Università degli Studi di NapoliFacoltà di Medicina e Chirurgia

Corso di Laurea per Tecnico della Prevenzione nell’Ambiente e nei Luoghi di Lavoro

Corso di Medicina del Lavoro 4

Tossicologia Ambientale ed Occupazionale

Docente: Prof. Maurizio Manno

Three detective stories:

• A double case of acute chemical poisoning

• An unusual epidemics: the shoemakers’ polyneuropathy

• Two interesting cases of selective acute hepato-nephrotoxicity

A double case of acute chemical poisoning

Two workers were found dead in a well where they were burying barrels containing solvents and solid chemical waste from a nearby chemical plant.

brain

lung

lung

kidney

liver

An unusual winter epidemics: the shoemakers’ polyneuropathy

Two interesting cases of selective acute hepato-nephrotoxicity

In the 20’s carbon

tetrachloride was

used to treat

anchilostomiasis

infection

CONCLUSIONS

1. Understanding mechanisms of toxicity may help to clarify the causes and the clinical features of human poisoning.

2. Cases of human poisoning may help to validate mechanistic hypotheses developed in animal models.