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Transcript of © 2004 Current Medicine Group Ltd NEOPLASIAS DE PANCREAS Dra Marianella Madrial Borloz HOSPITAL...
© 2004 Current Medicine Group Ltd
NEOPLASIAS DE PANCREAS
Dra Marianella Madrial Borloz
HOSPITAL MEXICO
© 2004 Current Medicine Group Ltd
AUNQUE NO SE HAN IDENTIFICADO CAUSAS ESPECIFICAS.....
• Factores relacionados con : Alto riesgo: Bajo Riesgo:1. Edad, sexo 1. Frutas y Verduras2. Urbano 2. Historia de alergias3. Pobl negra (USA) 3. Amigdalectomía4. Clase econ5. Tabaco6. OH?7. Pancreatitis,8. Dieta: café, té,carne, grasa9. Fact ocupacionales: Rx, Qx10. Gastrectomía, DM
© 2004 Current Medicine Group Ltd
CLASIFICACION HISTOLOGICA. TUMORES EXOCRINOSTABLE 7 - 2. HISTOLOGIC CLASSIFICATION OF EXOCRINE PANCREATIC TUMORS
Ductal cell origin
Ductal cell carcinoma
Giant cell carcinoma
Giant cell carcinoma
Osteoclastoid
Adenosquamous carcinoma
Spindle - cell carcinoma
Microadenocarcinoma
Mucinous carcinoma
Mucinous cystadenocarcinoma
Papillary cystic tumor
Mucinous carcinoid carcinoma
Carcinoid
Oncocytic carcinoid
Oncocytic carcinoma
"Oat cell" carcinoma
Ciliated cell carcinoma
Acinar cell origin
Acinar - cell carcinoma
Acinar cystadenocarcinoma
Uncertain histogenesis
Pancreaticoblastoma (simple)
Pancreaticoblastoma (mixed type)
Unclassified
Small - cell carcinoma
Large - cell carcinoma
Clear - cell carcinoma
Mixed cell type
Duct - islet - cell carcinoma
Duct - islet - acinar - cell carcinoma
Acinar - islet - cell carcinoma
Carcinoid - islet - cell carcinoma
Connective tissue origin
Leiomyosarcoma
Malignant fibrous histiocytoma
Hemangiopericytoma
Fibrosarcoma
Malignant neurilemoma
© 2004 Current Medicine Group Ltd
DIAGNOSTICO
© 2004 Current Medicine Group Ltd
SINTOMATOLOGIA
SINTOMAS SON TARDIOS, 1er PERIODO LATENTE
Pérdida de peso (91 %)
• Dolor (83%)
• Ictericia ( 71%9
• Anorexia,nauseas ( 44%)
Otros:
• Malestar, vómitos, dis
pepsia, cambios del hábito
intestinal
• PANCREATITIS
• S. TROMBOTICO
• SDA
• NECROSIS GRASA
• DM
• TRAST PSIQUIATRICOS
• METASTASIS
© 2004 Current Medicine Group Ltd
EXAMEN FISICO
• HEPATOMEGALIA
• LEY DE COURVOISIER TERRIER
• MASA ABDOMINAL
• ESPLENOMEGALIA (C Y C)
• ASCITIS
• EDEMAS Ms Is
• ASOC A COMPLICACIONES
© 2004 Current Medicine Group Ltd
DIAGNOSTICO- LABORATORIO
• Bilirrubina, FA• PFH alteradas• Glucosa• Amilasa, lipasa...• Guayacos, Anemia, hipoprot• Marcadores Tumorales: Ca 19-9, ACE,Ca 50,AFP,
Antígeno Oncofetal Pancreático• Marcadores Genéticos: p 52, K ras
© 2004 Current Medicine Group Ltd
GABINETE
• EGD• ESTUDIOS BARITADOS• ERCP ( 70-80 %), CON CITOLOGIA (92-95%)• US (80%)• TAC ( 80%)• RESONANCIA MAGNETICA• BX AGUJA FINA DIRIG POR TAC• ANGIOGRAFIA, GAMMA• LAPAROTOMIA
© 2004 Current Medicine Group Ltd
ESTUDIOS BARITADOS
© 2004 Current Medicine Group Ltd
ESTUDIOS BARITADOS
© 2004 Current Medicine Group Ltd
ULTRASONIDO. PTE CON ICTERICIA DE ORIGEN DESCONOCIDO
© 2004 Current Medicine Group Ltd
TAC, BIOPSIA DIRIGIDA
© 2004 Current Medicine Group Ltd
BIOPSIA POR ASPIRACION (TAC)
© 2004 Current Medicine Group Ltd
MASA EN CABEZA DE PANCREAS
© 2004 Current Medicine Group Ltd
DILAT INTRAHEPATICA SECUNDARIA
© 2004 Current Medicine Group Ltd
MASA EN CUERPO PANCREAS
© 2004 Current Medicine Group Ltd
MASA EN CUERPO PANCREAS
© 2004 Current Medicine Group Ltd
MASA EN COLA DE PANCREAS,TAC HELICOIDAL
© 2004 Current Medicine Group Ltd
LESION EN COLA DE PANCREAS
© 2004 Current Medicine Group Ltd
AMPULLOMAS
• MEJOR PX
• COLEDOCO TERMINAL,AMPULLA,PARED DUODENAL, PORCION DISTAL DEL WIRSUNG
• SINTOMAS: ICTERICIA, MELENA, COLANGITIS
• TRATAMIENTO QX
© 2004 Current Medicine Group Ltd
TUMORES ENDOCRINOS DEL PANCREAS
Nombre Sínd Sg, S+ Local. HormonaInsulinoma Insulinoma S+ hipoglic Panc 97% Insulina
Gastrinoma Zollinger-Ellison
Dolor abd, diarrea, s+ esofàgicos
Panc 60%
Duod 30%
gastrina
Glucagono ma Rash,anemia, DM,PePeso..
Pancreas glucagón
VIPoma Verner-Morrison
Diarrea acuo
sa severa
Páncreas (90%)
PIV
Somatosta tinoma DM, colelit,esteat
Panc 56%
ID 44%
Somatosta
tina
GRF oma idem Acromegalia Pancreas Fact Lif HC
PPoma idem Pepeso, masa abd, hepatom
Pancreas No