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ACTIVITY REPORT

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3I T E R G - 2 0 1 9 A C T I V I T Y R E P O R T

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ary 1.1 ITERG

1.2 WORK OF GENERAL INTEREST

1.3 THE PROTEIN-RICH OIL PLANT SECTOR

1.4 PARTNERS AND NETWORKS

1ITERG AND ITS ENVIRONMENT

2 RESEARCH & INNOVATION2.1 FOCAL AREAS FOR RESEARCH AND INNOVATION

2.2 RESOURCING

2.3 ILLUSTRATION OF RESEARCH PROJECTS

2.4 TESTIMONIALS

3 SERVICES FOR THE INDUSTRY

3.1 MARKETS & SERVICES

3.2 NEW SERVICES

3.3 HIGHLIGHTS OF THE WORK

ANNEXES 2019 EVENTS

BOARD OF DIRECTORS

SCIENTIFIC COMMITTEE

SCIENTIFIC COMMUNICATIONS

5E D I T O R I A L I T E R G - 2 0 1 9 A C T I V I T Y R E P O R T

Could it be that "Heaven fell on our heads"?

We were all amazed by the quick spread of the Covid-19 pandemic around the planet, exceeding the forecasts of all the

"experts", although there have already been serious alerts in recent years (SARS, MERS etc). Our world is ill: we must admit

it, but without resigning ourselves to this. And managing, in a spirit of solidarity, the scale of the human, health and economic

disaster. It is in a spirit of trust and responsibility that we will draw solutions from our resources, solutions to bounce back

after this ordeal.

Among these is the idea that growth is only possible if it is responsible and inclusive. Let us learn to measure the added value

of our consumption patterns on health, the environment, society, and our relationships with territories in general. All of this

represents a cost which is yet to be recognised anywhere. ITERG, through its activity and skills, is a long-standing player in

this regard.

Becoming 70 years old in 2020, is ITERG more exposed than others to the devastating effects of Covid-19? Sustainable and

adaptive organisations will also be those that unite communities of stakeholders, and capitalise on knowledge, excellence

and a sense of service. ITERG is founded on that. The Cattelot Grandjean mission clearly perceived the treasure that the

network of Industrial Technical Centres could be, albeit old, for meeting the challenge of "Factory of the Future".

ITERG has thus built, with its industrial sector, a new ambitious COP (Objectives and Performance Contract for the period

2020-2023) after having successfully carried out all the objectives of the previous one, and ended with a very good financial

year 2019, despite the significant drop in collective and collaborative funding. Congratulations to staff for once again taking

up the challenge, leading to a more than doubled operating surplus, while maintaining focus on the excellence and relevance

of our research work. This is presented in this annual report, which testifies to the strength of partnerships which are also

ITERG’s strength: maturation projects with industry, piloting or co-piloting of three new RMTs, dynamics of the Carnot

Institute 3BCAR, enhanced cooperation with agrifood technical centres, etc.

The 2020-2023 COP signed on 14 February by Ms. Pannier-Runacher, State Secretary to the Minister of the Economy and

Finance, and Yves Delaine, announces the new face of ITERG. It formulates ITERG’s decisive contribution to the major

challenges of the profession and of the oil-protein sector: transformation processes that consume less energy, and limit use

of solvents, qualities of oil and vegetable proteins that are better preserved and valued, agriculture and industry that are more

closely connected in the regions and healthy, sustainable, well-defined food with added value for health.

A large site project follows, strengthened by the absorption of OLEAD in January 2020. We are engaged in a process of

modernising equipment and services, serving a bio-based economy respectful of people and the environment on which we

must now count, so that "the sky no longer falls on our heads”...

It is up to us to act so that this crisis catalyses an indispensable acceleration of the changes underway.

Yves DELAINEChairman

of the Board of Directors

Guillaume CHANTREDirector-General

6 INNOVATIVE BY N A T U R E2 0 1 9 A C T I V I T Y R E P O R T - I T E R G

MAJOR FIELDS OF SCIENTIFIC AND TECHNICAL EXPERTISE

TURNOVER

OF SCIENTIFIC AND TECHNICAL STAFF

PEOPLE AT YOUR SERVICE

6

6.6 M€

82 %88

1ITERG AND ITS ENVIRONMENT

7ITERG AND ITS ENVIRONMENT I T E R G - 2 0 1 9 A C T I V I T Y R E P O R T

Protein-rich oi l plant sector

Cosmetics Pharmacy

IAA Green chemistry

Animal feed

Monitoring Information

Nutrit ion

Formulation

Analysis

Training

Green chemistry

Processes

Environment

Audit ing board

1.1 ITERG

(1) National Federation of Oils and Fats Industries(2) Vegetable oils and proteins inter-professional organisation

UniviaTerres

InoviaTerres

l’Interprofession des huiles et protéines végétales

l’agronomie en mouvement

Values• Scientific and technological excellence

• Naturalness of products and processes

• Development of local cultures

• Social Responsibility (sustainability, environment, health)

• Independence and customer satisfaction

• Motivation and personal development of employees

Markets

Skills

ITERG is the CTI of the industries producing vegetable oils and proteins. It participates in the development of the fats and related products industries: fats, vegetable oils and co-products of oils, vegetable proteins and minor compounds, derivatives of these products.

ITERG provides companies with the skills and infrastructure in Production, Research and Expertise. It contributes to value creation and the competitivity of the industrial base, upstream and downstream in the sector.

Industrial Technical Centre• General Management: Guillaume CHANTRE• Governed by private law• Reporting to the Minister of Economy and Finance

Fat and related products sectorrepresented by the FNCG 1 and the Terres Univia2 inter-professional organisation

ISO 9001 certification: 2015

Identity sheet

Means• A team of 88 people

• A platform of chemical, physico-chemical,

sensory and biological analysis laboratories

• An oleochemistry platform

• A technological platform for crushing and refining


GOVERNANCEITERG is administered by a Board of Directors featuring representatives of companies under State control. It delegates to its Director General all powers necessary for management of the

Institute.

The Board of Directors draws on the work of various bodies, in particular the Finance Commission and the Scientific Committee.

Since 2016, a Board has been set up which brings together several representatives of the profession. Its purpose is to prepare major decisions subject to the opinion and approval of the

Board of Directors: change of strategy, methods for financing the Centre, significant investments, creation of a subsidiary, etc.

The BD ensures representation of companies and their federation, as well as their involvement in the decision-making processes of the Institute.

New Presidency ITERG’s directors approved the candidacy of Mr. Yves Delaine for the post of President during the Board of Directors

meeting (CA) of 18 December, 2019.

Current President of the Fédération Nationale des Corps Gras (National Federation of Fatty Substances), previously

Deputy CEO of the AVRIL Group, he succeeds Mr. André Pouzet who held the position for 4 years.

During this last CA, Paul-Joël DERIAN, Director of Innovation & Sustainable Development at APRIL and President

of PIVERT, was appointed to the position of Vice-President. This application was also approved unanimously. Yves DELAINE Paul-Joël DERIAN

CODIR

Guillaume CHANTRE Carine BONNET Jean-David LEAO Stéphane MAZETTE Florence LACOSTE David MATEOS Franck DEJEAN Claudie GESTIN

Director-General

President Vice-President

Innovation & Transfer Director

Collective Activities Manager

Head of the Support Services Department

Head of the Analysis and Expertise Department

Head of Department 1st Transformations

Project Manager Analysis & Expertise

Info Comm Manager

Internally, governance is provided by a Management Committee (CODIR) which meets every month. Systematic reports to staff are provided by managers, to inform employees of the

Centre's strategy, projects and operational decisions. These information feeds promote employee engagement and align services with common goals.


ORGANISATION: OLEAD becomes ITERG’s 1st Transformation Department

On 2 December, 2019, the General Meeting of OLEAD Shareholders approved the amicable liquidation of OLEAD. It also

approved cessation of its extraction activity, and takeover of the assets of ITERG’s R&D, pressure and refining activities.

In a context where the hexane extraction pilot tool no longer met the sector's priorities in terms of R&D, and no longer found

the conditions for its economic equilibrium, reintegration of the Trituration Refining competence within ITERG involves a logic

of refocusing the CTI on its core business, taking advantage of a suitable technical and scientific environment to create an R&D

dynamic around the "factory of the future".

There were thus 9 people integrated into ITERG in January 2020. This integration of staff is accompanied by an internal

reorganisation around 4 areas:

- Analysis and Expertise

- Seed crushing / Refining

- Food development

- Non-food development

The Support Services department and the Information & Communication Watch Unit remain unchanged.

Analysis & Expertise Department

1st Transformations Department

Vegetable Oils and Proteins Promotion

Department

Non-Food Development Department,

Vegetable Oils and Proteins

Comm Info Watch UnitSupport Services

DepartmentGeneral

Management

Collective actions and services to the Profession

Innovation Management & Sector Development


MISSIONS - APPROACHES

ITERG’s expectations of national and professional organisations are regularly

expressed during thematic exchange seminars. The guidelines in line with these

expectations were again discussed in September 2019 with the FNCG to update the

vision and action priorities.

The expectations expressed by the industry are primarily:

- improving the technical and environmental performance of the industrialcapacities in place (energy consumption, air and water emissions) and theirsustainable integration into their territorial ecosystem (circular economy),

- the more radical transformation, in the medium term, of crushing and refiningprocesses in order to evolve towards biorefinery models ensuring developmentof all parts of interest of the seed in sustainable sectors, with low Carbon that istraced and of high quality, for human and animal nutrition,

- making safe food production vis-à-vis chemical contaminants,

- the creation of value for edible oils, by analysing and promoting their nutritionalproperties, but also the innovative formulation of new food products usingvegetable oils and proteins,

- the creation of new non-food outlets for oils and by-products from the oil millthanks to innovation in plant chemistry (chemistry, cosmetics, etc.),

- on a more prospective basis, the use of biotechnologies in terms of production oflipid biomass (green biotechnologies, in particular by microbial route for production of micro-nutrients of interest) and industrial production (white biotechnologies).

Faced with these expectations, ITERG mobilises its multidisciplinary skills through

three types of activities:

- research activity, and missions of general interest

via a programme developed by and for nationals in the sector

grouping together seven Priority Action Areas (DAP)

- product and process innovation activity

that is, by nature, competitive and structured by +Strategic Innovation Areas

(SIA)

- services for the industry.

The economic stakes are high

since the crushing, oil and

vegetable protein and biodiesel

sector, for a turnover of around

€7 billion, involves upstream

more than 100,000 farmers, and

downstream a significant part of

the national agrifood fabric (17,000

companies for a turnover of €166

billion).

In addition, the cosmetic and

chemical industries are widely

involved in the greening of their

activities and products, and the

use of fatty and vegetable protein

bases.


OBJECTIVES AND PERFORMANCE CONTRACT

2016-2019 PERFORMANCE CONTRACT REPORT

- ITERG has maintained its capacity for scientific coordination and anticipation of questions posed to agro-industrial sectors linked to fatty substances• by developing the technological and technical-economic watch activity • through a process of listening to and co-constructing collective research projects • by maintaining an original partnership network with the academic world, from local

to international (Carnot 3BCAR, collaborative structures of the UMT/RMT type, collaboration with ITE PIVERT, EU projects, etc.)

- ITERG has created favourable conditions for product innovation and transfer in order to amplify the creation of value in companies producing and processing fatty substances• by developing the research and transfer activity under contract, as well as a process

for enhancing its Intellectual Property• by initiating a specific action programme for SMEs, linked to technological collaboration

networks• by creating two subsidiaries over the period, reflecting the opening of partnerships and

the desire to develop skills: LIPTHER (production of a structured phospholipid) and OLEAD SAS, which brings together the crushing and refining pilots of the Canéjan site, leading to its integration in 2020.

NEW COP 2020-2023 ITERG’s Objectives and Performance Contract (COP) was signed between the State, represented by Agnès PANNIER-RUNACHER, the

National Federation of Fatty Substance Industries (FNCG) and ITERG, Tuesday, 18 February in Paris.

This new COP sets ITERG’s strategic approaches and objectives for the 2020-2023 period.

Overall by 2023, it announces a tripling of the partnership research effort and a growth of nearly 40% in the volume of services for SMEs in

order to support the digital, environmental and food transitions linked to the production, processing and uses of vegetable oils and proteins.

- ITERG contributed to defining positions engaging the professions and the public authorities, in terms of standardisation, regulation and risk prevention • by actively participating in standardisation bodies • by building (inter) professional positions in connection with public policies: in addition

to nutritional policies and promotion of the health benefits of vegetable oils, ITERG mobilised on contamination issues and environmental positions with the FNCG (best available technologies BREF).

- ITERG has offered the industry expertise and excellent service capacity, contributing to its development• through an innovative range of services: with remarkable growth in private contractual

activity, going from €2.8 million to €4.3 million / year in four years, new analytical services, new skills developed within the lipochemistry and nutrition team.

• through recognition of its excellence (ISO 9001 quality certification, very high customer satisfaction rate, success in intercomparison circuits, certifications and approvals: ISO 17025, COI, FOSFA, Ecocert etc).

Most of the indicator criteria of the Objectives and Performance Contract 2016-2019 are met. This confirms that ITERG has succeeded in carrying out its fundamental work for the identified targets with, however, points of vigilance linked to the difficulty of keeping the desired level of activity of collaborative research in 2018, due to the decrease in co-funding.

Five key projects structure this COP with, in particular, a redesign of the Pessac-Canéjan site to meet the challenges of the biorefinery and the Factory of the Future.


Good manufacturing practices, towards certification!

In order to meet the expectations of our customers in the Cosmetics sector, ITERG

has embarked on deploying the requirements of the NF EN ISO 22716 (BPF) standard

in Lipochemistry workshops.

In 2019, we set out to reduce the gaps between the requirements of the standard

and our practices. A pre-audit in the second semester concluded that there are

still non-conformities which must be reduced before presenting the organisation for

certification at the end of 2020.

Staff are motivated and benefit from the support of General Management who will

mobilise the material and human resources necessary to finalise this project.

Training & Quality

The ITERG training team took note of the requirements of the national reference system

and of the NF EN ISO 22993 standard for the certification of professional training

organisations, and identified deviations from internal practices. If ITERG’s wish is not

to move towards the certification of its training activity, it is to use these benchmarks

as part of its continuous improvement approach.

Other recognitions

- The ISO 9001 surveillance audit revealed no deviations.

- COI approvals for sensory analysis and analysis of contaminants in olive oil have

been renewed for the period 01/12/2019 - 31/11/2020

- Assembly of three method accreditation files presented to the COFRAC surveillance

audit of January 2020.

The details of our scope are available at the COFRAC website: www.cofrac.fr

In terms of safety

Monitoring of incidents and accidents, training of new arrivals regarding the risks

present on site, and safety rules, drafting of a rescue organisation plan for the Canéjan

site, progress of the safety action plan and start-up of new hydrogenation equipment

were the priorities for 2019 in terms of safety.

QUALITY

• ITERG is an Industrial Technical Centre (CTI).

• It is also an Agro-Industrial Technical Institute (ITAI) -

This qualification has been renewed for the 2018-2022 period.

• ITERG is a member of the Carnot Institute 3BCAR (Bio-energies, Biomolecules

and Bisourced Materials from Renewable Carbon).

• Finally, in a regional context, ITERG also acts as a Technological Resources

Centre (CRT).

STATUTES

"New metrology team, new qua-lity correspondent for the Ana-lysis, recruitment and training of internal auditors department, the QSE process is evolving to be as close as possible to staff, so that each best contributes to achie-ving the organisation's objectives."

Céline BIROT Quality Safety Environment Manager

Photo Telework March 2020


KEY FIGURES

Sold products

Collective Activity Financing

Other products

Total income

Private contracts

Collective activity

financing

Co-financed collective activities

6526

9

Staff

Other charges

Purchases

Taxes and levies61

22

15 2

TURNOVER (in %)

EXPENSES (in %)DEVELOPMENT OF RESOURCES OVER 5 YEARS (K€)

Transfer of the Refining

activity to OLEAD


ITERG carried out reference laboratory work with the Professions, in particular in the case

of commercial litigation or international crisis. The Provision of effective analysis methods,

that are validated and recognised by standards, enable this mission to be accomplished.

ITERG develops its expertise for the benefit of manufacturers during the work of groups of

national and international standardisation, and regulatory experts (AFNOR, CEN, ISO, CE,

ISO) in the field of methods for analysing fatty substances and co-products.

ITERG also participates in the Chemists working groups and that of the sensorial analysis

Expert groups organised by the International Olive Council and the European Commission.

This participation enables manufacturers in the sector to have access to information on

the development of analysis methods and future regulatory constraints

1.2 MISSIONS OF GENERAL INTEREST

STANDARDISATION AND EXPERTISE

As a Technical Centre, ITERG carries out missions of general interest in the field of standardisation and technological monitoring. These two missions allow manufacturers to

have a vision of their environment in the medium and long term, and to be able to influence it.

STANDARDISATIONWorking groups on ITERG’s analytical methods:

• AFNOR1 T60C & ISO2/TC34/SC11 Fats Presidency (Florence LACOSTE)

• CEN3/TC19/JWG1 Biodiesel Project Manager

• CEN/TC275/WG13 Process contaminants

• CEN/TC327/WG1 Animal feed

• COI4 - Group of Chemists & Group of experts in organoleptic evaluation. Analysis of olive oils. Expert & Project Manager

• European Commission “Olive Oil” Expert Group. Analysis of olive oils

EXPERT GROUPS• ANSES5: "Evaluation of substances and processes subject to authorisation,

in Human Food" working group (ESPA)

• BIPEA6: Technical Committee of circuit 21 Fatty Substances

• CCRDT7 Nouvelle-Aquitaine Region

• FNCG : Technical Committee

• FOSFA8: Technical Committee

• TERRES UNIVIA: The Human Food Committee

The FR delegation at the ISO/TC34/SC11 fats

and oils meeting in Sydney. On the agenda this

year: fatty acids, sterols, phthalate residues,

pesticide residues ... Florence LACOSTE

(ITERG), Benjamin BEUDAERT (Avril), Mickael

WATIEZ (Lesieur), Sandrine ESPEILLAC

(AFNOR Group) ISO - International

Organization for Standardization.1 - The French Standardisation Agency 2 - The European Standardisation Committee 3 - The International Organization for Standardization 4 - The International Olive Oil Council

5 - The National Agency for Health and Safety in Food, Work & the Environment 6 - The Interprofessional Office of Analytical Studies 7 - The Regional Advisory Committee on Technological Research and Development 8 - The Federation of Oils, Seeds and Fats


MONITORING INFORMATION AND COMMUNICATION

COMMUNICATIONCVIC regularly provides social networks and the ITERG website with news from the

Centre, the industry, or its partners.

To keep up to date with the latest news from the Centre, you can subscribe to our

newsletter directly from our website.

KNOWLEDGE MANAGEMENTThe Information & Communication Monitoring Unit (CVIC) systematically references

forms of internal knowledge such as theses defended at ITERG, publications, posters

and conference presentations.

“Each year, the Monitoring & Information Unit responds to more than 400 requests from manufacturers and ITERG project managers. The deliverables are diverse and adapted to needs: data figures, reasoned responses, bibliographies, maps.”

Claudie GESTIN

Information Communication Monitoring Manager


SCIENTIFIC, REGULATORY AND STANDARDS MONITORINGITERG offers a comprehensive pooled monitoring service in the oil-protein sector thus

enabling manufacturers to keep abreast of current events in this area: press, scientific

and technical publications, regulations, standardisation.

The documentary base and the database, specific to the field, as well as proximity to

experts at the Centre, allow a targeted and rapid response to requests from companies

or partners.

INFORMATION ANALYSISWith its expertise in the field of oils and fatty substances, ITERG offers relevant

scientific and technical clarification, and high value-added analysis, to map its

environment:

• create an overview

• identify the players in a market that presents challenges

• target the main patent applicants

• assess the dynamics of innovation

• detect opportunities for new collaborations


1.3 THE PROTEIN-RICH OIL PLANT SECTOR

In France, the protein-rich oil plant sector comprises 110,000 oilseed producers and 20,000 protein producers who cultivate 2.5 million hectares in mainland France, for

an average annual volume of 8 Mt of seeds. France is the leading oilseed producer in the EU, ahead of Germany.

110,000 oilseed product producers 2.5 million hectares in mainland France

6 million tonnes of seeds in value chainsfor human food and animal feed 2.6 million tonnes of raw oil for food, fuel

production and other non-food applications

3.7 million tonnes of meal intendedfor animal feed AREAS OF USE

The vast majority of seeds are from France thanks to the work of 600

traders and cooperatives marketing these raw materials to around thirty

industrial operators.

The latter process these seeds (primary processing) to supply the raw

material to a large number of operators in the food, animal feed, green

chemistry and renewable energy sectors.

The social impact of the French vegetable oils and proteins sector is

estimated at more than 150,000 direct and indirect jobs. It is estimated

that around 90% of French households currently consume products from

this sector every day.

Agrifood industries

Animal feed

Green chemistry

Cosmetics

PharmacySources: FNCG, Terres Univia


1.4 NETWORKS AND PARTNERS

NETWORKS

REGION

SECTOR

The National Federation of Oils and Fats Industries www.fncg.fr

The Industrial Technical Centres network www.reseau-cti.com

Agri Sud-Ouest Innovation agrisudouest.com

Cosmetic Valley, a cosmetic sciences cluster specialising in beauty and well-being cosmetic-valley.com

THE IAR bioeconomy cluster iar-pole.com

The French Network of Agrifood Technical Institutes actia-asso.eu

The CARNOT Institutes network as part of our involvement in the CI 3BCAR www.instituts-carnot.eu

The vegetable oils and proteins inter-professional organisation www.terresunivia.fr

Vegetable industries industriesduvegetal.fr

Oilseed, proteins and hemp technical institute terresinovia.fr

Nouvelle-Aquitaine region nouvelle-aquitaine.fr

The University of Bordeaux u-bordeaux.fr

National School of Chemistry, Biology and Physics http://enscbp.bordeaux-inp.fr

Aquitaine Sustainable Chemistry aquitainechimiedurable.fr

COMPETITIVENESS CLUSTERS


COLLECTIVE RESEARCH TOPICS

SCIENTIFIC PUBLICATIONS CONVENTION

INTERVENTIONS

MTAMATERIAL TRANSFER

AGREEMENT

ACTIVE PATENTS

30

27

2013

2RESEARCH AND INNOVATION

19RESEARCH AND INNOVATION I T E R G - 2 0 1 9 A C T I V I T Y R E P O R T

2.1 FOCAL AREAS FOR RESEARCH AND INNOVATION

Carine BONNET

Director of Innovation and Transfer

Contracted activities (incentive type):


ITERG is developing an ambitious Research, Development and Innovation programme, available across all of the Centre's skills, and

with a view towards sustainable industrial development of bioresources. Its work is integrated into public policies to support digital,

environmental and food transitions in connection with the production, processing and use of vegetable oils and proteins.

“ITERG, by virtue of its CTI status, is bound by the Research Code and benefits from the same provisions as Public Research establishments for Research Tax Credit. The cost of your invoices, issued as part of your R&D project, can therefore be reduced by 60%. Contact us for more information.”

Called DAP (Priority Activity Areas), their results can be communicated in the form of

publications, reports, oral statements:

- Activities of collective interest or precompetitive research for industrial nationals via

the Affected Fiscal Tax, the ITAI allocation, and the entire oil and protein sector, via

the support of Terres Univia.

- Research activities conducted with the support of the Nouvelle-Aquitaine Region,

the Ministry of Agriculture (ITAI allocation) and possibly ITERG’s own resources.

- Research activities of pre-competitive research supported by the Carnot Institute

3BCAR.

1 / Evaluating the benefits of consuming lipid-based or liposoluble nutrients for

preventing obesity and cerebral ageing,

2 / Preventing and eliminating chemical contamination,

3 / Protecting, characterising, outlining and authenticating oils and fats,

4 / Increasing the environmental efficiency of processes and responding to the

related economic and societal challenges,

5 / Providing the chemicals industry with functionalised biomolecules to accelerate

the industrial transfer of bio-sourced solutions.

6 and 7 / Two other DAPs, relating to transfer, dissemination and monitoring

operations on the one hand, and to standardisation operations on the other, offer

cross-functional support to the Professional organisation and to all ITERG activities.

The Research topics meet the needs of companies positioned in upstream and downstream markets. They take into account a multidisciplinary approach and coordination with academic

laboratories or other technical centres by activating scientific partnerships (RMT, UMT, Carnot Institute 3BCAR).

There are two types of RDI actions:

Activities of collective or pre-competitive interest:

Referred to as DIS (Strategic Innovation Areas), they provide a competitive advantage

to an actor or group of actors:

- Competitive research and innovation activities (co-financed) via various grants from

ITERG’s labels of excellence. These activities can also occasionally benefit from the

support of the interprofessional fund FASO,

- Contractual activity in oleochemistry and technology: research and private

technological maturation, technological services of the pre-series type.

STRUCTURING OF RESEARCH AND INNOVATION ACTIVITIES

The 7 DAPs


Nouvelle-Aquitaine is characterised by a very dense and highly exporting agrofood and

agro-industrial fabric, whose dynamism is based on a large number of companies of

all sizes, as well as on a great diversity of processing activities, in synergy with quality

agricultural production based on recognised know-how.

In this context, the seven ACTIA centres in the territory of Nouvelle-Aquitaine (including

ITERG) have been strategically assessing for the past two years, with the aim of creating

the ACTIA centres network in Nouvelle-Aquitaine. The latter aims to mobilise all the

technological expertise of the seven centres, to develop competitiveness of the regional

agrifood industries. By relying on complementary skills, the ACTIA Nouvelle-Aquitaine

network strengthens its support capacity for businesses, anticipates the challenges of

tomorrow, develops the capacity for innovation, and contributes to creating more value

within regional sectors.

2.2 RESOURCING

THE NOUVELLE-AQUITAINE ACTIA NETWORK

This network, fully operational in 2020, offers the chance to:

- bring to the knowledge of the agro-industrial fabric and in particular VSEs

and SMEs, the skills of technical centres, but above all the technical advances

produced within their expertise networks (RMT and ACTIA networks) so

that they can be used and used quickly, and for the best, by all operators,

- support agrifood companies through strengthened presence in the

territories and a more active territorial involvement, in their daily problems,

- to launch projects in touch with socio-economic realities, if possible of a collective

nature, throughout the Nouvelle-Aquitaine territory.

The stakes are high because it is a question of boosting innovation within SME/

SMI and supporting integration with a view to succeeding in the food, digital and

ecological transitions with which they are confronted.


STRONG INVOLVEMENT IN THE ACTIA RMT SYSTEM (Mixed Technological Networks)

The Mixed Technological Network (RMT) is a place of synergy and exchange. It is a scientific and technical partnership tool, set up and supported by the Ministry in

charge of Agrifood, under the coordination of ACTIA for the agrifood sector.

ITERG participates at different levels in 5 RMTs on various themes: proteins, packaging, chemical contamination, eco-design.

- RMT ACTIA PROTEIN: "Diversification of the food products supply, assisted by development of innovative modes of production and processing

of vegetable proteins, to meet societal needs".

(Coordination ADIV, Coanimation ITERG / ADIV) - https://www.actia-asso.eu/projets/protin-2020/

– RMT ACTIA Propack Food: “Sustainable packaging, the circular economy and food waste”.

(Coordination: LNE, CTCPA / ITERG Partner) - https://www.actia-asso.eu/projets/propack-food-2020/

– RMT ACTIA Al-Chimie: “Chemical contamination of the food chain”

(Coordination ACTA / Co-animation ACTA, INRA, ITERG) - https://www.actia-asso.eu/projets/al-chimie/

– RMT ACTIA ECOVAL: “Eco-design”

(Coordination ITERG / Animation Fabrice Bosque) - https://www.actia-asso.eu/projets/ecoval-2020/

– RMT ACTIA ECOFLUIDS: “Energy and Water Efficiency” (Coordination:

CRITT Agroalimentaire, CTCPA, / ITERG Partenaire) - https://www.actia-asso.eu/projets/ecofluides-2020/

To learn more about ACTIA RMTs: https://www.actia-asso.eu/rmt-presentation/


NEW PROJECTS ADOPTED VIA THE INVITATION TO TENDER

PERUBIO Microbial production of erucic acid POLARLIPID Development of new polar lipids

Today erucic acid (fat ty acid C22:1, having 22 carbon atoms and

a single unsaturation) is a plat form molecule of interest to ITERG.

Its unsaturation may be functionalised by chemical or enzymatic means. The

compounds obtained can then be used as monomers for the synthesis of various

polymers. Currently, in France, it is produced from erucic rapeseed oil, the production

of which is very limited.

The objective of our project is to convert substrates rich in oleic acid (C18:1) (used

oils, by-products from refining such as deodorisation condensates and acid oils,…)

into lipids rich in erucic acid and lacking microbial polyunsaturated fatty acids.

This project brings together two research teams, from TBI (Toulouse Biotechnology

Institute) and ITERG, who have a common interest in lipids. Two microbial chassis with

different production models were selected to maximise the chances of success, both

in terms of production, and in the downstream process stages. Strain engineering

will primarily consist of introducing enzymes capable of lengthening the fatty acid

chains. An engineering strategy for these enzymes, based on molecular modelling,

will improve their specificity so as to have more centered profiles around the target

molecule.

In parallel, metabolic engineering strategies will be developed for each chassis in

order to increase the quantity of lipids produced, while improving

the selectivity for erucic acid. Fermentations to produce batches

of microbial lipids will be carried out. The lipids will then be

extracted and purified to reach the target molecule. All the

microbial production, extraction and purification data will allow

a technical and economic analysis of the process as a whole.

Coordinator: INSA Toulouse - Partner: ITERG

Two main classes of molecules characterise polar lipids: phospholipids and glycolipids.

Phospholipids are amphiphilic structures which, depending on their chemical nature,

can specifically assemble in solution, thus making it possible to create more or less

complex and functional structures: micelles, reverse micelles, bilayers.

In nature, natural phospholipids generally have a heterogeneous chemical structure

(length of the lipid chains and variable unsaturations), and their use can be limited by

problems of chemical stability (peroxidation, degradation, oxidation).

It is proposed in this project to develop a rapid and efficient synthesis pathway

allowing access to double-stranded polar lipids which could potentially be organised

in solution, like phospholipids.

The synthesis strategy implemented is based on the synthesis of a 100% biobased

reaction intermediate based on fatty alcohols and itaconic acid.

The synthesised derivatives will then be post-functionalised in

order to introduce polar groups and thus form bi-catenary polar

lipids (Figure 1).

The objective of this project is to validate, at the laboratory stage,

the technical feasibility of the synthesis of amphiphilic double-

stranded derivatives, and to study the surfactant properties of

these molecules compared to natural phospholipids.

Coordinator: ITERG - Partner: LCPO

Polar type PS lipid


The SURBAR project is part of new alternative distribution

circuits, including:

- a first step of transporting the "bulk" packaged products to the distribution point

- a second (consumer) stage of transporting the products without packaging or with

containers having a very primary conservation functionality.

Today this method of distributing products only applies to dry products, for which

bulk packaging is easy, but above all for which sale via distribution dosing equipment

poses no problem with regard to controlling microbiological risk, and few product

quality issues.

To extend this distribution method to perishable products, one solution consists of

distributing in “secondary bulk” products packaged in primary packaging.

In this project, applications are envisaged for which the overwrap provides the oxygen

barrier. More specifically, the project deals with oxygen barrier functionalisation

technologies for paper and cardboard.

At the end of the project, three demonstrators (overwrapped products on the

basis of selected technologies) will be evaluated, in relation to standard packaging

(“standard” packaging with multilayer barriers). The product lifetimes will be evaluated

in real conditions for the “fresh catering product” demonstrator, and in accelerated

conditions for “canned ready meals” and “bakery products with a high fat content”.

In addition, a calculation tool (simulation of the quantity of oxygen permeated over

time) will be made available to the network, allowing design of a two-compartment

packaging, with an intermediate headspace. This tool will be used for the design of

the three demonstrators.

Coordinators: Agroparitech - Partners: ITERG - AgrosupDijon – ENSIACET – CTCPA

Phase Change Materials (MCPs) are compounds capable of absorbing and returning a

certain amount of energy in the form of latent heat. In the case of a solid/liquid transition,

an increase in temperature causes the compound to melt, and a finite amount of energy is

absorbed. The latter can be restored in the form of heat when the compound crystallises,

that is, when the temperature drops below the transition temperature (Figure 1).

This property can advantageously be exploited in different application sectors:

energy storage (solar thermal batteries), thermal insulation of buildings, passive air

conditioning, or technical textiles.

If many materials are studied and defined as having an interesting transition, the problem

is now more linked to the need for their renewable nature (bio-based), non-toxic for the

user, respectful of the environment, as well as to their shaping. Among the different

solutions, microencapsulation is one of the most studied, because it offers a larger

exchange surface and allows for easier shaping: incorporation into fabrics, bags or

insulation panels. However, it is often expensive, difficult to transpose to an industrial

scale, and almost routinely involves the use of organic solvents.

This project proposes a study of the feasibility of obtaining a microencapsulated

and biobased phase transition material by drying emulsions. The strategy adopted

is based on the manufacture and atomisation

of emulsions stabilised by amphiphilic solid

particles, and does not involve organic

solvents. The particles and the encapsulated

phase will come from low-value and little-

processed biomass (agricultural by-products

and oils).

Coordinator: ITERG - Partners: LCA, CATAR

SURBAR MBCP


2.3 ILLUSTRATIONS OF RESEARCH PROJECTS

At the request of the inter-branch organisation, the Analytical Development team was asked to work on the

accreditation of a method for determining isoflavones in soy-based products. In 2019, the Analytical Development

team tested the two official methods - AOAC 2001 and AOAC 2008.03 - and found that neither of them allows an

optimal response both in terms of products and quantification limit. Therefore the decision was made to develop an

internal method mixing the two methods, namely the 2008 analytical approach applied to products containing few

isoflavones (milk, tofu, etc.).

In 2020, there is a plan to build the accreditation file on the samples, with data on repeatability, reproducibility,

recovery rate, fidelity, detection and quantification limit, seeds on the soybean matrices, natural juice, natural tofu,

fermented and textured soy dessert.

ACCREDITATION OF AN ISOFLAVON ASSAY METHOD

R1 R2

Daidzein H H

Glycitein H OCH3

Genistein OH H

Daidzin

Glycitin

Genistin

Glucoside forms

acetyl(COCH3) or malonyl (COCH2COOH)

Aglycone forms

Structural similarity with estradiol

Acetyl or malonyl-daidzin

Acetyl or malonyl-glycitin

Acetyl or malonyl-genistin

Jean-David LEAO

Head of Collective Activities


Leslie COUEDELO

Project Manager

Nutrition-Health & Lipid Biochemistry Unit


ITERG was thus able to determine that, in a diet,

a distribution of up to 40% of ALA in the internal

position of a cooking oil, are necessary and sufficient

to improve the levels of ALA in the blood and the

tissues of interest. In addition, ITERG has observed

that enriching the internal position with ALA not only

improves its bioavailability but also its bioconversion

to EPA in red blood cells and the liver. Beyond 40%

internally, it would then be the bioavailability of DHA

that would be improved, and no longer that of ALA

and EPA.

This study demonstrates the advantage of

favouring consumption of food triglycerides

whose internal position is relatively rich in ALA

(up to 40%), in order to improve its blood and

tissue bioavailability as well as its bioconversion

into EPA.

HOW CAN THE BIOAVAILABILITY OF OMEGA 3 BE IMPROVED?For several years ITERG has been working on studying how to improve the bioavailability of omega-3,

and in particular that of the precursor, alpha linolenic acid (ALA), to improve the nutritional status of the

population.

ITERG is the benchmark in this sector by being one of the few teams to lead numerous projects on

this plant-based omega-3. Among the factors influencing the bioavailability of a fatty acid, that of the

molecular distribution on dietary TG is of particular importance. Indeed, ALA is a preferential substrate

for beta-oxidation. Keeping ALA internally from the food structure to the target tissues of the body would

preserve it and promote its storage and bioconversion in long n-3 chains (EPA and DHA) with recognised

health properties.

In this context, ITERG is the only one to have followed the impact of the molecular structure of TG on the

absorption phase of ALA, through projects carried out using combined oils (Boulos and Combe, 2000)

or synthetic molecules whose position of ALA was perfectly controlled (Couëdelo et al. 2011). This first

data reformed the preconceived ideas according to which the internal position was strictly maintained, by

demonstrating that it was evolutionary during the stages of absorption of lipids.

In the METATRIAL project, ITERG went further by studying ALA enrichment to be favoured internally for

food TGs to improve both its bioavailability and its bioconversion in long omega-3 chains during a long-

term diet.

OMEGA 3 AND INFLAMMATION

The development and optimal functioning of our immune

system are directly influenced by our diet. Among the

nutrients identified, dietary fatty acids are described as

having major effects on immunity. Indeed, the fatty acid

composition of the membranes of immune cells seems to

be easily modulated under the effect of edible fats, and

the rapid changes in composition which result therefrom

are capable of generating functional effects on the reacti-

vity and the functioning of these cells in a very short time

period.

Benjamin BUAUD, NSBL Project Manager, OCL 2020, 27, 22


The DEACOL project, coordinated by ITERG and

carried out by OLEAD, aimed to offer a refining solution

for oils which, like certain nut oils, can combine high

acidities, high levels of polyunsaturated fatty acids,

and the presence of phthalates.

Chemical refining poses problems of neutralisation

losses linked to free fatty acids and partial glycerides,

while physical refining can cause the appearance

of trans fatty acids and promote the formation of

3-MCPD esters.

The solution studied aims to achieve a liquid/liquid

extraction of free fatty acids and phthalates at low

temperature.

DEACOL PROJECT

Patrick CARRE

Head of R&D Trituration – Refining

Department 1 Transformations

The process is only economically interesting when

the other processes are lacking, because if it requires

additional operations but is carried out in batch by

static decantation it can be sufficiently economical to

be an industrial reality.

Our work has shown that the water content in the

solvent had an effect on losses of neutral oil and on

efficiency of phthalate extraction:

the more water the solvent contains, the lower

the losses, but the less effective the removal of

contaminants.

The best compromise is in the range of 10 to 18%

water. Thus an oil initially at 5.8 acidity could be

reduced to 0.3-0.4% oleic acidity with losses of 4.0%

neutral oil.

One oil experimentally contaminated with 116 ppm of

butyl-benzyl-phthalate could be decontaminated to

94% with ethanol at an azeotropic concentration and

88% with ethanol at 17% of water.

In both cases, the residues fall below the regulatory

thresholds.


Discoloration of oilsfrom left to right: initial oil, deacidified,

discoloured with 0.5% earth, then 0.75% then 1%


The Agence de l'Alimentation Nouvelle-Aquitaine (AANA), in partnership with the

ACTIA Nouvelle-Aquitaine network, has initiated a project to support industries in

Nouvelle-Aquitaine under the Official Quality and Origin label (SIQO) using an eco-

design approach.

The ECOQUALINA project will take place over 3 years, from October 2019 to

December 2021.The objective is to identify, with a view to their possible integration

alongside product-specific quality criteria, criteria for improving the environmental

performance of the product throughout its value chain.

ECOQUALINA will lead to:

- proposals, for each sector under SIQO, of developments likely to be included in

the specifications, and making it possible to improve the product’s environmental

performance,

- an identification of the obstacles and success factors of the actions carried out as

part of the project, in order to facilitate the implementation of eco-design approaches

for other products under the quality label.

ITERG is involved at various levels in ECOQUALINA (ECO design of products

under the Nouvelle-Aquitaine sign of Quality):

- co-coordination, with CRITT La Rochelle, of the work carried out by the

technical partners

- technical contribution for the "Bayonne ham", "Pork from the South-West",

"Prunes from Agen" and "Oysters from Marennes Oléron" sectors.

Fabrice BOSQUE

Head of Environment

and Eco-Industries Unit

ECO-DESIGN OF NOUVELLE-AQUITAINE QUALITY-CERTIFIED PRODUCTS

15 products under SIQO will be studied: Lamb from Poitou-Charentes IGP/LR, Lamb

from Limousin IGP, Lamb from Périgord IGP/LR, Lamb from the Pyrenees IGP/LR,

Ossau-Iraty PDO Cheese, Butter Charentes-Poitou PDO, Bayonne Ham IGP, Pork from

the South-West IGP, Prunes from Agen IGP, Oysters from Marennes Oléron IGP/2 LR.

• Coordination: AANA

• Co-funders: ADEME and the Nouvelle-Aquitaine region

• Project’s total budget: 748 K€

• 9 SIQO Defence and Management Organisations involved: Association for the Defence and Promotion of Lambs certified

in Poitou-Charentes, Lamb Association in Limousin, Regional Association of Meat and Aquitaine Sheep Breeders, Ossau-

Iraty Syndicate (4 ODG federated within the Regional Nouvelle-Aquitaine Sheep Association), Charentes-Poitou Dairy Union,

Bayonne Ham Consortium, Association of Pork Products from South-West, PGI Defence Union of Prunes from Agen, Marennes

Oléron Oyster Quality Group

• Institutes and technical centres: ACTALIA, AGROTEC, CTIFL, CRITT Agroalimentaire, IDELE, IFIP, INRAe, ITERG.


2.4 TESTIMONIALS

As part of the promotion of vegetable sourcing, the company CHANEL PARFUMS

BEAUTÉ asked ITERG to develop different products that can be integrated into its

cosmetic formulations.

ITERG has applied itself to working with processes conventionally used in

lipochemistry, namely transesterification and hydrogenation. Quality control has been

of utmost importance throughout the development process. Indeed, the products

were developed on a laboratory scale before following all scaling-up steps until

reaching production of several hundred kilos for some of them.

These developments were made in close collaboration with the formulation and

regulatory departments at CHANEL PARFUMS BEAUTÉ, in order to always anticipate

potential risks and constraints.

At this stage, the products are in the evaluation phase, in make-up and skincare

applications. One ingredient is already incorporated into a finished product launched

on the market in April 2020 "Hydra Beauty Camellia Repair Mask".

Transparency, responsiveness, and rigour were and are the keys to the success of the projects led by ITERG. ITERG's expertise in lipochemistry and processes has been essential to the proper development of the exclusive CHANEL PARFUMS BEAUTÉ ingredients.Their CEDOP and Premier Transformations (formerly OLEAD) platforms are unique in France and have enabled custom manufacturing of these raw materials for the brand.CHANEL PARFUMS BEAUTÉ wishes to continue this fruitful collaboration in 2020 by starting new R&D studies.

Guillaume CHOLLET Head of the RDI Lipochemistry Unit

Photo Telework March 2020 Nicola FUZZATIInnovation and Materials Development Director CHANEL Parfums Beauté


Based near Bordeaux, Activ'Inside was created

in 2009 by three innovation enthusiasts

wishing to give new impetus to natural active

solutions. An expert in saffron and grapes,

Activ'Inside operates on the international

nutraceutical (food supplements) market,

offering a range from premium botanical

extracts to ready-to-use product concepts.

In the context of new analytical developments relating to the metabolism of very specific carotenoids

in our nutritional active ingredients, we turned to ITERG. Very quickly, we came to an agreement both on the expected deliverables and on the financial side.Today the results are in: ITERG has developed a new method of analysis on a truly unique biological sample, with all points necessary for its validation based on data of fidelity and robustness of the method (repeatability, reproducibility, limit of quantification and detection).The “biological” effectiveness of these compounds being conditioned by their bioavailability in the organism, the method allows us to determine the bioavailability of our product on biological samples in humans. This allowed us to correlate its clinical efficacy with metabolites derived from our active ingredient.A scientific publication has just been submitted, with ITERG being associated with it.

Building on this first success, we decided to strengthen our partnership with this institute, on some of our research programmes.

The Daudruy Van Cauwenberghe group has been manufacturing and marketing vegetable fats and oils, marine oils and animal fats for several generations. Its skills acquired over these decades have enabled it to develop constantly and to count, among its customers, the largest food, zootechnical, oleochemical and various other industries.The group is constantly evolving, and has been engaged since 2006 in the production of biodiesel from semi-refined vegetable oils, then from animal fats unfit for human consumption and frying oils with its own collection network (via its subsidiary Oléovia) in restaurants and communities throughout France. Development in bioenergy continues today, with the commissioning of an energy node allowing recovery of waste energy from the urban community of Dunkirk and also with an important project of biomethanation from different co-products and under-products generated on site: neutralisation pastes and used earth from the refining of oils, glycerin from the production of biodiesel, sludge from the wastewater treatment plant, etc. The biomethanisation project is designed to ultimately be able to inject 750 Nm³/h of biomethane into the network.

This development project was based on work carried out in collaboration with ITERG since 2008 on determination of the methanogenic potential of the various co-products and by-products of the fat industry, the conditions for co-methanisation of these products, and understanding the potential phenomena of inhibition of biogas production.

David GAUDOUTCo-founder - Chief Innovation OfficerActiv’inside

Benoit COFFREHead of Safety & EnvironmentSAS Daudruy Van Cauwenberghe


ANALYSES CARRIED OUT

NOTE OF APPRECIATION OF ITERG’S OVERALL

SERVICE

CONTRACTS

SME/SMI PARTNERS

4500018.5

5000 300

3SERVICES FOR THE INDUSTRY

31MARKETS & SERVICES I T E R G - 2 0 1 9 A C T I V I T Y R E P O R T

The range of ITERG services is aimed at the oilseeds sector but also at applied sectors:

agrifood, green chemistry (bio-materials, bio-products, eco-processes), cosmetics,

pharmacy. Close links are maintained with manufacturers to support them in their Quality,

Research and Innovation initiatives. In 2019, ITERG therefore met 270 companies or

industrial groups, at its premises, on site, or at trade fairs and conventions.

Sixty percent of contractual revenues relate to the agrifood sector essentially on analytical

services: compliance research, looking for adulteration, alteration or contamination.

In 2019, the Analysis & Expertise Department carried out 45,000 tests and generated a

turnover that represents 75% of contractual revenue. It uses high-level expertise skills

coupled with excellent services (COFRAC accreditation on numerous analyses). This is a

valuable operational capacity in the event of a health crisis for all industrial players.

Breakdown of turnover (€) according to activities, excluding collective financing 2019

60%

17%

9%

6%

IAA

Cosmetics - Pharmacy

Chemistry

Distributors

1,000,000 2,000,000

ITERG develops and offers a range of services and benefits, constantly evolving thanks to scientific advances from Research and

Innovation activities. Its dual culture, industrial and scientific, specific to CTI, is a real advantage in offering companies adapted solutions

that meet the constraints of their environment. 3.1MARKETS & SERVICES

The second market segment is that of Cosmetics/Pharmacy. Manufacturers in this sector are

demanding product analyses but also innovations: rare oils, interesting compounds with high

added value, natural formulations, soft processes. The refining and deodorisation services for

organic raw materials, carried out at ITERG, are controlled by Ecocert Greenlife according to

the Ecocert and Cosmos standards. In addition, membership in the Cosmetic Valley division

makes it a partner of choice for the Cosmetics sector.

The Green Chemistry sector is particularly interested in limiting dependence on petroleum

resources, reducing environmental impacts, and providing new functionalities. The new 300L

pressure reactor, installed in 2019 in the heart of the semi-industrial workshop, now allows us

to offer, in addition to custom production, pressure reactions of hydrogenation and hydrolysis

type, but also to carry out certain operations allowing us to accelerate the reaction kinetics,

increase the solubility coefficients and thus aid the extraction or precipitation/crystallisation

of certain compounds. Finally, there is a new strong line of services in this sector, for bio-

control formulations (see below).

“In 2019, we obtained an overall satisfaction rating of 18.5/20 from all of our clients, on all of our services. This obviously reflects our expertise but also how we meet manufacturers’ expectations in terms of delivery and support."

Fabrice FARRUGIA

Technical-Commercial Attaché


3.2 NEW SERVICES

With this equipment, of 300L capacity, ITERG has been able, since summer

2019, to offer its customers and partners a tool allowing them to carry out

development and production operations such as hydrogenation, hydrolysis

under pressure, and recrystallisation…

Thanks to this new state-of-the-art reactor and a technical team that is an

expert in the field, ITERG can now ensure the qualitative production of a certain

number of products established on the market (vegetable oils, esters, specialty

hydrogenated products).

As for the entire platform, this tool is managed by supervision, allowing the

real-time acquisition of experimental data (pressure, temperature, consumption,

etc.) thus facilitating transfer of the process to a third party.

PROCESS CAPACITIES

This 316L stainless steel reactor is installed in an ATEX environment; the strong

shears (blades and counter blades) allow flexibility in the type of operations

carried out.

RAW MATERIALS - BIOMASS IN QUESTION

Vegetable oils and fats, terpenes, carbohydrates... and their derivatives.

Cosmetics, Nutraceuticals, Pharmacy, Chemistry TARGET MARKETS

On our industrial transfer platform, 2019 was marked by the installation and

commissioning of a new synthesis reactor, enabling work with gases at high pressure

(H2, CO2, CO/H2 - Pmax 65 bars).

Contact: Didier PINTORILipochemistry Workshop [email protected]


For your active substances• Hydrophilic / lipophilic• Liquids / solids (powders) • Solubles / insolubles

For the preservation of your assets• Immobilisation of volatile compounds• Chemical stability with regard to oxygen, light, T°C, water, pH• Protection against enzymatic bioconversion or microorganisms• Enhancement of the properties of oils (antioxidants, etc.)

To control release• Immediate (rupture)• Prolonged/gradual (degradation, diffusion, rehydration)• Triggered (T°C, pH, humidity, pressure…)

To develop or improve the formula for use in the field• Spraying (liquid/solid)• Dilution in water, oil, other organic liquid

To reduce doses / hectares used• Penetration agent• Concentration

To obtain the desired textural properties • Film-forming• Foaming• Fluids / viscous

- Different formula typologies: solutions, dispersions, suspensions, emulsions, granules

- Evaluation of chemical and physical stability, characterisation of droplets, anticipation of evolution kinetics

- Measurement of texture properties: crystallisation of fat, rheological behaviour, texturometric analysis

BIOCONTROL FORMULATIONS

Our Formulation Laboratory offers you support for developing or optimising your biocontrol formulations based on your specifications:

Contact: Cécile JOSEPHFormulation Project [email protected]


3.3 ACTIVITY HIGHLIGHTS

LIPOCHEMISTRY - CEDOP (European Centre for Oil Products) PLATFORM

ENVIRONMENT AND ECO-INDUSTRIES

HEALTH NUTRITION & LIPID BIOCHEMISTRY

FORMULATION• Design and acceptance of the ECOVAL RMT project for the 2020-2024

period

• Start of the ECOQUALINA project (ECO design of products under the Nouvelle-Aquitaine sign of Quality) - see page 27

• Creation of tools for calculating the environmental footprint of olive oil and packaged water, as part of the PEFMED project in collaboration with CRITT PACA. The main objectives of this project are the reduction of products’ environmental footprint, and the implementation of green innovations throughout the agrifood supply chain. https://pefmed.interreg-med.eu/

• 20 MTAs with manufacturers from various sectors

• Installation, validation and production start-up of a new hydrogenator

• Resumption of audit activity on industrial site (frying audits)

• New RMT ACTIA Propack Food: "Sustainable packaging, the circular economy, and food waste".

• Webinars on UMT ACTIA AgroChem as well as on biosurfactants and their environmental impact

• 5 scientific publications

• New RMT ACTIA PROTEIN: "Divers i f icat ion of the food products supply, assisted by development of innovative modes of production and processing of vegetable proteins, to meet societal needs". (ADIV Coordination, ITERG/ADIV Co-facilitation)

• Webinar Impact of lipids on the nutritional quality of breast milk

• 6 blog articles and 8 scientific publications

• Launch of a new offer on the formulation of biocontrol products

• Webinar on emulsions stabilised with vegetable powders

• 2 scientific publications


LIPOCHEMISTRY - CEDOP (European Centre for Oil Products) PLATFORM

ANALYSIS AND EXPERTISE

• Accreditation files for analysis methods (phytic acid, pesticides,

toluene insoluble)

• Development of methods (isoflavones, DAG of crude oils, carotene)

• Rapid analysis methods (NIR within the framework of the European

project OLEUM, rapid method on phytic acid)

• RMT ACTIA Al-Chimie: “Chemical contamination of the food chain”

(ACTA Coordination / ACTA, INRA, ITERG co-facilitation)

• Development of a 194m2 laboratory extension project(see opposite)

Faced with the need to adapt ITERG’s premises to the development of the work

of the Analysis & Expertise Department, in place since 2002, the DAVE 4 project

consists of constructing a building for the laboratories.

The extension will be compact, built over two levels (total area 194m2 including

130m2 of laboratory) in continuity with the two levels of the existing building

occupied by the Analysis & Expertise Department. A light steel structure is planned,

covered with metal cladding with vertical slats.

These new laboratories will be mainly dedicated to gas chromatography activity.

The works started in May 2020 and should be completed before the end of 2020.

This project benefits from funding from the Nouvelle-Aquitaine region.


SCIENTIFIC COMMUNICATIONS

NUTRITION HEALTH & FAT BIOCHEMISTRY

• Organogels from trehalose difatty ester amphiphiles.

G. Hibert, M. Fauquignon, J.F. Le Meins, D. Pintori, E. Grau, S. Lecommandoux, H Cramail

Soft Matter, 2019

• Cross-Linking of Polyesters Based on Fatty Acids

S. Dworakowska, C. Le Coz, G. Chollet, E. Grau, H. Cramail

European Journal of Lipid Science and technology, Vol. 121, n°11, 2019

• Benefit of the reactive extrusion in the course of polyhydroxyurethanes synthesis by

aminolysis of cyclic carbonates

F. Magliozzi, G. Chollet, E. Grau, H. Cramail

ACS Sustainable Chemistry and Engineering, 2019

FORMULATION• O/W Pickering emulsions stabilized by cocoa powder: Role of the emulsification process

and of composition parameter

C. Joseph, R. Savoire, C. Harscoat-Schiavo, D. Pintori, J. Monteil, F. Leal-Calderon, C. Faure

Food Research International, vol. 116, p. 755-766

• Redispersible dry emulsions stabilized by plant material: Rapeseed press-cake or cocoa

powder

C. Joseph, R. Savoire, C. Harscoat-Schiavo, D. Pintori, J. Monteil, C. Faure, F. Leal-Calderon

LWT, vol. 113, 2019

• Synthesis and self-assembly of Xylan-based amphiphiles: from bio-based vesicles to

antifungal properties.

J. Rosselgong, M. Chemin, C. Cabral Almada, G. Hemery, J.M. Guigner, G. Chollet,

G. Labat, D. Da Sliva Perez, F. Ham-Pichavant, E. Grau, S. Grelier, S. Lecommandoux,

H. Cramail

Biomacromolecules, vol. 20, n°1, 2019

• Versatile cross-linked fatty acid-based polycarbonate networks obtained by thiol–ene

coupling reaction

P.L. Durand, G. Chollet, E. Grau, H. Cramail

RSC Advances, 2019, 9, p. 145-150

• Very low inadequate dietary intakes of essential n-3 polyunsaturated fatty acids (PUFA) in

pregnant and lactating French women: the INCA2 survey

J. Tressou, B. Buaud, N. Simon, S. Pasteau, P. Guesnet

Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 140, 2019, p. 3-10

• Milk Polar Lipids in a High-Fat Diet Can Prevent Body Weight Gain: Modulated Abundance

of Gut Bacteria in Relation with Fecal Loss of Specific Fatty Acids

M. Milard, F. Laugerette, A. Durand, C. Buisson, E. Meugnier, E. Loizon, C. Louche-Pelissier,

V. Sauvinet, L. Garnier, S. Viel, K. Bertrand, F. Joffre, D. Cheillan, L. Humbert, D. Rainteau,

P. Plaisancié, L.B. Bindels, A.M. Neyrinck, N.M. Delzenne, M.C. Michalski,

Molecular nutrition & food research, 2019

PUBLICATIONS

OLEOCHEMISTRY

37APPENDICES I T E R G - 2 0 1 9 A C T I V I T Y R E P O R T


• Development of new biobased extender oils made from renewable sources Biopol 2019 M. Reulier, G. Chollet, M. Charman, D. Chauffaille, H. Cramail, E. Grau

• European validation of the determination of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in animal feed (CEN/TC327/WG1) Euro Fed Lipid 2019 F. Lacoste

• Influence of marine phospholipid formulation on intestinal absorption of DHA, EFL, Belfast 16-19 septembre A. Sehl

OLEOCHEMISTRY

ANALYSIS & EXPERTISE

POSTERS

COMMUNICATIONS & CONGRESSES

• Niveaux de consommation en acides gras polyinsaturés de la femme allaitante en France : étude de

consommation INCA 2 et évolution du contenu en acides gras essentiels du lait maternel de 1997 à

2004.

C. Vaysse, N. Simon, J. Tressou, S. Pasteau, B. Buaud, P. Guesnet, L. Couedelo et C. Billeaud

Cahiers Nutrition et Diététique, vol. 54, n°1, 2019, p. 35-43

• Benefits of dimension reduction in penalized regression methods for high-dimensional grouped data: a

case study in low sample size.

S. Ajana, N. Acara, L. Bretillon, B.P. Hejblum, H. Jacqmin-Gadda, C. Delcourt, B. Buaud, C. Vaysse

BLISAR Group

Bioinformatics, 2019

• Milk polar lipids reduce lipid cardiovascular risk factors in overweight postmenopausal women:

towards a gut sphingomyelin-cholesterol interplay.

C. Vors, L. Joumard-Cubizolles, M. Lecomte, E. Combe, L. Ouchchane, J. Drai, K. Raynal, F. Joffre,

L. Meiller, M. Le Barz, P. Gaborit, A. Caille, M. Sothier, C. Dominques-Faria, A. Blot, A. Wauquier,

E. Blond, V. Sauvinet, G. Gézan-Guiziou, J.P. Bodin

Gut, juin 2019

• In vitro lipolysis and lymphatic absorption of n-3 long-chain polyunsaturated fatty acids in the rat:

influence of the molecular lipid species as carrier

A. Sehl, L. Couëdelo, I. Chamekh-Coelho, C. Vaysse

British Journal of Nutrition, 2019, vol. 122, p. 639-647

• Bioavailability and metabolism of dietary lipids

M.C Michalski, L. Couëdelo, A. Penhoat, C. Vaysse, C. Vors

In: Lipids and edible oils, 1st Ed, 2019

• Rapeseed oil fortified with micronutrients improves cognitive alterations associated with metabolic

syndrome

C. Fourrier, Kropp, A. Aubert, J. Sauvant, C. Vaysse, J.M. Chardigny, S. Layé, C. Joffre, N. Castanon

Brain, Behavior, and Immunity, 2019

• Vegetable lecithins: a review of their compositional diversity, impact on lipid metabolism and potential

in cardiometabolic disease prevention

C. Robert, L. Couëdelo, C. Vaysse, MC Michalski

Biochimie, 2019



OLEOCHEMISTRY

• French tool for the environmental assessment of vegetable oil products, EFL, 22 octobre 2019, L. Badey

• L’emballage dans l’évaluation environnementale du produit alimentaire, Séminaire d’informations sur les emballages (organisé par FNCG et FEDALIM pour leurs adhérents) Paris, 12 novembre 2019, F. Bosque

• Développement de produits biosourcésà partir d’huiles végétales, Rencontres ACD Innovation : Quelles innovations chimie et matériaux pour la filière sport et loisirs février 2019, C. Bonnet

• Besoins Filière corps gras et huiles végétales, Séminaire 3BCAR, M. Reulier

• Current development in biobased polyester: PRIC range, 10th Workshop on Fats and Oils as renewable feedstock for the chemical industry, 17-19 mars 2019, M. Reulier

• Développement de produits biosourcés à partir d’huiles végétales, SIAL2019, C. Bonnet

• Current Development in biobased polyester : PRIC range, ISGC, La Rochelle, 13-17 mai 2019, G. Chollet

• A new range of biobased additives for large scale market, Plant Based Summit, lyon 22-24 mai 2019, G. Chollet

• Sustainable bio-based surfactant «Industrial alternative to coprah oïl: cuphea oïl - development and challenges», Adebiotech, Paris, C. Bonnet

• A new range of biobased additives fro large scale market, EFL, 22 octobre 2019, G. Chollet

• Utilisation de polymères lipidiques comme additifs pour matrice polymère de type PLA, Rencontre Ecotech Plastiques et Emballages, 25 novembre 2019, C. Bonnet

ENVIRONMENT

• Encapsulation de molécules et leur libération via des formulations d’émulsions multiples Journée Technique du Bois, 18 juin 2019, C. Joseph

• Émulsions multiples, Journée Agri Sud-Ouest Innovation sur le biocontrôle animal, 18 juin 2018, Toulouse, C. Bonnet

ORAL PRESENTATIONS

• The importance of interlaboratory studies for the development of analytical methods The control of methods from the technique to the norm: oil as a model system - 24-25 janvier 2019, Turin, Italie, F. Lacoste

• Standardization work for determination of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in vegetable oils, seeds and meals INNOVHUB, Milan, 15 novembre 2019, F. Lacoste

• Standardization work for determination of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in vegetable oils PIPOC, Kuala Lumpur, 20 novembre 2019, F. Lacoste

• Update of the polyunsaturated fatty acid and fat-soluble vitamin composition of the breast milk in a population of french lactating women, EFL, 22 octobre 2019, B. Buaud

• Bioavailability and metabolic fate of ALA according to its food level in rodents, EFL, 22 octobre 2019, L. Couëdelo, I. Chamek-Coelho, H. Abrous, L. Fonseca, C.Vaysse

• Création d’un observatoire des habitudes de consommation en lipides en France à partir d’une population de femmes allaitantes, JFN, 27-29 novembre 219, B. Buaud

ANALYSIS & EXPERTISE

FORMULATION

39APPENDICES I T E R G - 2 0 1 9 A C T I V I T Y R E P O R T

YOUR CONTACTS

1ères Transformations

Administration / Qualité

Cellule VeilleInformation

Communication

MarketingCommercial

Unité Environnement et Eco-Industries

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CARINE BONNET

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RessourcesHumaines

Comptabilité Achats

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DAVID MATEOS

YVES DELAINE GUILLAUME CHANTRE

PATRICK CARRE

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Direction InnovationAUDREY COMITIS

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