Tossicologia ambientale e occupazionale
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Transcript of Tossicologia ambientale e occupazionale
Università degli Studi di NapoliFacoltà di Medicina e Chirurgia
Corso di Laurea per Tecnico della Prevenzione nell’Ambiente e nei Luoghi di Lavoro
Corso di Medicina del Lavoro 4
Tossicologia Ambientale ed Occupazionale
Docente: Prof. Maurizio Manno
Three detective stories:
• A double case of acute chemical poisoning
• An unusual epidemics: the shoemakers’ polyneuropathy
• Two interesting cases of selective acute hepato-nephrotoxicity
A double case of acute chemical poisoning
Two workers were found dead in a well where they were burying barrels containing solvents and solid chemical waste from a nearby chemical plant.
brain
lung
lung
kidney
liver
An unusual winter epidemics: the shoemakers’ polyneuropathy
Two interesting cases of selective acute hepato-nephrotoxicity
In the 20’s carbon
tetrachloride was
used to treat
anchilostomiasis
infection
CONCLUSIONS
1. Understanding mechanisms of toxicity may help to clarify the causes and the clinical features of human poisoning.
2. Cases of human poisoning may help to validate mechanistic hypotheses developed in animal models.