111 human carotid mri spio
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Transcript of 111 human carotid mri spio
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Non-invasive Detection of Vulnerable Plaque Using
SPIO Enhanced MRI
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Everybody has atherosclerosis, the question is who has Vulnerable Plaque
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The Online Cardiovascular Research Community
www.VulnerablePlaque.org
All slides will be available on:
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Vulnerable Plaque?
Atherosclerotic plaques that cause sudden luminal clot formation and lead to heart attack and stroke.
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Different Types of Vulnerable Plaque As underlying Cause of Acute Coronary Events
NormalRupture-prone
Fissured ErodedCritical Stenosis Hemorrhage
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Carotid artery plaqueCCA
Carotid bifurcation
ICA stenosis & plaque
Courtesy of
Dr. Chun Yuan University of Washington, Seattle
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Plaque Morphology Vs.
Plaque Activity
Why do we need to go beyond morphological assessment of plaques? Why do we need both?
The short answer is: because not all plaques with similar morphology would result in similar outcome.
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SPIO Super Paramagnetic Iron Oxide
Colloidal coated particles of iron oxide, e.g. dextran coated SPIO (Feridex I.V.)
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Weissleder R et al. (1997)
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Schmitz et al J. Inv. Radiol. 2000
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Non-invasive MRI study of atherosclerotic plaques using SPIO (pre and post injection comparison) may be a likely method for detection of vulnerable plaques
Further studies particularly human clinical trials are warranted
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SPIO Clinical Trial:- The first human clinical trial on
detection of carotid vulnerable plaque using SPIO in patients undergoing carotid endartherectomy
Baseline
Scan
SPIO Injection
1hr post-injection
5days
ScanSurgery
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