INNOVATIVE BY 2018 ACTIVITY REPORT...

A n a l y s i s I P r o c e s s e s I N u t r i t i o n I G r e e n c h e m i s t r y I E n v i r o n m e n t I F o r m u l a t i o n

I N N O VAT I V E BYN A T U R E2018 AC T I V I T Y R E P O R T

I N N O VAT I V E BY N A T U R E

ITERG - 2018 ACTIVITY REPORT

1.1 ITERG

• Strategic priorities

• Qualifications

• Governance

• Quality

• Key figures

• Statement on the performance agreement

• OLEAD

1.2 GENERAL INTEREST WORK

• Standardisation and Expertise

• Monitoring Information and Communication

1.3 THE VEGETABLE OILS SECTOR

1.4 PARTNERS AND NETWORKS

1 ITERG AND ITS ENVIRONMENT CONTENTS

2 RESEARCH AND INNOVATION2.1 FOCAL AREAS FOR RESEARCH AND INNOVATION

2.2 REGIONAL STRUCTURING

• “Chemistry and materials” regional roadmap

• The Nouvelle-Aquitaine ACTIA (Technical Coordination Association for the Agrifood Industry) network

2.3. RESOURCING AND USE

• Creation of the ACTIA AGROCHEM MTU / About ACTIA MTUs

• 3BCAR projects

• Patents / Theses

2.3 EXAMPLES OF RESEARCH PROJECTS

• Recent developments around the PRIC range

• The VALORMAP project

• Development of a method for determining the dosage of phytic acid

• THE BALI ACTIA MTU

3 SERVICES PROVIDED TO THE INDUSTRY

3.1 MARKETS

3.2 TESTIMONIALS

3.3 2018 HIGHLIGHTS

ANNEXES 2018 EVENTS

BOARD OF DIRECTORS

SCIENTIFIC COMMITTEE

SCIENTIFIC COMMUNICATIONS

EDITORIAL

I N N O VAT I V E BY N A T U R E

EDITORIAL

EDITORIAL 5ITERG - 2018 ACTIVITY REPORT

Technological and societal changes are accelerating the development of the industrial landscape, right across the

spectrum. Anticipating and then supporting these developments are at the heart of the work being done at Industrial

Technical Centres, assisted by their Professional Federations. Therefore, despite the difficulties with public financing, the

ITERG continues to provide a valuable contribution to the industrial collective in order to respond to these challenges.

For example, in 2018, for the vegetable oils and proteins industries, this valuable contribution was pre-treating oils for

taste in order to remove any undesirable component from them, developing new analysis methods and introducing new

methods for managing effluents on industrial sites. Scientific partnerships are getting stronger, with a number of examples

of the amazing results featuring in this annual report. The Bali MTU (Mixed Technological Unit) helps us to explore new

aspects of nutritional quality in vegetable oils and emulsions in conjunction with intestinal microbiotics, while the brand

new Agrochem MTU creates scope for non-food uses of varieties of erucic acid. Having also received support from the

Terres Univia inter-professional organisation and the Nouvelle-Aquitaine region, the portfolio of our specimens has been

enhanced by new certified amphiphilic biomolecules.

Simultaneously, ITERG’s private operations grew by almost 13%, after the exceptional year in 2017. Analysis operations

and the increasing level of activity of the lipochemistry platform have led to this trend, which is offsetting a sharp fall in

co-financing. The extension of the analysis laboratory has begun, which is the first step in the gradual development of

the Pessac-Canejan site. Joint discussions are continuing with the professional organisation in order to set up a leading

technology centre in Nouvelle-Aquitaine, which would meet the needs stated by the Nouvelle France Industrielle project:

functional food, food safety, vegetable and vegetable-protein chemistry.

André POUZETChairman

of the Board of Directors

Guillaume CHANTREDirector-General

EDITORIAL

LARGE FIELDS OF SCIENTIFIC

AND TECHNOLOGICAL EXPERTISE

TURNOVER

OF SCIENTIFIC AND TECHNICAL STAFF

CORRESPONDENTS

6

€6.3M

82% 78

1 ITERG AND ITS ENVIRONMENT

INNOVATIVE BY N A T U R E2018 ACTIVITY REPORT - ITERG 6

7

Protein-rich oil plant sector

Cosmetics Pharmacy

IAA Green chemistry

Animal feed

Monitoring Information

Nutrition

Formulation

Analysis

Training

Green chemistry

Processes

Environment

Auditing board

ITERG - 2018 ACTIVITY REPORT

ITERG is the Industrial Technical Centre specialising in fats and related products (vegetable oils, fats, by-products and minor compounds). It boasts analysis and technology platforms, laboratories and expertise, which are constantly changing to meet the industrial ecosystem’s needs. 1.1 ITERG

(1) National Federation of Oils and Fats Industries(2) Vegetable oils and proteins inter-professional organisation (3) Industrial Technical Centres network (4) The French network of agrifood technical institutes

Industrial Technical Centre• General Management: Guillaume CHANTRE• Governed by private law• Reporting to the Minister of Economy and Finance

Fat and related products sector represented by the FNCG 1 and the Terres Univia2 inter-professional organisation

ISO 9001 certification: 2015

PROFILE

RESOURCES• A team of 78 people

• A laboratory platform for chemical, physico-chemical,

sensory and biological analyses

• An oleochemistry platform

(the chemical study of vegetable oils)

• A technology platform focusing on

crushing and refining (OLEAD SAS)

ATTRIBUTES

• Transversal expertise in lipids

• Technological and scientific excellence

• Capacity for Innovation and industrial transfer capacity for a variety of industrial sectors

• Discipline and Independence

• Prevalent network operations (CTI3, ACTIA4, CARNOT)

• Eligible for Research Tax Credits, dual account

MARKETS

EXPERTISE

STANDING AND QUALIFICATIONS

STRATEGIC PRIORITIES

> Collective-interest research

Meeting the expectations of fat industrialists, producers and processors, through collective-interest research activity and work to provide technical, regulatory and normative support. Adopting an approach for subsidiaries which encourages cooperation among economic stakeholders from upstream agriculture and the industry;

> Excellent services

Developing excellent services (relating to analysis, technology and the environment), which make the ITERG’s expertise available to the industry and help to balance its books.

• ITERG is an Industrial Technical Centre (ITC).

• It is also an Agro-Industrial Technical Institute (ITAI). This qualification has been renewed for the period 2018-2022.

• As an ITAI, the ITERG coordinates 2 MTUs: ACTIA-AGROCHEM (Fatty Acids for Chemistry and Materials - Technical Coordination Association for the Agrifood Industry) and BALI (Bioavailability for Intestinal Lipids from Food Products). It also coordinates an ECOVAL (Eco-conception and Promotion) MTN (Mixed Technological Network).

• ITERG is a member of the Carnot Institute 3BCAR (Bio-energies, Biomolecules and Bio-based Materials of Renewable Carbon).

• Finally, in a regional context, ITERG is also involved as a Technological Resources Centre (TRC).

In all its areas of activity, ITERG plays a role in bio-technology taking flight, drawing on the corporate values of expertise, scientific excellence, creativity, efficiency and the creation of sustainable value.

> Innovation and Transfer

Supporting value creation through the transfer of industrial solutions in the regions and building capacity for innovation relating to processes/fat products, based on making use of the ITERG’s Intellectual Property, skills and expertise;

2018 ACTIVITY REPORT - ITERG INNOVATIVE BY N A T U R E8

JEAN-DAVID LEAO

FLORENCE LACOSTE FRANCK DEJEAN STÉPHANE MAZETTE CLAUDIE GESTIN

The ITERG governance structure includes a Board of Directors, which meets at least twice a year. Half of the board is made up of industrialists representing the professional sector (including the FNCG) and half of it is made up of staff representatives and qualified individuals (see Appendix). A board comprised of a number of representatives from the profession draws up the major decisions that are submitted to the Board to be discussed and approved. These include changes in strategy, methods for financing the Centre, significant investments and creating subsidiaries. The Board of Directors may set up subsidiary Committees with consultative functions. In particular, it has a Financial Committee made up of three to six people chosen from among the members of the Board of Directors (including the State and the CGEFI (the General Financing and Economic Monitoring Office) representatives), who provide the Board with advice on the Institute’s administrative and financial management. A Scientif ic Committee made up of (academic and industr y) representatives from outside the Board, who have been appointed by the Board, is renewed through co-option, subject to its approval. It sets up and appraises non-economic research projects, and the quality of the ITERG’s scientif ic output from these projects. The Scientif ic Committee’s operations are governed by Internal Rules which are proposed, as well as updated, upon approval by the Board of Directors. Since 2013, the Scientific Committee has been supported by thematic subgroups made up of industry experts (affiliates) working to identify, in addition to the Scientific Committee and with the approval of the FNCG, collective-interest scientific work that must be conducted as a priority for the year (n+1).

GUILLAUME CHANTRE CARINE BONNET

Head of Collective Activity Financing

Head of the Analysis and Expertise

Department

Business Director in the Analysis and Expertise

department

Head of the Support Services

Department

Head of Monitoring Information &

Communication

Director-General Head of Innovation and Transfer

9

GOVERNANCE

ORGANISATION

ITERG has been organised along its business lines in a matrix structure in order to enhance each of them, but not isolate them in the process.

Specific processes relate to:

• creating and managing pre - competit ive collective activities (PAA (Priority Action Areas, see page 19) in project environments, based on collective resources, with a dedicated manager, a principal point of contact for industrialists and the FNCG,

• competitive co-f inanced activities, and RDI (Research, Development and Innovation) under contract (SIA (Strategic Innovation Areas), see page 19) with an associated commercial organisation,

• private services (such as analysis, research and transfer), with commercial support shared with the SIA.

Board committee

FATS E X P E R T I S E 9ITERG - 2018 ACTIVITY REPORT

QUALITY

> Successful transition to the ISO 17025 2017 version

Part of 2018 was devoted to grasping the 2017 version of the NF EN ISO/CEI 17 025 standard and implementing it in our analy tical services laboratories. Our accreditation was renewed by COFRAC1 for five years following the inspection in October 2018 (assessment monitoring on the site every 15 months).

It is worth noting that ITERG was the first of our Industrial Technical Centres to be accredited using the new version of the standard.

The renewal of our accreditation certifies the technical skill and the proper functioning of our laboratories, within a management system which is able to quickly respond to changes in standards.

The details of our capacity are available on the COFRAC website: www.cofrac.fr

> Other recognitions of Analysis and Expertise’s operations

IOOC2 approval for the physico-chemical and sensory analysis of olive oil was renewed for the period from 01/12/2018 to 31/12/2019.

FOSFA3 approval was renewed until 31 March 2020.

> A new certification project

In order to meet the demands of the Lipochemistry unit’s customers, a process for obtaining certification under the NF EN ISO 22716 standard (Cosmetics - Good Manufacturing Practices) was approved at the end of 2018. After spending time grasping the standard, we will be focusing on introducing measures to move our practices closer to the practices laid out in the standard.

We are aiming to get the certification by the end of 2019.CÉLINE BIROT

Head of Quality, Safety

& the Environment

Changes in standards and new standards provide a new challenge in terms of Quality each year. I am constantly striving to work closely together with all of the teams in order to deliver projects which would not succeed without their efforts and their commitment.

The conclusions from the ISO 9001 monitoring audit in July 2018 certify that the new version of the standard was being properly applied (no non-conformities opened).

The customer satisfaction level is still very high; the main reasons why our customers choose us are our skill and our reliability.

The Analysis and Expertise department is part of a number of interlaboratory networks (such as BIPEA, FAPAS, FOSFA, DRRR, AOCS and IOOC); the 2018 results are very good, with the level of conforming results standing at 98.6%.

“

“

Quality guarantees

1 - The French Accreditation Committee 2 - The International Olive Oil Council 3 - The Federation of Oils, Seeds and Fats


Private contracts

Staff

Collective Activity

Financing

Other charges

Collaborative Research Financing

Purchases

Taxes and levies

income (in %)

expenses (in %)development of resources over 5 years (in €K)

Sold products

Collective Activity Financing

Other products

Total income

Subsidiarisation of OLEAD (turnover of €1.6m).

KEY FIGURES


19

142

22

21

59

63

COMMENTS ON THE 2016-2019 PERFORMANCE AGREEMENT

The performance agreement signed between ITERG, FNCG and the State for the 2016-2019 period is coming into its final year. The analysis of the indicators, which are part of a ISO 9001- v2015 Quality policy, retrospectively outlines the salient aspects and the ITERG’s ability to fulfil its commitments.

• Strengthening our ability to transfer our research findings across the industry;

• Increasing the visibility of our operations through a shared communication plan across our networks;

• Strengthening partnership research, by identifying new public and industry co-financing sources.

• Financial ratios were in line with expectations, with a significant wave of investment (€830K in 2018), thanks to a level of investment which exceeded objectives, at around €1m per year;

• Excellent performance was maintained, whether this relates to interlaboratory comparisons or measuring customer satisfaction;

• The level of competitive research activity was in line with predictions, but there were problems in keeping collective research efforts at the expected level;

• ITERG continued to have an active presence on French and international standardisation committees;

• A wave of new projects was proposed to the professional and interprofessional organisation, following constant listening work;

• There were a number of maturation projects for growing technologies leading to a number of success stories;

• There was noticeable visibility on a global scientific level, both in terms of levels of annual publications and presence in seminars, theses and patents.

Successes:Successes:

Areas which require work:


Originating from ITERG and Terres Inovia, and supported by the financial unit of the protein-rich oil plant sector, OLEAD has brought together all the initial processing tools on the same site, making it possible to crush the seeds in order to extract the oil from them and then refine it.

Its main purpose is to serve the whole value chain for the vegetable oil and protein sector, while making it possible to shape industrial processes at a scale which meets R&D requirements. This technology platform is focusing on innovation to enable projects to move through the initial manufacturing by transferring laboratory conditions on a closer scale to industrial-production conditions.

Its services are geared towards all stakeholders using these technologies (agrifood, cosmetics, the vegetable component and active ingredients sector, and equipment manufacturers) and are willing to work in partnership with academic research.

OLEAD is also becoming avidly interested in vegetable proteins, particularly in the defatting stage, which is often essential for extracting and using them.

Some of the workshops are also willing to adjust their production processes for rare materials available in limited quantities.

OLEAD

A FEW FIGURES • 2018 turnover: €1.6m

• Permanent staff: 12 people

• 7 workshops, with approximately 1100m² of premises

AREAS OF FOCUS> husking seeds by removing their fibrous shells, drying them, cleaning them and crushing them.

Preparation

Seed technology

Refining

Chemical extraction

Mechanical extraction (Pressure)

Predevelopment platform

> making it possible to extract the oil using a f lattening process and granulation; hydro -thermal conditioning and extrusion.

> compressing the seeds to extract the oil and then filter it.

> extracting the oil from the oil cake using solvents and separating the defatted proteins.

> working on miniature equipment (extraction, cooking and shelling) on a small scale.

> removing unwanted compounds from oils in order to make them neutral, only slightly coloured and free from unwanted smells and tastes.


GENERAL INTEREST WORK 1.2

STANDARDISATION

Working group on the ITERG’s analysis methods

• AFNOR1 T60C & ISO2/TC34/SC11 Fats Presidency (Florence LACOSTE)

• CEN3/TC19/JWG1 Biodiesel Project Manager

• CEN/TC275/WG13 Process contaminants

• CEN/TC327/WG1 Animal feed

• IOOC4 - Group of Chemists & Group of experts for organoleptic evaluation. Analysis of olive oils. Expert & Project Manager

• European Commission “Olive Oil” Expert Group. Analysis of olive oils

EXPERT GROUPS

• ANSES 5: The "Evaluation of Substances and Processes Subject to Authorisation for Food” (ESPA) working group • BIPEA6 : Technical Commission for the Fat Substances circuit 21 • CCRDT7 Nouvelle-Aquitaine Region • FNCG : Technical Committee • FOSFA8: Technical Committee • TERRES UNIVIA: The Human Food Committee

In order to sustainably anticipate and support the development and competitivity of industries, ITERG plays a leading role in standardisation bodies which ensure excellence in analytical checks and, therefore, ensure that products are high-quality. Furthermore, ITERG makes its expertise available to industrialists through national and international expert committees.

As a Technical Centre, ITERG must carry out general interest work: offering a medium-term and long-term vision to industrialists in the fat sector and providing access to research. Experts from ITERG actively work with public and private bodies, both at national and international levels, on a collective basis, in relation to scientific, regulatory and normative issues. It is therefore a major partner which can react quickly should there be a health crisis in the Fats sector. These transversal issues are regularly monitored by the Monitoring Unit and relayed to industrialists through the information departments.

STANDARDISATION AND EXPERTISE

Participation by Florence Lacoste, Head of the Analysis & Expertise department in the IOOC’s work in Madrid, surrounded by approximately forty international experts.

IOOC photo, April 2019

1 - The French Standardisation Agency 2- The European Standardisation Committee 3 - The International Organization for Standardization 4 - The International Olive Oil Council

5 - The National Agency for Health and Safety in Food, Work & the Environment 6 - The Interprofessional Office of Analytical Studies 7 - The Regional Advisory Committee on Technological Research and Development 8 - The Federation of Oils, Seeds and Fats


15

GENERAL INTEREST WORKMONITORING INFORMATION AND COMMUNICATION

REDESIGN OF THE WEBSITE ITERG.COM

ENHANCEMENT OF MONITORING PLANS

Objectives

Make access to information easier

Promote referencingFocus on current issues

The ITERG’s Monitoring Information and Communication Unit manages an organised set of procedures and human and material resources intended for collecting, storing, sharing, divulging, analysing and using the different types of data needed for the Institute to operate properly and for informing industrialists. Thanks to our unit, industrialists can stay informed of news (press, scientific and technical, regulatory and standardising) and can use the Q&A service.

In 2018, key actions were carried out in project environments.

In 2018, all monitoring plans which related specifically to ITERG’s operations were redefined in conjunction with the heads of Units.

Four types of monitoring were therefore classified into themes and based on different tools:

• Information monitoring Customised and periodic availability of processed information (such as press, websites and social networks), image monitoring (e-reputation) and sectoral monitoring

• Regulatory monitoring Alerts on national and European regulations • Technological and scientific monitoring Monitoring of scientific publications, patents, theses, forums and works

• Standardising monitoring as part of our ISO 9001:2015 certification and accreditation for our laboratories

2018 operations in a few figures

• +800 documentar y references in ourinternal database;

• +90% of information requests processed within a week;

• + 90,000 visits to our website and approximately 150 contact forms filled in.

• 680 recipients of our information letter.

The VIC unit monitors the fat sector and analyses information using a mapping tool. The proximity of the ITERG’s experts makes it possible to use the large database in order extract strategic information on invention trends and major stakeholders.

«

«

CLAUDIE GESTIN

Head of Monitoring Information &

Communication


110,000 oilseed producers

25 industrial sites

6MT 65%

21%

9%

3.7 MT

2.3 MT

2.4 MT

seeds processed

oil cakes

rapeseed

sunflowers

soya

raw oils

refined oils

Sources : FNCG, Terres Univia

France is the leading oilseed producer in the EU, ahead of Germany. In 2018, 6 million tonnes (MT) of seeds were crushed, providing an output of 2.3 MT of raw oil intended for food and non-food uses, and more than 3.7 MT of non-GMO oil cakes for animal feed. The production of French olive oil is slightly lower at 4,000 tonnes, having used around 100,000 tonnes of seeds.

FOOD800,000 tonnes of edible vegetable oils are consumed each year in France.70% of edible oils are consumed without further processing by humans, while the rest are used by the agrifood industry and are turned into margarines, for example.

GREEN CHEMISTRYNon-food represents an ever-increasing proportion of uses for vegetable oils and their derivatives because they come from renewable raw materials and are biodegradable or compostable.The green chemistry market currently accounts for 7% of the global vegetable oil market.USES: biofuels, cosmetics, detergents, agrochemicals, paints, coatings, plastics, materials, additives and more.

Moving towards “Made in France”

for vegetable oils and proteinsTerres Univia, the vegetable oils and proteins inter-professional organisation, presented its ‘Moving towards “Made in France”’ sector plan for 2018-2022 at the end of 2017. In particular, it relates to making value chains more competitive: increasing the economic output of

operations by 10 to 20% and increasing productivity in crushing factories by 5 to 10%.

The aim is to be self-suf f icient with vegetable proteins by 2030, meaning that 500,000 additional hectares of land will be developed in the next five years (soya, sunflowers, peas, pulses and dehydrated alfalfa). A n o t h e r av e n u e i s a n “a m b i t i o u s ” b i o f u e l s p l a n w i t h “a t l e a s t 7 % b i o d i e s e l f r o m r a p e s e e d ” i n o n - r o a d d i e s e l f u e l . For the ecological transition, the plan sets out to reduce the use of crop protection products by 20 to 30%. The sector is convinced that ensuring that the French processing sector (industrial tools, the two research institutes, Terres INOVIA, ITERG, and Terres OléoPro and GEPV promotional tools) remains competitive is just as essential as the sustainability of the 100,000 farms in order to implement this plan.

In terms of the social impact of the vegetable oil and proteins sector, it is deemed to have directly and indirectly led to the creation of 150,000 jobs. 90% of French households consume products from the French sector every day.

THE VEGETABLE OILS SECTOR 1.3


PARTNERS AND NETWORKS 1.4

17

NETWORKS

COMPETITIVENESS CLUSTERSREGION

SECTOR

The National Federation of Oils and Fats Industries www.fncg.fr

The Industrial Technical Centres network www.reseau-cti.com

Agri Sud-Ouest Innovation agrisudouest.com

Cosmetic Valley, a cosmetics cluster specialising in beauty and well-being science cosmetic-valley.com

THE IAR bioeconomy cluster iar-pole.com

The French Network of Agrifood Technical Institutes actia-asso.eu

The CARNOT Institutes network as part of our involvement in the CI 3BCAR www.instituts-carnot.eu

The vegetable oils and proteins inter-professional organisation www.terresunivia.fr

Vegetable industries industriesduvegetal.fr

Oleaginous, proteins and hemp technical institute terresinovia.fr

New-Aquitaine region nouvelle-aquitaine.fr

The University of Bordeaux u-bordeaux.fr

Aquitaine Sustainable Chemistry aquitainechimiedurable.fr


INNOVATIVE BY N A T U R E

2 RESEARCH AND INNOVATION

SCIENTIFIC PUBLICATIONS

MTA (MATERIAL TRANSFER

AGREEMENT)

ACTIVE PATENTS

FOCAL AREAS FOR RESEARCH

17

12

13

10

2018 ACTIVITY REPORT - ITERG 18

• Evaluating the benefits of consuming lipid-based or liposoluble nutrients for preventing obesity and cerebral ageing;

• Preventing and eliminating chemical contamination;

• Protecting, characterising, outlining and authenticating oils and fats;

• Increasing the environmental efficiency of processes and responding to the related economic and societal challenges;

• Providing the chemicals industr y with functionalised biomolecule ranges in order to accelerate the industrial transfer of bio-sourced solutions.

Two other PAAs, relating to transfer, dissemination and monitoring operations on the one hand, and to standardisation operations on the other, offer cross-functional support to the Professional organisation and all ITERG activities.

Exploration Basic research

Technology demonstration Market orientation

Commercialisation


ITERG carries out multi-disciplinary collective research for industrialists from the fats sector. In addition, it undertakes pre-competitive research projects in order to make use of oils and derivatives on downstream markets. The results obtained and the skills developed as part of this research process help to maintain xITERG’s Scientific Excellence and its position as a recognised Centre of Expertise for lipids at an international level.

FOCAL AREAS FOR RESEARCH

& INNOVATION 2.1

STRUCTURING FOR RESEARCH AND INNOVATION

The work financed or co-financed by the Assigned Tax Duties are prioritised by agreement with the professional organisation and the resources are assigned per project, in line with the workload for each department for the year (n+1). The results may b e wide ly and f re e ly d is tr ibute d to a l l a f f i l iates , and gen eral ly p ub l ish e d or evaluate d by sc ient i f ic publications. Therefore, ITERG classif ies the contents and the f inancing into 7 Priorit y Ac tion Areas (or PAAs). They differ from the Strategic Innovation Areas (or SIAs), which relate to competitive innovation, provide a competitive advantage and are earmarked for a smaller group of beneficiaries.

These actions feed into each other and complement each other on the TRL scale (technology readiness level).

7PAAs

3S I A s

Industrial competitiveness is essential for innovation and requires experts who are fully aware of industrial needs and the technological and financial constraints. The proximity of the researchers to industrialists means that the industrialists can enjoy constant support, from the idea right up to going to market.

C A R I N E B O N N E T Head of Innovation and Transfer

• Formulating value-added health-enhancing food matrices, and designing nutritional studies on the health benefits of lipid-rich food matrices;

• Developing or adapting methods for analysing the characterisation of lipids and their derivatives found in complex or formulated matrices;

• Designing and developing innovative molecules and bio-sourced products from oils and fats, that are high-performance and economically attractive.

1 2 9876543

REGIONAL STRUCTURING 2.2

ITERG has helped to co-create the “Chemistry and materials” regional roadmap for 2019-2022 for the Nouvelle Aquitaine region.

This document sets out the strategic direction for the Region in relation to the development of the chemistry and advanced materials sector over a 4-year period.

This roadmap fits into European and national strategies. Europe identifies materials as a key technology for industrial and environmental challenges. At a national level, a “Chemistry and Materials” sector contract was drawn up in 2018 between the State and professional federations.

At a regional level, establishing a roadmap is part of a process which intends to apply the Regional Strategy for Economic Development, Innovation and Internationalisation (SRDEII). The approach plays a role in developing the smart specialisation strategy (S3) for Nouvelle-Aquitaine as part of the next programme for European structural funds.

After drawing up and implementing a “Composites and Advanced Materials” roadmap in 2009, as well as a second “Plant Chemistry” roadmap in 2013, chemistry and materials have been identified as the key technological areas by the Region. Indeed, these technologies support leading regional industries, such as the aviation, space, defence, water sports, energies, healthcare and farming sectors.

In order to develop innovation and increase the competitiveness of its local stakeholders, the Nouvelle-Aquitaine Region has created a network of technological development centres, particularly in the areas of chemistry and materials. These structures have the technological resources and engineering skills to enable it to carry out maturation, transfer and industrialisation activities which are beneficial to the companies.

- APESA (Pau) - Eco-innovation and environmental assessment - CANOE (Pessac, Pau and Lacq) - Composites and advanced materials, formulation and manufacturing practices- CITRA (Limoges) - Treatment engineering and advanced surface coatings- COMPOSITADOUR ADDIMADOUR (Bayonne) - robotised processes for using composites - CTTC (Limoges) - Ceramic technologies- CRAIN (La Rochelle) - Nautical architecture and industries-Sport and Leisure CRITT (Châtellerault) -Mechanics, fluid mechanics, materials and automation for sport and leisure equipment- CVA (Brive) - using agroresources and extraction - FCBA (Bordeaux) - Forests, cellulose, wood and furniture - IFTS (Agen) - Filtration and techniques to separate liquids and solids- ITERG (Pessac) - Lipochemistry, bioproducts, biopolymers, biomaterials, eco-design, LCA (Life Cycle Analysis), circular economy and CSR analysis- RESCOLL (Pessac and Rochefort) - Soldering, functional coatings, conductive polymers and high-performance materials

The Nouvelle-Aquitaine Region is spearheading many technologies, particularly ceramics, thermoplastics, carbon f ibres, nanomaterials and biosourced materials.

Network of technological development centres, particularly in the areas of chemistry and materials

THE “CHEMISTRY & MATERIALS” REGIONAL ROADMAP


21

GENERAL INTEREST WORK

THE NOUVELLE-AQUITAINE ACTIA NETWORK

The seven partner centres for the ACTIA network in Nouvelle-Aquitaine (ACTALIA, AGIR (Agrifood Innovation and Research), AGROTEC (Agrifood Technology Centre), BNIC, Agrifood CRITT, the IFV (French Winemaking Institute) and ITERG) have been involved in two years of discussions on how transfer and innovation centres working for regional agrifood industries could work together as a network.

The joint coordination of ITERG and agrifood CRITT is crucial in this structuring.

They represent 170 collaborators, about ten platforms and many partners with academic laboratories, and are involved in a collaborative process based around four strategic priorities for agrifood businesses:

• Nutritional and organoleptic qualities, and functional food

• Food product safety

• Monitored sectors, official labelling and organic products

• The environment, eco-design and overall performance

A specific programme of measures was reinforced in 2018 and drawn up for 2019.

Building on the existing ACTIA structuring (MTNs and MTUs), the collective plans to establish a concerted 2020-2022 programme, in close collaboration with the local agrifood companies.

Finally, the introduction of interprofessional sector plans in the region is laying the groundwork for successful structuring with upstream agriculture.


RESOURCING AND USE 2.3

The AGROCHEM MTU project proposed by ITERG and LCPO (The Organic-Polymer-Chemistry Laboratory of the ENSCPB of the University of Bordeaux and CNRS) follows on from the two previous certified MTUs, the POLYGREEN MTU and the POLYGREEN2INDUSTRY MTU.

In line with the ITERG’s customers’ requirements across the entire value chain (fat producers, processors and users), at national and international levels, we are trying to keep up our efforts to help to create innovative and effective products biosourced from fats, as part of an approach which aims to improve economic, societal and environmental competitiveness.

The AGROCHEM MTU strives to support the structuring and introduction of two French sectors, derived from fat sourcing, which focus on the agro-industrial markets for chemistry and materials. In order to do this, we are banking on very high-performance products on key markets, in terms of production volumes and capacities, which can compete with petrochemistry’s products. The two sources selected for producing original fatty acids are erucic rapeseed oil from the oilseed sector, and oil high in oleic fatty acids from the biotech sector.The sharing process is based around the working processes for oleochemistry and combined-polymer chemistry in order to create and then prototype target products. The functional assessment will be performed in partnership with French and foreign workers recruited thanks to the results of the two previous MTUs.

Upon recommendation by the ACTIA’s Scientific and Technical Committee (STC), the MTU is approved for 5 years from 1st January 2019.

a close partnership between public laboratories and technical institutes• The Mixed Technology Unit (MTU) is a partnership tool between technical institutes and public research units, set up

and supported by the ministry responsible for agrifood. For this sector, Actia organises 16 MTUs into themes which complement each other and complement the Mixed Technology Network’s (MTN) themes.

• In relation to their particular theme, MTUs provide a unique and recognised point of entry for research and development for its different professional, industrial, research and public points of contact.

• The MTU transforms the expectations of professionals into research issues and is dedicated to technological research that produces operational results which can broadly be applied in the short and medium term. Its technical advances are circulated, so that they can be used rapidly by all operators as far as possible.

To learn more, go to: http://www.actia-asso.eu

CREATION OF THE AGROCHEM ACTIA MTU

THE MTU:


23

GENERAL INTEREST WORK2 NEW PROJECTS CHOSEN THROUGH THE 3BCAR CALL FOR PROJECTS

Development of an innovative epoxidation process

The ENZEPOX project - duration: 12 months

Epoxides are components in many day-to-day products. For example, epoxidised fatty acids are used as PVC plastifiers for diluting paints, as platform molecules for anti-rust agents, as additives in lubricants and more. In order to obtain these molecules on an industrial scale, the processes currently used require a strong acid which results in equipment being worn, and requires the equipment to be neutralised and the waste to be treated. In addition, there may be secondary reactions which lead to weak selectivity.

The ENZEPOX project strives to develop a chemo-enzymatic process for epoxydation by introducing more selective and more environmentally friendly synthesis pathways. This new process will help to produce epoxidised derivatives from biosourced ω-unsaturated compounds which will be included in the process of synthesising polymers for areas such as lubricants, detergents and cosmetics. Partners: ISBP (The Engineering Laboratory for Biological Systems and Processes), LCPO (The Organic-Polymer-Chemistry Laboratory) and ITERG

A new sector for producing monohydric fatty acids

The HYAGRAM project - duration: 24 months

12-hydroxystearic acid from castor oil has useful properties for synthesising polymers in industry. However, as part of a sustainable development approach which involves bio-refining locally, the source and the production systems must be taken into account. So with this in mind, the HYAGRAM project intends to develop a new sector for producing monohydric fatty acid from plant-based oleochemicals.

The development of new oilseed varieties and the work to characterise the oils have made it possible to identify a crop which produces fatty acids which are structurally close to 12-hydroxystearic acid. As part of this project, the research teams will test the hydrogenolysis of this oil using a continuous monolith reactor. These monohydric fatty acids will then be incorporated into polymers for comparison with polymers from castor oil.

Partners: LGC (The Chemical Engineering Laboratory) and ITERG

PATENTS THESES

- WO201908145 “Method for producing pickering emulsions from biosourced particles” - 10th January 2019 - CNRS, BORDEAUX POLYTECHNICAL INSTITUTE, ITERG, PIVERT, THE UNIVERSITY OF BORDEAUX

- WO201908147 “Method for producing dry emulsions from biosourced particles” - 10 January 2019 - CNRS, BORDEAUX POLY TECHNICAL INSTITUTE, ITERG, PIVERT, THE UNIVERSITY OF BORDEAUX

- The industrial trends of sectors: application to the area of protein-rich oil plants, CIFRE (Industrial Training Agreements through Research) ITERG / GRETha (Theoretical and Applied Economic Research Group) Thesis, Guillaume Assogba.

- Impact of the molecular and supramolecular vectorisation form for n-3 polyunsaturated fatty acids on their bioavailability- physico-chemical and in vivo studies on rats, ITERG/CBMN (Institute of the Chemistry and Biology of Membranes and Nano-objects), Anthony Sehl.

- Reactive extrusion for synthesising biosourced polymers, ITERG/OPCL, Fiona Magliozzi.


EXAMPLES OF RESEARCH PROJECTS 2.4RECENT DEVELOPMENTS AROUND THE PRIC RANGE

For about a decade now, ITERG has focused some of its operations on developing a range of estolide macromolecules. These biosourced oligomers obtained through polycondensation reactions are grouped under the PRIC generic name.

Following their assessment by industrialists from different sectors, the very promising results strengthen our confidence in our strategy. This range’s strong point lies in the fact that it can adapt to fit a very broad range of specifications The range is therefore constantly evolving to fit with variations in terms of functionalities, viscosity and physico-chemical properties in particular. Estolides, which have new alcohol, acid, isocyanate and now acrylate functionalities, have been developed for uses as a precursor for polymeric materials or as an additive for polymer matrices.

The work is now focusing on adding new physico-chemical properties. Indeed, adding amphiphilic properties is a real challenge, but also provides added value in order to expand the PRIC range. Therefore, different structures have been synthesised, which has resulted in partially and fully biosourced oligomers, with different hydrophilic/lipophilic balances (HLB).

Furthermore, the cosmetics market poses a real challenge when it comes to positioning our products. For this reason, a large number of evaluations and regulatory steps have been taken. Therefore, there is proof that the products evaluated are safe, based on a number of criteria.

Finally, finding an alternative to castor oil or at least limiting our dependence on it is crucial; this is why one of our focal areas for research is continuing to develop the PRIC range, starting from plant-based oleochemicals.

Contact : Guillaume CHOLLET, Head of Oleochemistry Unit -

[email protected]


The VALORMAP project (2015-2018), launched by the ACTIA ECOVAL MTU and coordinated by ITERG, has made it possible to conduct analysis on by-product deposits for 5 agro-industrial sectors, including by-products from the fat and margarine-producing industry (but also alcohol production, the wine-production sector, paper-making and the pork sector), and 3 French regions (Provence-Alpes-Côte d'Azur, Auvergne and Lorraine), as well as evaluation of the methanogenic potential of more than 90 residues. Within this particular area, it has been estimated that there are 3.5 million tonnes of solid waste produced each year and 5 million m3 of liquid waste produced per year, which means 509 million Nm3 CH4 theoretically produced each year. The waste identif ied cannot be completely put into use through methanisation, due to certain regulatory, technical and f inancial constraints. If you are optimistic about the rate that it can be put into use, the annual biomethane production rate would be around 123 million Nm3

of CH4.

The main results from the project are available online at www.valormap.fr.

25

GENERAL INTEREST WORKCREATION OF A SPATIALISED DATABASE ON ENERGY RECOVERY BY METHANISING RESIDUES AND ORGANIC BY-PRODUCTS FROM AGRO-INDUSTRIES

Contact : Laureen BADEY, Environmental & Eco-Industry Project Manager -

[email protected]

An interactive map, which provides a visual overview of the amounts of biogas that can be produced at a cantonal level, has been proposed in particular, as well as approximately twenty “product” sheets summarising the main results by type of by-product studied.

This project has been co-financed by ADEME.

Project partners:Grand Est AGRIA, CTP (Paper Technical Centre), PACA Agrifood CRITT, IFIP, IFV, INRA LBE (the Environmental Biotechnology Laboratory), Clermont IPC (Integrated Food Security Phase Classification), IRSTEA (National Institute of Environmental Science and Technology Research), ITERG and UNGDA (National Union of Alcohol-Distilling Groups).


DEVELOPMENT OF A METHOD FOR DETERMINING THE DOSAGE OF PHYTIC ACID

In the middle of the 19th century, plant-based particles rich in phosphorus, calcium and magnesium which have an important role in germinating plants were discovered. As they are only present in the plant kingdom, scientists named them “phytin”. They are a molecule with a structure composed of a carbohydrate cycle with six phosphate groups linked to each carbon atom. The phosphate groups enable the molecule to complex with various minerals (see the illustration below).

In plants, phytates store phosphorus and other minerals for seeds; and are hydrolysed during germination. They may form stable complexes with proteins and are complexed or can be complexed with minerals (iron, zinc, calcium and magnesium in particular). Therefore, in animal feeds, they are considered anti-nutrients for oil cakes because they reduce the amount of digestible proteins provided in the portion, they reduce the mineral supply and help to increase the level of phosphorus in excrement (which is an environmental problem for some productive farm animals).

Even though the dosage of phytic acid is widely researched in scientific literature, it is still a problem for oil cakes and oilseed crops. In fact, very little data on phytic acid content are available or there are sometimes very significant errors in the data. Finally, phytic acid can be found in different forms which are more or less phosphorylated, which, based on the analysis methods, may also result in significant variations in phytic acid content. Finally, other aspects, such as the extent to which the seeds are matured, the pre-treatment of the seeds and the way that oil cakes are produced, may have an impact on the amount of phytic acid in oilseeds.

In order to better grasp the effects of technological processes on the amount of phytic acid in oil cakes and, therefore, the bioavailability of the proteins from them, in 2018, ITERG set out to develop a method for analysing the total phytic acid in oil cakes and oilseeds.

This project, supported by Terres Univia, should lead to an application for accreditation being submitted to CoFrAc (French Accreditation Committee) in 2019. This official recognition will guarantee the quality and accuracy of our phytic acid analysis.

Contact : Florent JOFFRE, Head of Analytical Research and Development Unit -

[email protected]


27

THE BALI ACTIA MTU: INNOVATING IN THE AREA OF BIOAVAILABILITY, LIPID-BASED NUTRIENTS AND INTESTINAL MICROBIOTICS

Improving the nutritional status of the population is a major challenge for public health policies in France. Agrifood industrialists are therefore being encouraged to help to improve food by offering healthy and balanced products which reflect the reality of the population’s nutritional status. Promoting new fat sources, designing new fat stocks and developing foods or food supplements carrying lipid-based nutrients which can appropriately meet the population’s nutritional needs (such as newborns, the elderly and people with inflammatory bowel diseases) is therefore a real financial challenge for agrifood and healthcare industrialists.

For this reason, the BALI ACTIA MTU “Bioavailability, Food, Fats and the Intestine” (approved by the Directorate-General for Education and Research for a period of 5 years (2017-2021)) is pursuing a research programme aiming to (i) improve the bioavailability and functionality of lipid-based and liposoluble nutrients naturally found in oilseed, vegetable, marine (such as polyunsaturated fats and vitamins A, D and E) or dairy raw materials, in relation to intestinal health and (ii) help to develop innovative lipid formulations which target the nutritional needs of the population.

BALI ACTIA MTU partners• ITERG - The Health Nutrition and Lipid Biochemistry Team (MTU coordination)

• Bordeaux Agro Sciences - Microbiology and Applied Biochemistry Laboratory (LMBA), UMR 5248, Interactions between Probiotic Bacteria and Hosts Team (IBPH)

• INRA UMR1397 - INSERM U1060 / University of Lyon 1 / INSA-Lyon (National Institute of Applied Sciences) Unit - the CarMeN (Laboratory for Cardiovascular, Metabolism, Diabetology and Nutrition Research), the LIPO (Postprandial Fat and Lipoprotein Team): regulations and functional impacts

Objectives BALI Actia MTU operations In order to further the four strands of the strategic vision set out as part of this programme, the BALI ACTIA MTU’s partners offer original expertise acquired as part of in vitro and in vivo (animals and humans) approaches, revolving around two areas:

• the first focuses on evaluating healthy subjects for the effect of parameters specific to food matrices on the bioavailability of lipid-based or liposoluble nutrients of interest:

• the second aims to evaluate the capacity of lipids to positively adjust intestinal microbiota and related intestinal functions (integrity of the intestinal barrier, immunity and inflammation statuses), particularly in cases involving pathological dysfunctions (inflammatory bowel diseases and malabsorptions).

The BALI ACTIA MTU’s work is part of downstream R&D projects, but also contractual projects, based on a wide industrial network, including fat producers and processors, the agrifood industry and ingredient suppliers.

Contact : Carole VAYSSE - Head of Health Nutrition & Fat Biochemistry Unit -

[email protected]


INNOVATIVE BY N A T U R E

3 SERVICES FOR THE INDUSTRY

ANALYSIS CONDUCTED

SME/SMI PARTNERSRECIPIENTS OF THE

INFORMATION LETTER

INDUSTRY WORKERS TRAINED BY ITERG

45000

300 680

150

2018 ACTIVITY REPORT - ITERG 28

Sectorial distribution of clients for 2018 services (% of the total turnover)

Turnover distribution (€) based on operations, excluding 2018 collective financing

IAA

Cosmetics Pharmacy

Chemistry

Laboratories

DistributorsMiscellaneous

63

20623

5TrainingTraining


ITERG provides a tailored response to market needs by of fering a unique and multidisciplinary service. By keeping its services relevant to the industry and its competitive environment, ITERG can develop this dual industrial and scientific culture which its customers value. MARKETS

3.1 MULTIPLE KINDS OF EXPERTISE / A WIDE RANGE OF MARKETS

2/3 customers are linked to the agrifood sectors (oils, the dairy industry, bread and biscuits, and pet food), in view of the weighting of analytical operations. 1/3 are linked to the vegetable chemistry, cosmetics and pharmaceutical industries. The analysis services account for 70% of the turnover (excluding collective finance) and are significantly increasing each year (growth in private turnover by more than 8.5% between 2017 and 2018 on physico-chemical and sensory studies and analysis).

For chemistry/technology/environmental operations (21%), ITERG mainly provides platforms for scaling up processes and increasing its testing capability and its techno-economic and environmental assessments, with the support of very specialised and flexible teams, which can respond quickly.

The clear positioning of Nutrition operations in Collective Research makes it possible for us to provide industrialists with original biochemical analysis of lipid metabolites, characterisation of the bioavailability of fats and their impact on health in order to help make products more innovative (ingredients or nutritional supplements), in conjunction with formulation operations.

Approximately 70% of the raw materials used in cosmetic products (emulsions, oleogels and lipsticks) are lipids and lipid derivatives. Our Research & Innovation services in this sector increased by 9% in a year (processing, synthesising and formulating operations)

M A R I E R EU L I ER

Oleochemistry Project Manager

Training Nutrition Audit Expertise

Chemistry Analysis & Studies

TESTIMONIALS 3.2

To many people, ITERG is famous for its analysis department, but, in reality, our Industrial Technical Centre carries out many other operations for the professional organisation.

In order to better understand its work and ensure that its teams benefited from it as much as possible, the AVRIL group decided to be a member from the outset.

In addition to enjoying preferential prices for particular services, members enjoy all the member services earmarked specifically for collaborators wanting to join.

A range of services, including monitoring, panoramas, alerts and news, are available, but members can also attend information days and focused webinars aiming to provide high levels of skills.

However, most of all, the sound advice from each of its employees makes ITERG a vital and essential tool even within a large group like AVRIL.

The group’s work with ITERG receives funding via Research Tax Credits at 60%.

In a world which is significantly changing, where healthy, natural and sustainable food is becoming a social issue, ITERG and its subsidiary OLEAD are the best-placed tools for supporting AVRIL entities, particularly in relation to new technologies.

The nutritional and health-enhancing quality of food products, the development of proteins, the increasing level of activity in lipochemistry and, more generally, environmental aspects, the largest of industrialists’ concerns, are at the heart of ITERG’s operations and are completely appropriate in light of the developments in the subsidiary.

As a significant stakeholder both in France and within Europe, it’s our responsibility as industrialists to ensure that this unique tool lasts and develops, both in terms of collective research benefiting from funding on invitations to tender and on more general interest work.

ITERG is a unique institute in Europe

Pierre CHERVIER Head of the Project


31

GOVI N.V. develops and manufactures high-quality engineered process chemicals combining top performance and full flexibility.

Over the years, GOVI N.V. has built extensive knowledge of emulsions, dispersions, oleochemicals and blends. The main objective is to offer top-quality products that are completely tailored to our customers’ needs. GOVI N.V. continuously invests in research and development on their products.

ITERG helped GOVI N.V. with the development and upscaling of a specific oleochemical process.

It was fascinating and pleasant to work with them in their highly scientific but still hands-on facilities. The combination of numerous analytical techniques, hi-tech upscaling equipment and knowledgeable staff is quite unique in the oleochemistry field.

This collaboration helped GOVI N.V. to make our project successful and furthermore, new interesting insights were gained that went well beyond the scope of the original project.

“...It was fascinating and pleasant to work with them...”

Evelien VAN DE STEENE, PhDEster Research & Development


Since its creation in 1978, ALBAN MULLER International’s policy is based on a fundamental commitment: respecting Humans and the Planet, which is intrinsic to its sustainable economic growth and its capacity for innovation. Since 2012, the company has complied with an internal CSR Charter, which structures all the social, environmental and economic aspects of its actions around 3 commitment areas: Humans, the Planet and Products.

Alban Muller International was recently honoured with the CSR initiative prize (at the “Trophées des Usines” awards) and is regularly GOLD-rated by ECOVADIS, meaning that it has positioned itself as a market leader in creating active ingredients, components and natural cosmetic products.

The company is known for its expertise in developing high-added-value natural products, which are genuine alternatives for cosmetic products and contain no petrochemical by-products.

Its active ingredient Lipolami® ER, esters made from 100% natural milk thistle oils, is a perfect example. This Cosmos-approved ingredient is a perfect sensory alternative to silicones and, in addition, works to increase skin-barrier protection, operating as a cosmetic.

This Lipolami® ER was born out of close collaboration between ITERG and ALBAN MULLER International over environmentally friendly uses of milk thistle seeds, which resulted in five new products for cosmetics and pharmacy.

Within ITERG, ALBAN MULLER International has found all the skills and expertise to make manufacturing this product possible.

AMI hopes to continue this collaboration as part of efforts to improve or develop its products.

“...Within ITERG, Alban Muller International has found all the skills and expertise to make manufacturing this product possible...”

Jean-Marc SEIGNEURET

Technical Director


In 2014, many industrial and academic partners came together as part of the PolyOil2Industry project, including POLYMEREXPERT (a company focusing on research into and development of polymers), the Organic-Polymer-Chemistry Laboratory (LCPO) and ITERG, a company with expertise in developing fats. The collaboration was pursuing a common goal: promoting new biosourced polymers from polyol intermediates. One of the developments achieved was inventing EstoGel, an oil gelling agent which is more than 90% biosourced, making it possible to obtain transparent gels. ITERG provided support in this project, from designing the fatty polyols right up to the industrial transposition of these molecules. The oil gelling agent from these polyols is now starting to be used by the major leading stakeholders in the cosmetics industry.

This success was only possible thanks to the precursors of the PRIC range developed by ITERG, which boasts the required expertise and flexibility for obtaining the desired EstoGel properties.

This collaboration between POLYMEREXPERT and ITERG was then extended to other innovative polymers, which could meet the needs of a range of markets, such as buildings, packaging and cosmetics. These new polymers are both high-performance and environmentally friendly because, with time, they make it possible to replace fossil-based molecules with biosourced molecules of renewable origin.

“...This success was only possible thanks to the precursors of the PRIC range developed by ITERG...”

Marc DOLATKHANIManaging Director


ITERG ACTIVITIES 2018 HIGHLIGHTS 3.3

• Renewal of the approval from the International Olive Oil Council for 2018/2019

• Renewal of the COFRAC accreditation, based on the new version of the ISO 17025 (2017) standard

• Renewal of the FOSFA approval

• Introduction of analysis-planning software in April 2018

• Renovation of the fume cupboards in the extraction/indices laboratory

• Replacement of the low-resolution NMR spectrometer

• Development of a method for determining the dosage of phytic acid

ANALYSIS AND EXPERTISE

• Relocation of the unit in the CEDOP building

• Development of synergies with the analysis development team

• Momentum for the Bali MTU

• Renewed satisfaction among the industry and the inter-professional organisation on Monitoring’s efforts (oils and vegetable proteins)

• Collaboration with CarMen and the BSA on fat-microbiota interaction

HEALTH-ENHANCING NUTRITION AND FAT BIOCHEMISTRY


35

• New version of ACéVOIL following a critical review (oil and formulated products)

• Start of the ANR (National Regulatory Authority) MINIMEAU project: a new effluents approach for industrial sites

• VALORMAP: a spatialised database in order to methanise agro-industrial and paper by-products

• Two patents taken out in partnership with Pivert: use of oil cake proteins

• 5 new amphiphilic molecules developed and certified / specifications

• Launch of the MTA approach within the Cosmetics and Detergents sectors

• Cooperation with the LISBP (Toulouse biotech) and the LGC/LCA (Toulouse process engineering) as part of Carnot 3BCAR

• New AGROCHEM MTU approved: Biopolymers - oilseeds and oils high in oleic acids

• 2 projects accepted in the 2018 3BCAR calls to tender (AAP): Biotech & Hydrogenation

• 1 new thesis accepted (ANRT Region), in partnership with CTCPA (Agrifood Technical Centre) and LCPO

• Industrial hall: Cosmetics Good Manufacturing Practices benchmark

ENVIRONMENT AND ECO-INDUSTRIES

LIPOCHEMISTRY - CEDOP (European Centre for Oil Products) PLATFORM

MONITORING AND COMMUNICATION• Economical thesis: - The industrial trends of sectors: application to the area of

protein-rich oil plants

• Redesign of the website

• Lipids & Cosmetics Congress, Bordeaux, January 2018

• 5 webinars

• New DataDock referencing

• Development of intra-company services

TRAINING

• Strengthening of the team with the arrival of Cécile JOSEPH, a physico-chemist and Formulation Development Engineer

• Innovation of IAA rupture / multiple-emulsion processes

FORMULATION



BOARD OF DIRECTORS Public Authority Representatives• M. Thomas PILLOT Ministère de l’Économie et des Finances, - DGE

• M. Marc RICO, Ministère de l’économie et des finances - DGE

• M. Gary NORDEN, Ministère de l’Économie et des Finances - DGE

• M. Alexandre MARTIN, Ministère de l’Agriculture et de l’Alimentation - DGPE

• Mme Sylvie DONNE, Ministère des finances et des comptes publics, CGEFI

• M. Mathias TAN (GTAC)

As representatives of CEOs• Hubert BOCQUELET, Délégué Général de la FNCG

• Pierre CHERVIER, Chargé de Mission, SAIPOL Groupe AVRIL

• Patrick CAHUZAC, Président Directeur Général de SAINT HUBERT

• Yves DELAINE, Président de la FNCG

• Maxime KOHLMEYER, Directeur général de LA TOURANGELLE

• Olivier NASLES, Président de l’AFIDOL

• Marc LIOTTA, Directeur Général Délégué de GRANDES HUILERIES MEDIACO/PROVENCE HUILES

• Dominique DAUDRUY, Directeur Général de DAUDRUY VAN CAUWENBERGHE & fils

As representatives of the technical staff • Michel DAVID (FNIC-CGT)

• Francis OROSCO (CFTC-CMTE)

• Gérald COUPÉ (FCE-CFDT)

As representatives of Higher or Technical Education or of quali-fied persons, either on behalf of the oils and fats industry or on behalf of users• Anne-Laure BEDU, Déléguée Transfert, innovation et accélération, Région Nouvelle Aquitaine

• Laurent ROSSO, Directeur Terres Univia

• Dominique REBIERE, Directeur DRRT Nouvelle Aquitaine

• André POUZET, Président de l’ITERG

• Monique AXELOS, Chargée de Mission Stratégie Européenne auprès de la Directrice Scientifique Alimentation et Bioéconomie, INRA, Nouvelle Aquitaine

• Stéphanie GAILLARD, Ingénieur Environnement, SARIA Industrie

• Christophe MASSON, Directeur Scientif ique, Pôle de compétitivité Cosmetic Valley

Staff Observers• Sylvie MARSAN (ITERG)

• Loic LEITNER (ITERG)

37FATS E X P E R T I S E 37ITERG - 2018 ACTIVITY REPORT

Professional bodies• M. Hubert BOCQUELET, Délégué Général, FEDALIM, FNCG, SYFAB, GEPV

Competent persons• Mme Marie Caroline MICHALSKI, Directeur de Recherche, INRA, GIS IMBL

• M. Michel LAGARDE, Professeur émérite, INSA Lyon

• M. Didier MAJOU, Directeur, ACTIA

• M. Pierre VILLENEUVE, Chercheur, CIRAD

• Mme Pascale SUBRA-PATERNAULT, Directeur de Recherche, CNRS,

• Mme Véronique PALLET, Professeur, IPB - Directrice Adjointe NUTRINEURO

• M. Frédéric FINE, Directeur Valorisation des Graines Oléagineuses, TERRES INOVIA

• M. Michel LINDER, Professeur, ENSAIA Directeur du LIBio

• Mme Corinne PEYRONNET, Responsable Pôle AVAL, TERRES UNIVIA

Guests• M. Antoine CHARDON , Chargé d’affaire Réglementaires et Scientifiques, FNCG

• M. Sylvain CORBEL, Chargé de Projets, FNCG

• Mme Céline LE GUILLOU, Ingénieur d’Études et de Recherche, TERRES UNIVIA

• M. André POUZET, Président, ITERG

Chairman: Isabelle LEMARIE, Directrice Qualité & Innovation, SAIPOL GROUPE AVRIL

Secretary : Claudie GESTIN, Responsable Cellule Veille, Information et Communication, ITERG

Public Authority Representatives• Thomas PILLOT, Sous directeur de la chimie, des matériaux et des éco-industrie -

Ministère de l’Économie - Secrétariat d’État à l’Industrie et au Numérique, DGE/SI

• Gary NORDEN, Adjoint au chef de bureau, chargé de la chimie du végétal et des biotechnologies - Ministère de l’Économie et des Finances

• Alexandre MARTIN, Adjoint à la cheffe du bureau, Bureau des grandes cultures, semences végétales et produits transformés, MAA - DGPE/SDFE/SDFA

Industrial members• Henri BENATS, Sales Manager Technical Applications, CARGILL

• Anne RENAULT, Directeur R&D Qualité, SAINT HUBERT

• Jean-Pierre LALLIER, Responsable veille & Relations extérieures Innovation, OLEON

• Martine JEAN, Business Unit QA Manager, CARGILL OIL PACKERS

• Stéphanie BUREAU, Responsable Recherche et Support technique clients SIO

• Sylvain BRIDOUX, Responsable Assurance Qualité, HUILERIES CROIX VERTE & TOURANGELLE,

• Edouard CAZALA, Responsable Affaires Réglementaires et Scientifiques, BUNGE

• Michel WATIEZ, Responsable Centre Recherche Innovation & Développement, LESIEUR.

• Florent ETIENNE, Responsable Qualité, Huilerie DE LAPALISSE

SCIENTIFIC COMMITTEE


SCIENTIFIC COMMUNICATIONS

ENVIRONMENT

NUTRITION HEALTH & FAT BIOCHEMISTRY

• Bilan de l’UMT FOLIES (Formulation of LIpids Emulsified System). Quels résultats transférables dans l’industrie ? C. Bonnet IAA, septembre-octobre 2018

• L’évaluation environnementale des produits comme vecteur de différenciation - présentation de l’outil ACéVOIL pour le secteur des huiles végétales L. Badey, F. Bosque OCL, 2018

• Évaluation de la durabilité de la filière Indication Géographique Protégée « Canard à foie gras du Sud-Ouest » L. Farrant, M.P. Labau, M. Padilla, C. Deneufbourg, L. Fortun-Lamothe, S. Penavayre, A. Besnier INRA Productions animales, vol. 31, n°2, 2018, p. 131-144

• A critical assessment of transmethylation procedures for n-3 long-chain polyunsaturated fatty acid quantification of lipid classes A. Sehl, L. Couëdelo, L. Fonseca, C. Vaysse, M. Cansell Food Chemistry, vol. 251, 2018

• Hospital Diet Enriched With Rapeseed or Sunflower Oils Is Associated With a Decrease in Plasma 16:1n-7 and Some Metabolic Disorders in the Elderly. Combe N., Henry O., Lopez C., Vaysse C., Fonseca I., Ribaud D., Driss F, Simon N., Le Guillou C., Mendy F. Lipids, 2018

FORMULATION

• Dietary canolol protects the heart against the deleterious effects induced by the association of rapeseed oil, vitamin E and coenzyme Q10 in the context of a high-fat diet Thibault Leger, Isabelle Hininger-Favier, Frédéric Capel, Alain Geloen, Jean-Paul Rigaudière, Chrystèle Jouve, Elodie Pitois, Gaelle Pineau, Carole Vaysse, Jean-Michel Chardigny, Marie-Caroline Michalski, Corinne Malpuech-Brugère and Luc Demaison Nutrition & Metabolism, 2018

• Rapeseed oil fortified with micronutrients can reduce glucose intolerance during a high fat challenge in rats F. Capel, A. Geloen, C. Vaysse, G. Pineau, L. Demaison, J.M. Chardigny, M.C. Michalski, C. Malpuech-Brugère Nutrition & Metabolism, vol. 15, 2018, 12 p.

• Inadequacy of N-3 polyunsaturated fatty acid dietary intakes in the general French population of elderly (65 to 79 years old) : the INCA 2 survey B. Buaud, J. Tressou, P. Guesnet, N. Simon, S. Pasteau J Aging Res Clin Practice 2018;7:69-74

• Inadequate daily intakes of n-3 polyunsaturated fatty acids (PUFA) in the general French population of children (3-10 years) and adolescents (11-17 years): the INCA2 survey P. Guesnet, J. Tressou, B. Buaud, N. Simon, S. Pasteau European Journal of Nutrition, vol. 58, n°2, 2019

• Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring. C. Rey, A. Nadjar, F. Joffre, C. Amadieu, A. Aubert, C. Vaysse, V. Pallet, S. Layé, C. Joffre Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 133, 2018

• Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm Infants. C. Billeaud, C. Boué-Vaysse, L. Couëdelo, P. Steenhout, J. Jaeger, C. Cruz-Hernandez, L. Ameye, J. Rigo, J-C Picaud, E. Saliba, N.P. Hays and F. Destaillats Nutrients 2018, 10(6), 690

PUBLICATIONS

39FATS E X P E R T I S E 39ITERG - 2018 ACTIVITY REPORT


ENVIRONMENT• Commission Méthanisation du Pôle IAR - 19 juin 2018

Intervention de Fabrice Bosque « VALORMAP Base de données spatialisée relative à la valorisation énergétique par méthanisation des résidus et coproduits organiques des agro-industries »

TECHNOLOGY

• Niveau de consommation en acides gras polyinsaturés de la femme allaitante en France : étude de consommation INCA2 et évolution du contenu en acides gras essentiels du lait maternel de 1997 à 2014 C. Vaysse, N. Simon, J. Tressou, S. Pasteau, B. Buaud, P. Guesnet, L. Couedelo et C. Billeaud OCL, n°3, 2018

• Les acides gras polyinsaturés n-3, modulateurs de notre immunité B. Buaud Lipid’Nutri+, septembre-octobre 2018, n°38

• Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain C. Reya, J.C. Delpech, C. Madored,Nadjar, A.D. Greenhalgh, C. Amadieu, A. Aubert, V. Pallet, C. Vaysse, S. Layé, C. Joffre Brain, Behavior and Immunity, 2018

• A New High Hydrostatic Pressure Process to Assure the Microbial Safety of Human Milk While Preserving the Biological Activity of Its Main Components G. Demazeau, A. Plumecocq, P. Lehours, P. Martin, L. Couëdelo and C. Billeaud Frontiers in public health, novembre 2018

• Acute effects of milk polar lipids on intestinal tight junction expression: Towards an impact of sphingomyelin through the regulation of IL-8 secretion? M. Milard, A. Penhoat, A. Durand, C. Buisson, E. Loizon, E. Meugnier, K. Bertrand, F. Joffre, D. Cheillan, L. Garnier, S. Viel, F. Laugerette, M.C. Michalski The Journal of Nutritional biochemistry, 2018

• Amélioration du rendement d’extraction et de la qualité de l’huile de colza par séparation à froid du miscella éthanol M. Citeau, S. Albe Slabi, F. Joffre, P. Carré OCL, 2018

COMMUNICATIONS & CONGRESSES

POSTERS

• Valorisation du tournesol oléique en entier dans une logique de bioraffinerie et d'économie circulaire Congrès Lipides & Cosmétique, Janvier 2018, Bordeaux

• Influence of marine phospholipid formulation on intestinal absorption of DHA , EFL, Belfast 16-19 septembre A. Sehl

OLEOCHEMISTRY

ORAL PRESENTATIONS



• Congrès Lipids & Cosmetics - Bordeaux 25-26 janvier Interventions de : Guillaume Chollet « Oleochemistry for cosmetics », Florent Joffre « Unsaponifiable, a source of active ingredients for cosmetics » Carine Bonnet « Lipids, a natural raw material at the heart of cosmetics innovation »,

• Journée technologique « Quelles utilisations des huiles végétales ? » organisée par Matikem et l’IUT de Béthune-Université d’Artois - Béthune 20 février Intervention de Guillaume Chollet « De la valeur dans nos co-produits agricoles et agroalimentaires - valorisation en tant qu’intermédiaires chimiques »

• Forum Recherche & Industrie sur les matériaux biosourcés - Paris, 23 mai Interventions de Carine Bonnet et Marie-Odile Hecht (PolymerExpert) « Estogel® une nouvelle perspective pour la gélification des huiles », Guillaume Chollet « Du biosourcé dans l’emballage : cas concret du PLA », Carine Bonnet « Bioraffinerie des oléoprotéagineux »

• Les dynamiques industrielles des filières : une application au domaine des oléoprotéagineux, Guillaume Assogba, Thèse Cifre ITERG/GREThA,

• 16ème Congrès Euro Fed Lipid - Belfast 16-19 septembre Interventions de : Anthony Sehl « N-3 long-chain polyunsaturated fatty acids were differently distributed into tissues according to their chemical form of intake », « In vitro lipolysis and in vivo intestinal absorption of EPA and DHA according to their chemical form of intake », Leslie Couedelo « Bioavailability and metabolic fate of ALA according to its food level in rodents »

• Congrès NutriForm’ Business Days - Saint-Raphaël 19-20 septembre Intervention de Carole Vaysse « Microbiote intestinal et biodisponibilité de nutriments d’intérêt »

• J-TECH Agri Sud-Ouest Innovation - Toulouse 13 novembre Intervention de Benjamin Buaud « Microbiote intestinal et la biodisponibilité de nutriments d’intérêt »

OLEOCHEMISTRY ECONOMY

YOUR CONTACTS

Florent JOFFRE

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Unité R&D analytique

Innovation and Transfer Management

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Collective Research

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INNOVATIVE BY 2018 ACTIVITY REPORT...

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