Post on 05-Jan-2016
description
Suppl. Fig. 1 Marcotte et al. 2008
RRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKG IWIPD
RRLLQE ELVEPLTPSG PNQA +RILKETE +K +KVLGSGAFGTVYKG+WIP+
RRLLQERELVEPLTPSGE APNQAL LRILKETEF KKI KVLGSGAFGTVYKGLWIPE
ErbB2
EGFR
GENVKIPVAIKVLRENTSPKANKEILDEAYVMAG VGSPY VSRLLGICLTSTVQLVT
GE VKIPVAIK LRE TSPKANKEILDEAYVMA V +P + V RLLGICLTSTVQL +T
GEKVKIPVAIKELREATSPKANKEILDEAYVMA SVDNPHVCRLLGICLTSTVQL IT
ErbB2
EGFR
QLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNV
QLMP+GCLLD+VRE+ + + GSQ LLNWC +QIAKGM +YLED RLVHRDLAARNV
QLMPFGCLLDYVREHKDNI GSQYLLNWC VQIAKGMNYLEDRRLVHRDLAARNV
ErbB2
EGFR
LVKSPNHVKITDFGLARLLD I DETEYHADGGKVPIKWMALESILRRRFTHQSDVWS
LVK+P HVKITDFGLA+LL + E EYHA+GGKVPIKWMALESIL R +THQSDVWS
LVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWS
ErbB2
EGFR
YGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMI
YGVTVWELMTFG+KPYDGIPA EI +LEKGERLPQPPICTIDVYMI
YGVTVWELMTFGSKPYDGIPA SEIS S ILEKGERLPQPPICTIDVYMI
ErbB2
EGFR
TK1
TK2
M5 loop
*
**
875
907
819
851
766
798
710
742
922
954
Suppl. Fig. 2 Marcotte et al. 2008
100 101 102 103 104FL1-H
100
101
102
103
104
FL4-H
100 101 102 103 104FL1-H
100
101
102
103
104
FL4-H
100 101 102 103 104FL1-H
100
101
102
103
104
FL4-H
100 101 102 103 104FL1-H
100
101
102
103
104
FL4-H
A
EGFR
EV EGFR
YHAD TK
Suppl. Fig 3 Marcotte et al. 2008
Suppl. Fig 4 Marcotte et al. 2008
A
B