2013 KIEC - Directed Self-Assembly Of Nanostructures To Develop Tools And Devices To Interface...
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Transcript of 2013 KIEC - Directed Self-Assembly Of Nanostructures To Develop Tools And Devices To Interface...
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By
Mehdi M. Yazdanpanah, PhD
CEO-Founder, NaugaNeedles LLC
DEVELOP TOOLS AND DEVICES TO
INTERFACE BIOMATERIAL-TO-
ELECTRONIC
Presented at:
Kentucky Innovation and Entrepreneurship Conference
Aug 2013
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NaugaNeedles History
Established in 2007 by name and become operational in 2009
Licensed UofL technology and filed for 4 utility patents
Established its fabrication facility in Louisville KY
Currently have more than 200 customers world wide
Have 8 employees (4 full time and 4 part time)
Supported by SBIR grants from NSF and NIH
Supported by State and local program (e.g. SBIR matching fund, DCI forgivable loan, Vogt award)
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Outline
NaugaNeedles platform technology
Our current product and tools
Current R&D toward future product development
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Formation of Ag2Ga Needles in Ambient Condition
10 mm A gallium line on top of silver
Highly crystalline Ag2Ga
nanowires are spontaneously
self-assembled in few seconds
inside the gallium line
Ag-coated substrate
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10 mm Ga droplet
Ag2Ga nano-needle 120 nm in diameter and 70 µm long
Growing from a melted drop of gallium at room temperature
SELECTIVE GROWTH IN AMBIENT CONDITION
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200 mm
(a)
(b)
(c)
(d)
(e)
10
mm
Gallium substrate
Array of silver coated tips
Tips are not visible at this magnification
30 mm
Nanoneedles Batch Fabrication
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Mechanical Ultra sensitive cantilever
(k < 0.1 mN/m, f0 > 100 KHz)
E = 84 ± 1 Gpa
Electrical Highly conductive:
comparable to platinum and copper
High current capability: 5 mA
Thermal:
Melting point: Experimentally measured: 950 ºC,
• Long term stability in air
• A thin layer of oxide forms around the nanowire and
protect the rest
Highly resistant to Reactive Ion Etching
PROPERTIES OF NANONEEDLES IN A GLANCE
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Example of NaugaNeedles Products
5 mm
Customers: Researchers ( e.g. material scientist, biologist,
chemist, pharmaceutical industry)
8 types of products and more than 100 part number is
currently offered
More details at http://nauganeedles.com/products.html
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CURRENT R&D TOWARD FUTURE PRODUCT
DEVELOPMENT
Metrology tools for MEMS and
semiconductor industry
Device for Capturing Circulating Tumor
Cell in Human Blood
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Gap in
Metrology
Tools
GAP IN METROLOGY TOOLS IN
MICROSTRUCTURES IMAGING
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(a) (b)
spring loaded kinematic
mount
Tuning fork
Alumina Chip
Vib
rate
d N
ee
dle
in a
ctio
n
Preamplifier board
Nanoneedle
NANOTOUCH FOR SIDEWALL SCANNING AND DEPTH MEASUREMENTS AT MICROSCALE
NaugaNeedles in collaboration with InSituTec is
developing the NanoTouch to address the gap in
metrology
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Results of Sidewall Imaging Using NanoTouch
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Depth Measurement Using NanoTouch
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A Handheld detector to detect and capture low dose Circulating Tumor
Cell (CTC) in 1 ml of blood
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Circulating tumor cells (CTC) are cells that detach from
primary tumors and circulate in the blood stream
Early detection of low counts of CTCs in patient blood
sample can be used as a valuable indicator for diagnosis
How can 1 to 10 CTCs mixed with 5 billion Red and White
blood cells be detected?
PROBLEM REGARDING DETECTION AND CAPTURING OF LOW DOSE CTC
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EXAMPLE OF A MICROCHIP CTC CAPTURING DEVICE
Detection Method:
florescence
microscopy
Capturing method:
micropillar array
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EXAMPLE OF A MICRO FLUIDIC DEVICE FOR CTC CAPTURING
Capturing method: microstructure array
Detection Method: florescence microscopy
http://www.msnbc.msn.com/id/40881967/ns/health-cancer/
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CTC
RBC
WBC
A
THE PROPOSED MECHANISM FOR CTC CAPTURING AND COUNTING
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SELECTIVE CAPTURING MECHANISM USING METALLIC NANONEEDLES ARRAY
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Biotinylated
Antibody
Neutravidin
GMBS
Silane
A CTC from a MCF-7
cell line stuck to a
nanoneedle in the array
10
µm
PRELIMINARY RESULT OF CAPTURING INDIVIDUAL CTC
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In Summary
Briefly introduced NaugaNeedles history and the platform technology
Future device development for depth and sidewall imaging for MEMS and semiconductor industry
Preliminary results for developing a blood test kit for capturing and counting circulating tumor cells
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