Post on 13-Jan-2016
The Cell Migration ConsortiumThe Cell Migration Consortium
5 min;8hrPD 8
www.cellmigration.orgwww.cellmigration.org
Why Cell Migration?
Cancer Osteoporosis
Atherosclerosis
Tissue Repair& Regeneration
Birth Defects
Arthritis
Tissue Engineering
CELL MIGRATIONCELL MIGRATION
Cell Migration – Complex and Cell Migration – Complex and IntegrativeIntegrative
30 sec; 2hrs
Origins of the Consortium
• There exist significant ‘barriers to progress’ that inhibit progress in migration (and other) research
• These barriers are beyond the intellectual and financial resources of individual investigators
• The NIGMS “Glue Grant” initiative provided a mechanism to address these barriers
-require collaborative, interdisciplinary approaches-not readily supported by the R01 mechanism
Glue grant - objectives
Non R01 type research
Multi-institutional collaborations
Complex processes
- Not hypothesis driven, few experiments
- reagents, technology, information, & measurements
Glue grant - expectations
•Robust data sharing
•Significant bioinformatics via website- Organize information in the field
- Protocols, data, papers, links, & information
•Clear objectives and milestones
Consortium Objectives
• Create a “virtual institute” - multi-institutional, interdisciplinary research initiatives and facilities
• Develop innovative, cutting edge technologies and reagents and produce important new data
• Develop web-based communications for collaborative interactions information sharing
• Promote interdisciplinary research
• Promote synergy among initiatives and facilities
Consortium Research Goals
• A census of the migration proteome
• The structure of the large multi-molecular complexes that drive migration
• Probes and technology to locate, quantify, & perturb signals that are regulated spatially and temporally
• Mathematical models of migration
• Conditional knockout and knockin mice and cell lines for key migration related genes
• Imaging technology for studying migration in vivo
Bioinformatics goals
• Organize information & data
- Simple, useful, & databases
- Migration knowledge database
Annotation environment
Evidence codes – gene ontology
Readily queried
Outreach to the Community
• Timely sharing of reagents, information and data• Organize information via the comprehensive website• Sponsor migration meetings and workshops• Unify the migration community• Promote new interdisciplinary interactions• Community participation
– New opportunities and objectives
– New collaborators
Organization
Web Site
Steering Committee
Administrative Core
Development InitiativesProtein DiscoveryStructureSignalingTransgenic & Knockout Mouse Modeling
Research Support FacilitiesImaging & PhotomanipulationMass SpectrometryProtein PurificationBiomaterials
Bioinformatics Core
Migration Community
Advisory Committee
Web Site
Steering Committee
Administrative Core
Development InitiativesProtein DiscoveryStructureSignalingTransgenic & Knockout Mouse Modeling
Research Support FacilitiesImaging & PhotomanipulationMass SpectrometryProtein PurificationBiomaterials
Bioinformatics Core
Migration Community
Advisory Committee