ADVANCES IN MUCOSALINIMUNOLOGYPart A

Jiri Mestecky,

Helena Tlaskalovä-Hogenovä

PART A

B AND T CELLS OF THE MUCOSAL IMMUNE SYSTEM :TRAFFICKING AND CYTOKINE REGULATIO N

INDUCTION AND RECALL OF THE SECONDARY IMMUNE RESPONS EENTIRELY IN TISSUE CULTURE 1

J . Sterzl, J . Milerova, L. Mackova, and J . Travnice k

IN VIVO SWITCHING: IDENTIFICATION OF GERMLINE TRANSCRIPTSFOR HUMAN IgA 9

C .I .E . Smith, B . Baskin, E . Pattersson, L . Hammarstrom, and K .B. Islam

ANALYSIS OF THE SECOND MESSENGER SYSTEMS INVOLVE DIN THE SYNERGISTIC EFFECT OF CHOLERA TOXIN AND INTER -LEUKIN-4 ON B CELL ISOTYPE-SWITCHING 1 5

N. Lycke

TRANSFORMING GROWTH FACTOR BETA (TGF[3) DIRECTS IgA lAND IgA2 SWITCHING IN HUMAN NAIVE B CELLS 2 1

F . Briere, T . Defrance, B . Vanbervliet, J .-M. Bridon, I . Durand ,F . Rousset, and J . Banchereau

LYMPHOKINE mRNA EXPRESSION IN THE HUMAN INTESTINA LMUCOSA AND PBL DETERMINED BY QUANTITATIVE RT/PCR 2 7

L. Braun-Eiwert, G .E. Muffin, and S.P . Jame s

REGULATION OFT CELL REACTIVITIES BY INTESTINALMUCOSA 3 1

L. Qiao, G. Schürmann, S .C . Meuer, R . Wallich, A . Schirren ,and F. Autschbach

VECTOR-ENCODED INTERLEUKIN-5 AND INTERLEUKIN- 6ENHANCE SPECIFIC MUCOSAL 1M MUNOGLOBULIN AREACTIVITY IN VIVO 3 5

A.J . Ramsay

PERSISTENT IN VIVO ACTIVATION AND TRANSIENT ANERGY T OTCR/CD3 STIMULATION OF NORMAL HUMAN INTESTINA LLYMPHOCYTES 43

R. DeMaria, S . Fais, and R . Test i

FUNCTIONAL LACTOFERRIN RECEPTORS ON ACTIVATE DHUMAN LYMPHOCYTES 47

M.-L. Hammarström, L . Mincheva-Nilsson, and S . Hammarström

SUBSTANCE P PROMOTES PEYER'S PATCH AND SPLENIC B CELLDIFFERENTIATION 5 5

D.W. Pascual, K.W. Beagley, H . Kiyono, and J .R. McGhee

THE MIGRATION OF PERITONEAL CELLS TOWARDS TH EGUT 6 1

T. Sminia, M. Soesatyo, M . Ghufron, and T . Thepen

HML-1, A NOVEL INTEGRIN MADE OF THE 07 CHAIN AND OF ADISTINCTIVE a CHAIN, EXERTS AN ACCESSORY FUNCTION INTHE ACTIVATION OF HUMAN IEL VIA THE CD3-TCR PATHWAY 67

B . Begue, S . Sarnacki, F . Deist, H. Buc, J . Gagnon, T . Meo ,and N. Cerf-Bensussan

PHENOTYPE OF HML-1-POSITIVE AND HML-1-NEGATIVE TLYMPHOCYTES IN THE HUMAN INTESTINAL LAMINA PROPRIA 77

H.L . Schieferdecker, D.C. Schmidt, R. Ullrich, H.-U . Jahn ,H . Hirseland, and M . Zeitz

ADHERENCE OF PORCINE PEYER'S PATCH, PERIPHERAL BLOODAND LYMPH NODE LYMPHOCYTES TO PEYER'S PATCH LAMIN APROPRIA 8 1

A. Kadioglu and P . Sheldo n

ASSESSMENT OF ENGRAFTMENT AND FUNCTION OF HUMANTONSILLAR AND BLOOD MONONUCLEAR CELLS IN IMMUNO-DEFICIENT MICE 8 5

B. Albini, D . Nadal, C. Chen, E . Schlapfer, B .K. Mookerjee ,T . Stulnig, P .L. Ogra, G. Wick, and S .A. Cohen

EXPRESSION OF VLA-4 AND L-SELECTIN IN HUMAN GUT -ASSOCIATED LYMPHOID TISSUE (GALT) 9 1

I .N . Farstad, T .S . Halstensen, D . Kvalel, O . Fausa, andP. Brandtzaeg

COMPARTMENTALIZATION WITHIN THE COMMON MUCOSA LIMMUNE SYSTEM 9 7

Z. Moldoveanu, M .W. Russell, H .Y. Wu, W .-Q. Huang ,R.W. Compans, and J . Mestecky

INTRAPERITONEAL ADMINISTRATION OF TETANUS TOXOI DELICITS A SPECIFIC RESPONSE OF ANTIBODY-SECRETIN GCELLS IN THE PERITONEAL CAVITY 103

C . Lue, A.W.L. van den Wall Bake, S .J . Prince, B .A. Julian ,M. Tseng, C .O. Elson III, H.H. Hale, and J . Mestecky

THE COLON AND RECTUM AS INDUCTOR STYES FOR LOCAL AN DDISTANT MUCOSAL IMMUNITY 10 7

B. Haneberg, D. Kendall, H .M. Amerongen, F .M. Apter, andM.R. Neutra

A BASEMENT MEMBRANE MOLECULE PREFERENTIALL YASSOCIATED WITH MUCOSAL POST-CAPILLARY VENULES 11 1

T. Hussell, P .G. Isaacson, and J . Spencer

ANALYSIS OF INTRAEPITHELIAL LYMPHOCYTES AND PEYER' SPATCH LYMPHOID TISSUE IN TCR-ALPHA KNOCKOUT MICE 11 7

J. Viney, K. Philpott, and M. Owen

INTESTINAL T CELLS IN CD8a KNOCKOUT MICE AND T CELLRECEPTOR TRANSGENIC MICE 12 1

W.-P. Fung-Leung, K . Kishihara, D . Gray, H.-S . Teh ,C .Y. Lau, and T .W. Mak

ANALYSIS OF INTESTINAL INTRAEPITHELIAL LYMPHOCYTE(IEL) T CELLS IN MICE EXPRESSING ANTI-CD8 IMMUNO-GLOBULIN TRANSGENES 12 5

W.K. Aicher, H. Eibel, K. Fujihashi, T . Boehm, K.W. Beagley ,J .R. McGhee, and H . Kiyon o

EFFECT OF NEONATAL THYMECTOMY ON MURINE SMALLINTESTINAL INTRAEPITHELIAL LYMPHOCYTES EXPRESS-ING T CELL RECEPTOR aß AND "CLONALLY FORBIDDEN Vßs" 12 9

T. Lin, H. Takimoto, G . Matsuzaki, and K. Nomoto

DESIALYLATION OF RAT INTRAEPITHELIAL LYMPHOCYTES :EFFECTS ON PROLIFERATION AND DIPEPTIDYL PEPTIDASEIV ACTIVITY 13 3

P.N. Boyaka, M . Coste, and D . Tom e

MINIMAL SIGNAL REQUIREMENTS FOR SUPERANTIGEN-SPECIFICT CELL-DRIVEN B CELL PROLIFERATION 13 7

G.D. Wetzel

EXPRESSION OF CELL ADHESION MOLECULES IN THE FETA LGUT 14 1

A. Dogan, T . T . MacDonald, and J . Spencer

A ROLE FOR ANTIGEN IN THE EVOLUTION OF GASTROINTES -TINAL MALT-TYPE B CELL LYMPHOMA 14 5

T. Hussell, P .G. Isaacson, and J . Spencer

IN VIVO PROLIFERATION OF T AND B LYMPHOCYTES IN TH EEPITHELIUM AND LAMINA PROPRIA OF THE SMALL INTESTINE 149

H. J . Rothkötter, T . Kirchhoff, and R . Pabst

CYTOTOXIC ACTIVITY OF T CELLS EXPRESSING DIFFERENT T CELLRECEPTOR VARIABLE GENE PRODUCTS IN THE INTESTINA LMUCOSA 15 1

M.E. Baca-Estrada and K . Croitoru

B-CELL PROMOTING ACTIVITY OF HUMAN COLOSTRUM 15 3

I .I . Slukvin, V .V. Pilipenko, V .P. Chernyshov, and A .A. Philchenkov

EXPRESSION OF ADHESION MOLECULES ON THE SURFACE OFMALIGNANT CELLS AND CELL LINES 15 9

J. Marinov, K. Koubek, and J . Stary

ERGOT ALKALOID-INDUCED CELL PROLIFERATION, CYTO-TOXICITY, AND LYMPHOKINE PRODUCTION 16 3

A. Fiserovä, G . Trinchieri, S . Chan, K . Bezouska, M . Flieger ,and M. Pospisi l

EFFECT OF CORTICOSTEROID ON LYMPHOCYTE ADHESION

167

D. Pearson and P. Sheldo n

ADHERENCE OF RHEUMATOID LYMPHOCYTES TO ENDOTHELIU MOF LAMINA PROPRIA 17 1

A. Kadioglu and P. Sheldo n

NON-LYMPHOID CELLS OF THE MUCOSAL IMMUNE SYSTEM :EPITHELIAL CELLS, APC, AND OTHER CELL TYPES

EXPRESSION OF SC, IL-6 AND TGF-131 IN EPITHELIAL CELLLINES 17 5

I. Moro, T. Takahashi, T . Iwase, M. Asano, N. Takenouchi, S .Nishimura, I . Kudo, P. Krajci, P . Brandtzaeg, Z. Moldoveanu ,and J . Mesteck y

BUTYRATE DIFFERENTIALLY AFFECTS CONSTITUTIVE AND CYTO-KINE-INDUCED EXPRESSION OF HLA MOLECULES, SECRETOR YCOMPONENT (SC), AND ICAM-1 IN A COLONIC EPITHELIAL CEL LLINE (HT-29, clone m3) 18 3

D. Kvale and P . Brandtzaeg

CYTOKINES INDUCE AN EPITHELIAL CELL CYTOKIN ERESPONSE 18 9

S . Hedges, M. Svensson, W . Agace, and C . Svanborg

MODULATION OF THE MHC CLASS I AND II MOLECULES B YBACTERIAL PRODUCTS ON INTESTINAL EPITHELIAL CELLS 195

E.J . Schiffrin, Y. Borel, and A. Donnet-Hughe s

THE EFFECT OF MEDIUM DERIVED FROM ACTIVATE DPERIPHERAL BLOOD MONONUCLEAR CELLS ON TW OINTESTINAL CELL LINES 197

U. Kärnström, O . Nora, and H . SjOstri5 m

THE LEUCOCYTE PROTEIN LI (CALPROTECTIN) : A PUTATIVENONSPECIFIC DEFENCE FACTOR AT EPITHELIAL SURFACES 20 1

P . Brandtzaeg, T .-0. Gabrielsen, I . Dale, F . Müller, M. Steinbakk ,and M .K. Fagerhol

DIFFERENTIAL EXPRESSION OF LEUCOCYTE PROTEIN L 1(CALPROTECTIN) BY MONOCYTES AND INTESTINA LMACROPHAGES 207

J. Rugtveit, H. Scott, T .S . Halstensen, O . Fausa, and P. Brandtzaeg

COMPLEMENT COMPONENT C3 PRODUCTION AND ITS CYTOKIN EREGULATION BY GASTROINTESTINAL EPITHELIAL CELLS 21 1

A . Andoh, Y . Fujiyama, T . Bamba, S . Hosoda, and W.R. Brown

THE POLYMERIC IMMUNOGLOBULIN RECEPTOR: SIGNALS FORPOLARIZED EXPRESSION 21 7

O. Poulain-Godefroy, R .P . Hirt, N . Fasel, and J .P. Kraehenbüh l

NEURAL, ENDOCRINE AND IMMUNE REGULATION OF SECRE-TORY COMPONENT PRODUCTION BY LACRIMAL GLAN DACINAR CELLS 22 1

R .W . Lambert, J . Gao, R .S . Kelleher, L .A . Wickham, and D .A. Sulliva n

ANTIGEN PRESENTATION BY A MOUSE DUODENAL EPITHELIALCELL LINE (MODE-K) 22 5

K. Vidal, I . Grosjean, and D . Kaiserlian

THE REGULATION OF IL-6 SECRETION FROM IEC-6 INTESTINALEPITHELIAL CELLS BY CYTOKINES AND MUCOSALLY IMPORTAN TANTIGENS 22 9

D.W. McGee, K.W. Beagley, W.K. Aicher, and J .R. McGhee

EPITHELIAL CELLS IN SOW MAMMARY SECRETIONS

23 3

C. Le Jan

MICRODISSECTED DOMES FROM GUT-ASSOCIATED LYMPHOI DTISSUES : A MODEL OF M CELL TRANSEPITHELIAL TRANSPORTIN VITRO 23 5

Z. Kabok, T .H. Ermak, and J . Papp o

EVIDENCE THAT MEMBRANOUS (M) CELL GENESIS I SIMMUNO-REGULATED 23 9

T.C. Savidge and M .W. Smit h

A CONFOCAL MICROSCOPICAL ANALYSIS OF PEYER'S PATC HMEMBRANOUS (M) CELL AND LYMPHOCYTE INTERACTIONS I NTHE SCID MOUSE 243

T.C. Savidge, M.W. Smith, and P.S . James

THE MODULATION OF CLASS I AND CLASS II MHC MOLECULE SON INTESTINAL EPITHELIAL CELLS AT DIFFERENT STAGES O FDIFFERENTIATION 247

A. Donnet-Hughes, Y . Borel, and E .J . Schiffri n

CRYPTDINS : ENDOGENOUS ANTIBIOTIC PEPTIDES OF SMALLINTESTINAL PANETH CELLS 25 1

S .S .L . Harwig, P .B . Eisenhauer, N.P. Chen, and R .I . Lehre r

PHYSICAL INTERACTION BETWEEN LUNG EPITHELIAL CELL SAND T LYMPHOCYTES 25 7

R. Lutter, B . Bruinier, B .E.A. Ho!, F .H. Krouwels, T.A . Out, an dH.M. Jansen

THE ROLE OF LYMPHO-EPITHELIAL INTERACTION IN TH EREGULATION OF SMALL INTESTINAL EPITHELIUM PRO -LIFERATION 265

A.N. Shmakov, N.G. Panteleeva, A .V. Fedjanov, and V.A. Trufaki n

DENDRITIC CELLS "IN VIVO" : THEIR ROLE IN THE INITIATIONOF INTESTINAL IMMUNE RESPONSES 27 1

L. Liu and G.G. MacPherson

DIRECT MODULATION OF ENTEROCYTE GROWTH BY ACTIVATEDMACROPHAGES 275

A.K . Hutton and A . Mel . Mowat

PENETRATION OF FLUORESCENT NEUTROPHILS THROUG HCULTURED EPITHELIUM STUDIED BY CONFOCAL MICROSCOPY 279

K .H . Peterson, B . Johansson, M . Johansson, and K .E. Magnusson

IMMUNOSTAINING WITH MONOCLONAL ANTIBODIES T OEOSINOPHIL CATIONIC PROTEIN (EG 1 AND EG2) DOES NOTDISTINGUISH BETWEEN RESTING AND ACTIVATED EOSINO -

PHILS IN FORMALIN-FIXED TISSUE SPECIMENS 28 3

F. Jahnsen, T .S . Halstensen, and P . Brandtzaeg

THE ROLE OF MAST CELLS IN INTESTINAL IMMUNO -PHYSIOLOGY 28 7

L. Wang, S . Savedia, M . Benjamin, and M .H . Perdue

MODULATION OF TUMOR NECROSIS FACTOR-ALPHA mRN ALEVELS BY INTERFERONS IN DIFFERENT POPULATION SOF MAST CELLS 293

J .A. Enciso, E .Y. Bissonnette, and A.D. Befu s

AGGREGATION OF THY-1 GLYCOPROTEIN INDUCES TYROSIN EPHOSPHORYLATION OF DIFFERENT PROTEINS IN ISOLATED RA TMAST CELLS AND RAT BASOPHILIC LEUKEMIA CELLS 29 7

L. Dräberovä and P . Drdber

EFFECTS OF SUBDIAPHRAGMATIC VAGOTOMY ON MUCOSA LMAST CELL DENSITIES IN STOMACH AND JEJUNUM OF RATS 30 3

T.P. Gottwald, S . Lhotak, and R .H. Stead

MECHANISMS OF NK RECOGNITION AND ACTIVATION BASE DON LECTIN-SACCHARIDE INTERACTIONS 30 7

M. Pospisil, K. Bezouska, M. Campa, A. Fiserova ,J . Kubrycht, N . Huan, S . Chan, and G. Trinchier i

DETECTION OF CELLS WITH NK ACTIVITY FROM HISTOLOGICALL YNORMAL MUCOSA IN RELATION TO DISEASE 31 3

E.A.F . van Tol, H.W. Verspaget, A .S . Pena, and C .B .H .W. Lamers

EFFECTS OF MESALAZINE ON LAMINA PROPRIA WHITE CEL LFUNCTIONS 31 7

H.W. Verspage t

DEVELOPMENT OF MUCOSAL IMMUNITY : REPRODUCTIVETRACT, ONTOGENY, PHYLOGENY, AND IMMUNODEFICIENC Y

THE SIGNIFICANCE OF CULTIVATING CELLS AND HEMO -POIETIC TISSUE FROM TUNICATES 32 1

E.L . Cooper and D .A . Raftos

PERIENTERAL CHLORAGOGEN TISSUE AND ITS ROLE I NDEFENSE IN LUMBRICID WORMS 32 7

P. Sima, M . Bilej, and J . Slipk a

THE SPLEEN AND ITS COELOMIC AND ENTERIC HISTORY

33 1

P. Sima and J . Slipka

THE FATE OF PROTEIN ANTIGEN IN ANNELIDS - IN VIVO ANDIN VITRO STUDIES 33 5

L. Tuckovä, M. Bilej, and J . Rejnek

HEMOLYTIC FUNCTION OF OPSONIN-LIKE MOLECULES I NCOELOMIC FLUID OF EARTHWORMS 34 1

M. Sinkora, M. Bilej, K. Drbal, and L. Tuckovä

ROLE OF LECTINS (C-REACTIVE PROTEIN) IN DEFENSE O FMARINE BIVALVES AGAINST BACTERIA 34 3

J .A. Olafsen

BACTERIAL ANTIGEN PRIMING OF MARINE FISH LARVAE

34 9

J .A. Olafsen

PHYLOGENY OF THE IMMUNOGLOBLIN JOINING (J) CHAIN 35 3

T. Takahashi, T . Iwase, K. Kobayashi, J . Rejneck, J . Mestecky,and I . Moro

GENITAL-ASSOCIATED LYMPHOID TISSUE IN FEMALE NON -HUMAN PRIMATES 357

T. Lehner, C . Panagiotidi, L .A. Bergmeier, L. Tao, R . Brookes ,A. Gearing, and S . Adam s

IMMUNOMORPHOLOGIC STUDIES OF HUMAN DECIDUA-ASSOCIATED LYMPHOID CELLS IN NORMAL EARL YPREGNANCY 367

L. Mincheva-Nilsson, V . Baranov, M. Mo-Wai Yeung,S. Hammarstrom, and M .-L. Hammarstro m

IMMUNOCYTES AND CELL-MEDIATED IMMUNITY IN THEPATHOLOGY OF REPRODUCTION 373

K. Nouza, R . Kinsky, M. Petrovskä, D. Dimitorv, R . Sedläk ,J . Laitl, and J . Presl

INFLUENCE OF ESTROUS CYCLE AND ESTRADIOL ON MITO -GENIC RESPONSES OF SPLENIC T- AND B-LYMPHOCYTES 379

R.H. Prabhala and C.R. Wira

SECRETORY COMPONENT PRODUCTION BY RAT UTERIN EEPITHELIAL CELLS IN CULTURE 38 3

J .M. Richardson and C .R. Wira

HUMAN DECIDUAL CD7 + LYMPHOCYTES DISPLAY A UNIQU EANTIGENIC PHENOTYPE 38 7

I .I . Slukvin, V.P. Chernyshov, and G.I . Bondarenko

IMMUNE CELLS ON INTRAUTERINE CONTRACEPTIV EDEVICES 39 1

I. Trebichavsky, O . Nyklicek, and M . Pospisi l

CELLULAR AND HUMORAL IMMUNITY TO SPERM IN OVULA -TORY CERVICAL MUCUS FROM INFERTILE WOMEN 39 5

Z. Ulcovä-Gallovä and D. Sedläcek

HISTOLOGY OF THE CONTINUOUS PEYER'S PATCHES IN TH ETERMINAL ILEUM OF PIGS IN THE PERINATAL PERIOD 39 9

R. Halouzka and F . Kovär u

EMBRYONIC LIVER : DIVERSIFICATION SITE OF LYMPHOCYTELINEAGES 403

1 . Trebichavsky, R . Pospisil, O. Nyklicek, I . Splichal, and L . Mandel

RETICULUM CELLS IN THE ONTOGENY OF NASAL ASSOCIATE DLYMPHOID TISSUE (NALT) IN THE RAT 407

J. Biewenga, M.N.M. van Poppel, T .K. van den Berg, E .P. van Rees ,and T. Sminia

THE PRODUCTION OF TNF, IL-1 AND IL-6 IN CUTANEOU STISSUES DURING MATURATION AND AGING 41 1

S .S . Stosic-Grujicic and M .L. Lukic

ONTOGENY OF THE MUCOSAL IMMUNE RESPONSE AGAINS TDIFFERENT TYPES OF PNEUMOCOCCAL POLYSACCHARIDE INRAT 41 5

G.P.J .M. van den Dobbelsteen, K. Brunekreef, H. Kroes ,T. Sminia, and E .P . van Ree s

INCREASED MANNOSE-SPECIFIC ADHERENCE AND COLONIZ-ING ABILITY OF ESCHERICHIA COLI083 IN BREASTFE DINFANTS 42 1

M. Slavikovä, R . Lodinovä-Zädnikovä, I . Adlerberth ,L .A. Hanson, C . Svanborg, and A .E. Wold

THE INFLUENCE OF MILK FACTORS ON THE COURSE O FNEONATAL MOUSE CRYTOSPORIDIOSIS - A PRELIM'NAR YREPORT 425

J . Hermanek and B . Koudela

GNOTOBIOLOGY, ENVIRONMENTAL, NUTRITIONAL, AN DINTRINSIC FACTORS IN MUCOSAL IMMUNOLOG Y

CELLULAR AND MOLECULAR BIOLOGIC APPROACHES FORANALYZING THE IN VIVO DEVELOPMENT AND MAINTENANC EOF GUT MUCOSAL IgA RESPONSES 429

J .J . Cebra, N .A. Bos, E .R. Cebra, D .R. Kramer, F .G.M. Kroese ,and C .E . Schrade r

A DUAL ORIGIN FOR IgA PLASMA CELLS IN THE MURINE SMALLINTESTINE 435

F.G.M. Kroese, W.A. Ammerlaan, G .J . Deenen, S . Adams ,L.A. Herzenberg, and A .B. Kantor

DEVELOPMENT OF MUCOSAL HUMORAL IMMUNE RESPONSESIN GERM-FREE (GF) MICE 44 1

K.E. Shroff and J .J . Cebra

INHIBITION OF BACTERIAL TRANSLOCATION FROM THE G ITRACT TO THE MESENTERIC LYMPH NODES IN SPF MICE BUTNOT GNOTOBIOTIC MICE BY NONSPECIFIC MACROPHAG EACTIVATION 447

R.D. Berg

EXPRESSION OF Thy-1 ANTIGEN IN GERM-FREE AND CONVEN -TIONAL PIGLETS 453

R. Pospisil, I . Trebichavsky, J . Sinkora, M. Lipoldovä ,L. Mandel, L . Tuckovä, and J . Rejne k

TRANSIENT APPEARANCE OF CIRCULATING INTERLEUKIN-6AND TUMOR NECROSIS FACTOR IN GERM-FREE C3H/HeJ AN DC3H/HeN MICE UPON INTESTINAL EXPOSURE TO E. COLL 459

U.I . Dahlgren, T . Midtvedt, and A. Tarkowsk i

STIMULATION OF INTESTINAL IMMUNE CELLS BY E. Coll INGNOTOBIOTIC PIGLETS 463

L. Mandel, I . Trebichavsky, I . Splichal, and J . Schulze

IMMUNOMODULATION OF THE GNOTOBIOTIC MOUS ETHROUGH COLONIZATION WITH LACTIC ACID BACTERIA 465

H. Link, F . Rochat, K.Y. Saudan, and E . Schiffrin

EXPRESSION OF INTERLEUKIN-2 RECEPTOR ONENTEROCYTE SIN CONVENTIONAL AND GERM-FREE RATS Al-TER STIMULATIONWITH GLIADIN 469

J . Sinkora and R . Stepänkovä

FACTORS INFLUENCING THE FATE OF ESCHERICHIA COLI ANDSALMONELLA TYPHIMURIUM IN GERM-FREE PIGLETS AND RATS 47 3

V. Dlabac, M . Talafantovä, L . Mandel, and R . Stepänkovä

BIFIDOBACTERIA AND ESCHERICHIA COLT TRANSLOCATION INGNOTOBIOTIC MICE 479

V. Kmet, M. Kmetovä, M . Contrepois, and Y . Ribot

EFFECTS OF NOCARDIA-DELIPIDATED CELL MITOGEN ON IN-TESTINAL MUCOSA AND SPLEEN LYMPHOCYTES OF GERM -FREE RATS 48 3

H. Kozäkovä, R . Stepänkovä, H . Tlaskalovä, R . Barot-Ciorbaru ,and J . Kolinskä

STIMULATION OF GALT BY NOCARDIA-DELIPIDATED CELLMITOGEN IN IRRADIATED GERMFREE PIGLETS 48 9

I. Trebichavsky, L. Mandel, H . Tlaskalovä, I . Splichal ,and R. Baro t

MUCOSAL ADAPTATION AND DESTRUCTION IN RESPONSE TOLAMINA PROPRIA T CELL ACTIVATION IN EXPLANTS O FHUMAN FETAL INTESTINE 493

P. Lionetti, S .H . Murch, J . Taylor, and T .T . MacDonal d

DEVELOPMENT OF IgE ANTIBODIES AND T CELL REACTIVIT YAGAINST INTESTINAL BACTERIAL ANTIGENS IN RATS AN DTHE INFLUENCE OF FEEDING 49 7

A. Dahlman, L .Ä. Hanson, E . Telemo, and U .I . Dahigren

EXPRESSION OF MHC CLASS II ANTIGENS AND ENZYMATI CACTIVITY IN ENTEROCYTES OF GERM-FREE AND CONVEN -TIONAL RATS: DEPENDENCE ON NUTRITIONAL FACTORSDURING SUCKLING 50 1

R. Stepänkovä, P. Kocna, J . Sterzl, and B . Dvorak

QUANTIFICATION OF SALIVARY, URINARY AND FECAL SECRE-TORY IgA, AS WELL AS IN SALIVA TITERS AND AVIDITIES OF IgAANTIBODIES IN CHILDREN LIVING AT DIFFERENT LEVELS OFANTIGENIC EXPOSURE AND UNDERNUTRITION 507

A.T . Nagao, MIDS . Pilagallo, A .B . Pereira, MMS. Carneiro-Sampaio,and L .A. Hanso n

ALTERATIONS OF GALT DUE TO MALNUTRITION AND DECREASEIN THE SECRETORY IMMUNE RESPONSE TO CHOLERA TOXIN 51 3

J. Flo, R. Benedetti, C . Feledi, S .G . Ariki, H. Goldman ,

M.E. Roux, and E . Massouh

DIETARY ANTIGEN HANDLING BY MOTHER AND OFFSPRING I NA TWO GENERATION STUDY 51 7

E. Telemo, U . Dahlgren, L .A. Hanson, and A . Wold

THE EFFECT OF CALORIC SUPPLEMENTATION ON LEVELS OFMILK IgA ANTIBODIES AND THEIR AVIDITIES IN UNDER -NOURISHED GUATEMALAN MOTHERS 52 1

M.V . Her as, J .R. Cruz, T . Gonzalez-Cossio, F . Nave, B . Carlsson ,and L .A. Hanson

THE EFFECT OF ELEMENTAL DIET ON GUT-ASSOCIATEDLYMPHOID TISSUE (GALT) IN RATS 52 5

S. Miura, H . Serizawa, H . Tashiro, H . Imaeda, H . Shiozaki ,N. Ohkubo, S . Tanaka, and M . Tsuchiy a

EFFECT OF BACTERIAL ANTIGENS ON LOCAL IMMUNITY 52 9

C. Ruedl, G . Wick, and H. Wolf

INTESTINAL AND SYSTEMIC IMMUNE RESPONSES IN RATS TODIETARY LECTINS 53 3

E. Gomez, V . Ortiz, J. Ventura, R . Campos, and H. Bourges

THE EFFECT OF AN ANTI-GLUCOCORTICOID (ZK 98299) O NTHYMUS EVOLUTION AND ON HYDROCORTISONE-INDUCE DTHYMOLYSIS, INTESTINAL BRUSH-BORDER ENZYMES AN DTHEIR DESIALYLATION IN SUCKLING RATS 53 7

J . Kraml, J . Kol nskä, L. Kadlecovd, M . Zäkosteleckä,D. Hirsovä, and V . Schreiber

A COMPARATIVE STUDY OF THE IMMUNE RESPONSE T OPOLY-[a(2-->8)-N-ACETYL NEURAMINIC ACID] 543

J .D. Romero and I .M. Outschoorn

IN VIVO ACTIVATION OF EXTRATHYMIC T CELLS IN MICE B YSTAPHYLOCOCCAL ENTEROTOXIN B 549

K. Ohtsuka, H . Watanabe, H. Asakura, and T . Abo

INTERACTION OF A SULFHYDRYL ANALOGUE OF VASOACTIVEINTESTINAL PEPTIDE (VIP) WITH MURINE LYMPHOCYTES 55 3

C.A. Ottaway

ANALYSIS OF SP/VIP FIBER ASSOCIATION WITH T4 AND T8LYMPHOCYTES IN NORMAL HUMAN COLON 559

P. Weisz-Carrington, N. Nagamoto, M. Farraj, R . Buschmann ,E .B . Rypins, and A . Stanisz

CHOLECYSTOKININ-OCTAPEPTIDE (CCK-OP) AND SUBSTANC EP (SP) INFLUENCE IMMUNE RESPONSE TO CHOLERA TOXIN I NLIVE ANIMALS 56 3

S. Jarrah, M . Eran, S, Freier, and E, Yefenof

NEURITE OUTGROWTH INDUCED BY RAT LYMPHOID TISSUE SIN VITRO 56 7

Y. Kannan, R .H. Stead, C .H. Goldsmith, and J . Bienenstoc k

EXERCISE, STRESS AND MUCOSAL IMMUNITY IN ELIT ESWIMMERS 57 1

M. Gleeson, W .A. McDonald, A .W. Cripps, D .B . Pyne,R.L. Clancy, P .A. Fricker, and J .H . Wlodarczy k

STRUCTURE, PROTEOLYSIS, AND FUNCTION OF MUCOSALIMMUNOGLOBULINS : CELLULAR RECEPTOR S

STRUCTURE OF IgA : FACTS AND GAPS IN OUR DAT AON DISULFIDE BONDS 57 5

J. Biewenga

INTRA- AND INTER-CHAIN DISULFIDE BRIDGES OF J CHAIN I NHUMAN S -IgA 58 1

A. Bastian, H. Kratzin, E . Fallgren-Gebauer, K . Eckart ,and N . Hilschman n

CHARACTERIZATION OF IgAI, IgA2 AND SECRETORY IgACARBOHYDRATE CHAINS USING PLANT LECTINS 58 5

A.E. Wold, C. Motas, C. Svanborg, L .A. Hanson, and J . Mestecky

HUMAN IgAl AND IgA2 HAVE DISTINCT SPECTROTYPES BUTDISPLAY SUBCLASS SIMILARITIES BETWEEN INDIVIDUALS 59 1

P.A. Crowley-Nowick, J .E . Campbell, A .L . Mullins, and S . Jackson

PEPTIC FRAGMENTS OF RAT MONOMERIC IgA 59 5

J .P . Vaerman, A. Langendries, C . Van der Maelen, J .P. Kints ,F. Cormont, F. Nisol, and H. Bazin

ANTIGENIC AND GENETIC HETEROGENEITY AMONG HAEMO -PHILUS INFLUENZAE AND NEISSERIA IgAl PROTEASES 59 9

H. Lomholt, K . Poulsen, and M. Kilian

TITRATION OF INHIBITING ANTIBODIES TO BACTERIAL IgA lPROTEASES IN HUMAN SERA AND SECRETIONS 605

J . Reinholdt and M . Kilian

CLEAVAGE OF IgG AND IgA IN VITRO AND IN V1VO BY THEURINARY TRACT PATHOGEN PROTEUS MIRABILIS 60 9

M.A. Kerr, L .M. Loomes, and B .W . Senior

CLEAVAGE OF HUMAN IMMUNOGLOBULINS BY PROTEINASEFROM STAPHYLOCOCCUS AUREUS 61 3

L. Prokesovä, B . Potuznikovä, J . Potempa, J . Zikän, J . Radl ,Z. Porwit-Böbr, and C. John

CLONING, CHROMOSOMAL LOCALIZATION, AND LINKAG EANALYSIS OF THE GENE ENCODING HUMAN TRANSMEMBRANESECRETORY COMPONENT (THE POLY-Ig RECEPTOR) 61 7

P. Krajci, D. Kvale, and P . Brandtzaeg

THE COVALENT LINKAGE OF THE SECRETORY COMPONENTTO IgA 62 5

E. Fallgren-Gebauer, W . Gebauer, A . Bastian, H . Kratzin ,H. Eiffert, B . Zimmermann, M . Karas, and N . Hilschmann

MOUSE SECRETORY COMPONENT 629

P.G. Pierre, X .B . Havaux, A . Langendries, P.J . Courtoy ,K . Goto, P . Maldague, and J .-P . Vaerman

ANTIBODY PRODUCTION TO SECRETORY COMPONENT (SC )USING RECOMBINANT SC FRAGMENT 63 3

M. Kamei, T . Iwase, P . Krajci, P . Brandtzaeg, and I . Moro

A LACK OF RELATIONSHIP BETWEEN SECRETORY COMPONENT AN DGALACTOSYLTRANSFERASE IN HUMAN MILK 63 7

K. Kobayashi, N . Mafune, H. Narimatsu, H. Nakao, and N . Taniguchi

SUBSTANCE P ACCELERATES SECRETORY COMPONENT -MEDIATED TRANSCYTOSIS OF IgA IN THE RAT INTESTINE 643

D. McGee, M. Eran, J .R . McGhee, and S . Freie r

NEW FUNCTIONS FOR MUCOSAL IgA

647

M.E. Lamm, M.B. Mazaneca, J .G. Nedrud, and C .S . Kaetze l

INTRACELLULAR NEUTRALIZATION OF SENDAI AND INFLU -ENZA VIRUSES BY IgA MONOCLONAL ANTIBODIES 65 1

M.B. Mazanec, C.S . Kaetzel, M .E. Lamm, D. Fletcher, J . Peterra,and J .G . Nedru d

THE BINDING OF MONOMERIC IgA TO MYELOID FcaR : EVIDENCEFOR RECEPTOR RE-CYCLING AND DETERMINATION OF IT SAFFINITY 655

W.W. Stewart and M .A. Kerr

SIGNAL TRANSDUCTION VIA Fc RECEPTORS; INVOLVEMENT O FTYROSINE KINASE AND REDOX REGULATION BY ADF 65 9

S . Iwata, M . Matsuda, K . Sugie, Y. Maeda, T . Kawabe,H. Nakamura, H. Masutani, T. Hori, and J . Yodoi

A NEW IgA RECEPTOR EXPRESSED ON A HIGHLY ACTIVATEDMURINE B CELL LYMPHOMA 66 3

A.M.C. Faria, T . Dharma Rao, and J .M. Phillips-Quagliat a

ANTI-INFLAMMATORY CAPACITIES OF HUMAN MILK:LACTOFERRIN AND SECRETORY IgA INHIBIT ENDOTOXIN-INDUCED CYTOKINE RELEASE 669

L.A. Hanson, I . Mattsby-Baltzer, I . Engberg, A . Roseanu ,J . Elverfors, and C . Motas

INHIBITION OF ENTEROPATHOGENIC ESCHERICHIA COLI(EPEC) ADHERENCE TO HeLa CELLS BY HUMAN COLOSTRU MDETECTION OF SPECIFIC sIgA RELATED TO EPEC OUTER-MEMBRANE PROTEINS 67 3

L.M. Camara, S .B . Carbonare, I .C .A. Scaletsky, M .L .M . da Silva ,and M .M.S . Carneiro-Sampaio

SALIVARY SPECIFIC ANTIBODIES IN RELATION TO ADHESIO NOF STREPTOCOCCUS PYOGENES TO PHARYNGEAL CELLS O FPATIENTS WITH RHEUMATIC FEVER AND RHEUMATIC HEAR TDISEASE 67 7

K.S .N. Kumar, N.K. Ganguly, Y . Chandrashekher, I .S . Anand ,and P.L . Wah i

ENTAMOEBA HISTOLYTICA ADHERENCE : INHIBITION BY Ig AMONOCLONAL ANTIBODIES 68 1

0. Leyva, G . Rico, F . Ramos, P. Moran, E .I . Melendro,and C . Ximenez

BIOLOGICAL PROPERTIES OF YOLK IMMUNOGLOBULINS

68 5

A.K . Janson, C.I .E . Smith, and L. Hammarström

ROLE OF ALPHA-HAEMOLYSIN IN RESISTANCE OF ESCHE-RICHIA COLI STRAINS TO BACTERICIDAL ACTION OF HUMA NSERUM AND POLYMORPHONUCLEAR LEUKOCYTES 69 1

L. Siegfried, J . Filka, and H . Puzovä

OPSONO-PHAGOCYTOSIS OF NON-ENCAPSULATED HAEMO-PHILUS INFLUENZAE 695

L. Vogel, L . van Alphen, F. Geluk, H. Jansen, and J. Dankert