37th Annual Meeting & Expositionof the Controlled Release Society2010

Portland, Oregon, USA10-14 July 2010

Volume 1 of 2

ISBN: 978-1-61782-022-9

TABLE OF CONTENTS

Volume 1

MINI-SYMPOSIUM: THERANOSTICS: DIAGNOSIS AND TREATMENT IN ONE BOX

1 MULTIFUNCTIONAL NANOPARTICLES FOR OPTICAL IMAGING N/AJck Chan Kwon

I DESIGNED FABRICATION AND ASSEMBLY OF UNIFORM-SIZED NANOPARTICLES FOR

MULTIFUNCTIONAL BIOMEDICAL APPLICATIONS 1

Taeghwan Hyeon, Nohyun Lee, Yong II Park, Ji Etin Lee

3 MAGNETIC MICROBUBBLES FOR MULTIMODALITY IMAGING AND TARGETED THERAPY 3Eleanor Stride, C. Porler, A. Prielo, Q. Pankhurst

4 IN VIVO TRANSPORT OF POLYMERIC MICELLES AT THE WHOLE BODY, TUMOR, ANDCELLULAR LEVELS 5

Christine Allen, Helen Lee, Bryan Hoang, Humphrey Fonge, Raymond M. Reilly

NEW CHEMISTRIES FOR DRUG DELIVERY

5 MULTIFUNCTIONAL DENDRITIC POLYGLYCEROL ARCHITECTURES FOR DRUG AND DYEDELIVERY 7

Rainer Haag

6 EXTENDING THE DURATION OF ACTION OF PROTEINS: SITE SPECIFIC PEGYLATION AND

TISSUE-TABLETS 8Steve Brocchini

7 NOVEL HIGHLY CRYSTALLINE BIODEGRADABLE POLYMERS FOR SUSTAINED RELEASE DRUGDELIVERY 10

Steven Bitler, D, D. Taft, Q. Zheng, S. Oltensmann, Y. Sanjaya, S. Tzannis

8 SYNTHESIS AND CHARACTERIZATION OFPOLY(ACRYLIC ACID) AND POLYMER CONJUGATESFOR SIRNA DELIVERY 12

Jeisa Pelet, David Putnam

9 MULTIMERIZED SIRNA: NOVEL STRATEGY FOR EFFICIENT GENE SILENCING 14

Hyejung Mok, Soo Hyeon Lee, Ji Won Park, Tae Gwan Park

10 POLYMERSOMES OF ASYMMETRIC BILAYER MEMBRANE FORMED BY PHASE-GUIDED

ASSEMBLY 16TuoJin, Yulong Zhang

NON-PARENTERAL DELIVERY OF BIOLOGICS

II GLUCAN PARTICLES AS AN ORAL TARGETED ANTIGEN-ADJUVANT-SIRNA DELIVERY SYSTEM 18

Gary Ostroff, HaibinHuang, Jinhee Lee, Ernesto Soto, Donald Tipper, Hardy Kornfeld, Smart Levitz

12 NASAL DELIVERY OF PEPTIDES AND PROTEINS - ARE WE THERE YET? 19Lisbeth Ilium, F. Jordan, A. Lewis

13 A NEW NANOVESICULAR CARRIER FOR NASAL DELIVERY OF DRUGS FOR CNS DISEASESTREATMENT N/A

Elka Totillou

14 DIRECT NOSE TO BRAIN DISTRIBUTION OF A HUMAN FC AFTER INTRANASALADMINISTRATION TO RATS 21

KuiLiu, H. Bentz, G. Ciambrone, M. Hutchins, L. Ponomarenko, A. Wong, B. Hill

15 BUCCAL TRANSMUCOSAL DELIVERY OF NICOTINE: CHOICE OF MOLECULAR FORM 23Shasha Rao, Y. Song, F. Peddie, A. M. Evans

NOVEL MATERIALS AND RELEASE SYSTEMS

16 IMPROVING THE PERFORMANCE OF LIPH) BASED FORMULATIONS USING SPECIFICALLYENGINEERED NANOPARTICLE LAYERS 25

Clive Prestidge, Nasrin G. Eskandar, Angel Tan, Mohanraj Vellore Janarthanan, Tim Barnes, Spomenka Simovic

17 SAFERTHAN SAFE: SOL-GEL ENCAPSULATION OF SUNSCREENS 27HowardEpstein, Michelle Quinn, FrankPJIuecker, Gabrlele Witte, Jutta Zur Lage, Ruediger Graf, Sabine Hitzel

18 ANTIMICROBIAL ACTIVITY OF ZEOLITE EXCHANGED AND LIPOSOME ENCAPSULATED SILVERIONS 29

Claire Martin, W. L. Low, M, A. Kenward

19 REGIONAL DRUG ABSORPTION STUDY IN CANINES WITH INTELLIGENT PILL SYSTEM 31Hans Zou, JeffShimizu, Ventzeslav Iordanov, Frits Dijksman

20 A NEW ENCAPSULATION PROCESS TOOL: THE ENCAPSULATION PRINTER 33

Nicole Papen-Bolterhuis, G. Pielerse, R. J. Houbcn, E. G. U. Craenmehr, L. A. M. Brouwers, J. Evcrsdijk, A. Rijfers, R. J. Van Ee.A. T. Ten Gate, K. J, C, Van Bommel

21 CHARACTERIZATION OF POLYMERIC HOT-MELT EXTRUDED DOSAGE FORMS INCLUDING ANEW POLYMER, SOLUPLUS 35

MichaelRepka, Sindhuri Maddineni, SunilKumar Ballu, Soumyajit Majumdar, Karl Koller. Nigel Langley

11 ANALYSIS OF CONSTRAINED RELEASE FROM NANOCHANNEL DRUG DELIVERY SYSTEMS 37Arturas Ziemys, A. Grattoni, J. Gill, E, Zabre, U. Ferrari

OPHTHALMIC

23 TRANSLATABLE TECHNOLOGIES FOR OCULAR DELIVERY: SIMPLE APPROACHES TO PROTECTAND, POTENTIALLY, RESTORE VISION 39

Erin Lavik, J. Beriram, R. Robinson, J. Tsai, A. Shqffslall. M. Kuehn, Y. Kwon

24 THE PARADOXICAL BEHAVIOR OF DRUG RELEASE FROM OCULAR IMPLANTS:UNDERSTANDING THE IMPACT OF PHASE SEPARATION OF POLYMER-DRUG MATRICES 41

Ruiwen Shi, Patrick M. Hughes25 POLYMERIC-MICELLE ANTIANGIOGENIC DRUG FOR OCULAR NEOVASCULAR DISEASES 43

Ofra Benny, K. Nakai, T. Yoshimura, L. Bazinel, R. J. D'Amalo

26 PROLONGED LOCAL OCULAR DELIVERY OF AN ANTIBODY FROM A TABLET 45Ashkan Khalili, J. S. Ellis, D. J. Paul!, H. Fadda, P. T. Khaw, S. Brocchini

11 ELECTRICALLY ASSISTED TRANSPORT OF CHARGED NANOSPHERES INTO RABBIT

CORNEOSCLERAL EXPLANTS - THE PROMISE OF A NON-INVASIVE DRUG DELIVERY SYSTEM FOROCULAR DISEASE 47

Peyman Moslemy, Hong Wang, Jenisha Gandhi, William Schubert, Michael Patane

IS PHARMACOKINETIC MODELING ANALYSIS OF DRUG RELEASE FROM A NOVEL DOUGHNUT-

SHAPED MINITABLET INTRAOCULAR DRUG DELIVERY DEVICE 49Yahya Choonara, Viness Pillay, Michael P. Danckwerls, Trevor R. Carmichael

PREDICTION AND APPLICATION OF IVIVC FOR VETERINARY SPECIES

29 APPLYING BCS CRITERIA TO PREDICT ORAL ABSORPTION OF DRUGS IN DOGS: CHALLENGESAND PITFALLS 51

MarkPapich30 USING THE BCS AS A TOOL FOR INTERPRETING THE IN VIVO RELEVANCE OF IN VITRODISSOLUTION DATA IN DOGS N/A

Marilyn Martinez

31 USE OF GASTROPLUS MODELS IN VETERINARY RESEARCH AND DEVELOPMENT 53S. Sutton

32 USE OF IN VITRO DERMAL PENETRATION MODELS TO ESTIMATE IN VIVO ABSORPTION OFTOPICALDOSAGE FORMS 55

Jim Riviere, N, A, Monteiro-Riviere

TRANSDERMAL

33 TRANSCUTANEOUS IMMUNIZATION STUDIES IN MICE USING DIPHTHERIA TOXOID-LOADEDCATIONIC LIPOSOMES AND A MICRONEEDLE ARRAY 56

Joke Boimstra, Z. Ding, S. M. Bal, S. Romeijn, G. Kersten, W. Jiskool

34 MULTILAYER-COATED MICRONEEDLE ARRAYS: A MATERIALS PLATFORM FORTRANSDERMAL DELIVERY OF PLASMID DNA AND DEGRADABLE POLYMER NANOPARTICLES 58

Peter Demuth, Paula T. Hammond, Darrell J. Irvine

35 DOSE SPARING OF INFLUENZA VIRUS-LIKE PARTICLE VACCINE ADMINISTERED TO THE SKINUSING MICRONEEDLES 60

Yeu-Chun Kim, Fu-Shi Quan, Richard W. Compans, Sang-Moo Kang, MarkR. Prausnitz

36 INDUCTION OF PHOSPHORYLATION OF THE GAP-JUNCTION PROTEIN IN THE SKIN BYIONTOPHORESIS 62

Yuki Kimura, S. Hama, K. Kigasawa, T. Takahashi, K. Kanamura, K. Kajimoto, K. Kogure37 FINITE ELEMENT MODELING OF DRUG TRANSPORTTHROUGH THE HUMAN STRATUMCORNEUM 64

Jessica Wen, Nancy K. Lape38 PLGA NANOSPHERES FOR TRANSDERMAL DELIVERY 66

Hirolo Terashima, Keishiro Tomoda, Kimiko Makino

39 TRANSDERMAL DELIVERY OF FITC-BSA MEDIATED WITH "SKINROLLER" 68Qing Wang, L, B. Lawson, V. T. John, K. D. Papadopoulos

MINI-SYMPOSIUM: BIOMARKERS: THE NEEDLE IN THE HAYSTACK

40 DISCOVERY OF PROTEIN BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ALZHEIMER'SDISEASE 70

Kelvin Lee

41 THE IMPORTANCE OF LEVERAGING BIOMARKERS AND PHARMACOKINETIC (PK) ANDPHARMACODYNAMIC (PD) KNOWLEDGE IN EARLY CLINICAL DRUG DEVELOPMENT 71

EneEtle

42 MOLECULAR SIGNATURE SPECIFIC TARGETING PEPTIDES FOR DRUG DELIVERY ANDIMAGING N/A

In-SanKim

NANOPARTICLES AND FIBERS FOR CONTROLLED RELEASE SYSTEMS

43 GOLD NANOCAGES FOR CONTROLLED RELEASE WITH NEAR-INFRARED LIGHT 72YounanXia

44 NANOPARTICLES BY SPRAY DRYING:THE NEW TECHNOLOGY OF THE BUCHI NANO SPRAYDRYER B-90 73

Thierry Vandamme, X Li, N. Anion, C. Arpagaus, F. Belleteix

45 ENCAPSULATION WITH ELECTROSPINNING FOR FOODAPPLICATIONS 75Igor Bodnar, A. C. Stijnman, R. H. Tromp

46 PREPARATION OF ATACTIC POLYVINYL ALCOHOL)/GELATIN BLEND NANOWEBS BYELECTROSPINNING 77

Won SeokLyoo, J. W. Cha, K. 1. Oh, Y. J. Lee, S. S. Han, S. K. Noh

48 DEVELOPMENT OF POLYURETHANE BASED SUBMICRON SIZED DRUG DELIVERY SYSTEMSFOR PERSONALIZED TREATMENT OF SKIN DISEASES 79

Stephan Kubowicz, Ruth Schtnid, Yoram Milner, Yoram Soroka, Marina Zlotkin, Miriam Oron

PEPTIDES AND PROTEINS

50 INTESTINAL PERMEATION ENHANCEMENT FOR POORLY ABSORBED DRUGS: MATCHINGMECHANISM OF ACTION WITH BIOLOGICAL ASSESSMENT 81

DavidBrayden

51 "SMART" BASAL INSULIN FORMULATION THAT RELEASES INSULIN IN RESPONSE TO BLOODGLUCOSE CONCENTRATIONS OF DIABETIC SWINE 83

Nandini Kashyap, Roderike Pohl, Kristina Bruen, Emily Leone, Solomon S. Sleiner

52 DISPERSIVE EFFECTS AND BIODISTRIBUTION OF RECOMBINANT HUMAN HYALURONIDASESUPPORTIVE OF IV TO SC ROUTE OF ADMINISTRATION CONVERSION 85

Monica Zepeda, David W. Kang, Sinisa Nadjsambati, Michael F. Haller, Marie Printz, Bany J. Sitgarman53 A PASSIVELY TARGETED AND EXTENDED RELEASE FORMULATION OF AN ANTI-MRSAPROTEIN WITH THE PGC METAL-BRIDGE CARRIER 87

Elijah Bololin, A. Nishimolo-Ashfieid, G. Castillo, M. S. Lai, S. Reichstetter, P. Markham, D, Andes

54 CONTINUOUS BASAL LEVEL DELIVERY OF INSULIN IN VITRO AND IN VIVO 89

Jagdish Singh, KhaledAl-Tahami

55 SALMON CALCITONIN REDUCES EXPRESSION OF A NOVEL BIOMARKER FAMILY ININFLAMMATORY ARTHRITIS: A NEW TARGET FOR CONTROLLED RELEASE FORMULATIONS? 91

SineadRyan, Jason P. McMorrovi, EvelynP. Murphy, David J. Brayden

56 IMPROVING SAFETY OF VENOM IMMUNOTHERAPY USING MICROSPHERES OF PLGA FOR

ANTIGEN DELIVERY 93Reginaldo Trindade, V. C. Rescia, O. A. B. Sant'Anna, M.V.A. Lopes-Ferreira, F. M. Brtmi, P. S. Araujo, R. Nicolete, D, F.

Santos, M. H. Bueno Da Costa

POLYMERS IN MEDICINE

57 DESIGN AND DEVELOPMENT OF A NEW GENERATION OF ALBUMIN-BINDING PRODRUGS 95Felix Kratz

58 PEGYLATED HEMIN, A WATER-SOLUBLE MICELLE WITH THERAPEUTIC POTENTIAL AGAINSTISCHEMIA-REPERFUSION INJURY VIA INDUCTION OF HEME OXYGENASE-1 97

JunFang, Haibo Qin, Takahiro Seki, Hideaki Nakamura, Gahininath Y, Bharate, HiroshiMaeda

59 POLYOXAZOLINE: A BIOPOLYMER FOR THE DELIVERY OF PROTEINS AND PEPTIDES 99Tacey Viegas, Michael D. Bentley, J. Millon Harris, ZhihaoFang, Francesco Veronese. Anna Mero, Gianfranco Pasut

60 THERMOSENSITIVE POLYPHOSPHAZENE-ANTICANCERDRUG CONJUGATES: LOCALLYINJECTABLE AND CONTROLLED DELIVERY OF CANCER THERAPEUTICS 101

Changju Chun, Sun M. Lee, Chang W. Kim, Ki-YunHong, Han K. Yang, Sang Y. Kim, Soo-Chang Song61 SYNTHESIS AND CHARACTERIZATION OF HEPATOCYTE-TARGETED PH-RESPONSIVE SIRNADELIVERY VECTOR 103

Chen-Chang Lee, A. Shubin, A. Paschal, M, Prieve, P. H. Johnson, A, S. Hoffman, P. S. Stayton

62 SYNTHESIS AND IN VITRO EVALUATION OF ANIONIC PAMAM-SN38 CONJUGATES 105Nirmalkumar Vijayalakshmi, A. Ray, A. Malugin, H. Ghandehari

63 DUAL TARGETED NANOCONJUGATES FOR ANGIOGENESIS-DEPENDENT CALCIFIED TUMORS 107EhudSegal, H. Pan, T. Udagawa, P. Kopeckova, J. Kopecek, R. Satchi-Fainaro

PULMONARY DELIVERY

64 THE INFLUENCE OF CRYSTALS, PARTICLES AND POWDERS ON INHALED DRUG DELIVERY

SYSTEMS N/A

Jag Shur

65 PULMONARY ABSORPTION AND ORGAN DISTRIBUTION OF POLYSTYRENE NANOPARTICLES 109

JoshuaReineke, A. Mohammad, M. Li, Q. Zhao

66 SIMULATION OF TOBRAMYCIN PHARMACOKINETICS AFTER PULMONARY ADMINISTRATION Ill

Viera Lukacova, Siladitya RayChaudhuri, Neil A. Miller, Valeria Damien-Iordache, Michael B. Bolger, Walter S, Woltosz

67 NU77 NANOCLUSTERS AS AN INALED LUNG CONTRAST AGENT 113

Cory Berkland, Kristin L. Aillon, NashwaEl-Gendy, Jake McDonald, Connor Dennis

68 CORTICOSTEROID LOADED NANO-FIBROUS CALCIUM PHOSPHATE MICROSPHERES INHIBIT

AIRWAY INFLAMMATION 115

Harry Karmouty-Quintana, F. Tamimi, T. K. McGovern, D, C. Bassetl, James G. Martin, Jake E. Barralet

69 NOVEL ENGINEERED PARTICLE FORMULATION FOR INHALED PYY(3-36) ANDDEMONSTRATION OF APPETITE SUPPRESSION IN A MOUSE MODEL 117

David Vodak, DanielE. Dobry, Tracey Boyden, MelanieDoyle-Eisele, Philip J. Kuehl, Rachel W. Spindle, Dwayne T. Friesen,David K. Lyon

70 PREPARATION OF ELONGATED POLYELECTROLYTE PARTICLES FROM PARTICLES 119

Dorothee A Kohler, Marc Schneider, Clans-MichaelLehr, Michael Kriiger, Helmuth Mohwald, Dayang Wang

TRANSLATIONAL STUDIES

71 ENGINEERINGTISSUE-TISSUE INTERFACES VIA CONTROLLED SCAFFOLD DESIGN N/AHelen Lu

72 TRANSLATING Gl PHARMACEUTICS INTO PUTATIVE ORAL THERAPEUTICS N/AAbdul Basil

74 ERYTHROPOIETIN COATED ZP-MICRONEEDLE TRANSDERMAL SYSTEM: PRECLINICAL

FORMULATION AND DELIVERY 121

Elaine Peters, M. Ameri, X. Wang, P. E. Daddona, Y.-F. Maa

233 MELT-CONGEALED MICROSPHERES ENABLE SINGLE DOSE ANTIBIOTIC THERAPY 123

Scott Herbig, J. Lo, A. Thombre, L. Appel

506 MANUFACTURING SCALE-UP OF LIPOSOMAL IRINOTECAN - A COOL PROCESS 125Marcel Bally, D. Singh, M. Anantha, S. Smith, D. Waterhouse

691 WHAT FORCES DO PILLS EXPERIENCE IN THE STOMACH? 127

Bryan Laulicht, Anubhav Tripathi, Vincent Schlageter, Pavel Kticera. Edith Mathiowitz

ENCAPSULATION FOR ENVIRONMENTAL PROTECTION

76 INTRODUCTION TO SELF-HEALING MATERIALS TECHNOLOGY AND APPLICATIONS IN

CORROSION-RESISTANT SELF-HEALING COATINGS 129

Gerald Wilson, M, Andersson

77 COMPARING THE INFLUENCE OF THE FILM COATING FORMULATION ON THE OXYGEN GAS

AND WATER VAPOUR TRANSMISSION RATES 131T. Agnese, T. Cech, V. Gciselhart, Eva Wagner

78 WATER BARRIER COATINGS FROM BIOPOLYMERS WITH SPECIFIC RELEASE PROPERTIES 133Ted Slaghek, J. W. Timmermans, M. J. M. Burgering, J. M. Jelten

MEDICAL DEVICES

79 INTEGRATED GLUCOSE SENSING AND INSULIN DELIVERY BASED ON HYDROGELS, CHIPS, ANDBLOCK POLYMERS 135

Ronald Siegel80 A 'MULTILAYERED' APPROACH TO THE SURFACE-MEDIATED DELIVERY OF DNA: DESIGNING

POLYELECTROLYTE MULTILAYERS TO ACHIEVE TUNABLE RELEASE AND MULTI-AGENT

DELIVERY 137DavidLynn

81 MULTILAYER-COATED IMPLANTS FOR THE TREATMENT OF EXISTING BONE INFECTION INDIRECT EXCHANGE ARTHROPLASTY 139

Joshua Moskowitz, M. Blalsse, R. Samuel, H.-P. Hsu, M. Spector, P. Hammond

83 IN VIVO DRUG RELEASE KINETICS FROM A BIOABSORBABLE MATRIX OF NEVO SIROLIMUS-

ELUTING CORONARY STENT 141

MichellneMarkey, Y. Sun, G. Steese-Bradley, P. Johnson, G. Junnarkar, L. Alquier, S. Price

84 A THEORETICAL MODEL TO MATHEMATICALLY DESCRIBE THE DRUG RELEASE PROFILES OF

DRUG ELUTING STENTS WITH DURABLE POLYMER MATRIX COATING , 143

Hugh Zhao. DudleyJayasinghe, Syed Hossainy, Lewis B Schwartz

733 AN INORGANIC COATING FORDRUG RELEASE IN ORTHOPAEDICAPPLICATIONS 145Andrew Flynn, Y. L. Zhang, F. Tamimi, J. E. Barralel

MINI-SYMPOSIUM: SIRNA/MICRO RNA

85 LIPID NANOPARTICLE DELIVERY OFRNAI THERAPEUTICS 147Akin Ak'mc, W. Querhes, S. De, J, Qin, M. Frank-Kammetsky, K. N, Jayaprakash, M. Jayaraman, K. G. Rajeev, W. Cantley, L. Qin,T. Racie, S. Semple, M. J. Hope, M. Zerial, D. Sah, R, Alvarez, K. Fitzgerald, M, A. Tracy, R. Longer, D. G, Anderson, V.

Koteliansky, M. Manoharan, A. DeFougerolles, M. A. Mater

86 INVITED SPEAKER: TARGETED POLYMER NANOPARTICLES FOR RNA BASED CANCER

THERAPY N/AErnst Wagner

87 INVITED SPEAKER - TBA ROCHE (SIRNA -SPEAKER 2) N/ARocheRoche

88 INVITED SPEAKER - TBA ROCHE (SIRNA -SPEAKER 3) N/A

Roche Roche

ORAL DELIVERY I

89 ORAL DELIVERY OF MACROMOLECULES 149

Samir Mitragolri90 MECHANISMS OF PAMAMDENDRIMER TRANSEPITHELIAL TRANSPORT AND TIGHT JUNCTION

MODULATION 151

Deborah Goldberg, P. W, Swaan, H. Ghandehari

91 PHARMACOKINETIC STUDY OF RIZATRIPTAN ORALLY DISSOLVING FILM (ODF)FORMULATIONS IN HEALTHY VOLUNTEERS 153

Zheng Wang, O, Chu, G. Lu, P. Lai, J. Ryoo

92 THE IN-VIVO EVALUATION OF USING A GAS EMPOWERED DRUG DELIVERY SYSTEM FOR

INSULIN DELIVERY IN THE SMALL INTESTINE 155

A. M. M. Sadeghi, M. R, Avadi, Sh. Ejtemaimehr, Sh. Abashzadelt, A. Parloazar, F. Dorkoosh, M. Raftee-Tehrani, H. E. Jtmginger

93 SITE-SPECIFIC DELIVERY WITH THE HS CAPSULE: A GAMMA SCINTIGRAPHIC STUDY 157

Fiona Mclnnes, D. Pecek, K. A. Sime, V. E, Ronaldson, S. M. Connolly, L. A. Hodges, H. N. E. Stevens

94 ENHANCED ORAL BIOAVAILABILITY OF POORLY WATER SOLUBLE DRUGS BY A NOVEL SOLID

SMEDDS FORMULATION 159

Han-Gon Choi, Prabagar Balakrishnan, Dong Hoon Oh, Chul Soon Yong

95 DEVELOPMENT OF SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) FOR VALSARTAN

AND BIOAVAILABILITY ASSESSMENT 161

Peijin Zhang, George Vamvakas,AqeelFatmi, Shingai Majutu

PEGYLATED TECHNOLOGIES

96 SURFACE CAMOUFLAGE USING PEG FOR THE TRANSPLANTED PANCREATIC ISLETS 163

Youngro Byun, D. Y. Lee, J, H. Jeong

97 BEYOND PEGYLATION - PROTEIN MODIFICATION WITH BLOCK COPOLYMERS FOR CNS

DELIVERY N/A

Alexander Kabanov

98 A NOVEL FOLATE BASED CARRIER FOR LYMPHATIC TARGETING 165

Bing Gti, C. Xie, W. Y. Lu

99 DISULFIDE BRIDGING PEGYLATION OF AN ANTIBODY FRAGMENT DERIVE FROM

BEVACIZUMAB 167

Hanieh Khalili, A. Godwin, R. Lever, S. Brocch'mi

101 MULTIFUNCTIONAL MICELLES CONTAINING PH-SENSITTVE BONDS AND PEGYLATED TAT

PEPTIDE FOR ENHANCED IN- VITRO CELLULAR INTERNALIZATION 169

ErezKoren, A. Apte, R. R. Sawant, V. P. Torchilin

628 POLYHISTIDINE PEGYLATION OF INTERFERON-ALPHA 171

Estera Pawlisz, S. Balan, A. Godwin, E. Laurine, S. Dubey, R. Tommasi, K. Peciak, Y. Cong, P. Bryant, S. Brocch'mi, K. Powell, J.

Choi

VACCINES

102 INFLUENZA VACCINATION USING A MICRONEEDLE PATCH 173

MarkR. Prausnitz

103 FROM FORMULATION TO FUNCTION: DEVELOPING LIPOSOMAL VACCINE DELIVERY

SYSTEMS 175

Yvonne Perrle, Malou Henriksen-Lacey, M. Jubair Hussain, RandipKaur, Sarah E, McNeil

104 CONJUGATION OF OVALBUMIN TO TRIMETHYL CHITOSAN IMPROVES IMMUNOGENICITY OFTHE ANTIGEN. A STRATEGY FOR (MUCOSAL) SUBUNIT VACCINATION 177

BramSliltter, Peter Soema, Zhi Ding, Rolf Verheul, Wim Hennink, WimJiskool

105 SELF-ADJUVANTING POLYACRYLATE DENDRIMER BASED GROUP A STREPTOCOCCUS (GAS)VACCINE CANDIDATE 179

Mehfuz Zaman, Mariusz Skwarczynski, Carl N. Urban!, I-Chun Lin, Zhongfan Jia, Michael R. Balzloff, Michael F. Good, Michael

J. Monteiro, lstvan Toth

106 DEGRADABLE LIPID-COATED POLYMERIC NANOPARTICLES FOR CYTOSOLIC DELIVERY OFMRNA VACCINES 181

XingfangSu, D. Kavanagh, D. J. Irvine

107 A MICROPARTICLE-HYDROGEL BASED ARTIFICIAL IMMUNE PRIMING CENTER: TOWARDS

AN EFFECTIVE VACCINE AGAINST LYMPHOMA 183

Krishnendu Roy, Ankvr Singh, Irina Fernandez, Shalu Suri, Hong Qin, Larry W. Kwak

DNA DELIVERY

108 BIODEGRADABLE POLY(DISULFIDE AMINE) FOR GENE DELIVERY WITH HIGH EFFICIENCY

AND LOW CYTOTOXICITY 185

Sung Wan Kim

109 PEPTIDE-BASED POLYMERS FORNEURON GENE DELIVERY 187Stole Pun, E. J. Kwon, R. N. Johnson, R. S, Burke, B. E. Jacobson, J. Lasiene, I. K. Park, A. Converline, A. S. Hoffman, P. S.

Staylon, P. J. Homer

110 COMBINATORIAL INHALATORY CO-DELIVERY OF DRUG AND ANTISENSE

OLIGONUCLEOTIDESFOR TREATMENT OF LUNG CANCER 189

Oiga Garbiaenko, M. Saad, K. Reuhl, G. Mainalis, T. Minko

111 PROTEIN KINASE C (PKC)a-RESPONSIVE POLYMERIC CARRIER: ITS APPLICATION TO GENE

DELIVERY INTO HUMAN CANCERS 191Yoshiki Katayama, R. Toila, T. Tomiyama, J-H. Kang, T. Mori, T. Niidome

112 DNA VACCINATION AGAINST H5 AVIAN INFLUENZA USING COATED MICRONEEDLES 193

Yeu-Chun Kim, Jae-Min Song, Richard W, Compans, Sang-Moo Kang, MarkR. Prausnitz

466 LIPOSOME MEDIATED DELIVERY OF DNA TO MAMMALIAN MITOCHONDRIA 195Gerard G. M. D'Soiiza, Valbhav Saxena, Mayura A, Wagle, Laura E. Marlinville

ENCAPSULATION OF CELLS AND MICROORGANISMS

114 ENCAPSULATION FOR CONTROLLED DELIVERY OF PROBIOTIC CULTURES IN FOODS 197

Claude Champagne115 HYPOXIA DETECTION IN LIVING PEG-ENCAPSULATED PANCREATIC TISSUE: A NOVEL

FLUORESCENT MARKER SYSTEM 201Matthew Skiles, Romone Fancy, James O. Blanchette

116 CHARACTERIZATIONOF STABILIZED FORMULATIONS OF THE ATRAZINE DEGRADING

BACTERIUM PSEUDOMONAS SP. STRAIN APD 203

Scoll Sielling, R. G. Burns, A. Sunna, G. Visnovsky, C. R. Bunt

117 SYNTHETIC BLOOD CELLS: A BIOMIMETIC APPROACH FOR THERANOSTICS 205Nishit Doshi, Alisar S. Zahr, Srijanani Bhaskar, Joerg Lahann, Samir Mitragotri

118 ELECTROSPINNING DROPLETS ASSISTED SYNTHESIS OF MAGNETIC-RESPONSIVE INSULIN-

LOADED ALGINATE MICROCAPSULES 207

Keng-SMang Huang, Chih-Hui Yang, Yung-Sheng Lin, Chih-Yu Wang, Yu-Fan Chang, Yi-Ling Wang

INTRACELLULAR TRAFFICKING

119 OPENING THE INTRACELLULARTARGET UNIVERSE TO BIOLOGIC DRUGS 209

Patrick Stayton, AnthonyJ, Converline, CraigL. Duvall, DanielleS. W. Benoit, Allan Hoffman, Chen-ChangLee, BilalGhosn

120 ENDOCYTOSIS AND INTRACELLULAR PROCESSING OF BIOREDUCIBLE POLYAMIDOAMINE -

GENE COMPLEXES IN CELLS OF THE RETINAL PIGMENT EPITHELIUM 211Dries Vercauteren, M. Piest, M. Al Soraj, A. T. Jones, J. F, J. Engbersen, S. C. DeSmedt, K, Braeckmans

121 ENDOSOMAL ESCAPE OF DOXORUBICIN-LOADED LIPOSOMES MODIFIED BY PHAGE FUSION

PVHI COAT PROTEIN ENHANCES THEIR EFFICIENCY IN TUMOR CELL KILLING 214

Tao Wang, Shenghong Yang, ValeryA. Petrenko, Vladimir P, Torchllin

122 INTRACELLULAR TRAFFICKING OF LINEAR-DENDRITIC BLOCK COPOLYMER MICELLES IN

DNADELIVERY 216DanielBonner, C. Leung, J. Chen-Liang, R. Longer, P. Hammond

123 INDUCTION OF APOPTOSIS BY SMACN7 COUPLED TO THE NOVEL CYSTEINE-RICH CELL-

PENETRATING PEPTIDE CYLOP-1 218Sven Gottschalk, Deepti Jha, Ritu Mishra, Kamil Ugurbil, Jdm Engelmann

124 EFFECTS OF PEGYLATION IN INTRACELLULAR UPTAKE AND DEPEGYLATION FOR DRUGRELEASE IN PEGYLATED ZINC PROTOPORPHYRIN (PEG-ZNPP) MICELLE 220

Kenji Tsukigawa, HldeakiNakamura, Haibo Qin, G. Y. Bharate, Jun Fang, Hiroshi Maeda

125 SPECIFIC LYSOSOMAL TARGETING BY LIPOSOMES MODIFIED WITH OCTADECYL-

RHODAMINE B 222Alexander Koshkaryev, R. Thekkedath, C. Pagano, I. Meerovlch, V. Tarchilin

LIPOSOMES

126 MULTIFUNCTIONAL ENVELOPE TYPE NANO DEVICE FOR NON-VIRAL GENE DELIVERY

CONCEPT AND APPLICATION FOR NANOMEDICINE 224

Hideyoshi Harashima

111 THERMOSENSITIVE LIPOSOMES OF EPIRUBICIN COMBINED WITH HYPERTHERMIA ENHANCE

BRAIN DELIVERY OF EPIRUBICIN AND PROLONG SURVIVAL OF MICE WITH METASTATIC

TUMORS 226

Xingguo Mei, Yuan Yang, Wei Gong, Kun Lou, Yan Wu, Wan-LiangLu

128 IMMUNOSTIMULATORY CATIONIC LIPOSOMES AS ADJUVANTS IN A NOVEL TBVACCINE 228Malou Henriksen-Lacey, V. W. Bramwell, D, Christensen, E. M. Agger, P. Andersen, Y. Perrie

U9 A CONTROLLED RELEASE FORMULATION OF 5-FLUOROURACIL FOR PARENTERAL

INJECTIONS: PHARMACOKINETICS & EFFICACY 230

Marcel Bally, Anitha M. Thomas, Euan Ramsay

130 IMAGE-GUIDED CANCER THERAPY USINGLIPOSOMAL COPPER-DOXORUBICIN, RAPAMYCINAND ULTRASOUND WITH REDUCED TOXICITY 232

Lisa M. Mahakian, Chun-Yen Lai, Heather A. Llndjors, Jai Woong Seo, Kalherine D. Watson, Eric M. Haynam, Elizabeth S.

Ingham, Li Xing, R. HollandCheng, Alexander D. Borowsky, RobertD. Cardiff, Kalherine W, Ferrara

131 LIPOSOMES FORMULATED WITH TAT MODIFIED CHOLESTEROL FOR ENHANCING BRAIN

DELIVERY 234Yao Qin, Huali Chen, Wcnmin Yuan, Rui Kuai, Fulan Xie, Jie Tang, Zhirong Zhang, Qin He

132 ANTIGEN DELIVERY SYSTEM BY COMBINATION OF BUBBLE LIPOSOMES AND ULTRASOUND

FOR CANCER IMMUNOTHERAPY 236

Kazuo Maruyama, Y. Oda, R. Suzuki, K. Hirata, Y. Taira, N, Uloguchi

ORAL DRUG DELIVERY II

133 POLY(ANHYDRIDE) NANOPARTICLES AS ADJUVANTS FOR VACCINATION AND

IMMUNOTHERAPY 237

Juan Irache, Carlos Gamazo

135 COMPUTER AIDED DESIGN OF EUDRAGIT® BASED CONTROLLED RELEASE MATRIX TABLETS 239

Y. Zhou, J. X. Li, X. Y. Wu

136 ACYCLOVIR LOADED ALGINATE MICROSPHERES FOR GASTRORETENTIVE DRUG DELIVERY

SYSTEM: IN VIVO EVALUATION 241

Shadab Md, Alka Ahuja, Roop KKhar, Sanjula Bahoota, SavedAli

137 MODEL CALIBRATION OF PEO DISSOLUTION USING MRI IMAGING 243

Erik Kaunisto, S. Abrahmsen-Alatni, A. Larsson, B. Nilsson, A. Axelsson

138 MISUSE RESISTANT FORMULATIONS FOR CONTROLLED RELEASE OPIOIDS DRUGS 245

Damon Smith, M. Rahmouni, V. Sant, S. Gervais, D. Le Garrec, A- El-Jammal, J, M.Ndong139 CONTROLLED DELIVERY OF NIFEDIPINE VIA NANOFIBROUS SHEET BASED SYSTEM 247

Chun-Gwon Park, Young Bin Choy

552 QD DIFFUCAPS® DRUG DELIVERY SYSTEMS FOR WEAKLY BASIC PHARMACEUTICAL

ACTIVES 249

Gopi Venkatesh, Jin-Wang Lai, Nehal H. Vyas, Philip J. Stevens, Michael Gosselin, James Cfevenger, Phillip Percel, Paolo Gatti,Christian Strollberg, Flavio Fabiani, Luigi Boltri, Luigi Mapelli, halo Colombo, C. Author

TUMOR TARGETING

141 THE AP-1 PEPTIDE AS POTENTIAL ANTI-BRAIN TUMOR LIGAND 251

Ya-Chin Lo, Yi-Ju Ko, Ming-Cheng Wei, Li-Wen Chang, Byung-Heon Lee, Hsiang-FaLiang, Maggie Lu

140 VASCULAR TARGETING TO PENETRATE SOLID TUMORS N/A

JanSchnitzer

142 DACHPT-LOADED MICELLES FOR THE TARGETING OF LYMPHATIC METASTASIS IN

ORHOTOPIC GASTRIC CANCER 253

Md. Raft, H. Cabral, N. Nishfyama, C. Iviata, M. R. Kano, M. Yashiro, K. Hirakawa, K. Miyazono, K. Kataoka

143 A NOVEL STRATEGY FOR CANCER-TARGETING USING CLAUDIN-4 BINDER 255

Hidehiko Suzuki, RieSaeki, Masuo Kondoh, Kiyohito Yogi

144 LYMPHOCYTES AS CARRIERS FOR CELL-MEDIATED CHEMOTHERAPEUTIC NANOPARTICLE

DELIVERY TO DISSEMINATED LYMPHOMA TUMORS 257

Bonnie Huang, Darrell J, Irvine

145 A "LEUKOLIKE" MULTISTAGE DELIVERY SYSTEM TO OVERCOMEBIOLOGICAL BARRIERS 259

Nicoleila Quattrocchi, Ciro Chiappini, Laurence Cooper, Maura Ferrari, Ennio Tasciotti

146 CYCLIC RGD CONJUGATED POLY(ETHYLENE GLYCOL)-CO-POLY(LACTIC ACID) MICELLEENHANCES PACLITAXEL ANTI-GLIOBLASTOMA EFFECT 261

Weiyue Lu, C. Y. Zhan, C. Xie, J. Pan

BIOMATERIALS

147 BIOMATERIAL DESIGN AND SYNTHESIS FROM METABOLIC SYNTHONS N/ADavidPutnam

148 HUMAN EXTRACELLULAR MATRIX POWDERS AS A BIOMATERIAL FOR INJECTABLE CELL

DELIVERY AND TISSUE ENGINEERING 263

JiSuk Choi, Beob SooKim, JaeDongKim, Young Chan Choi, Kinam Park, Hee YoungLee, Yong Woo Cho

149 MICRO/NANO-STRUCTURED IMPLANTS DELIVERING PACLITAXEL: ENHANCED

PHARMACOKINETICSAND THERAPEUTIC EFFICACY IN TREATING INTRACRANIAL

GLIOBLASTOMA IN MICE 265Sudhir Ranganath, Yilong Fu, Davis Arifin, Irene Kee, Lin Zheng, How-Sung Lee, Pierce Chow, Chl-Hwa Wang

150 SPONTANEOUS FORMATION OF NANO-SIZED PICSOMES WITH THEIR PROPERTIES 267Yasutaka Anraku, Akihiro Kishimura, Makoto Oba, Yuichi Yamasaki, Kazunori Kataoka

151 CONTROLLED RELEASE OF BMP-2 FROM PLATELET-ENRICHED NANOFIBER-COLLAGEN

SCAFFOLDS 269Michael Doschak, Kevin Unrau, Arash Panahifar, Larry Unsworth, PaulJurasz, Joseph Bergman

152 SCREENING OFM CELL-HOMING PEPTIDEFOR PEYER'S PATCH TARGETING BY PHAGE

DISPLAY AND VALIDATION OF ITS TARGETING EFFICIENCY USING CHITOSAN NANOPARTICLES 271

Chong-Su Cho, Mi-Kyong Yoo, Jin-Huk Choi, Tao Jiang, Sang-Ki Kang, Yun-Jaie Choi, Sang-Joon Lee, In-Kyu Park, Hee-SamNa, Hyun-Chui Lee

153 SIMULTANEOUS IMMOBILISATION OF BIOACTIVES DURING 3D POWDER PRINTING OF

BIOCERAMIC DRUG RELEASE MATRICES 273Jake Barralel, E. Vorndran, U. Kiammerl, A. Ewald, U, Gbureck

BLOOD BRAIN BARRIER

154 SINGLE-DOMAIN ANTIBODY-MEDIATED DELIVERY OF THERAPEUTICS ACROSS THE BLOOD-

BRAIN BARRIER 275Danica Stanimirovic, A. Abuirob, U. Iqbal, A. Haqqani, E. Brunette

155 DRUG DELIVERY AND THE BLOOD-BRAIN BARRIER 277Eric Shitsta

156 CELLULAR VEHICLES DERIVED FROM AN ESTABLISHED HUMAN NEURONAL LINEAGE

PRECURSOR CELL LINE FOR GENE DELIVERY INTO GLIOBLASTOMA IN THE BRAIN 278Shu Wang, YingZhao

157 A NOVEL BRAIN-TARGETING SYSTEM OF MYRISTIC ACID-CONJUGATED

POLYETHYLENIMINE: PREPARATION AND CHARACTERIZATION 280

Qinggang Meng, W, Y. Lu

159 RECOMBINANT AAV SEROTYPES AS NATURAL NANOPARTICLES CAUSED GLOBAL ANDSTABLE TRANSGENE EXPRESSION IN MOUSE BRAIN BY INTRAVENOUS ADMINISTRATION 282

HongweiZhang, Bin Yang, Guangping Gao693 THE HUMAN BRAIN CAPILLARY ENDOTHELIAL CELL LINE, HCMEC/D3 IS TAKING UP HUMAN

ALBUMIN NANOPARTICLES TARGETED WITH APO E3 284Larisa Mihoreanu. D. J. Begiey, A. Zensi, T. Vogel, P. 0. Couraud, I. A. Romero, B. Weksler, J. Kreuler

ENVIRONMENTALLY FRIENDLY AND BIODEGRADABLE CONTROLLED RELEASE SYSTEMS

160 MICROENCAPSULATED TOXINS - A TROJAN HORSE APPROACH TO THE CONTROL OF ZEBRA

MUSSELS 286

Geoffrey Moggridge, P. Elliott, X. Costa, D. C. Aldridge

161 EFFECT OF PEPSIN ON THE RELEASE OF ALPHA-TOCOPHEROLFROM WHEAT PROTEIN

MICROSPHERES 288Harmit Singh, JennyDancourt, June Ganl, Olivia Tzau, Sunil Manglassary

162 NANOPOROUS SILICON PARTICLES WITH TAILORED FEATURES FOR CONTROLLED

BIODEGRADATION 290Jonathan Martinez, C. Chiappini, X. Liu, M. Ferrari, E. Tasciotli

163 BIOLOGICALLY RESPONSIVE, AMINO ACID BASED POLYESTERAMIDES AND

POLYESTERURETHANESFOR DRUG DELIVERY 292

Aylvin Dias, G. Mihov, B. Plum, M. Hendriks, Z. Gomurashvilli, B. Turnell

164 HIGHLY EFFICIENT ENCAPSULATION PROCESSES FOR WIDE RANGE INDUSTRIAL

APPLICATIONS FROM FOOD TO PHARMACEUTICS TO CONSUMER PRODUCTS 294Thorsten Brandau, Egbert Brandau

MINI-SYMPOSIUM: BIOMEDICAL PHOTONICS: IN VIVO DIAGNOSTICS OF MALIGNANCY WITH

TARGETED DELIVERY TOOLS

165 ACTIVATABLE STRATEGIES FOR FLUORESCENTPROBE DESIGN IN THE MOLECULAR

IMAGING 297Hisalako Kobayashi

166 POLYP-SPECIFIC CONTRAST AGENTS FOR VIRTUAL COLONOSCOPY: RATIONALE AND EARLY

DEVELOPMENTS 299

RonSummers, C. Roney, J. Xie, B. Xu, G. Griffiths167 MOLECULAR PROBES AND MINIATURE MICROSCOPES FOR DETECTION OF GI CANCERS N/A

Christopher Conlag

168 NOVEL PLATFORMS FOR OPTICAL DETECTION OF CANCER BIOMARKERS IN THE LUMEN OF

THE GI TRACT N/A

Abraham Rubinstein

MINI-SYMPOSIUM: STEM CELLS - YES. WE CAN!

169 CO-CULTURES, 3D SCAFFOLDS AND LOCAL STIMULATIONS FOR CONTROLLED

DIFFERENTIATION AND ORGANIZATION OF EMBRYONIC STEM CELLS N/A

Shulamit Levenberg

170 STEM CELL DELIVERY AND REGENERATIVE MEDICINE N/A

Jennifer Elisseeff171 USING DRUG DELIVERY SYSTEMS TO BUILD 3D STRUCTURES FOR REGENERATIVE MEDICINE

APPLICATIONS 301

Kevin Shakeshejf, CherylRahman, Robin Quirk, Helen Cox, Jane McLaren, LloydHamilton, FelicityRose

172 CONTROLLING ANGIOGENIC FACTOR REGULATION BY UTILISING A 3D COLLAGEN MODEL

AND HYPOXIA-INDUCED SIGNALLING 303

U. Cheema, E. Hadjipanayi, V. Mudera, R. A. Brown

NANOMEDICTNES I

173 SELF-ASSEMBLY OF MAGNETIC NANOCOMPOSITES AS MULTIFUNCTIONAL MRI PROBES 305

HuaAi, X. Shuai, F. Gao, X. Zhao, Z. Gu

174 NANOMEDICINES THAT BREAK THE MUCUS BARRIER N/A

Justin Hanes

175 NEUROPROTECTIVE PROPERTIES OF IDEBENONE IN INJECTABLE NANOEMULSION 306

Joseph Schwarz, Michael Weisspapir, Philip Liang, Peter Carlen

176 CELLULAR UPTAKE AND BIODISTRIBUTION OF SURFACE FUNCTIONALIZED GOLD

NANORODS FOR PHOTOTHERMAL THERAPY 308

Adam Gormley, Ryan Robinson, Joe Hui, Alexander Mahigin, Abhijit Ray, Hamid Ghandehari

177 PREPARATION OF PNIPAM-MODIFIED GOLD NANORODS AND THEIR DELIVERY TO SPECIFIC

TISSUE 310

Takuro Niidome, A. Shiotani, T. Mori, Y. Katayama

178 POLYETHYLENE GLYCOL) (PEG)-GRAFT-HOLLOW SILICA VESICLES FOR DRUG DELIVERY 312

Ye Liu, Chee Leng Lay, Hui Qi Liu,Decheng Wu

BIOMEDICAL IMAGING

179 STIMULATED RAMAN SCATTERING IMAGING REVEALS HETEROGENEITY OF RETINOIC ACID

IN POLY(LACTIC-CO-GLYCOLIC ACID) MICROSPHERES 314

Ji-Xin Cheng, Mikhail Slipchenko, Kyeongsoon Park, HaoLou, Kinam Park

180 USING CARS TO FOLLOW NANOPARTICLE DRUG DELIVERY 316

Julian Moger, N. L. Garrett, A. Slew, I. F. Uchegbu

181 EVALUATION OF TEMPERATURE-SENSITIVE, INDOCYANINE GREEN-ENCAPSULATING

MICELLES FOR NONINVASIVE NEAR-INFRARED TUMOR IMAGING 318

TaeHee Kim, C. W. Mount, Y. P. Chen, W. R. Gombotz, X D. Li, S. H. Pun

182 DESIGN OF NITROXYL RADICALS CONTAINING NANOPARTICLE FOR MR IMAGING OF TUMOR 320

7b Yoshitomi, S. Matsumoto, M. C. Krishna, K. Malsumoto, K. Anzai, H. Matsui, A. Hirayama, Yukio Nagasaki

183 IN VIVO LONG-TERM MONITORIAL MAGNETIC RESONANCE IMAGING AND THERAPY SYSTEM

FOR SOLID TUMORS USING INTRATUMORALADMINISTRATION OF THERAGNOSTIC SUBSTANCES 322

JangIIKim, BeomsukLee, Chang/u Chun, Jung-Kyo Cho, Gui ChulKim, Sang YoonKim, Soo-Chang Song

184 MEASUREMENT OF IN VIVO TRACER DISTRIBUTION DURING CED IN THE RAT BRAIN USING

DCE-MRI 324

Jung Hwan Kim, Garrett Astary, Svetlana Kantorovich, Thomas H. Mareci, Paul Carney, Mallsa Sarntinoranont

HYDROGELS

185 WHERE HAVE ALL THE SMART HYDROGELS GONE? 326Kinam Park. Sungwon Kim, Yong Woo Cho

186 GLUCOSE SENSITIVITY OF HYDROGELS CONTAINING PHENYLBORONIC ACID AND APROTOTYPE FOR MEASURING SWELLING PRESSURE OF HYDROGELS 328

Arum Kim, RonaldA. Siege!187 ENHANCED ANTI-TUMOR EFFECT OF S-FLUOROURACIL-LOADED THERMORESPONSIVE

CONJUGATED LINOLEIC ACID-INCORPORATED POLOXAMERHYDROGEL ON METASTATIC

COLON CANCER MODELS 330

In-Kyu Park, Woo Kyun Bae, JiBeeLee, Sang Joan Lee, Myong SukPark, Jun EulHwang, Hyun Jeong Shim, Sang Hee Cho,

Ding-Ding Guo, Chong-Su Cho, IkJoo Chung188 COMPARISON OF RECOMBINANT SILK-ELASTINLIKE HYDROGELS FORVIRAL GENE

DELIVERY WITH POLOXAMERS 332

RobertPrice, K, Greish, J. Frandsen, J, Gustafson, H. Ghandehari

189 PHOTO-CROSSLINKABLE CHITOSAN HYDROGELS AS A NERVE ADHESIVE 334Zohreh Amoozgar, J. Park, T. Rickett. R. Shi, Y. Yeo

190 SUSTAINED RELEASE OF STROMAL DERIVED FACTOR-1 ENHANCES MIGRATION OF MARROW

STROMAL CELLS 336

EsmaielJabbari, JunyuMa, XuezhongHe

191 CHARACTERIZATION OF ALGINATE NANOPARTICLES PREPARED BY SPRAYING AND

EMULSIFICATION METHODS FOR ORAL DELIVERY OF INSULIN 338

MaryamAghajamali,J. Mohammadi Rovshandeh, M. Haghbin Nazarpak, T. Toliyal, M. N. Sarbolouki

MINI-SYMPOSIUM: VAGINAL DRUG DELIVERY: PAST. PRESENT. AND FUTURE

192 INTAVAGINAL RINGS: CONTRACEPTIVES, PROTEINS AND MICROBICIDES 340DavidFriend

193 ENVIRONMENTALLYRESPONSIVE DELIVERY AND BARRIER SYSTEMS FOR THE VAGINA 342Patrick Kiser, Julie Jay, Kristofer Langhelnrich, Shetha Shukair, Meredith Clark, Melissa C. Hanson, Gianguido C. Ciancl, ToddJ. Johnson, Thomas J. Hope

194 DEVELOPMENT OF MUCOADHESIVE FORMULATIONS FOR VAGINAL DELIVERY OF NITRIC

OXIDE 344ChiLee

195 TOPICAL MICROBICIDES TO PREVENT THE TRANSMISSION OF HIV: FORMULATION AND

DELIVERY CHALLENGES AND OPPORTUNITIES 346Jim Turpin

NANOMEDICINESII

196 TACROLIMUS ENTRAPPED LIPID NANOPARTICLES FOR IMPROVED SAFETY AND ENHANCEDTARGETING TO DEEPER SKIN LAYERS FOR TREATMENT OF ATOPIC DERMATITIS 347

Pallavi Pople, Kamaiinder K. Singh197 TARGETING STENTS WITH PACLITAXEL-LOADED MAGNETIC NANOPARTICLES USING

UNIFORM FIELDS 349Michael Chorny, I. Fishbein, I. Alferiev, R. Adamo, R. J. Levy

198 PARTICLE GEOMETRY INFLUENCES BIODISTRIBUTION OF GOLD NANOPARTICLES IN TUMOR

BEARING MICE 351ArnidaAnwar, A. Ray, M. Janat-Amsbury, C, M. Peterson, H. Ghandehari

199 IMAGING SMALL PROSTATE CANCER LESIONS PRETARGETED WITH BOMBESIN-BISPECIFIC

ANTIBODY COMPLEXES AND TC-99M LABELED POLYMER DRUG CONJUGATES 353Ban-An Khaw, V. Pali!, K. Gada, R. Panwar, D. Weisenberger, S. Majewski, Y. Tekabe, A. Varvarigou, C. Ferris, B. Gershman

200 IRINOTECAN-LOADED NANOPARTICLES BASED ON HYALURONIC ACID FOR TUMOR IMAGING

AND THERAPY 355Ki Young Choi, Kwangmeyung Kim, Ick Chan Kwon, JaeHyung Park, Seo Young Jeong

201 ANTI-CANCER DRUG DELIVERY TO THE CENTRAL NERVOUS SYSTEM. 357Kar WaiChooi, A. J. L. Siew, A. Schalzlein. I. F. Uchegbu

202 RECEPTOR-TARGETED SURFACE-ENGINEERED PPI DENDRIMER FOR EFFICIENT

INTRACELLULAR AND INTRATUMORAL SIRNA DELIVERY 359Oleh Taratula, O. B. Garbuzenko, P. Kirkpatrtck, I, Pandya, R. Savla, V. P. Pozharov, H. He, T. Minko

203 SELF-ASSEMBLED RECOMBINANT HUMAN GELATIN NANOPARTICLES FOR ANTI-CANCER

DRUG DELIVERY 361Sun-Mi Yoon, Young-Wook Won, Yong-HeeKim

793 SUSTAINED RELEASE OF RHBMP-2 GRAFTED TO BIODEGRADABLE NANOPARTICLESENHANCES OSTEOGENIC EXPRESSION OF MARROW STROMAL CELLS 363

EsmaielJabbari, J. Ma. A. E. Mercado,X.He

TISSUE ENGINEERING

204 MODIFYING BIOMATERIALS TO REGULATE CELL BEHAVIOR: CONTROLLED BINDING AND

RELEASE OF GROWTH FACTORS FOR CARTILAGE TISSUE ENGINEERING 365

Lawrence Sonassor, S. Degala, J. Tsui, S. Millon, N. Yu, I. Aguilar

205 CREATION OF TEMPORALLY STABLE AND SPATIALLY RESTRICTED ANGIOGENIC REGIONS

BY SIMULTANEOUS DELIVERIES OF STIMULATORY AND INHIBITORY FACTORS 367William Yuen, Nan R. Du, Eduardo A. Silva, David J, Mooney

207 HUMANIZED VASCULATURE REGENERATED FROM HUMAN ADIPOSED-DERIVED STEM CELLSIN MICE 369

Sang-Heon Kim, In Su Park, Jong- Won Rhie, SooHyun Kim

209 INJECTABLE COLLODIAL GELS OFFER ZERO-ORDER DEXAMETHASONE RELEASE AND

CRANIAL DEFECT FILLING 371

Cory Berk/and, Qun Wang, Jinxi Wang, QinghuaLu, Michael S. Delamore

814 AN INJECTABLE, BIOMIMETIC, THREE-COMPONENT NANOCOMPOSITE FOR NON-INVASIVE

BONE GRAFTING: DEVELOPMENTAND IN VITRO EVALUATION. 373

Shalini Verma, NeerajKumar

815 ANGIOGENESIS BY CONTROLLED RELEASE OF H2S FROM A CYSTEINE CONTAINING

BIOCERAMIC 375

Faleh Tamimi, C. J. Daillon, D, C. Basselt, J. E. Barralet

210 AN INJECTABLE SCAFFOLD EXHIBITING STAGGERED BIOACTIVE RELEASE THROUGH

MULTI-FUNCTIONAL COMPONENTS FOR BONE FRACTURE REPAIR 377Rachel Buchanan, C. Smid, M. Murphy, D. Slashki. D. Fan, E. De Rosa, D. Yoon, K, Kasper, X, Liu, H. Jones, P. Noble, B, Weiner,P. Simmons, 4. Mikos, M. Ferrari, E. Tasciotti

POSTER SESSION I: DIAGNOSTICS

212 METAL-ALLOY NANOSHELLS AS NEW NANOTHERAPEUTIC AND DIAGNOSTIC AGENTS 379

Malavosklish Bikram, D. E. Cheorghe, J, M, Penalaia, B. Lorem, C. Karmonik

213 SILICON NANOBELT FIELD EFFECT TRANSISTORS TOWARD HEPATOCELLULAR CARCINOMA

DETECTION 381

Fu-HsiangKo, C.-C. Wu, F.-K. Liu, C. Huang, P.-H. Hsu

POSTER SESSION I: MICROPARTICLES

214 ACHIEVING IMMUNOMODULATION USING PLGA DELIVERY OF SIRNA TO ANTIGEN

PRESENTING CELLS 383

Ariel Gilerl, M. Machluf216 AU NANOPARTICLES ENHANCED THE ULTRASOUND-MEDIATEDDRUG RELEASE OF

ALGINATE MICROCAPSULES 385

Keng-Shiang Huang, Kuen-Cheng Ju, Chin-Hsin Chen, Chih-Hui Yang, Ren-Jiunn Wang217 BIODEGRADABLE MICROSPHERES FOR SUSTAINED RELEASE OF CNS DRUGS 387

Pohong Lai, Chia-Wen Liu, Yo-Wen Lo, Sung-En Chen, Min-Yin Lin, Jin-Chung Chen, MaggieLu

218 CANCER VACCINATION USING PLGA DELIVERY OF SHORT PEPTIDES TO ANTIGEN

PRESENTING CELLS 389Ariel Gilerl, I, Zaflr-Lavle, Y. Reiter, M. Machluf

219 CHARACTERIZATION AND PHARMACOKINETIC STUDY OF SUSTAINED RELEASEMICROSPHERES CONTAINING GONADOTROPIN RELEASING HORMONE(GNRH) 391

Deokkeun Lee, Nakhyun Lim, Seyeon Kim, Sungsu Kim, Hyungfoon Jung, Kyunghoi Cha

220 DEGRADATION-CONTROLLED RELEASE OF BSA FROM MICROSPHERES OF HYDROXYLATED

PLGA 393Amir Ghassemi, M. J. Van Steenbergen, H. Talsma, C. F. Van Nostrum, W. Jiskoot, D. J. A. Crammelin, W. E. Hennink

111 DESIGN OF CONTROLLED RELEASE PLGA MICROSPHERES FOR HYDROPHOBIC FENRETIN1DE 395

Ying Zhang, Christian Wlschke, Sachin Miltal, Amilava Ultra, Steven P. Schwendeman

224 ENZYME-TRIGGERED RELEASE OF ANTIMICROBIALS FROM GELATIN MICROPARTICLES 397

Nicole Papen-Botterhuis, J. Kolijn, J. Eversdijk, R. M. A. Nagtegaal, A. T. Ten Gate, T. M. Slaghek225 FORMULATION AND CHARACTERIZATION OF GLUTATHIONE LOADED PLA

MICROPARTICLES 399

Yong Zhi Zhou, Pel Ting Mah, Raid G. Alany, SamralaAnand, Ping Gong, Augustine Jang, Jingyuan Wen

228 HIGH DEFINITION MICROEXTRUSION (HDME) OF SOLID 100% FDA COMPLIANTPOLYMER

MICROSPHERES FOR TARGETED DRUG DELIVERY 401

Peter Gabriele, AndrewHogan

235 NANO-STRUCTURED SILICON/PLGA COMPOSITE MICROSPHERES FOR THE SUSTAINED

RELEASE OF BIOMOLECULES 402

Dongmei Fan, Y. Peng, C, Smid, C. Chiappini, M. Murphy, X. Liu, M. Ferrari, E. Tasciotti

236 NEAR-INFRARED LIGHT TRIGGERS RELEASE OF PACLITAXEL FROM BIODEGRADABLE

MICROSPHERES CONTAINING HOLLOWGOLD NANOSHELLS 404Jian You, Chun Li

237 NOVEL MICROPARTICLES HAVING IMPROVED INJECTABIL1TY THROUGH SMALL-DIAMETERNEEDLES 406

Peter Markland, G. A. Winchester

238 LONG CIRCULATING PEG-PLGA BLOCK COPOLYMER MICROPARTICLES OF LOWMOLECULAR WEIGHT HEPARINS (LMWH) FOR PULMONARY DELIVERY 408

Brijeshkumar Pate), Vlvek Gupta, Fakhm)Ahsan

239 PREPARATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF AMOXICILLINTRIHYDRATE AND POTASSIUM CLAVULANATE TO ERADICATE H. PYLORI IN TREATMENT OFGASTRIC ULCER 410

Vikesh Kumar Shukla, Abhijeel Pinglekar, Vineet Bhardwaj, R. S. Massareddy, F. V. Manvi

240 PREPARATION OF SUSTAINED RELEASE LL-37 FORMULATION BASED ON BIODEGRADABLEMICROSPHERES

412Chung-Yih Wang, Pei-Chun Kao, Yi-Chien Ho

241 PREPARATION, CHARACTERIZATION OF MEGESTROL ACETATE MICROCRYSTALS USINGANTI-SOLVENT PRECIPITATION PROCESS 414

Simg-Joo Hwang, Eunbi Cho, KlyulPark, Wong! Yeon, Heejun Park242 PROTA7 AND PROTA3 MICROSPHERES FOR THE ORAL DELIVERY OF INSULIN 416

Achuthamangalam Madhankumar, C, Shanthi, A. Jayakumar, K. Panduranga Rao

243 PROTEOMIC ANALYSIS OF SURFACE DETERMINANTS IMPACTING BIODISTRIBUTION ANDCELLULAR ASSOCIATION OF POROUS SILICON MICROPARTICLES 418

Rita Serda, A. Mack, E, Blanco, J. E. Wiktorawicz, M. Ferrari

244 QUANTIFYING ENCAPSULATION IN POLYELECTROLYTE MICROCAPSULES FOR ANTIGENDELIVERY. 420

Marie-Luce De Temmerman, F. De Vos, J. Demeesier, S. C. De Smedt

245 REGULATING THE MORPHOLOGY OF MICROPARTICLES USING MICROFLUIDIC TECHNIQUE 422Chih-Hui Yang, Yi-YaoHsu, Ren-Jiunn Wang, Yung-Sheng Lin, Keng-ShiangHuang

246 SILK FIBROIN MICROSPHERES FOR CONTROLLED RELEASE 424Chue Yang, T. Dyakonov, W. Bush, S. Gosangari, S. Majuru, A. Fatmi

248 TASTE MASKING OF ROXITHROMYCIN BY SPRAY DRYING TECHNIQUE 426KrzysztofCal, K. Sollohub, P. Ciosek, M. Janczyk, A. Kutyla, H. Wosicka

249 THE PHOSPHOLIPID VESICLE-BASED BARRIER: A TOOL FOR IN VITRO DRUG PERMEABILITYSCREENING

428Gari) Eide Flaten, OpeyemiAwoyemi, Ulrich Massing, Krtstina Luthman, Martin Brand!

250 UNIFORM AGAR MICROPARTICLES MANUFACTURED VIA TEMPERATURE-CONTROLLEDMICROFLUIDIC CHIP 430

Chih-Hui Yang, Yitig-Zhen Zheng, Yung-ShengLin, Keng-Shiang Huang, Ren-Jiunn Wang251 UPTAKE AND TRANSLOCATION OF YEAST-DERIVED GLUCAN MICROPARTICLES ACROSS ANIN VITRO M-CELL MODEL 432

TauseefAhmad, GaryR. Ostrojf, Mengxi Wang, Michael P. Czech, David J. Brayden

POSTER SESSION I: NANOPARTICLES

253 A NOVEL METHOD FOR THE FABRICATION OF DOUBLE-WALLED NANOSPHERES BYSEQUENTIAL PHASE INVERSION NANOENCAPSULATION 434

Daniel Cho, K. M. Estrellas, C. Tian, J. J. Reineke, E. Mathiowitz

254 A NOVEL W/O/O DOUBLE EMULSION SOLVENT REMOVAL METHOD FOR THENANOENCAPSULATION OF DOXYCYCLINE 436

Roshni Patel, D. Cho, C. Tian, A. Chang, D. Decoteau, J. Morgan, E. Mathiowitz255 ANALYSIS OF RESIDUAL SOLVENTS IN POLY(LACTIDE-CO-GLYCOLIDE) NANOPARTICLES 438

In-Joon Oh, Eun-Jung Han, Sang-Chul Shin, Yong-Bok Lee257 ANTI-TUMOR EFFICACY OF CONTROLLED RELEASE DOXORUBICIN NANOPARTICLES 440

S. Pamujula, S. Hazari, R. Graves, D. Devanga-Chinta, Vimal Kishore, Srlkanta Dash, Tarun K. Mandal258 APPLICATION AND PREPARATION OF MODIFIED WATER-SOLUBLE CHITOSANNANOPARTICLES 442

Jae-Woon Nah, Changyong Choi, Mi-Kyeong Jang259 BLOCK COPOLYPEPTIDE VESICLES: TOXICITY, ENCAPSULATION, AND RELEASE 444

Daniel Kamei, Uh-Joo Choe, April R. Rodriguez, James-Kevin Y. Tan, William Lou, Timothy J. Deming261 CELL-PENETRATING TAT PEPTIDE IN DRUG DELIVERY SYSTEMS: NEED FOR PROTECTIVESHIELDING

446ErezKoren,A. Apte, R. R. Sawant, J. Grunwald, V, P. Torchilin

262 CELLULARUPTAKE AND TOXICITY OF GEOMETRICALLY DEFINED SILICA NANOPARTICLES 448Heather Herd, A, Malugin, H. Ghandehari

265 CHITOSAN/TRIPOLYPHOSPHATE NANOPARTICLES FOR ZIDOVUDINE NASAL DELIVERY 450Maria Palmira Gremiao, M. S. Barbi, F. C, Carvalho, C. P. Kiill

266 CLOBETASOL-17-PROPIONATELOADED LECITHIN-CH1TOSAN NANOPARTICLES: SKINPERMEATION AND HISTOLOGICAL EVALUATION. 452

Taner Senyigit, Fabio Sonvico, Stefano Barbieri, Isil Tekmen, Ozgen Ozer, Palrizia Santi, Paolo Colombo

267 CO-DELIVERY OF TRANSGENE AND QUANTUM DOTS BY BACULOVIRAL VECTORS 454Shu Wang, SeongLoong Lo, Elaine Tan, Yuangang Zheng, Jun Yang, Jiakai Lin, Ying Zhao, Jackie Y. Ying

268 COATED PACLITAXEL NANOSUSPENSIONS FOR TARGETED CHEMOTHERAPY 456

Sarah Lee, S. F, Bairstow, M. V. Chaubal, J. Werling, B, Rabinow

269 COMPARISON OF CHARACTERISTICS OF PLGA NANOPARTICLES OF CATALASE PREPARED

USING EMULSION SOLVENT DIFFUSION, NANOPRECIPITATION AND MIXED MICELLE METHODS 458Poonam Saraf, M. Ibrahim, X. Li, B. Jasli

270 COMPLEX OF BIOCOMPATIBLE POLYSACCHARIDE/POLYCATIONICPOLYMER CONJUGATED

VITAMIN-A: HOLE FORMATION ON CELL MEMBRANE 460Kun Na, Hyeona Yim, EnnaeJo

111 DEVELOPMENT AND CHARACTERIZATION OF A NOVEL LIPID NANOCAPSULE FORMULATION

OF SN38 FOR ORAL ADMINISTRATION 462

Emilie Roger, F. Lagarce, J.-P. Benoit

272 DEVELOPMENT OF A NOVEL SIRNA CARRIER PENETRABLE INTO TUMOR 464

Yuri Shtmatani, S. Hama, K. Kogure

274 DEVELOPMENT OF NANOSTRUCTURED LIPID MATRICES OF GLYCERYL MONOSTEARATE BY

HOT MICROEMULSIONS FOR INCORPORATION OF PRAZIQUANTEL 466

Maria Palmira Gremiao, Ana Luiza R. Soma, Fernanda K. Santos, Charlene P. Kiill

275 DOXORUBICIN LOADED ZEIN NANOPARTICLES 468

Salheesh Podaralla, Omathanu P. Perumal

276 DOXORUBICIN-DEXTRAN SULFATE NANOCOMPLEXES FORDRUGDELIVERY 470Parisa Yousefpour Ghassab, Falemeh Alyabi, Ebrahim Vasheghani Farahani, AHAJcbar Mousavi Movahedi

111 DRUG DELIVERY SYSTEM USING NANOPARTICLE PREPARED BY BLOCK COPOLYMER 472Jae-Woon Nah, Young-ll Jeong, Mi-KyeongJang

278 EFFECT OF DIFFERENT PARAMETERS ON CHARACTERISTICS OF DOXORUBICIN LOADED

PCLF NANOPARTICLES AND EVALUATION OF LYMPHATIC UPTAKE BY IN VIVO IMAGING 474

Hamid Akbari Javar, N. Shokri, E. Az'ai

219 EFFECT OF FUNCTIONAL TO NON-FUNCTIONAL MONOMERS MOLE RATIO ON THE

CHARACTERISTICS OFMOLECULARLY IMPRINTED NANOSPHERES 476Mehran Javanbakhl, M. Esfandyari-Manesh, A. Mohammadi, R. Dinarvand, F. Alyabi

280 EFFECT OF POLYMER MOLECULAR WEIGHT ON PHARMACOKINETICS OF QUERCETINNANOPARTICLES 478

Wen-Chuan Lee, T.-H. Tsai

281 EFFECT OF POROGEN ON THE CHARACTERISTICS OF CARBAMAZEPINE-IMPRINTED

NANOSPHERES 480Falemeh Alyabi, M. Esfandyari-Manesh, M. Javanbakhl, A. Mohammadi, R. Dinarvand

282 EFFECTS OF NITRIC OXIDE RELEASING MATRIX SYSTEM ON HEART VALVE COMPLICATIONS 482

Chi Lee, Gayathri Acharya283 EXCEPTIONALLY HIGH PAYLOAD OF DOXORUBICIN IN HOLLOW GOLD NANOSPHERES FOR

NEAR-INFRARED LIGHT-TRIGGERED DRUG RELEASE 484Jian You, GuodongZhang, Chin Li

284 FLUORESCENT HYALURONIC ACID CONJUGATED GOLD NANOPROBES FOR ROS

NANOTOXICITY EVALUATION OF PEGYLATED NANOPARTICLES 486

Kyuri Lee, Hyukjin Lee, Geun Woo Lee, Tae Gvian Park

285 FOLATE ANCHORED RIFAMPICIN NANOPARTICLES 488

PraveenDale, Sharmila B. Majee, Abdul Samad, Padma V. Devarajan286 FORMULATION AND EVALUATION OF BENZYL ISOTHIOCYANATE (BITC) NANOEMULSIONS 490

Hussaini Syed Sha Qhaltal, Megan K. Scott, Tri Salihima, SanjayK, Srivastava, Xinli Liu

287 FORMULATION AND EVALUATION OF BIODEGRADABLE NANOPARTICLES FOR CONTROLLED

AND TARGETED DELIVERY TO THE CNS 492

Zeibunissa Ramloola, MarwaAl Bahama, Rilesh Pabari, Brian Kirby288 FORMULATION AND IN VIVO ASSESSMENT OF BACALEIN SOLID LIPID NANOPARTICLES FOR

ENHANCED BRAIN DELIVERY 494

Yi-Huang Tsai, Ming-Jtm Tsai, Pao-Chu Wu, Yaw-Bin Huang, Chin-Lin Lin

290 FORMULATION OPTIMIZATION OF POLY (LACTIDE-CO GLYCOLIDE) NANOPARTICLES FOR A

MODEL HYDROPHILIC COMPOUND USING FACTORIAL DESIGN 496

Sunny Kumar, Preety Sahdev, Hemachand Tummala, Omathanu Perumal

291 FORMULATION STRATEGIES FOR IMPROVING SOLUBILITY AND CELLULARABSORPTION OF

PACLITAXEL WITH SOLID LIPID NANOPARTICLES AND CYCLODEXTRIN. 498

Jong-Suep Baek, Jae-WooSo, Ji-Sook Hwang, Cheong-Weon Cho

292 FUNCTIONALIZED NANOPARTICLES TO TARGET CELLS EXPRESSING CD8 500

/«&Peca, A, Bicho, A, C. A. Rogue, M. Margarida Cardoso

293 GOLD NANOPARTICLES AS TRANSDERMAL AND INJECTABLE CARRIER 502

Keishiro Tomoda, Ganeshchandra Sonavane, Akira Sana, Hiroyuki Ohshima, Hiroshi Terada, Kimiko Makino

294 HEPARIN-PLURONIC NANOGELS AS A PLATFORM OF DRUG CARRIERS FOR INTRACELLULAR

DRUG DELIVERY 504

Dai HaiNguyen, JongHoon Choi, Yoon Ki Joung, Ki DongPark

297 IN VITRO RELEASE CHARACTERISTICS AND CELLULAR UPTAKE OF POLY(D,L-LACTIDE-CO-

GLYCOLIDE) NANOPARTICLES FOR TOPICAL DELIVERY OF ANTISENSE OLIGONUCLEOTIDES TO

THE SKIN 506

Jlva Rupenthal, Ying-Shan Chen, Colin R. Green, Simon A. Young, RaidG.AIany

299 INFLUENCE OF MECHANICAL STRESS DURING PROCESSING ON THE STABILITY OF THE

MONOCLONAL ANTIBODY, TRASTUZUMAB 508Zelbunissa Ramloola, Catherine McCarthy, Rilesh Pabari

300 INFLUENCE OF VISCOSITY ON ENTRAPMENT AND IN VITRO RELEASE OF FITC-OVA FROM

POLY(ALKYLCYANOACRYLATE) NANOPARTICLES DISPERSED IN SELF-GELLINGMICROEMULSION TEMPLATES 510

RinkuSingh, Sarah Hook, Thomas Rades, Artja Graf

302 INVESTIGATION OF SOLID LIPID NANOCARRIERS AS POTENTIAL VEHICLES FOR THE ORAL

DELIVERY OF DIDANOSINE TO PAEDIATRIC PATIENTS 512Roderick Walker, Kasongo Wa Kasongo, Rainer H. Mailer

303 IRREGULAR GLYCERYLMONOSTEARATE LIPOMER OF DOXYCYCLINE HYDROCHLORIDE FOR

ENHANCED SPLENIC UPTAKE 514Padma V. Devarajan, Anil B. Jindal, Rajesh R, Paiil, Rajiv V. Gaikwad, AbdulSamad

304 LEUKOCYTE-MIMETIC NANOPARTICLES FOR TUMOR-TARGETED DRUG DELIVERY 516

Zohreh Amoozgar, J. Park, Y. Yeo

305 MECHANISMS OF ETHYLENE OXIDE/PROPYLENE OXIDE BLOCK COPOLYMER ABSORPTION IN

NANOPARTICLE STABILIZATION FOR A POORLY WATER SOLUBLE COMPOUND 518Lauren Wiser, S. Li, B. Jasti, X. Li

307 MULTILAYER COATING OF GOLD NANOPARTICLES WITH DRUG-POLYMER COADSORBATE 520

Nico Reum, C. Fink-Straube, T. Klein, R. W. Hartmann, C.-M. Lehr, M. Schneider

308 NANOCRYSTAL COLLOIDAL DISPERSION*FORMULATIONS OF POORLY WATER-SOLUBLEDRUGS: FORMULATION DESIGN, PRODUCTION AND CHARACTERIZATION 522

Aleksandra Martyniak-Stronczek, Gerril Hauck, WallerKamm

309 NANOCURCUMIN (CURCUMIN ENTRAPPED PLGA NANOPARTICLE) : A PROMISING TOOL FOR

CONTROLLED DRUG DELIVERY 524K, LekhaNair, G. Deepa, I. Deepa, Ruby John Anto, G. S. yimdKumar

310 NANOPARTICLE DELIVERY ACROSS EPITHELIUM VIA TRANSCYTOSIS: HIJACKING FOLATE

RECEPTORS 526

Emilia Moradi, G. Byrne, M. C. Garnell, F. H. Falcone, S. Slolnlk

312 NANOPARTICLES PREFERENTIAL EXTRAVASATION FROM TUMOR BLOOD VESSEL 528

Zhonggao Gao, Yuanyuan Shen

313 NEW LIGANDS FOR HEPATIC TARGETING OF NANOCARRIERS 530Anisha D'Sauza, Padma V. Devarajan

314 NOVEL CATIONIC NANOPARTICLES OF BIS(PLGA-PEG)-QDETA COPOLYMERS FOR GENETRANSFECTION 532

Chih-Kuang Wang, Y. H. Wang, S. P. Lo, B. H. Chen, G. J. Wang315 NOVEL SOLID LIPID NANOPARTICLE FORMULATIONS FOR THE CHEMOPREVENTION OF

PANCREATIC CANCER 534Dhruvitkumar Sularia, Ying Huang, SunilPrabhu

316 NUCLEAR ENCLOSURE OF NANOSPHERES IN ARTIFICIAL NUCLEI AND IN LIVING CELLS 536Nathalie Symens, K. Remaut, J. Demeester, S. C. De Smedt

317 OPTIMIZATION OF FREEZEDRYING CONDITION OF AMIKACIN SOLID LIPID NANOPARTICLES 538Solmaz Ghqffari, J. Varshosas, M. R. Khoshayand, F. Atyabi

318 PH-SENSITIVE NANOPARTICLES OF CURCUMIN-CELECOXIB COMBINATION FOR THE

TREATMENT OF INFLAMMATORY BOWEL DISEASE 540

Dalapathi Gugulothu, AdityaKutkami, Prajakta Dandekar, Vandana B. Palravale

319 PREPARATION AND CHARACTERIZATION OF AMORPHOUS CEFDINIR USING SPRAY DRYING

AND SUPERCRITICAL ANTI-SOLVENT PROCESS 542

Kihyang Jeong, JunsungPark, Donggeon Gu, Eunbi Cho, Sangkyo Seo, Sung-JooHwang320 PREPARATION AND CHARACTERIZATION OF HUMAN SERUM ALBUMIN NANOPARTICLES FORTHE DELIVERY OF AP02L/TNF-RELATED APOPTOSIS-INDUCING LIGAND (TRAIL) 544

Rang ChoonLee, T. H. Kim, S. M. Lim, H. H. Jiang, C. W. Park

321 PREPARATION AND CHARACTERIZATION OF PBN LOADED POLY(DL-LACTIDE-CO-GLYCOLIDE) NANO/MICROPARTICLES 546

Yilmaz Capon, Kivilcim Ozturk

322 PREPARATION AND EVALUATION OF CYCLOPSPORIN A NANOSUSPENSION BY TOP-DOWN,MEDIA MILLING METHODS 548

SangDug Han, HyungDon Hwang, Sun Woo Jang, JeoungHoon Kim, Soon Hoe Kim

323 PRODUCTION OF A POWDER FORMULATION OF FENOFIBRATE NANOCRYSTALS THROUGHANTISOLVENT PRECIPITATION FOLLOWED BY IN-SITU SPRAY DRYING 550

Jun Hu, Wai Kiong Ng, Yuancai Dong, Shoucang Shen, Reginald B. H. Tan

324 PRODUCTION OF SINGLET OXYGEN ON IRRADIATION OF PHOTOSENSITIZER-POLYLACTIDE

FORMED NANOPARTICLES 552

Ping-Shan Lai, C. Y. Hsu, M. J. Shieh

325 PULSED RELEASE FROMNANOTUBES 554David Bassetl, JakeE. Barralet

326 QUANTIFICATION OF THE CELLULAR BINDING, UPTAKE AND LOCALIZATION OF PROPIDIUMIODIDE-LABELLED NANOPARTICLES 556

Nicole Daum, A. Neumeyer, M. Bukowskl, M. Veith, C.-M. Lehr

327 ROLE OF NON-SOLVENT PHASE ON PARTICLE SHAPE OF GLYCERYLMONOSTEARATELIPOMER 558

Anil B. Jindal Rajesh R. Palil, Padma V. Devarajan

330 SURFACE PROPERTIES DETERMINE INTRACELLULAR LOCALIZATION AND TOXICITY OF

ANIONIC SILICA NANOPARTICLES 560Alexander Malugin, H. Ghandehari

332 SYNTHESIS OF MOLECULARLY IMPRINTED NANOSPHERES FOR DIPYRIDAMOLE 562Rassoul Dinarvand, M. Esfandyari-Manesh. M. Javanbakhl, A. Mohammadi, F. Atyabi

333 TARGETED DOXORUBICIN DELIVERY TO HEPATOCELLULAR CARCINOMA BY

GALACTOSYLATED NANOGEL 564Juan Wv, Tian-Meng Sun, Meng-Hua Xiong, Jun Wang

334 TEMPERATURE AND PH SENSITIVE NANOGELS BY SOAPLESS EMULSION POLYMERIZATION

USING AMPHIPHILIC ACID MONOMERS 566Jose Cornejo-Bravo, Aracely Serrano-Medina, Angel Licea-Claverie

335 TEMPERATURE DEPENDENT SYNTHESIS OF NIPAM-VP COPOLYMER FOR CONTROLLED DRUGDELIVERY 568

Swati Aerry, D. K. Majumdar, Subha Mozumdar

336 THE PRINT® NANOPARTICLE PLATFORMAS A PARADIGM FOR EXAMINING INTRACELLULAR

PROTEINDELIVERY 570Peter Mack, C. G. Clark Jr., H. Carroll, A. Beletskit, Z. Zhou, M. Diem, K. Roberts, A, King, K. O 'Neil

337 USE OF ANIONIC AND CATIONIC SURFACTANTS IN POLY(LACTIDE-CO-GLYCOLIDE)NANOPARTICLE PRODUCTION 572

Parissa Heshmati, A, T. Raiche, K. H. Miller

POSTER SESSION I: NASAL DRUG DELIVERY

338 ATIS GELLING NASAL SPRAY OF SUMATRIPTAN SUCCINATE: PHARMACOKINETICSAND

BRAIN UPTAKE STUDY 573

Sandhya Pranatharlhiharan, Padma V. Devarajan

340 INTRANASAL DELIVERY OF ZIDOVUDINE BY PLA AND PLA-PEG BLEND NANOPARTICLES 575

Maria Palmira Gremi&o, RubianaM. Mainardes

341 INTRANASAL DRUG DELIVERY SYSTEMS: NASAL ABSORPTION OF INSULIN IN RABBITS USING

PLURONIC F127 AS A CARRIER 577

Alsayed Sallam, A. Mousali, E. Khalil

342 NASAL TOPICAL APPLICATION OF NEW MOMETASONE FUROATE FORMULATION 579

Min-Stm Kang, Seung-Rae Kang, Yong-ffee Kim, Yong-Bok Lee

POSTER SESSION I: NEW CHEMISTRIES

344 DESIGN, SYNTHESIS AND EVALUATION OF NOVEL 1,3,4-THIADIAZOLE DERIVATIVES AS

POTENT ANTICONVULSANT AGENTS WITH LESSER NEUROTOXICITY 581Abhilasha Verma, ManojKumar

POSTER SESSION I: NON-PARENTERAL DELIVERY OF BIOLOGICS

346 NOVEL POLOXAMER HYDROGEL FORMULATIONS FOR SUSTAINED INNER EAR DRUG

DELIVERY 583

Qiang Ye, Luis Dellamary, Xiaobo Wang, Rayne Fernandez, AnneHarrop, Fabrice Piu, Jay Lichter, JeffreyHarris, RickFriedman, Carl Lebel

POSTER SESSION I: NOVEL MATERIALS AND RELEASE SYSTEMS

347 AN IN-VITRO CONTROLLED RELEASE STUDY OF VALPROIC ACID ENCAPSULATED IN A

TITANIA CERAMIC MATRIX 585Richard Gonzalez, M. J. Uddin, D. Mondal, C. A. Morris, V. Diebold

348 ANALYTICAL DIFFERENTIATION BETWEEN SOLID SOLUTIONS AND SOLID DISPERSIONS OF

POLYVINYL CAPROLACTAM-POLYVINYLACETATE-POLYETHYLENE GLYCOL GRAFTCOPOLYMER AND ITRACONAZOL 587

KarlKolter, D. Djuric, S. Fischer, K. Seidel

349 CALCIUM PHOSPHATE NANOPARTICLES WITH ASYMMETRIC LIPID COATING FOR SIRNA

DELIVERY 589

LeafHuang, Jun Li

351 IN SITU AFM ANALYSIS OF AN ELECTROCHEMICAL CONTROLLED RELEASE DRUG DELIVERY

SYSTEM 591Darren Svirskis, J. Travas-Sejdic, B. E. Wright, A. Rodgers, S, Garg

352 MOLECULAR DYNAMICS SIMULATION OF OCULAR TISSUE TABLETS 593

Qian Ru, C. T. Li, P. T. Khaw, S. Brocchini, M. Zloh

353 NANOSCALE DIFFUSIVITY MEASUREMENTS FORCONTROLLED RELEASE OF MOLECULES 595

Jaskaran Gill, A. Grattoni, A. Zlemys. E. Zabre, M, Ferrari

355 SOFTGEL CAPSULE CONTAINING POLYSACCHARIDE MICROSPHERES AS COLON TARGETING

DRUG DELIVERY SYSTEM 597

Yunhua Hit, Qi Fang, Ning Yu, Shingai Majuru356 TAILORED MOLECULAR WEIGHT GRADES OF HYPROMELLOSE TO REDUCE DRUG RELEASE

VARIABILITY IN MATRIX SYSTEMS 599

Diyya Tewari, Weldon W. Harcum, ThomasDOrig357 THE IMPACT OF DISSOLUTION ON PARTICLE SIZE AND SHAPE OF MULTICOMPONENT DRUG

DELIVERY SYSTEMS 601

Adam Keith, Peter Bouza

566 DESCRIPTION OF DIFFCORE TABLETS - A NOVEL MODIFIED DRUG DELIVERY

TECHNOLOGY 603

MatthewBurke. J. Kaye, J. Hempenstall

POSTER SESSION I: OPHTHALMIC DRUG DELIVERY

358 CHARACTERIZATION OF OCULAR NALTREXONE NIOSOMES USING DIFFERENTIAL SCANNING

CALORIMETRY (DSC) AND CRYO-SCANNING ELECTRON MICROSCOPY (CRYO-SEM) 605

HamdyAbdelkader, Amal Kamal, SayedIsmail, RaidAlany359 DESIGN AND EVALUATION OF LONG ACTING EUDRAGIT NANOPARTICLES FOR TOPICAL

OPHTHALMIC DELIVERY OF BRIMONIDINE TARTRATE 607

Sajeev Chandran, Prakash Bhagav, Hariom Upadhyay

360 EFFECT OF BIOADHESIVE POLYMERS ON RELEASE PROPERTIES OF IN SITU-GELLING

THERMOSENSITrVE OPHTHALMIC FORMULATIONS CONTAINING FLURBIPROFEN SOLID

DISPERSIONS 609

Tamer Guneri, I. Ozgiiney, P. Adisanoglu361 EFFECT OF SELECTED IONIC AND NON-IONIC MEMBRANE ADDITIVES ON THE ENTRAPMENT

EFFICIENCY OF NALTREXONE HYDROCHLORIDE IN NIOSOMES 611

Hamdy Abdelkader, Amal Kamal, SayedIsmail, Raid G. Alany

362 LEVOFLOXACIN NANOPARTICLE LADEN IN SITU GEL FOR CONTROL OCULAR DRUG

DELIVERY 613Himanshu Gupta, M. Aqll, R. K. Khar, AsgarAli, Aseem Bhatnagar, Gaurav Mittal

363 MINIMALLY INVASIVE DELTVERY TO THE BACK OF THE RABBIT EYE USING HOLLOW

MICRONEEDLES IN VIVO 615

Samirkumar Patel, DamianBerezovsky, Bernard E. McCarey, John M. Nickerson, Henry F. Edelhauser, MarkR. Prausnitz

364 MUCOADHESIVE NANOPARTICLES AND GLOBAL MODELING FORTOPICAL OCULAR DRUG

DELIVERY 617

CoreyBloom, Chris Craig, TanyaHoyden, Hovik Gukasyan, David Rewolinski, Moreno Cobbs

366 SIMULATION OF TOBRAMYCIN PHARMACOKINETICSAFTER TOPICAL OPHTHALMIC

ADMINISTRATION 619

Viera Lukacova, Siladitya Ray Chaudhuri, MichaelB, Bolger, Walters. Woltosz

367 STUDIES TO DETERMINE THE MATERIALS PROPERTIES OF AN ANTIBODY TISSUE-TABLET 621

Steve Brocchini, H. Fadda, A. Khalili, J, Ellis, H. Parkes, P. T. Khaw, N, Suarez

368 THE EFFECT OF OCULAR VITREOUS VISCOSITY ON ANTIBODY DIFFUSION AFTER

INTRAVITREAL INJECTION 623llva Rupenthal, Priya Sharma, Trevor Sherwin, Philip J. Polkinghorne

369 THE PREPARATION AND EVALUATION OF GEL FORMULATIONS FOR TREATMENT OF THE

OPHTHALMIC COMPLICATIONS IN CYSTINOSIS 625

Barbara Buchan, Graeme Kay, Anne Heneghan, Kerr H. Matthews, Donald Cairns

POSTER SESSION I: PEPTIDE AND PROTEIN MEDICINES

370 BIORESPONSIVE NANOPARTICLES FOR EFFICIENT INTRACELLULAR PROTEIN DELIVERY 626

Johan Engbersen, GregoryCoui

371 BSA STABILITY AND RELEASE FROM HOT MELT EXTRUDED POLY(LACTIDE-CO-GLYCOLIDE)IMPLANTS 628

Zahra Ghalanbor, M. Kdrber, R. Bodmeier

372 DEVELOPMENT OF A CELL SPECIFIC PEPTIDE-DRUG CONJUGATE FOR PROSTATE CANCER

THERAPY 630

Wanyi Tai, Kun Cheng

373 EFFECT OF EDTA CONCENTRATION ON ULTRA-RAPID ACTION OF VIAJECT® IN DIABETIC

MINIATURE SWINE 632

Roderike Pohl, R. Hauser, N. Kashyap, R. Seibert, S. Steiner

374 EFFECT OF ENCAPSULATION METHOD ON PROTEIN LOADED NANOSPHERES FABRICATED BY

PHASE INVERSION NANOENCAPSULATION 634Daniel Cho, C. Tian, K. M. Estrellas, E. Mathiowilz

376 FORMULATION AND CHARACTERIZATION OF POLY (LACTIC ACID) PLA NANOPARTICLES

FOR ORAL DELIVERY OF LACTOFERRIN 636Hemanl Kumar, Craig Bunt, Erica Chen, John Shaw, Jingyuan Wen

377 GLOBAL GENE EXPRESSION PROFILES IN U-937 HUMAN MACROPHAGES TREATED WITH

OCTAARGININE 638

Jung-HuaKm, Meng-Jie Lion, Hsueh-Chen Chiu

379 LONG-TERM PROTEIN DELIVERY FROM ORGANO GEL FORMULATIONS 640

Joram Stager, D. Babcock

380 MICROCRYSTALS FOR EXTENDED DELIVERY OF THERAPEUTIC PEPTIDES 642Steven Ren, Rubin Wang, Derrick Kalayama, Ellen Padriqiie, Jenny Jin, Johnny Gonzales, Thao Le, David Litzinger

381 MICROSPHERES FOR SUSTAINED-RELEASE DELIVERY OF ERYTHROPOIETIN (EPO) IN NATIVE

FORM 644Weien Yuan, Tianlian Ren, Fei Wu, Yan Geng, Tuo Jin

383 OSMOTIC RELEASE OF BIOACTIVE VEGFFROM BIODEGRADABLE ELASTOMER MONOLITHSIS THE SAME IN VIVO AS IN VITRO 646

Brian Amsden, R. Chapanlan, M. Y. Tse, S. C. Pang

384 PET IMAGING OF ALPHA-GALACTOSIDASE A PHARMACOKINETICS IN RATS AND MONKEYS 648Mikhail Papisov, V. Belov, A. J. Fischman, A, A. Bonab, J. Tilus, H. Xte, M. Heartlein, P. Calias

385 PROINSULIN-TRANSFERRINRECOMBINANT FUSION PROTEINIS A NOVELAND POTENTINHIBITOR IN HEPATIC GLUCOSE PRODUCTION 650

Yan Wang, Wei-Chiang Shen

386 PROTEIN RELEASE FROM LIQUID INJECTABLE POLYMERS BASED ON 5-ETHYLENE KETAL £-

CAPROLACTONE 652Brian Amsden, I. 0. Babasola

387 SUSTAINED RELEASE OF A MONOCLONAL ANTIBODY FROM LIPID TWIN-SCREW

EXTRUDATES 654

Gerhard Sax, Sandra Schtdze, Gerhard Winter

POSTER SESSION I: POLYMER THERAPEUTICS

389 5-FLUOROURACIL LOADED POLY (LACTIDE-CO-GLYCOLIDE) INJECTABLE IMPLANTS

PREPARED BY A SUPERCRITICAL ANTISOLVENT PROCESS 656Pardis Kalanlarian, A. Yatanara, A. Rouholamini Naja/abadi, I. Haririan, M. A. Shokrgozar

391 ANTIBIOTIC MODIFICATION FOR TUNABLE COMPLEXATION AND CONTROLLED RELEASE

FROM CYCLODEXTRIN HYDROGELS 658

Thimma Reddy Thaiiparti, H. A. Von Ream

392 CHARACTERISATION OF PROTEIN LOCALISATION IN POLYMER MICROPARTICLE DRUG

DELIVERY CONSTRUCTS USING SURFACE ANALYSIS TECHNIQUES AND CHEMOMETRICS 660

AliRqfati, A. Boitssahel, A. G. Shard, K. M. Shakesheff, U. R. Alexander, M. C. Davies

393 COMPARATIVE BIODISTRIBUTION OF PAMAM DENDRIMERS AND HPMA COPOLYMERS IN

OVARIAN TUMOR-BEARING MICE 662

Shraddha Sadekar, A, Ray, M. Janat-Amsbury, C. M. Peterson, H. Ghandehari

394 COMPARISON OF DIFFERENT POLYMERS AS DRUG CARRIER 664

Gianfranco Pasut, Chiara Clementi, Ruth Bolting, Francesco Greco

395 COMPATIBILITY BETWEEN HYALURONIC ACID AND DICLOFENAC SODIUM IN OPHTHALMIC

AND INJECTABLE FORMULATIONS 666

OleDall, B. Malle, K. Schwach-Abdellaoul, B. Kanfmann, R. Gurny397 DEVELOPMENT OF GRAFTED NANO-ASSEMBLY (GNA) AS AN ULTIMATE DRUG CARRIERPLATFORM 668

Hyun Jin Lee, Y. Bae

398 ENCAPSULATION, IN VITRO DRUG RELEASE, PH CHANGES AND TENSILE STRENGTH

CHARACTERISTICS OF WET SPUN POLY(L-LACTIC ACID) MICROFIBERS 670

Danya Decoteau, R. Stefani, L. Zhang, M. Harrison, R, Hopkins, E. Malhiowitz

400 HPMA COPOLYMER-AMINOHEXYLGELDANAMYCIN CONJUGATES FOR TARGETING GRP78

RECEPTORS 672

Nate Larson, A. Ray, A. Malugin, H. Ghandehari

401 HPMA COPOLYMER-DOCETAXEL-RGDFKCONJUGATES FOR PROSTATE CANCER THERAPY 674

AbhijitRay, K. Greish, D. B. Pike, N. K. Larson, M. Grilner, H. Ghandehari

402 IMMUNOSTIMULANT EFFECT OF BIODEGRADABLE MICROSPHERES CONTAINNING CELL-

FREE ANTIGENS FROM HISTOPLASMA CAPSULATUM ON MURINE BONE MARROW-DERIVEDMACROPHAGES 676

Daiane F. Dos Santos, Roberto Nicolele, Patricia R. M. De Soma, Claudia Da S. Bilencourl, CarlosA. Sorgi, Celio L. Silva, Lucia

H. Faccioli

403 PHARMACOKINTECI INVESTIGATION OFAN IMPLANTABLE FORMULATION OF RILPIVIRINE

FOR SUSTAINED ANTl-HIV THERAPY 678Deborah Schachter, John Zhang, Gary Campbell, Mathew John, Abla Creasey, Thomas Matalenas, Neil Cowley Lieven Baert,Gerben VanT Klooster, Katie Antssoms, Sophie Lachau-Durand, Ellen Clessens, Herman Borghys

404 POLYMER-DRUG CONJUGATES AS PLATFORMS FOR COMBINATION THERAPY IN THETREATMENT OF HORMONE-DEPENDENT BREAST CANCER 680

CoralieDeladriere, E. Masia, F. Greco, R. Lucas, Maria J. Vicent

405 SHAPE RECOGNITION BY MACROPHAGES 682

Nishil Doshl, Samir Milragotri406 THERMALLY SENSITIVE GELS BASED ON CHITOSAN FOR THE TREATMENT OF VAGINAL

MUCOSITIS 684

Carta Caramella, S. Rossi, F. Ferrari, A. Faccendini, G. Sandri, M. C. Bonferonl, M Mori, A. Puccio

POSTER SESSION I: PULMONARY DRUG DELIVERY

407 ANTI-TUMOR EFFECT OF ACTIVATED ALVEOLAR MACROPHAGES ON LUNG CARCINOMA

CELLS 686

Keiji Hirota, K. Sawachi, H. Taniguchi, Y. Shlmada, H. Jnagawa, C. Kohchi, G-I. Soma, H. Terada

408 BIORESPONSIVE MICROPARTICLES FOR TARGETED DRUG DELIVERY IN THE LUNGS 688

Neeraj Sivadas, Sally-Ann Cryan

409 A NOVEL CONSTRUCTIVE METHOD OF PREPARING COLON-SPECIFIC ORAL DRUG DELIVERY

SYSTEM USING INTERPOLYELECTROLYTE COMPLEXES CARBOPOL®/EUDRAGIT® EPO 690Rouslan Moustafine, Tatiana Kabanova,AlexandraBouchovech, Venera Garipova, Shamil Nasibullin, MnaSemina

410 ENHANCING THE AEROSOLISATION PROPRIETIES OF POLYESTER BASED MICROPARTICLES

AS NOVEL CARRIERS FOR DRY POWDER INHALATION 692Hesham Tawfeek, S. Khidr. E. Samy, S, Ahmed, G. Hulcheon, I. Saleem

POSTER SESSION I: TRANSDERMALDRUG DELIVERY

412 DESIGN OF NOVEL CONTROLLED RELEASE, MICROSPHERE CONTAINING GEL FORMULATION

OF TAZAROTENE WITH LOWER DERMAL IRRITANCY IN VIVO 694

Mangesh Deshpande, P. Bora, V, Nalamothu

413 FORMULATION AND PHYSICOCHEMICAL CHARACTERIZATION OFA TOPICAL SELF

MICROEMULSIFYING DRUG DELIVERY SYSTEM 696Sara Zargar Shoshlari. J.-Y. Wen, R. G. Alany

415 DEVELOPMENT OF A NEW AND IMPROVED DICLOFENAC SODIUM (DS) PATCH (NAL1219):STUDY OF SKIN PERMEATION, EFFICACY AND BIOEQUIVALENCE OF NAL1219 TO VOLTAREN

TAPE 698

Je Phil Ryoo, H. Yamauchi, N. Kawamura

416 DEVELOPMENT OF A NEW AND IMPROVED L1DOCAINE PATCH (NAL1282) FOR TREATMENT OF

POSTHERPETIC NEURALGIA 700Cheol Moon, G. Lu, K. Y. Lo, H. Yamauchi, N. Kawamura, J. Ryoo

417 DEXAMETHASONE ACETATE IN VITRO RELEASE PROFILE FROM NANOESTRUCTURED

SYSTEMS CONTAINING PROPOXYL 5 OP ETHOXYL 20 OP CETHYL, WATER AND ISOPROPYL

MIRISTATE 702

MariaPalmira Gremiao, G. M. Luz, H. R. Sllva, D. S. Landgraf, M. C. C. Urban

418 FORMULATION AND EVALUATION OF TRANSDERMAL PATCH CONTAINING SIBUTRAMINE 704

Hoo-Kyun Choi, Robhash-Kusam Subedi, Young-Joon Park

419 GOLD NANORODS COMBINED WITH SOLID IN OIL DISPERSIONS FOR TRANSDERMAL

MACROMOLECULES PROTEIN DELIVERY IN VITRO 706

DakrongPissuwan, K. Nose, K. Kaneko, T. Niidome

420 IN VITRO PERMEATION STUDIES OF NOVEL A'-TETRAHYDROCANNABINOLPRODRUGS IN

HUMAN SKIN 708

Stan Banks, Dana Hammell, Miroslaw Golinski, JeffHoward, Audra L. Slinchcomb

421 IS THERMAL ENHANCEMENT OF PERCUTANEOUS DRUG ABSORPTION RELEVANT TO

ENHANCEMENT TECHNIQUES? 710

Ajay Banga, J. Paluri, P. M. Friden

423 METHYLENE BLUE RELEASED TEST INTO HUMAN SKIN BY MALTOSE MICRONEEDLES 712Yoshikazu Tobinaga, TomoyaKitagawa

424 NANOEMULSION AS A POTENTIAL TRANSDERMAL CARRIER FOR POORLY WATER SOLUBLE

ANTIFUNGAL DRUG ITRACONAZOLE 714

SanjarAlam, R. KKhar, AsgarAli, Farhan J. Ahmad

425 OIL-FROZEN W1/OAV2 DOUBLE EMULSIONS FOR TRANSDERMAL BIOMACROMOLECULAR

DELIVERY CONTAINING ETHANOL AS CHEMICAL PENETRATION ENHANCER 717

Yuly Jaimes-Lizcano, LouiseB. Lawson, Kyriakos D. Papadopoulos426 PHASE-TRANSITION MICRONEEDLE PATCH FOR TRANSDERMAL DELIVERY OF PROTEINS

AND PEPTIDES 719

Sixing Yang, Tuo Jin

429 SIMULTANEOUS TRANSCUTANEOUS DELIVERY OF TWO MACROMOLECULES USING

CATIONIC TRANSFEROSOMES 721

Preety Sahdev, Radhey Kaushik, Omathanu Perumal

430 SKIN PERMEATION OF PROGESTERONEFROM DISPERSIONS PROCESSED WITH

SUPERCRITICAL CARBON DIOXIDE 723James Falconer, Farah Shehadeh, Krislen Zhao, Lisa Sue, Nathan Wu, NickBudd, Raid G. Alany

431 SUPPRESSION OF TUMOR GROWTH BY TRANSDERMAL DELIVERY OF OLIGONUCLEOTIDESVIA IONTOPHORESIS 725

Kentaro Kogure, K. Kigasawa, S. Hamma, T. Takahashi, K. Kanamura, K. Kajimolo

432 SURFACTANT-LIPID BASED MUCOADHESIVE DRUG DELIVERY SYSTEM: DEVELOPMENT ANDCHARACTERIZATION 727

MariaPalmira Gremiao, F. C. Carvalho, M. S. Barbi, T. Benini, I. N. Halakeyama433 DEVELOPMENT OF TEMPERATURE-SENSITIVE W/OAV DOUBLE EMULSION CONTAININGTACROLIMUS 729

Dong-Jin Yoo, Ju-HwanKim, Seung-Rae Kang, Yong-BokLee

434 THE EFFECT OF COMPONENT OF BUSPIRONE MICROEMULSIONS ON PERCUTANEOUSABSORPTION 731

Paa-Chu Wu, Jung Tzu Chang, Yi-Hung Tsai

435 THE EFFECTS OF UNIAXIAL STRETCHING ON THE BARRIER BEHAVIOR OF MAMMALIANSKIN 733

Susanna Lin, Krisllna Runas, Cole Maddaleno, Jessica Wen, Jin-Hwa Chun, Masanori Honda, NancyLope436 THE PHYSICAL CHEMICAL PROPERTIES OFLIQUID PARAFFIN LIPOGELS PREPARED WITHDIFFERENT PSEUDOPOLYMORPHS OF MIXED AND PURE HOMOLOGUE MAGNESIUM STEARATE 735

Gillian M. Eccleslon, K. A. Sheikh, J. J. Rouse, K. Yewbeng437 TOPICAL DELIVERY OF TRICLOSAN USING PRESSURE SENSITIVE ADHESIVES 737

Parveen Madher, Julian Smith, Yvonne Perrie

438 TRANSDERMAL DELIVERY OF BIOIDENTICAL PROGESTERONE IN COMBINATION WITH ANOVEL 5a-REDUCTASE INHIBITOR DUTASTERIDE, RANDOMIZED CONTROLLED PILOT STUDY 739

Sara Zargar-Shashtari, J- Y. Wen, R. G. Many

439 TRANSDERMAL DELIVERY OFVACCINES AND PROTEINS USING A HAND-APPLIED,POLYMERIC MICROSTRUCTURED ARRAY (SMTS-HAND AND PRESS&PATCH) 741

Kris Hansen, D. Duan, J. Gysbers, D. Brandwein, C. Moeckly, G. Prochnow, P. Johnson, T, Alston, K. Siebenaler

440 TRANSDERMAL DRUG DELIVERY BYMAGNETOPHORESIS IN COMBINATION WITH CHEMICALPERMEATION ENHANCERS 743

S. Narasimha Murthy, Srinivasa M. Sammeta

POSTER SESSION I: VETERINARY

441 COMPARISON OF CHITOSAN BASED GEL AND MICROPARTICLE FORMULATIONS FOR

MUCOSAL IMMUNIZATION AGAINST BOVINE HERPES VIRUS 1 (BOHV-1) 745Sevda Senel, M. Gunbeyaz, A. R. Faraji Majarashm, A. Ozkul, N. Purali

442 DESIGN AND DEVELOPMENT OF LONG ACTING INTRAVAGINAL VETERINARY PRODUCTS:PHYSICAL CHARACTERISATION OF THE VAGINAL CAVITY OF FARMED ANIMALS 747

MichaelRathbone, S. Bista, A. Haywood

443 LOW-ENERGY NANO-EMULSIFICATION TO DESIGN VETERINARY CONTROLLED DRUG

DELIVERY DEVICES 749Thierry Vandamme, N. Anton

444 RUMEN DELIVERY OF THE ANTHELMINTIC COMPOUNDS ALBENDAZOLE AND ABAMECTINFROM A NEW DELIVERY TECHNOLOGY 751

Michael Rathbone, M. Wunderlich, G. Rennie

POSTER SESSION II: GENE THERAPY

445 AMPHOTERIC POLYAMIDOAMINE NANOPARTICLES FOR THE IN VITRO AND INVIVODELIVERY OF NUCLEICACIDS 753

Roberta Cavalli, Agnese Bisazza, Roberto Sessa, Luca Prima, Ellsabetta Ramicci, Paolo Femtli

447 BIOREDUCIBLE POLYMER-TRANSFECTED SKELETAL MYOBLASTS FOR VEGF DELIVERY TO

INFARCTED RAT MYOCARDIUM 755Arlo McGinn, H. Y. Nam, M. Ou, N. Hu, C. Straub, D. Bull, S. W. Kim

448 CARDIOMYOCYTE-SPECIFICDELIVERY OF NUCLEIC ACID USING PCM-MODIFIED POLYMERS 757

Hye YeongNam, Sung Wan Kim, David A. Bull

450 CHAIN-LENGTH DEPENDENCE OF CATIONIC POLYMERS FOR DNA VACCINE DELIVERY 759

Weihang Ji, R. Noelle Palumbo, DavidPanus, Rupel Tang, Chun Wang455 DEVELOPMENT AND CHARACTERIZATION OF HYBRID-ADENOVIRUS COATED WITH AN

ARGININE-GRAFTED BIOREDUCIBLE CATIONIC POLYMER FOR CANCER GENE THERAPY 761

PyungHwan Kim, Tae-II Kim, James W. Yockman, Sung Wan Kim, Chae-Ok Yun

457 EFFICIENT AND TARGETED GENE DELIVERY BYPH-TRIGGERED TRANSFORMATION OFPOLYPEPTIDE MICELLES 763

Young Jik Kwon, MmSukSh im

458 ENHANCED TRANSFECTION EFFICACY OF POLYETHYLENIMINE BY SURFACE MODIFICATION

WITH ARGININE, LYSINE AND LEUCINE 765HibahAldawsari, Behin SundaraRaj, Ruangelie Edrada-Ebel, David R. Biatchford, Christine Dulls

459 EXPRESSION CONTROLLING OF TRANSGENE USING THE HIGH PRESSURE-COMPACTEDPLASMID DNA 767

Tsuyoshi Kimura, Hokuto Konno, Asami Sana, Kwangwoo Nam, Akio Kishida

460 HYBRID POLYMER-SUPERPARAMAGNETICIRON OXIDE NANOPARTICLES MEDIATED HIGHLY

EFFICIENT MAGNETOFECTION 768

WonJong Kim, Ran Namgung, Kaushik Singha, MiKyung Yu, SangyongJon

461 IMMOBILIZATION OF HIS-TAGGED POLYPLEXES TO NI-NTA SELF-ASSEMBLED MONOLAYERS

FOR NON-VIRAL GENE DELIVERY FROM SURFACES 770

ChungHuei Wang, ShaoyiJiang, Suzie H. Pun

462 IN VITRO EVALUATIONS OF NANOPARTICLES-IN-EMULSION FORMULATIONS FOR GENE

DELIVERY AND TRANSFECTION IN MACROPHAGES 772Husain Attarwala, MansoorAmiji

463 IN VIVO APPLICATION OF A RECOMBINANT TARGETED VECTOR IN CANCER SUICIDE GENE

THERAPY 774ArashHalefl, Yuhua Wang

467 LOW MOLECULAR WEIGHT POLYETHYLENEIMINE-BASED REDUCIBLE POLYCATIONS FOR

GENE THERAPEUTICS DELIVERY 776Han Chang Kang, H. J. Kang, Y. H. Bae

470 MMP-RESPONSIVE RELEASE OF DNA FROM ELECTROSPUN NANOFIBROUS MATRIX FOR

LOCAL GENE THERAPY 778

HyukSang Yoo, Hye SungKim, Ji Suk Choi, Youngju Son

471 MULTIPLE GENE SILENCING USING MULTI-SIRNA CONJUGATES 780

Soo Hyeon Lee, Hyejung Mok, Chul-Am Hong, TaeGwan Park

472 NON-VIRAL GENE DELIVERY OF POLYPLEXED WITH NANOPARTICLES TRANSFECTED INTOMSCS 782

Ji Sun Park, Keun-Hong Park

474 OPTIMIZATION OF HGP PEPTIDE FOR GENE DELIVERY 784Suzie Pun, E. J. Kwon, S. Liong

475 POLYCATIONIC GENE CARRIER FORMED OF AND DEGRADABLE TO SPERMINE 786Tuo Jin, Zixiu Du, Qianqian He, MayingChen

476 RATIONALE DESIGN OF MULTI-FUNCTIONAL NONVIRAL GENE DELIVERY VECTOR FOR

ANTITUMOR THERAPY 788

Sejin Son, Won JongKim

477 SAFETY OF MATRIX-MEDIATED ADENOVIRAL GENE DELIVERY WITH SILK-ELASTINLIKEHYDROGELS 790

Joshua Gustafson, R. Price, K. Greish, H. Ghandehari

478 SELF-ASSEMBLED NANOCARRIERS FOR CO-DELIVERY OF DRUG AND GENE 792

Rupa Sawant, G. Navarro, S. Biswas, V, P. Torchilin

479 'SOFT' CALCIUM CROSSLINKS ENABLE HIGHLY EFFICIENT GENE DELIVERY USING CELL-

PENETRATING PEPTIDES 794

Cory Berkland, AbdulgaderBaoum

480 TRANSDERMAL ADMINISTRATION OF INTERLEUKIN-13 ANTISENSE

OLIGONUCLEOTIDE/CATIONICELASTIC LIPOSOME FOR THE TREATMENT OF ATOPIC

DERMATISIS 796

Sung Tae Kim, C. K. Kim, K. M. Lee

481 TUFTSIN-MODIFIED ALGINATE NANOPARTICLES AS A NON-CONDENSING MACROPHAGE-

TARGETED GENE DELIVERY SYSTEM FOR ANTI-INFLAMMATORY THERAPY 798Shardool Jain, Mansoor Amiji

POSTER SESSION TI; INTRACELLULAR TRAFFICKING

484 INTRACELLULAR UPTAKE OF WATER SOLUBLE ZNPP MICELLES (SMA-ZNPP AND PEG-ZNPP)AND THE UNIQUE RELEASE MECHANISM OF THE DRUG FROM THEIR MICELLES 800

Hideaki Nakamura, Haiba Qin, G. Y. Bharate, Kenji Tsukigawa, Jun Fang, HiroshiMaeda

POSTER SESSION II: LIPOSOMES

485 A LIPOSOME DELIVERY SYSTEM CONTAINING DOXORUBICIN AND CE6 FOR POTENTIALCANCER TREATMENT 802

Chin-Tin Chen, Y.-J. Tsai, P.-C. Pong, T. Tsai

486 A NOVEL DELIVERY SYSTEM OF ANTISENSE OLIGONUCLEOTIDES AND EPIRUBICIN FOR

MODULATION OF MULTIDRUG RESISTANCE 804Yu-LiLo, C. T.Ho, Y.Liu

487 A PHOTOTRIGGERABLE LIPOSOME SYSTEM: CO-ENCAPSULATION OF HEMATOPORPHYRINAND DOXORUBICIN 806

Tsuimin Tsai, H, Wu, C.-T. Chen

488 A PLACKETT-BURMAN SCREENING STUDY TO UNDERSTAND FORMULATION AND PROCESS

VARIABILITY FORTENOFOVIR LIPOSOMES 808

Xiaoming Xu, Mansoor A. Khan, Diane J. Burgess

490 COMBINATION THERAPY OF NIK-SPECIFIC SIRNAS IN LIVER-TARGETING LIPOSOMES WITH 5-

FU FOR HEPATOCELLULAR CARCINOMA 810

JungHyun Kim, Min Ji Koo, Hye Jin Kim, Jin-Seok Kim

491 CONTROLLINGVISCOSITY OF AQUEOUS CORE OF LIPOSOME FOR ENHANCEMENT OF

STABILITYAND CONTROLLED RELEASE 812

MeereeHan, Sealing Youl Oh, Bokytmg Jung, Hyesun Jun, Jung-Hwan Park

492 DEVELOPMENT OF A CATIONIC LIPOSOME BASED ON QUASl-DRUG ADDITIVE COMPLIANT

INGREDIENTS FOR THE JAPANESE SKIN CARE MARKET 814FlorenlDurieux, Isabelle Bonnet, Valerie Andre-Frei, Nathalie Godard, Boris Vogelgesang

493 DEVELOPMENT OF LIPOSOMAL DNA REPAIRING ENZYMES FOR TOPICAL DELIVERY 816Ae-June Wang, Max Hu, SydneyPeng, Lilian Lin

494 DEVELOPMENT OF LIPOSOMES MODIFIED WITH NOVEL IMMUNOCONJUGATE OF

ANTINUCLEOSOME ANTIBODY 2C5 ATTACHED TO PEG-PE VIA A PH SENSITIVE BOND 817

Swati Biswas, R. R. Sawant, N. S. Dodwadkar, V. P. Torchilin

495 EFFECT OF CROMOLYN IN PEGYLATED LIPOSOME IN COMBINATION WITH GEMCITABINE

FOR PANCREATIC CANCER 819Min Ji Koo, ChaEunKim, Hye Jin Kim, Jung Hyun Kim, Jin-Seok Kim

496 EXPERIMENTAL NON-CARDIOGENIC ACUTE PULMONARY OEDEMA - EVALUATION USINGA

NEW TECHNIQUE USING GIANT UNILAMELLAR LIPOSOMES 821

Ana C Santos, Claudia MMatos, MariaA Silva, SofiaL. Perestrelo, Fernando J. Barges, Barbara Oliveiros, Teresa Almeida,Lurdes Gano, MariaNeves, Nuno Ferreira

497 FOLATE-CONJUGATED GEMCITABINE LIPOSOMES FOR TUMOR-TARGETED DRUG DELIVERY 823M. P, Venkataraju, A. S. Manjappa, SwetaSrivastava, Sudhir Krishna, A, K. Mishra, A. K. Babar, R. S. R. Murthy

498 FORMULATION AND EVALUATION OF PH-SENSITIVE, LONG CIRCULATING LIPOSOMES FOR

PACLITAXEL DELIVERY 825

Smlta Rane, Bala Prabhakar

499 FORMULATION OF LIPOPLEXES: INTERACTIONS OF LIPID GEOMETRY 827

Behfar Moghaddam, Qinguo Zheng, YvonnePerrie

500 GOLD NANOPARTICLE-EMBEDDEDPHOTOSENSITIVE LIPOSOMES FOR DRUG DELIVERY 829

Marjo Yliperttula, Lauri Paasonen, Tuomas Sipila, Michael Rappolt, Alton Yaghmur, Arto Urlli

501 IMPROVEMENT OF OLIGONUCLEOTIDES DELIVERY USING OLIGONUCLEOTIDE/CATIONIC

LIPOSOME COMPLEX TREATED WITH HIGH HYDROSTATIC PRESSURIZATION 831

Asami Sana, Kwangwoo Nam, Tsuyoshi Kimura, Akio Kishida

502 IN-VITRO EVALUATION OF LIPOSOMES CONTAINING BIO-ENHANCERS FOR THE ORAL

DELIVERY OF MACROMOLECULES 832

Johannes Parmentier, F. J. Hartmann, G. Fricker

503 INCORPORATION OF IMMUNOSTIMULATORY COMPONENTS TO DDA-TDB ADJUVANT

DELIVERY SYSTEMS 834

Randip Kaur, A, Milicic, A. Reyes-Sandoval, A. Hill, Y. Perrie

504 INHALABLE LIPOSOMES OF FASUDIL-ANOVEL RHO-KINASE INHIBITOR FOR THE

TREATMENT OF PAH 836

Fakhrul Ahsan, Vivek Gupta

505 LIPID-BASED NANOPHARMACEUTICAL FORMULATIONS OF IRINOTECAN (IRINOPHORE C),DOXORUBICIN AND VINCRISTINE TARGET TUMOR VASCULATURE IN GLIOBLASTOMA

MULTIFORME 838

MarcelB. Bally, M. Verreault, D. Strutt, D. Masin, M. Anantha, D. Waterhouse, D. T Yapp507 MATHEMATICAL ANALYSIS OF ULTRASOUND-INDUCED DRUG RELEASE FROM LIPOSOMES 840

Giora Enden

508 NEW POTENTIAL LIGANDS FOR LYSOSOMAL TARGETING OF LIPOSOMAL DRUG FORMS 843

Alexander Koshkaryev, I. Meerovich, R. Thekkedalh, V. Torchilin

509 NEW STABLE STEALTH PEG-LIPOSOMES 845

GianfrancoPasul, Adrian S. Joseph, Anna Mero, Francesco Veronese, Massimo Fresla, Qddone Schiavon

510 NOVEL RHODAMINE 123-CONJUGATED PHARMACEUTICAL NANOCARRIER TARGETS

MITOCHONDRIA 847

Swati Biswas, R. R. Sawant, A. Koshkaryev, V, P, Torchilin

511 PASSIVE LUNG TARGETING OF LAZAROID U-74389G WITH NANOSUSPENSION AND LIPOSOMAL

FORMULATIONS 849

Fady Ibrahim, P. New, D. Chow

512 PH-TRIGGERED RELEASE FROM NON-PHOSPHOLIPID LIPOSOMES MODULATED BY THE PKA

OF THE INCLUDED FATTY ACID 851

Michel Lajleur, Thida Phoeung, Pauline Aubron, Gaulthier Rydzek

513 POLYMER-MODIFIED THERMOSENSITIVE LIPOSOMES FOR CONTROLLED DELIVERY OF

DOXORUCD3IN 853

Terence Ta, T. Porter, P. Stayton, T, Convertine

514 PREPARATION OF VESICULAR PHOSPHOLIPID GELS CONTAINING BIO-ENHANCERS 855

Johannes Parmentier, G. Ghatore, G. Fricker

515 STUDY ON THE ULTRASONICALLY-TRIGGERED RELEASE BEHAVIORS OF HA-COATED

LIPOSOME 857

Hsin-Hui Huang, Tse-Ying Liu, Tina CuHuang, Hsiao-Che Fan

517 THE USE OF VESOSOMES AND ULTRASOUND IN DRUG DELIVERY 859

Ghaleb A. Husselni, William Pitt, James Lattin, Marfan Javadi

518 TRIGGERED DRUG RELEASE FROM STIMULI-RESPONSIVE LIPOSOMES FOR TARGETED

CHEMOTHERAPY 861

Young Jik Kwon, Yoon Kyung Kim, Joshua Wang519 ULTRASOUND-TRIGGERED RELEASE BEHAVIORS OF MAGNETIC-LIPOSOME 863

Tina CuHuang, Tse-YingLiu, Hsin-ffui Huang, Yan-Jhu Chen