TOOLS, OPTIONS AND ACCESSORIES

EQUIP YOUR BIOPRINTER WITH:

Laser or photo-crosslinking for hydrogel polymerization,

devices: bioactives encapsulation, signal

molecule immobilization,

coating or ablation processes

Printhead technologies: for optimal processing of abroad

biomaterial/bioactives portfolio:

– cell-friendly Ink-jet;

– thermopolymer extrusion;

– 2 component printhead;

– paste and hydrogel dispensing.

High precision temperature for biomaterials, mediums,

control devices: printheads and substrates

Electrospinning printhead: printhead for micro &

submicrometer bioarchitectures

manufacturing

Software Suite: to interact with bioprinting

instrument, medical imaging,

human machine interface

– including BioCAD™,BioCAM™,

BioCUT™ Industry standard

interfaces (STL, DICOM, AMF, DXF)

Calibration systems: calibration laser, needle,

substrate / lab device

APPLICATIONS TO STUDY & IDENTIFY BIOLOGICAL PROCESSES:

Cell-cell interactions

Differentiation

Response to stimuli

Differentiation, Proliferation and morphology

In vivo relevance

Drug metabolism and expression (gene, proteins)

Environment and Extracellular matrix contact

MATERIAL CANDIDATES

Cells, bioactives and signal molecules

Hydrogels and biopolymers

Polycaprolactone and thermopolymers

Calcium phosphates

Collagen, Hyaluronic acid, and gelatins

CREATE THREE-DIMENSIONAL ORGANOMIMETIC MODELS FOR TISSUE ENGINEERING

SWISS INNOVATION

DATASHEET_BIOPRINTER_3DDiscoveryTM

3DDiscoveryTM

The 3DDiscovery™ platform is a versatile and cell friendly

instrument. It can create three-dimensional models that

more closely mimic what happens in living organisms. It

allows scientists to pattern cells, biomolecules, and a range of soft

and rigid materials in desirable 3D composite structures.

BIOSAFETY CABINET SPECIFICATIONS

Biosafety cabinet class II (Product /Operator/Environment)

Plug-Ready Interface for 3DDiscovery™ options/accessories

EN12469

Ultraviolet Germicidal Lamp for environment decontamination

The 3DDiscovery™ platform is a versatile and cell friendly

instrument. It can create three-dimensional models that

more closely mimic what happens in living organisms. It allows

scientists to pattern cells, biomolecules, and a range of soft

and rigid materials in desirable 3D composite structures.

GENERAL SPECIFICATIONS

Working range 130 90 60 mm

SLAS standard compatible

Precision ± 5 μm

Modular printhead concept GENERAL

Nano liter dispensing resolution, minimal dead volume

Printing under physiological conditions

Temperature control from 0°C up to 80°C

(substrate holder, medias)

Overall dimensions (W L H) 600 700 670 mm

ENABLING TECHNOLOGY

Bioprinting is a rapidly evolving field; the FLEXIBILITY and

MODULARITY of your bioprinting instrument are key factors for your

future success.

Tissue Engineering/ biotechnology Sciences are complex areas where

multiple factors including material types, composition, cell viability

and bio-architectures are crucial.

Your needs and requirements for bioprinting hardware are

following this rapid evolution and are thus constantly changing. The

3DDiscovery™’ flexibility and modularity will assist you

along the path.

BIOPRINTING PLATFORM

The 3DDiscovery™ instrument is a cutting-edge platform to

explore the potential of 3D tissue engineering through bio printing

technology.

Spatial control of cells, bioactives, and extracellular matrix in a

three-dimensional cellular construct is an enabling approach to

construct designed organomimetic tissues for drug discovery and

regenerative medicine.

YOUR SOLUTION

The high FLEXIBILITY of regenHU’s bioprinting instruments can

be adapted to any situation thanks to more than 80 accessories and

nearly unlimited customization possibilities.

The 3DDiscovery™ bioprinter offers an high MODULARITY.

MODULARITY that permits you to follow your Research &

Development objectives:

• Modification or extension of instrument hardware at any time

• Process customization to fit your needs

• Worldwide technical and after sales support

BIOPRINTING TECHNOLOGY IS EXPANDING IN RESEARCH AND INDUSTRY

3DDiscoveryTM Bench–Top 3DDiscoveryTM Biosafety

SWISS INNOVATION

DATASHEET_BIOPRINTER_3DDiscoveryTM

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regenHU授权中国代理商---世联博研（北京）科技有限公司，电话：010-67529703

DATASHEET_BIOPRINTER_BioFactoryTM

SWISS INNOVATION

TOOLS, OPTIONS AND ACCESSORIES EQUIP YOUR BIOPRINTER WITH:

Laser or photo-crosslinking devices: for hydrogel polymerization, bioactives encapsulation, signal molecule immobilization,

coating or ablation processes

Printhead technologies: for optimal processing of abroad biomaterial/bioactives portfolio:

– cell-friendly Ink-jet;

– thermopolymer extrusion;

– 2 component printhead;

– paste and hydrogel dispensing.

High precision temperature control devices: for biomaterials, mediums, printheads and substrates

Electrospinning printhead: printhead for micro & submicrometer bioarchitectures manufacturing

Software Suite: to interact with bioprinting instrument, medical imaging, human machine interface

– including BioCAD™, BioCAM™, BioCUT™, Industry standard interfaces (STL, DICOM, AMF, DXF)

Calibration systems: calibration laser, needle, substrate / lab device

The BioFactory™ is a versatile and cell friendly three-dimensional manufacturing instrument allowing scientists to pattern cells, bio-molecules and a range of soft and rigid materials in desirable 3D composite structures, mimicking natural environments.

GENERAL SPECIFICATIONSWorking range 60 60 60 mmHigh degree of customizationPrecision ± 5 μmModular printhead concept GENERALNano liter dispensing resolution, minimal dead volumePrinting under physiological conditionsTemperature control from 5°C up to 80°C (substrate holder, medias)Overall dimensions (W L H) 1370 1030 2400 mm

BIOPRINTING TECHNOLOGY IS EXPANDING IN RESEARCH AND INDUSTRY

BioFactoryTM

SWISS INNOVATION

DATASHEET_BIOPRINTER_BioFactoryTM

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A POWERFUL TISSUE ENGINEERING INSTRUMENT TO MIMIC NATURE It has been well documented that cell culture in tissue culture

plates and flasks doesn’t mimic the in-vivo cell growth and has poor correlation with in-vivo animal as well as human clinical data. The BioFactory™ instrument provides a powerful tool for tissue engineering to create organotypic tissues with in-vivo-like morphology that better mirrors the environment experienced by cells in-vivo. Furthermore, it better reflects cell behavior, intercellular interactions and differentiation processes.

BIOPRINTING PLATFORM The BioFactory™ instrument is a cutting-edge platform to explore the

potential of 3D tissue engineering through bioprinting technology. Spatial control of cells, bioactives, and extracellular matrix in a three-

dimensional cellular construct is an enabling approach to construct designed organomimetic tissues for drug discovery and regenerative medicine.

KEY ADVANTAGES Printing under physiological conditions Laser units for photo polymerization/ biomolecule immobilization Modularity: Selection of multiple dispensing technologies Biomanufacturing within a sterile laminar flow hood Repeatability of micrometer-scale processes Fast and easy tissue modelling via Bioprinting Suite Customization options

regenHU授权中国代理商---世联博研（北京）科技有限公司，电话：010-67529703

MATERIALS FOR 3D TISSUE PRINTING

DATASHEET_BIOMATERIALS_BioInkTM_OsteoInkTM

BioInkTM OsteoInkTM

SWISS INNOVATION

DATASHEET_BIOMATERIALS_BioInkTM_OsteoInkTM

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UNIVERSAL MATRIX FOR 3D TISSUE PRINTING

BioInkTM is a chemically-defined hydrogel to support growth of different cell types. It allows cell adhesion, mimics the natural extracellular matrix and is biodegradable.

BioInkTM is provided as a ready-to-use chemically-defined hydrogel to print 3D tissue models. Exclusively designed for regenHU’s BioFactoryTM and 3DDiscoveryTM tissue and bioprinters.

A versatile, chemically-defined hydrogel, supporting cell attachment, growth, differentiation and migration. The BioInkTM is suitable for long-term tissue cultivation (in vitro human dermis for up to 7 weeks).

BioInk™: Modular matrix tailored to the need of your cells

Combined with BioFactoryTM or 3DDiscoveryTM tissue bioprinters, you will be able to create composite tissue models in a layer-by-layer fashioning with spatial control of bioactive components (matrix, cells, proteins) and biomaterials.

BioInk™: Printed dermis equivalent

Fibroblasts printed in a layer-by-layer fashioning in combination with BioInkTM. The dermis equivalent was cultivated for 13 days and the fibroblasts are stained with MTT (dark cells; life stain).

HE-staining of a printed dermis equivalent cultivated for 17 days. Cross section of a dermis equivalent harboring fibroblasts.

BioInkTM OsteoInkTM

OsteoInk™ is a ready-to-use calcium phosphate paste for structural engineering dedicated to regenHU’s BioFactoryTM and 3DDiscoveryTM bioprinters.

OsteoInk™ is a highly osteoconductive biomaterial close to the chemical composition of human bone. Dedicated for hard tissue engineering such as bone, cartilage or structural scaffold manufacturing. OsteoInk™ can be combined with regenHU’s biomaterial product portfolio (e.g BioInk™) to create complex 3D tissue mimetic models.

The uniqueness of BioFactoryTM and 3DDiscoveryTM bioprinters enables freeform fabrication of tissue models with controlled layers and pore structure and biological composition. It enables scientists to mimic nature by combining OsteoInk™ with natural or synthetic hydrogels, bioactive components, collagen or hyaluronic acid, BioInkTM or blood derivates.

OsteoInk™ : A tissue engineering kit to mimic nature: combine cells / proteins / hydrogels / calcium phosphate / blood derivates

Designed for BioFactoryTM and 3DDiscoveryTM tissue bioprinters

Osteoconductive calcium phosphate material

For Research and Development

Available in 5cc cartridge

Can be combined with BioInkTM and bioactive components

CALCIUM PHOSPHATE MATERIAL FOR 3D TISSUE PRINTING

SWISS INNOVATION

regenHU授权中国代理商---世联博研（北京）科技有限公司，电话：010-67529703