© 2004 Current Medicine Group Ltd NEOPLASIAS DE PANCREAS Dra Marianella Madrial Borloz HOSPITAL...

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© 2004 Current Medicine Group Ltd NEOPLASIAS DE PANCREAS Dra Marianella Madrial Borloz HOSPITAL MEXICO

Transcript of © 2004 Current Medicine Group Ltd NEOPLASIAS DE PANCREAS Dra Marianella Madrial Borloz HOSPITAL...

Page 1: © 2004 Current Medicine Group Ltd NEOPLASIAS DE PANCREAS Dra Marianella Madrial Borloz HOSPITAL MEXICO.

© 2004 Current Medicine Group Ltd

NEOPLASIAS DE PANCREAS

Dra Marianella Madrial Borloz

HOSPITAL MEXICO

Page 2: © 2004 Current Medicine Group Ltd NEOPLASIAS DE PANCREAS Dra Marianella Madrial Borloz HOSPITAL MEXICO.

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AUNQUE NO SE HAN IDENTIFICADO CAUSAS ESPECIFICAS.....

• Factores relacionados con : Alto riesgo: Bajo Riesgo:1. Edad, sexo 1. Frutas y Verduras2. Urbano 2. Historia de alergias3. Pobl negra (USA) 3. Amigdalectomía4. Clase econ5. Tabaco6. OH?7. Pancreatitis,8. Dieta: café, té,carne, grasa9. Fact ocupacionales: Rx, Qx10. Gastrectomía, DM

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CLASIFICACION HISTOLOGICA. TUMORES EXOCRINOSTABLE 7 - 2. HISTOLOGIC CLASSIFICATION OF EXOCRINE PANCREATIC TUMORS

Ductal cell origin

Ductal cell carcinoma

Giant cell carcinoma

Giant cell carcinoma

Osteoclastoid

Adenosquamous carcinoma

Spindle - cell carcinoma

Microadenocarcinoma

Mucinous carcinoma

Mucinous cystadenocarcinoma

Papillary cystic tumor

Mucinous carcinoid carcinoma

Carcinoid

Oncocytic carcinoid

Oncocytic carcinoma

"Oat cell" carcinoma

Ciliated cell carcinoma

Acinar cell origin

Acinar - cell carcinoma

Acinar cystadenocarcinoma

Uncertain histogenesis

Pancreaticoblastoma (simple)

Pancreaticoblastoma (mixed type)

Unclassified

Small - cell carcinoma

Large - cell carcinoma

Clear - cell carcinoma

Mixed cell type

Duct - islet - cell carcinoma

Duct - islet - acinar - cell carcinoma

Acinar - islet - cell carcinoma

Carcinoid - islet - cell carcinoma

Connective tissue origin

Leiomyosarcoma

Malignant fibrous histiocytoma

Hemangiopericytoma

Fibrosarcoma

Malignant neurilemoma

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DIAGNOSTICO

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SINTOMATOLOGIA

SINTOMAS SON TARDIOS, 1er PERIODO LATENTE

Pérdida de peso (91 %)

• Dolor (83%)

• Ictericia ( 71%9

• Anorexia,nauseas ( 44%)

Otros:

• Malestar, vómitos, dis

pepsia, cambios del hábito

intestinal

• PANCREATITIS

• S. TROMBOTICO

• SDA

• NECROSIS GRASA

• DM

• TRAST PSIQUIATRICOS

• METASTASIS

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EXAMEN FISICO

• HEPATOMEGALIA

• LEY DE COURVOISIER TERRIER

• MASA ABDOMINAL

• ESPLENOMEGALIA (C Y C)

• ASCITIS

• EDEMAS Ms Is

• ASOC A COMPLICACIONES

Page 7: © 2004 Current Medicine Group Ltd NEOPLASIAS DE PANCREAS Dra Marianella Madrial Borloz HOSPITAL MEXICO.

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DIAGNOSTICO- LABORATORIO

• Bilirrubina, FA• PFH alteradas• Glucosa• Amilasa, lipasa...• Guayacos, Anemia, hipoprot• Marcadores Tumorales: Ca 19-9, ACE,Ca 50,AFP,

Antígeno Oncofetal Pancreático• Marcadores Genéticos: p 52, K ras

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GABINETE

• EGD• ESTUDIOS BARITADOS• ERCP ( 70-80 %), CON CITOLOGIA (92-95%)• US (80%)• TAC ( 80%)• RESONANCIA MAGNETICA• BX AGUJA FINA DIRIG POR TAC• ANGIOGRAFIA, GAMMA• LAPAROTOMIA

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ESTUDIOS BARITADOS

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ESTUDIOS BARITADOS

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ULTRASONIDO. PTE CON ICTERICIA DE ORIGEN DESCONOCIDO

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TAC, BIOPSIA DIRIGIDA

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BIOPSIA POR ASPIRACION (TAC)

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MASA EN CABEZA DE PANCREAS

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DILAT INTRAHEPATICA SECUNDARIA

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MASA EN CUERPO PANCREAS

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MASA EN CUERPO PANCREAS

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MASA EN COLA DE PANCREAS,TAC HELICOIDAL

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LESION EN COLA DE PANCREAS

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AMPULLOMAS

• MEJOR PX

• COLEDOCO TERMINAL,AMPULLA,PARED DUODENAL, PORCION DISTAL DEL WIRSUNG

• SINTOMAS: ICTERICIA, MELENA, COLANGITIS

• TRATAMIENTO QX

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TUMORES ENDOCRINOS DEL PANCREAS

Nombre Sínd Sg, S+ Local. HormonaInsulinoma Insulinoma S+ hipoglic Panc 97% Insulina

Gastrinoma Zollinger-Ellison

Dolor abd, diarrea, s+ esofàgicos

Panc 60%

Duod 30%

gastrina

Glucagono ma Rash,anemia, DM,PePeso..

Pancreas glucagón

VIPoma Verner-Morrison

Diarrea acuo

sa severa

Páncreas (90%)

PIV

Somatosta tinoma DM, colelit,esteat

Panc 56%

ID 44%

Somatosta

tina

GRF oma idem Acromegalia Pancreas Fact Lif HC

PPoma idem Pepeso, masa abd, hepatom

Pancreas No