Sex determinatio

n&

differentiationMayank Agarwal

Kanika Singh

Sex DeterminationoEstablish at the time of fertilization

Sex Differentiationo Differentiation of gonadso Differentiation of internal genitaliao Differentiation of external genitalia

Differentiation of Gonads

6 weeks intrauterine life

6 weeks intrauterine life

Differentiation of Internal Genitalia

6 weeks

8 weeks

10-12 weeks

Differentiation of External Genitalia

5α reductase

Disorders of sex developmentChromosomal Abnormalitieso Seminiferous Tubule Dysgenesis (XXY)o Gonadal Dysgenesis (XO)o Super-female (XXX)o True hermaphroditism

Hormonal Abnormalitieso Pseudo-hermaphroditism Female

Male

Chromosomal Abnormalities

• Turner Syndrome • Klinefelter Syndrome

Hormonal Abnormalities Female Pseudo-hermaphroditism• Exposure to androgens during 8-13th weeks of

gestation• Congenital virilising adrenal hyperplasia

Male pseudo-hermaphroditism• Defective testicular development• Androgen resistance

5α reductase deficiency Mutation of androgen receptor gene

Androgen insensitivity syndrome

5α reductase deficiency

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ThankYou