Post on 22-May-2020
©2011 Waters Corporation
Waters OverviewWaters Overview
©2013 Waters Corporation 2
Introduction to WatersIntroduction to Waters
Established in 1958
Publicly traded corporation (NYSE:WAT)
$1.84 billion in annual revenue
Headquartered in Milford, Massachusetts
Manufacturing and distribution centers worldwide
5,700 employees many of whom were once customers
– Average of >10 years of service (>16 yrs in the field)
> 2,400 sales and service within the field organization
– maintains direct link with end users
Greatest proportion of revenue derived from new products
320$M
795$M
1.84$B
1994 2000 2012
All facilities cGMP-compliant & ISO 9001-2000 certified20,000 instruments180,000 columns1,400,000 parts / year
©2013 Waters Corporation 3
1963First liquidseparations SystemGPC-150
1973High-performance liquid chromatography M6000 HPLC Pump
1978Solid phase ExtractionSep-Pak®
Cartridges
1988PC-based Chromatography softwareMaxima Software
1996Quadrupole Time-of-flight MSQ-TofTM
Mass Spectrometer
2004First UPLC® System ACQUITY UPLC® System
2006High-Definition MSSYNAPT HDMSTM
System
2008/2009XEVOTM TQ MSXEVO QTof MS
Breakthrough TechnologyBreakthrough Technology
2010ACQUITY H-class
Patrol
2012UPC2
©2013 Waters Corporation 4
Application FocusApplication Focus
Pharmaceutical
Biopharmaceuticals
Chemical/Industrial
Environmental
Clinical
Food Safety
©2013 Waters Corporation 5
©2013 Waters Corporation 6
Waters Technologies
©2013 Waters Corporation 7
Waters Technologies
©2013 Waters Corporation 8
“Demand for UHPLC systems has continued to outpace demand for other HPLC techniques. UHPLC systems are fast becoming the standard tool for research and routine applications.”
– Strategic Directions International
The ACQUITY Difference
©2013 Waters Corporation 9
UPLC: Bridging the Gap From UPLC: Bridging the Gap From Laboratory to Manufacturing FloorLaboratory to Manufacturing Floor
Discovery/DevelopmentLab
QC Lab Process Lab ManufacturingFloor
©2013 Waters Corporation 10
La più ampia scelta di colonne per UPLCLa più ampia scelta di colonne per UPLC
BEH C18
BEH C8
BEH Phenyl
BEH Shield RP18
BEH HILIC
BEH Amide
CSH C18
CSH Fluoro-Phenyl
HSS T3
HSS C18
HSS C18 SB
Cinque substrati differenti
• 130Å, 200Å e 300Å BEH [Ethylene Bridged Hybrid], HSS [High Strength Silica] e CSH [Charged Surface Hybrid]
• Tutte disponibili per HPLC e UPLC
Ampio spettro fasi stazionarie
• 18 fasi stazionarie
• BEH 130Å C18, C8, Shield RP18, Phenyl, HILIC ed Amide, IEX
• BEH 300Å C18 e C4
• BEH 200Å SEC
• HSS-C18, HSS-T3, HSSC18-SB, HSS-PFP, HSS-CN
• CSH C18, Fluoro-Phenyl e Phenyl-Hexyl
Colonne per applicazioni speciali
• AAA, OST, PST, PrST e Glycan
Transferibilità tra HPLC ed UPLC
XBridge HPLC = ACQUITY BEH
HSS HPLC and= ACQUITY HSS
XSelect HPLC = ACQUITY CSH CSH Phenyl-Hexyl
©2013 Waters Corporation 11
Evolution of Separation TechnologyEvolution of Separation Technology
Gas Chromatography Liquid Chromatography Convergence Chromatography
GC
Capillary GC
HPLC
UPLC
SFC
UPC2
©2013 Waters Corporation 12
The Advent of The Advent of Convergence ChromatographyConvergence Chromatography
Convergence Chromatography
UltraPerformance Convergence Chromatography is the result of significant technological advancements in Supercritical Fluid Chromatography instrumentation and chemistry design while providing exceptional increases in available selectivity
SFC UltraPerformanceConvergence Chromatography
Data courtesy of Davy Guillarme, Jean-Luc Veuthey LCAP, University of Geneva, Switzerland
©2013 Waters Corporation 13
ACQUITY UPC² SystemACQUITY UPC² System
Built upon proven UPLC Technology– Quantifiable increase in productivity
Exceptional increase in available selectivity– Solve routine and complex separation challenges
©2013 Waters Corporation 14
Where is CC Applicable?Where is CC Applicable?
Pharmaceutical and Life Sciences– Metabolite ID, stability-indicating, impurity
profiling
– Purity assessment, final product analysis
– Chiral
– Orthogonal method screening (vs. RPLC)
Food and environment– Vitamins, essential oils, pesticides, lipids,
triglycerides, food additives
Chemical materials– Polymers, organometallics, dyes,
petroleum, surfactants, petrochemicals, biodiesel
Clinical research– Vitamin D metabolites
– Steroids
©2013 Waters Corporation 15
SQD2 XevoTQDXevoTQXevoTQ-S
Xevo G2 TofXevo G2 QTof
Synapt G2-SSynapt G2 HDMS
Soluzioni MS
©2013 Waters Corporation 16
©2013 Waters Corporation 17
Sessioni Sessioni
©2013 Waters Corporation 18
©2013 Waters Corporation 19
Grazie