Sex determination and differentiation
-
Upload
dr-mayank-agarwal -
Category
Health & Medicine
-
view
25 -
download
0
Transcript of Sex determination and differentiation
Sex determinatio
n&
differentiationMayank Agarwal
Kanika Singh
Sex DeterminationoEstablish at the time of fertilization
Sex Differentiationo Differentiation of gonadso Differentiation of internal genitaliao Differentiation of external genitalia
Differentiation of Gonads
6 weeks intrauterine life
6 weeks intrauterine life
Differentiation of Internal Genitalia
6 weeks
8 weeks
10-12 weeks
Differentiation of External Genitalia
5α reductase
Disorders of sex developmentChromosomal Abnormalitieso Seminiferous Tubule Dysgenesis (XXY)o Gonadal Dysgenesis (XO)o Super-female (XXX)o True hermaphroditism
Hormonal Abnormalitieso Pseudo-hermaphroditism Female
Male
Chromosomal Abnormalities
• Turner Syndrome • Klinefelter Syndrome
Hormonal Abnormalities Female Pseudo-hermaphroditism• Exposure to androgens during 8-13th weeks of
gestation• Congenital virilising adrenal hyperplasia
Male pseudo-hermaphroditism• Defective testicular development• Androgen resistance
5α reductase deficiency Mutation of androgen receptor gene
Androgen insensitivity syndrome
5α reductase deficiency
Bibliographyo Hall JE. Guyton and Hall text book of medical physiology. 13 ed. USA:
Elsevier; 2016.
o Barret KE, Boitano S, Barman SM, Brooks HL. Ganong’s review of medical physiology. 25 ed. New Delhi: Tata McGraw-Hill; 2016.
o Widmaier EP, Raff H, Strang KT. Vander’s human physiology the mechanism of body function. 14 ed. USA: Tata McGrwa-Hill; 2016.
o Fox SI. Human physiology. 14 ed. USA: Tata McGraw-Hill; 2016.
o Sherwood L. Human physiology from cells to systems. 9 ed. Canada: Cengage Learning; 2014.
o Rhoades RA, Bell DR. Medical physiology principles for clinical medicine. 4 ed. China: Lippincott Williams & Wilkins; 2013.
o Silverthorn DU. Human physiology an integrated approach. 6 ed. Delhi: Pearson Education; 2013.
ThankYou