Update on Diversity Cancer Training

Peter Ogunbiyi, DVM, PhDChief, Diversity Training Branch

NCI Center to Reduce Cancer Health Disparities

December 2, 2019

2

Outline

1. Overview of CRCHD Programs

2. The Continuing Umbrella of Research Experiences (CURE) Program

3. A Look at FY 2012-2018

4. Moving Forward

3

CRCHD Programs

Diversity Training

Partnerships• Partnerships to Advance

Cancer Health Equity (PACHE)

Networks• Geographic

Management of Cancer Health Disparities Program (GMaP)

• National Outreach Network (NON)

Cancer Health Disparities Research

• Basic research• Translational research

4

Outline

1. Overview of CRCHD Programs

2. The Continuing Umbrella of Research Experiences (CURE) Program

3. A Look at FY 2012-2018

4. Moving Forward

5

T R A I N E E S

Increase the size of the talent

pool

Emphasize scientific areas of

greatest need

Expand and extend the

period of training

Post-baccalaureate

Grades 6-12

Undergraduate

Predoctoral Investigators

PostdoctoralPost Masters

Continuing Umbrella of Research Experiences

6

4%4%

42%

1%

35%

3% 6%

2% 3% 0%Demographics

American Indian or Alaska NativeAsianBlack or African AmericanDisabilityHispanic or LatinoNative Hawaiian or Pacific IslanderUnknownWhiteLow SESMore than One Race

2%

17%

29%25%

2%11%

13%

1%Career Levels

Middle SchoolHigh SchoolUndergraduateGraduatePost-Bac/Post-MastersPostdocInvestigatorsUnknown

CURE Trainees (2001-2018, n = 4,753) Are Diverse

7

CURE is More Than a Pipeline

Mentored Research

Experience

Professional Development

Workshop

Mock Review

Virtual Platforms

GMaP:In-Region

Connections

Technical Assistance Workshop

Navigation of Trainees

Ecosystem of Support Set Clear Goals and Monitor Progress

8

Outline

1. Overview of CRCHD Programs

2. The Continuing Umbrella of Research Experiences (CURE) Program

3. A Look at FY 2012-20184. Moving Forward

9

Diversity and Re-entry Supplements Support Research Experiences Across NCI DOCs (FY 2012 – 2018)

DCB: Division of Cancer BiologyDCCPS: Division of Cancer Control and Population SciencesDCP: Division of Cancer PreventionDCTD: Division of Cancer Treatment and DiagnosisCRCHD: Center to Reduce Cancer Health DisparitiesOD: Office of the Director

n = 661

10%

41%

14%

9%

25%

1%Total Awards by DOC

020406080

100120

2012 2013 2014 2015 2016 2017 2018

Num

ber o

f Aw

ards

Fiscal Year

Supplement Award Distribution

10

Diversity and Re-entry Supplements - Demographics and Outcomes(FY 2012-2018)

Reported Supplement Outcomes# K Awards 23# R01 8# R03 2# R21 13# Other Awards 27# Publications 508# Oral Presentations 315

42%

4%

1%

3%47%

1%0%

2%

Diversity

Black / African AmericanAmerican Indian / Alaskan NativeAsianNative Hawaiian / Other Pacific IslanderHispanic / LatinoDisabilitySESRe-entry

Male43%

Female57%

Gender0% 2%

9% 2%

42%28%

17%

Career Level

High SchoolUndergraduatePost-BaccalaureatePost-MastersGraduate StudentPostdoctoralInvestigator

n = 661

11

0

20

40

2012 2013 2014 2015 2016 2017 2018Num

ber o

f Aw

ards

F31 Research Type

Basic Behavioral/Population Clinical Translational

F31- Demographics, Research Types and Outcomes (FY 2012-2018)

Cancer Health Disparities Research: 5%

Reported F31 Outcomes# Publications 380# K Awards 5# Other NIH Awards 8

31%2%

3%3%

1%0%

53%

4%

2%1%

Diversity Black / African American

American Indian / AlaskanNativeAsian

Native Hawaiian / OtherPacific IslanderMultiple Races

White

Hispanic / Latino

Disability

SES

Male43%

Female57%

Gender

n = 181

12

K Awards – Demographics, Research Types and Outcomes (FY 2012-2018)

Reported K Award Outcomes# Publications 539# R01 15# R03 4# R21 24# Other NIH Awards 10

n = 113

Cancer Health Disparities Research: 22%

010203040

2012 2013 2014 2015 2016 2017 2018

Num

ber o

f Aw

ards

K Award Research Types

Basic Behavioral/Population Clinical TranslationalFiscal Year

43%

2%1%2%1%

47%

4%Diversity

Black / African American

American Indian / AlaskanNativeAsian

Native Hawaiian / OtherPacific IslanderMultiple Races

Hispanic / Latino

Disability

Male40%

Female60%

Gender

13

Success Rates of CURE K Awardees in Obtaining Subsequent NIH Grants Compared with Other NIH K Awardees (FY 2001-2015)

Success rate of obtaining R01: CURE similar to other K awardees Success rate of obtaining R03 or R21: Black/African American

CURE K awardees, similar to other groups, perform significantly better than Black/African American Other NIH K Awardees

Comparison Groups: CURE K Awardees All Other NIH K Awardees

All Other NIH K Awardees

White CURE K Awardees

Black/African American Other NIH K Awardees

Black/African American CURE K Awardees

Hispanic/Latino Other NIH K Awardees

Hispanic/Latino

01020304050

Succ

ess

Rat

e (%

) *

05

1015202530

Succ

ess

Rat

e (%

) *

* p < 0.05

Awardee Success Rate Application Success Rate

CURE Ks, B/AA Other NIH Ks, B/AA CURE Ks, B/AA Other NIH Ks, B/AAn: 42 55 153 112 n: 120 128 427 229

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Purpose: YES promotes effective early intervention strategies to: Engage students from diverse backgrounds and

their teachers in cancer research Inspire interest in biomedical sciences and cancer

research Help envision cancer research as a career path Strengthen practical research and career skills

YES Application• Research experiences• Curriculum and Methods

Development• Outreach

YES Career Level• Middle school, high school

and undergraduate students

• Teachers and faculty

R25 Youth Enjoy Science (YES) Research Education Program – Initiated in November, 2016

Distribution of Current 11 R25 YES

15

32%

24%

0%

28%

2%3% 11%

Black / African American

Hispanic / Latino

Native Hawaiian / Other PacificIslanderAmerican Indian / Alaska Native

Asian

White

SES

21 21

35

55

0102030405060

High School Undergraduate

Num

ber o

f Stu

dent

s

Male Female

Middle School Teachers High School Teachers Undergraduate Faculty0 8 9

Student Diversity Student Gender and Career Level

n = 132

R25 YES Demographics, FY2018 (5 Programs, First Year)

3 of the programs will recruit middle school students starting Year 2

16

R25 YES Impact Scores: Awards Limited by Budget Constraints

How many can be awarded?

Budget per award per year:Up to $500k DC

($540k TC)

Each award: up to 5 years

Applications Awarded Excellent But Not Awarded Not Awarded Total

FY 2018Score 10-25 25-30 31-65 ND

33Number 5 8 12 8

FY 2019Score 10-20 23-28 36-70 ND

32Number 6 3 19 4

Applications Reviewed Awaiting Review Total

FY 2020Score 14-20 23-30 31-65 ND N/A

40Number 5 3 12 4 16

17

Intramural Diversity-Focused Training Program: Intramural CURE (iCURE) – Initiated in December, 2017

Website: https://www.cancer.gov/about-nci/organization/crchd/diversity-training/icure

Purpose: • Support research experiences of underrepresented students and scientists in the

NCI Intramural Research Program in Bethesda, Rockville and Frederick, Maryland • Promote professional and career development • Help the trainees achieve research independence

Post-baccalaureate (Incl. Post-master’s)

One-year research experience awards

Graduate Students Postdoctoral Fellows

Three-year research experience awards

Two-year research experience awards

Applications NOW OPENNov 20, 2019 – Jan 17, 2020

iCURE@nih.gov

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Outline

1. Overview of CRCHD Programs

2. The Continuing Umbrella of Research Experiences (CURE) Program

3. A Look at FY 2012-2018

4. Moving Forward

19

Improve the competitiveness of Postdoctoral Fellows and Investigators

Improve tracking of trainees to better evaluatethe impact of the programs

Moving forward …

Increase R25 YES budget: building a pipeline of diversity-focused training is the foundation of a diverse pool of R01 grantees

Promote training in quantitative sciences – new initiatives

Continue enhancement of training opportunities in cancer health disparities research

Diversity Training

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ContactPeter Ogunbiyi, DVM, PhD

ogunbiyp@mail.nih.gov

@NCICRCHDhttps://www.cancer.gov/about-nci/organization/crchd

Acknowledgements

DTBSara Hargrave, PhD, MSAlison Lin, PhDNicole McNeil Ford, PhDJohn Ojeifo, MD, PhD, MBAElena Schwartz, PhD, MSMulualem Tilahun, DVM, PhDRita LaPointe, MBASusan Macharia

iCUREAlison Lin, PhDJessica Calzola, PhD, PMPEric Johnson Chavarria, PhDEtaria Omekwe, MS

Training NavigationHana Odeh, PhD

www.cancer.gov www.cancer.gov/espanol