The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar...
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![Page 1: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/1.jpg)
The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody
Arthrodesis
by J. Michielsen, J. Sys, A. Rigaux, and C. Bertrand
J Bone Joint Surg AmVolume 95(10):873-880
May 15, 2013
©2013 by The Journal of Bone and Joint Surgery, Inc.
![Page 2: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/2.jpg)
The CONSORT (Consolidated Standards of Reporting Trials) diagram.
J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880
©2013 by The Journal of Bone and Joint Surgery, Inc.
![Page 3: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/3.jpg)
J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880
©2013 by The Journal of Bone and Joint Surgery, Inc.
![Page 4: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/4.jpg)
J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880
©2013 by The Journal of Bone and Joint Surgery, Inc.
![Page 5: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/5.jpg)
J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880
©2013 by The Journal of Bone and Joint Surgery, Inc.
![Page 6: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/6.jpg)
J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880
©2013 by The Journal of Bone and Joint Surgery, Inc.
![Page 7: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/7.jpg)
The difference between the groups with respect to the mean score (and standard deviation) for bone density on the CT scan at three, six, and twelve months (p = 0.002, p = 0.024, and p = 0.014,
respectively).
J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880
©2013 by The Journal of Bone and Joint Surgery, Inc.
![Page 8: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/8.jpg)
Difference between the groups with respect to the mean score (and standard deviation) for interbody healing on the BTB (bridging trabecular bone) scale at three, six, and twelve months (p
= 0.021, p = 0.004, p = 0.014).
J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880
©2013 by The Journal of Bone and Joint Surgery, Inc.
![Page 9: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/9.jpg)
J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880
©2013 by The Journal of Bone and Joint Surgery, Inc.
![Page 10: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/10.jpg)
J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880
©2013 by The Journal of Bone and Joint Surgery, Inc.
![Page 11: The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,](https://reader036.fdocuments.us/reader036/viewer/2022082622/5a4d1b8a7f8b9ab0599be2f4/html5/thumbnails/11.jpg)
A CT scan (sagittal and horizontal reconstruction) of the fused segment in a patient who received rh-BMP-2, showing resorption of the posterior aspect of the end plates at three months and
ectopic bone and cyst formation posterior to the cages at twelve mon...
J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880
©2013 by The Journal of Bone and Joint Surgery, Inc.