A close look at Bionanotechnology MCCB October 21 2011 Thomas L. Deits, Ph.D.
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Transcript of A close look at Bionanotechnology MCCB October 21 2011 Thomas L. Deits, Ph.D.
A close look at
BionanotechnologyMCCB
October 21 2011
Thomas L. Deits, Ph.D.
What is nanotechnology?
Any process or product that involves analysis or manipulation of materials at the nanometer scale
A thumbnail introduction to nanotechnology
Your fingernail is about as thick as 500 E. coli,
each of which is as thick as
500 1- nanometer slices
E. coli with Pili and FlagellaAng L National University of Singapore
http://www.icmm.csic.es/spmage07/spmageview.php?id=50
Why is the nanometerscale important?
Virtually every property of matter that we care aboutarises at the nanometer scale:
ColorOdorStrengthFlexibilityConductivityDurabilityBiological activity
Bionanotechnology
Biology happens at the nanoscale:
DNAenzymesmusclesnervessenses
Biology is a Big Idea in Nanotechnology
• Size and Scale• Structure of Matter• Forces and Interactions• Quantum Effects• Size-Dependent Properties• Self Assembly • Tools and Instrumentation• Models and Simulations• Science, Technology and Society
The Big Ideas of Nanoscale Science and EngineeringS.Y. Stevens et al. NSTA Press 209
Capillary net of alveolae showing erythrocytes within the blood vessels.Oliver Meckes
http://www.flickr.com/photos/fei_company/5679999618/in/set-2157626382741945
Human beta-amyloid fibrils and oligomers"Prof. Francesco MantegazzaUniversita' degli studi di Milano-Bicocca
http://www.icmm.csic.es/spmage07/spmageview09.php?id=165
Human malaria Infected red blood cellsDr. Li Ang Li
http://www.icmm.csic.es/spmage07/spmageview09.php?id=30
BionanotechnologyTools and Instrumentation
How do we work at the nanometer scale?
BionanotechnologyTools and Instrumentation
How do we work at the nanometer scale?TheAtomic Force Microscope
A workhorse of nanotech
Really…
TheAtomic Force Microscope
How does it work?
Prettymuchlikethis….
How does it work?
Mss. Elizaveta Drozd. A.V. Luikov Heat and Mass Transfer Institute (Belarus)
http://www.icmm.csic.es/spmage07/spmageview09.php?id=62
What can it do?
Pre-metastasis cell aggregateINASMET-Tecnalia
http://www.icmm.csic.es/spmage07/spmageview09.php?id=25
Pyrococcus furiosus(archaea)
http://www.sciencephoto.com/media/13219/enlarge
www.nanosurf.com
And it’s not so hard to do these days….
BionanotechnologyForces and Interactions
Examples from Physiology and Biotechnology
Kodera et. al Nature 468 72-76 (2010)
Myosinwalkingvisualizedby AFM
Yves F. Dufrêne Journal of Bacteriology, October 2002, p. 5205-5213, Vol. 184, No. 19
Yeast bud scar
High speed AFMCellulase enzymes – traffic jams on the cellulose fiber
Kiyohiko Igarashi, et al. Science 333, 1279 (2011)
High speed AFMCooperation between two types of cellulases
Kiyohiko Igarashi, et al. Science 333, 1279 (2011)
BionanotechnologyTools and Instrumentation
Manipulation at the nanoscale
Nanotweezers
http://www.amir.uni-oldenburg.de/en/37099.html
Optical tweezers – nanoscale tools for biology
P. Gross, et al. Nature Physics PUBLISHED ONLINE: 22 MAY 2011 |
P. Gross, et al. Nature Physics PUBLISHED ONLINE: 22 MAY 2011 |
Optical tweezers- There’s an app for that…
R. W. Bowman, et al. J. Opt. 13 (2011)
BionanotechnologySelf Assembly
DNA Origami
Toroidally supercoiled DNADr Jozef Adamcik Ecole Polytechnique Federale de Lausanne
http://www.icmm.csic.es/spmage07/spmageview.php?id=153
DNA Origami
Depending onthe sequenceof DNA, the double helix can be bent or straight
Using the simple rules of DNA pairing, bends can be introduced by design into a DNA molecule…
DNA Origami
…making it possible to design a shape that will assemble when the right pieces of DNA are mixed.
DNA Origami
DNA Origami
DNA Origami in 3 dimensions!
Han, et al. Science 332, 342 (2011)
ES Andersen et al. Nature 459, 73-76 (2009)
DNA Origamiboxes (with lids)
BionanotechnologyStructure and Function
The Lotus Leaf
Abaxial side of a tomato leaf with trichomes.Adriaan van Aelst
http://www.flickr.com/photos/fei_company/5636849589/in/photostream
http://www.gereports.com/nanotech-breakthrough-keeps-computers-fast-by-tackling-heat/
GE announces a thermal cooling system with twice the thermal conductivity of copper and a quarter of the weight usingsuperhydrophobicity
Forepart of a miteMargit WallnerAngelika Reichmann
http://www.flickr.com/photos/fei_company/5886650891/in/set-72157626985240386
RadiolarianLinnea Rundgren
http://www.flickr.com/photos/fei_company/5730242836/in/set-72157626382741945
Sponge spiculesMiranda Waldron
http://www.flickr.com/photos/fei_company/5889773523/in/set-72157626985240386
http://www.nanotechproject.org/inventories/consumer/analysis_draft
There are over 1,000 products incorporating nanotechnology on the market today
What are they? There’s an app
for that.....
http://nnin.org
Projected job opportunities in nanotechnology by 2015 are estimated at 2 million worldwide and 1 million of those will be in the United States….
If we educate ourselves and our children to be ‘nano-savvy’
But where are the nanobots?
The nano cargo truck
Laboratory for Nanobioelectronics P.I.: Dr. Joseph Wang Department of NanoEngineering University of California, San Diego 2009
ηanoDay
Saturday in March/April 2012 (date TBD)10 AM – 4 PM
Impression 5 Science CenterLansing, MI
Nanoday 2010, Impression 5 Science Center, Lansing Michigan. Lotus leaf investigation.
Thank [email protected]