Acromegaly-pathogenesis
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Transcript of Acromegaly-pathogenesis
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ACROMEGAL
YPAT H
OG
E NE S I S
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GROWTH HORMONE
-Growth hormone is secreted by the somatotrophs of the anterior pituitary.
-It is essential for linear growth.
-It acts by producing a group of hormones called somatomedins.
-The prime somatomedin, Somatomedin-C is synthesised in the liver and in bone.
-Hypothalamic secretion of growth hormone releasing hormone (GHRH) stimulates GH secretion and Somatostatin inhibits it.
-Other neurotransmitters are also known to influence GH secretion (Dopamine stimulates GH secretion by stimulating GRH).
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WHAT IS ACROMEGALY?
-It is a condition which results from excess secretion of growth hormone from Anterior Pituitary in adults after fusion of the epiphysis.
-A pituitary adenoma is usually the cause.
-They are usually classified by size and function.
•Microadenomas are <10 mm in diameter and cause clinical manifestations only if they produce excess hormone.
-Usually they are too small to produce mass effects. Nonsecretory microadenoma is common.
•Macroadenomas are >10 mm in diameter and may produce any combination of pituitary hormone excess.
- Pituitary tumours often reach the size of macroadenomas by the time the diagnosis is made.
-In rare cases ,GH excess is also caused by ectopic secretion of GH by carcinoid tumours and pancreatic islet cell tumours.
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PITUITARY ADENOMA
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ACROMEGALY-SIGNS AND SYMPTOMS
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MANIFESTATIONS OF ACROMEGALY
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CLINICAL AND ROENTGENOGRAPHIC FEATURES