PATHOPHYSIOLOGY

Chronic Hypertension with Superimposed Preeclampsia

PREDISPOSING FACTORS

-Age (42y/o) -Family History HTN -Medical History

PRECIPITATING FACTORS -High-salt, high-fat diet

Activation of Sympathetic

Nervous System

Endothelial damage

- heart rate - cardiac contractility - produces widespread vasoconstriction

in the peripheral arterioles

uterine placental blood flow

-severe headache

-dizziness - vomiting -loss of normal balance -Muscle Strength

Grading 2/5, left side of the body -unable to sit without support

VASOPASMS

Peripheral resistance

Abnormal clotting occurs

N.O., Prostacyclin, Endothelin

renal perfusion

Angiotensin I Angiotensinogen

renin

Juxtaglomerular cells

ELEVATED BP compression of brain

A-C-E

Acute Cerebellar Hemmorhage

Increased IOP

Premature delivery

Adrenal cortex

Angiotensin II

aldosterone

Na reabsorption

H2O reabsorption

Arteriolar vasoconstriction

-blurring of vision