SMB 28112013 Otto Boerman - PRIME Radboudumc
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Preclinical Imaging Centre Centrum voor preklinische imaging van het Radboud UMC Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Prof. dr. Otto C. Boerman
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Transcript of SMB 28112013 Otto Boerman - PRIME Radboudumc
Preclinical Imaging Centre
Centrum voor preklinische imaging van het Radboud UMC
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Prof. dr. Otto C. Boerman
Radboud University Nijmegen Medical Centre, The Netherlands
RTM: Radboud Translational Medicine
Discovery Screening preclinical testing Clinical trials
Radboud University Nijmegen Medical Centre, The Netherlands
RTM: Radboud Translational Medicine
Discovery Screening preclinical testing Clinical trials
Genetics
Bioinformatics Preclinical
pharmacology
Clinical
trials
Flow
cytometry
Cleanrooms
Neuroscience
unit
Robotic
operations
Preclinical
Imaging
Microscopy
Malaria lab Biobank
Big Data
Radboudumc Technology Centres
Proteomics
Metabolomics
Glycomics
Radboudumc
Technology
Centers
Alain van Gool Otto Boerman
Radboud University Nijmegen Medical Centre, The Netherlands
PRIME: Preclinical Imaging Centre
microSPECT
From human imaging to small animal imaging
Dopamine w/ 99mTc-TRODAT Neurology
Uptake of 123I-IBF by D2 receptors
Stress 99mTc-MIBI Cardiovascular
99mTc-MIBI
Renal Cell Carcinoma Oncology
[99mTc] Minigastrin
Mouse Human
*functional imaging
From human imaging to small animal imaging
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands
PRIME
Preclinical Imaging Centre
PET imaging in PRIME
microSPECT
Annihilation
Radboud University Nijmegen Medical Centre, The Netherlands
FDG-PET: imaging cancer
Normal FDG-PET Metastasized Melanoma
FDG-PET: functional imaging
Monitor response to treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment
FDG-PET: functional imaging
Monitor response to treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment 1 week after start of
imatinib treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
FDG-PET: functional imaging
Monitor response to treatment
Pre treatment 1 week after start of
imatinib treatment
Radboud University Nijmegen Medical Centre, The Netherlands
microPET/CT scanner
Radboud University Nijmegen Medical Center, The Netherlands
- 1 day
Monitor the therapeutic effect of a new anti-cancer drug
Radboud University Nijmegen Medical Center, The Netherlands
- 1 day 1 day
Monitor the therapeutic effect of a new anti-cancer drug
Radboud University Nijmegen Medical Center, The Netherlands
- 1 day 1 day 3 days
Monitor the therapeutic effect of a new anti-cancer drug
Radboud University Nijmegen Medical Center, The Netherlands
- 1 day 1 day 3 days 7 days
Monitor the therapeutic effect of a new anti-cancer drug
Radboud University Nijmegen Medical Centre, The Netherlands
PRIME
Preclinical Imaging Centre
SPECT imaging in PRIME
microSPECT
Small animal SPECT imaging
Radboud University Nijmegen Medical Centre, The Netherlands
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Radboud University Nijmegen Medical Centre, The Netherlands
microSPECT imaging
Radboud University Nijmegen Medical Centre, The Netherlands
Diabetes type 1: autoimmune destruction of insulin producing beta cells
Islet transplantation is a promising treatment for patients with type1 diabetes
AIM: Non-invasive in vivo determination of beta cell mass after islet transplantation.
islets
In-111-DTPA-Exendin
Imaging transplated islets of Langerhans
Radboud University Nijmegen Medical Centre, The Netherlands
Imaging transplated islets of Langerhans
Radboud University Nijmegen Medical Centre, The Netherlands
2D
3W
11W
Imaging transplated islets of Langerhans
6W
8W
In-111-Exendin
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands
PRIME
Preclinical Imaging Centre
Intravital fluorescence imaging in PRIME
microSPECT
Multi-photon fluorescence microscopy
Radboud University Nijmegen Medical Centre, The Netherlands
Monitoring of tumor development using the dorsal skinfold chamber model
Multi-photon fluorescence microscopy
Radboud University Nijmegen Medical Centre, The Netherlands
Tumor cells
Extracellular
matrix, collagen,
muscle fibers
Fat cells, nerves
Blood vessels,
immune cells
Multi-photon fluorescence microscopy
Radboud University Nijmegen Medical Centre, The Netherlands
Tumor cells
Extracellular matrix,
collagen, muscle fibers
Fat cells, nerves
Blood vessels, immune
cells
Multi-photon fluorescence microscopy
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Center, The Netherlands
Immunofluorescence Guided Surgery
Radboud University Nijmegen Medical Center, The Netherlands
Immunofluorescence Guided Surgery
Multi-modality Imaging
Radboud University Nijmegen Medical Centre, The Netherlands
Fluorescence imaging
MRI
PET
Multiphoton imaging
Radboud University Nijmegen Medical Centre, The Netherlands
Drug development Research
Hoffmann La Roche
Novartis
Sanofi
Fuji Biotechnology
Future Chemistry
Immunomedics Inc.
Synaffix
Wilex
Milabs
