Preclinical Imaging Centre

Centrum voor preklinische imaging van het Radboud UMC

Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Prof. dr. Otto C. Boerman

Radboud University Nijmegen Medical Centre, The Netherlands

RTM: Radboud Translational Medicine

Discovery Screening preclinical testing Clinical trials

Radboud University Nijmegen Medical Centre, The Netherlands

RTM: Radboud Translational Medicine

Discovery Screening preclinical testing Clinical trials

Genetics

Bioinformatics Preclinical

pharmacology

Clinical

trials

Flow

cytometry

Cleanrooms

Neuroscience

unit

Robotic

operations

Preclinical

Imaging

Microscopy

Malaria lab Biobank

Big Data

Radboudumc Technology Centres

Proteomics

Metabolomics

Glycomics

Radboudumc

Technology

Centers

Alain van Gool Otto Boerman

Radboud University Nijmegen Medical Centre, The Netherlands

PRIME: Preclinical Imaging Centre

microSPECT

From human imaging to small animal imaging

Dopamine w/ 99mTc-TRODAT Neurology

Uptake of 123I-IBF by D2 receptors

Stress 99mTc-MIBI Cardiovascular

99mTc-MIBI

Renal Cell Carcinoma Oncology

[99mTc] Minigastrin

Mouse Human

*functional imaging

From human imaging to small animal imaging

Radboud University Nijmegen Medical Centre, The Netherlands

Radboud University Nijmegen Medical Centre, The Netherlands

Radboud University Nijmegen Medical Centre, The Netherlands

Radboud University Nijmegen Medical Centre, The Netherlands

Radboud University Nijmegen Medical Centre, The Netherlands

Radboud University Nijmegen Medical Centre, The Netherlands

PRIME

Preclinical Imaging Centre

PET imaging in PRIME

microSPECT

Annihilation

Radboud University Nijmegen Medical Centre, The Netherlands

FDG-PET: imaging cancer

Normal FDG-PET Metastasized Melanoma

FDG-PET: functional imaging

Monitor response to treatment

Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre

Pre treatment

4 weeks after

start of treatment

24 weeks after

start of treatment

Pre treatment

FDG-PET: functional imaging

Monitor response to treatment

Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre

Pre treatment

4 weeks after

start of treatment

24 weeks after

start of treatment

Pre treatment 1 week after start of

imatinib treatment

Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre

Pre treatment

4 weeks after

start of treatment

24 weeks after

start of treatment

FDG-PET: functional imaging

Monitor response to treatment

Pre treatment 1 week after start of

imatinib treatment

Radboud University Nijmegen Medical Centre, The Netherlands

microPET/CT scanner

Radboud University Nijmegen Medical Center, The Netherlands

- 1 day

Monitor the therapeutic effect of a new anti-cancer drug

Radboud University Nijmegen Medical Center, The Netherlands

- 1 day 1 day

Monitor the therapeutic effect of a new anti-cancer drug

Radboud University Nijmegen Medical Center, The Netherlands

- 1 day 1 day 3 days

Monitor the therapeutic effect of a new anti-cancer drug

Radboud University Nijmegen Medical Center, The Netherlands

- 1 day 1 day 3 days 7 days

Monitor the therapeutic effect of a new anti-cancer drug

Radboud University Nijmegen Medical Centre, The Netherlands

PRIME

Preclinical Imaging Centre

SPECT imaging in PRIME

microSPECT

Small animal SPECT imaging

Radboud University Nijmegen Medical Centre, The Netherlands

26

Radboud University Nijmegen Medical Centre, The Netherlands

microSPECT imaging

Radboud University Nijmegen Medical Centre, The Netherlands

Diabetes type 1: autoimmune destruction of insulin producing beta cells

Islet transplantation is a promising treatment for patients with type1 diabetes

AIM: Non-invasive in vivo determination of beta cell mass after islet transplantation.

islets

In-111-DTPA-Exendin

Imaging transplated islets of Langerhans

Radboud University Nijmegen Medical Centre, The Netherlands

Imaging transplated islets of Langerhans

Radboud University Nijmegen Medical Centre, The Netherlands

2D

3W

11W

Imaging transplated islets of Langerhans

6W

8W

In-111-Exendin

Radboud University Nijmegen Medical Centre, The Netherlands

Radboud University Nijmegen Medical Centre, The Netherlands

PRIME

Preclinical Imaging Centre

Intravital fluorescence imaging in PRIME

microSPECT

Multi-photon fluorescence microscopy

Radboud University Nijmegen Medical Centre, The Netherlands

Monitoring of tumor development using the dorsal skinfold chamber model

Multi-photon fluorescence microscopy

Radboud University Nijmegen Medical Centre, The Netherlands

Tumor cells

Extracellular

matrix, collagen,

muscle fibers

Fat cells, nerves

Blood vessels,

immune cells

Multi-photon fluorescence microscopy

Radboud University Nijmegen Medical Centre, The Netherlands

Tumor cells

Extracellular matrix,

collagen, muscle fibers

Fat cells, nerves

Blood vessels, immune

cells

Multi-photon fluorescence microscopy

Radboud University Nijmegen Medical Centre, The Netherlands

Radboud University Nijmegen Medical Center, The Netherlands

Immunofluorescence Guided Surgery

Radboud University Nijmegen Medical Center, The Netherlands

Immunofluorescence Guided Surgery

Multi-modality Imaging

Radboud University Nijmegen Medical Centre, The Netherlands

Fluorescence imaging

MRI

PET

Multiphoton imaging

Radboud University Nijmegen Medical Centre, The Netherlands

Drug development Research

Hoffmann La Roche

Novartis

Sanofi

Fuji Biotechnology

Future Chemistry

Immunomedics Inc.

Synaffix

Wilex

Milabs