnepxlpoke vlr8%2 df+C%

Hngkxn n}ykr~xn1 8%6 df+C @~xoef n}ykr~xn 2 mxr1 8%7 df+C

@~xoef n}ykr~xn 7 mxr1 8%9 df+C

Lgpnx n}ykr~xn


30/31

Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr -?/

@orb~rroke le` bkebc~roke1

Pmn lelcpoblc dnpmk` vlr blylhcn kg `npnbpoef . n}kfnek~r


31/31

Lbjekvcn`fndnepr

PEK Pxorjncoke1

Xknc Nefnc_wkeen RpllcMler D~oarnxNwnxp @~orpnxdllp

PEK1X~~` Vk~pnxrne

GkxdlBlxn1Mnoeq$Ynpnx Fnchjn

\~nrpoker;;

Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne...

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