The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody

Arthrodesis

by J. Michielsen, J. Sys, A. Rigaux, and C. Bertrand

J Bone Joint Surg AmVolume 95(10):873-880

May 15, 2013

©2013 by The Journal of Bone and Joint Surgery, Inc.

The CONSORT (Consolidated Standards of Reporting Trials) diagram.

J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880

©2013 by The Journal of Bone and Joint Surgery, Inc.

J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880

©2013 by The Journal of Bone and Joint Surgery, Inc.

J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880

©2013 by The Journal of Bone and Joint Surgery, Inc.

J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880

©2013 by The Journal of Bone and Joint Surgery, Inc.

J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880

©2013 by The Journal of Bone and Joint Surgery, Inc.

The difference between the groups with respect to the mean score (and standard deviation) for bone density on the CT scan at three, six, and twelve months (p = 0.002, p = 0.024, and p = 0.014,

respectively).

J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880

©2013 by The Journal of Bone and Joint Surgery, Inc.

Difference between the groups with respect to the mean score (and standard deviation) for interbody healing on the BTB (bridging trabecular bone) scale at three, six, and twelve months (p

= 0.021, p = 0.004, p = 0.014).

J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880

©2013 by The Journal of Bone and Joint Surgery, Inc.

J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880

©2013 by The Journal of Bone and Joint Surgery, Inc.

J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880

©2013 by The Journal of Bone and Joint Surgery, Inc.

A CT scan (sagittal and horizontal reconstruction) of the fused segment in a patient who received rh-BMP-2, showing resorption of the posterior aspect of the end plates at three months and

ectopic bone and cyst formation posterior to the cages at twelve mon...

J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880

©2013 by The Journal of Bone and Joint Surgery, Inc.