180941 Toxicity and risk assessment 110x210mm · • Marco Binaglia • Heidi Foth • Lan Gao •...

Food Chemistry and Toxicology

Toxicity and risk assessment of pyrrolizidine alkaloids

current status and way forward

OCCURRENCE - TOXICITY - RISK ASSESSMENT

12.-13. September 2018 | Kaiserslautern

sponsored by: Kooperation Phytopharmaka

Number of participants is limited

INVITED SPEAKERS

SCIENTIFIC PROGRAMME

• Marco Binaglia• Heidi Foth• Lan Gao• Jacob van Klaveren• Alfonso Lampen• Ge Lin• Catherine Mahony

• Patrick Mulder• Stefan Pfuhler• Ivonne Rietjens• Lukas Rutz• Dieter Schrenk• Barbara Steinhoff• Anja These

Wednesday, September 12th, 2018

13:00 - 13:15 Welcome and introduction Dieter Schrenk, Kaiserslautern (D)

Chair: Björn Feistel, Andernach (D)13:15 – 13:45 Occurrence and levels of PAs in plants

Patrick P. J. Mulder, Wageningen (NL)13:45 – 14:15 Risk assessment of PAs in food and new

insights in toxicology Alfonso Lampen, Berlin (D)

14:15 – 14:45 PA contamination in herbal medicinal pro-ducts: limits and occurrence Barbara Steinhoff, Bonn (D)

14:45 – 15:15 Coffee break Chair: Tankred Wegener, Weinheim (D)15:15 – 15:45 PA toxicity and potential biomarker of PA

exposure for clinical use Ge Lin, Hong Kong (HK)

15:45 – 16:15 Role of toxicokinetics in PA toxicity Ivonne Rietjens, Wageningen (NL)

16:15 – 16:45 Role of metabolism in relative potency of PAs Catherine Mahony, Egham (GB)

Thursday, September 13th, 2018

Chair: Catherine Mahony, Egham (GB)08:30 – 09:00 In vitro testing of PA congeners for

equivalency assessment Lan Gao/Lukas Rutz, Kaiserslautern (D)

09:00 – 09:45 The EuroMix project: An integrated test strategy for testing the mixture effects Jacob van Klaveren, Utrecht (NL)

09:45 – 10:15 Relative potency of PAs for genotoxicity induction in human liver cells Stefan Pfuhler, Cincinnati (USA)

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Uni West105, 106 und 170

Uni Süd105

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Uni West105, 106, 115, 116, und 170

Uni Süd105, 115 und 116


Hermann-Löns-Str.105

Buchenloch105 und 107

Uni Ost116

BahnhofZentrum

A6 Richtung LudwigshafenA63 Richtung Mainz

L502B270 Richtung PirmasensA6 Richtung Saarbrücken/Trier A62

Universitäts-Wohngebiet

L503 Richtung Stelzenberg

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Erwin-Schrödinger-Straße

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ROUTES AND MEANS OF TRANSPORT

SCIENTIFIC PROGRAMME

10:15 – 10:45 Species differences in in vitro PA metabolismAnja These, Berlin (D)

10:45 – 11:00 Coffee break Chair: Olaf Kelber, Darmstadt (D) 11:00 – 11:30 EFSA’s risk assessment of PAs in food

Marco Binaglia, Parma (I) 11:30 – 12:15 HMPC’s risk assessment and recommenda-

tions for PAs in phytomedicinal productsHeidi Foth, Halle (D)

12:15 – 12:45 Principles of equivalency in PA risk assessmentDieter Schrenk, Kaiserslautern (D)

12:45 – 13:00 Summary and adjourn

Venue

University of KaiserslauternBuilding 42/110Paul-Ehrlich-Straße67663 Kaiserslautern, Germany

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Uni Ost105, 115 und 116



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Uni West105, 106, 115, 116, und 170

Uni Süd105, 115 und 116




Uni Ost116

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Travelling by carSee map as attached

Train and BusYou can use various connections to reach Kaiserslautern, inclu-ding Intercity or municipal trains. From the main station in Kai-serslautern to the University take bus line 115 to stop at “Uni-Sports Hall” or bus line 105, 106 to stop at “Uni-West”. Bus lines to and from University:https://www.swk-kl.de/de/busverkehr/fahrplaene/fahrplanauskunft.html

Travel by PlaneAirport Saarbrücken (one hour on motorway 6) Airport Frankfurt (1.5 hours on motorway or 2 hours by train) Airport Hahn (1.5 hours on motorway 62)

ROUTES AND MEANS OF TRANSPORT

RECOMMENDED HOTELS

CONTACT

Altstadt HotelSteinstr. 51 0631 / 3643-0Kaiserslautern 0631 / 3643-100www.altstadthotel.com [email protected]

Art Hotel LauterbachFruchthallstr. 15 0631 / 36240-0Kaiserslautern 0631 / 36240-12www.art-hotel-kl.de

B&B HotelBarbarossastr. 2 0631 / 41461-067655 Kaiserslautern 0631 / 41461-444 [email protected]

Hotel ZollamtBuchenlochstr. 1 0631 / 31666-0067663 Kaiserslautern 0631 / 31666-66www.hotel-zollamt.de [email protected]

Hotel Restaurant Bremerhof Bremerhof 1 0631 / 316322067663 Kaiserslautern [email protected] inquire for special rates for University of Kaiserslautern.

workshop fee 50 €[email protected]://www.chemie.uni-kl.de/schrenk/pa-workshop-2018/

180941 Toxicity and risk assessment 110x210mm · • Marco Binaglia • Heidi Foth • Lan Gao •...

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Transcript of 180941 Toxicity and risk assessment 110x210mm · • Marco Binaglia • Heidi Foth • Lan Gao •...